This book is about the field of brain-computer interfaces (BCI) and the unique and special environment of active implants that electrically interface with the brain, spinal cord, peripheral nerves, and organs. At the heart of the book is the matter of repairing and rehabilitating patients suffering from severe neurologic impairments, from paralysis to movement disorders and epilepsy, that often requires an invasive solution based on an implanted device. Past achievements, current work, and future perspectives of BCI and other interactions between medical devices and the human nervous system are described in detail from a pragmatic point of view. Reviews the Active Implantable Medical Devices (AIMDs) industry and how it is moving from cardiac to neuro applications Clear, easy to read, presentation of the field of neuro-technologies for human benefit Provides easy to understand explanations about the technical limitations, the physics of implants in the human body, and realistic long terms perspectives

This book examines discrete dynamical systems with memory-nonlinear systems that exist extensively in biological organisms and financial and economic organizations, and time-delay systems that can be discretized into the memorized, discrete dynamical systems. It book further discusses stability and bifurcations of time-delay dynamical systems that can be investigated through memorized dynamical systems as well as bifurcations of memorized nonlinear dynamical systems, discretization methods of time-delay systems, and periodic motions to chaos in nonlinear time-delay systems. The book helps readers find analytical solutions of MDS, change traditional perturbation analysis in time-delay systems, detect motion complexity and singularity in MDS; and determine stability, bifurcation, and chaos in any time-delay system.

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.

This book highlights the positive and negative impacts that hemp fibre and textiles have on environment, while studying the effects of climate change on the growth of fibre hemp. Human-induced climate change challenge the availability of textile fibres, whereas today's apparel industry leaves behind a substantial environmental footprint. Sustainable hemp textiles can lighten it. The book describes the environmental impact of hemp and how climate change influences future hemp growth. Hemp is considered in most literature as a sustainable alternative for the commonly used fibres polyester and cotton. However, most research does not go farther than the environmental impacts of hemp, and there is currently a lack of knowledge/literature that examines the possibilities of hemp growth under changing climate conditions.

'A dazzling, beguiling story . . . told at an exhilarating pace' Literary Review 'Henry Gee makes the kaleidoscopically changing canvas of life understandable and exciting. Who will enjoy reading this book? - Everybody!' Jared Diamond, author of Guns, Germs, and Steel For billions of years, Earth was an inhospitably alien place - covered with churning seas, slowly crafting its landscape by way of incessant volcanic eruptions, the atmosphere in a constant state of chemical flux. And yet, despite facing literally every conceivable setback that living organisms could encounter, life has been extinguished and picked itself up to evolve again. Life has learned and adapted and continued through the billions of years that followed. It has weathered fire and ice. Slimes begat sponges, who through billions of years of complex evolution and adaptation grew a backbone, braved the unknown of pitiless shores, and sought an existence beyond the sea. From that first foray to the spread of early hominids who later became Homo sapiens, life has persisted, undaunted. A (Very) Short History of Life is an enlightening story of survival, of persistence, illuminating the delicate balance within which life has always existed, and continues to exist today. It is our planet like you've never seen it before. Life teems through Henry Gee's lyrical prose - colossal supercontinents drift, collide, and coalesce, fashioning the face of the planet as we know it today. Creatures are engagingly personified, from 'gregarious' bacteria populating the seas to duelling dinosaurs in the Triassic period to magnificent mammals with the future in their (newly evolved) grasp. Those long extinct, almost alien early life forms are resurrected in evocative detail. Life's evolutionary steps - from the development of a digestive system to the awe of creatures taking to the skies in flight - are conveyed with an alluring, up-close intimacy.

This broad and thought-provoking volume provides an overview of recent intellectual and scientific advances that bridge the gap between psychiatry and neuroscience, offering a wide range of penetrating insights in both disciplines. The third volume on the topic in the last several years from a varying panel of international experts, this title identifies the borders, trends and implications in both fields today and goes beyond that into related disciplines to seek out connections and influences. Similar to its two Update book predecessors, Psychiatry and Neuroscience - Volume III presents the current state-of-the-art in the main disciplines - psychiatry and neuroscience - and attempts to provide deeper comprehension or explication of the normal and diseased human mind, its biological correlates and its biographical and existential implications. This engaging volume continues the previous style of exploring different disciplines and trying to integrate disciplinary evidence from varying points of view in an organic manner. Developed for clinicians and researchers in the fields of medicine, psychiatry, psychology and biology, this third volume also will be of great interest to students and university professors of diverse disciplines.

This volume covers the global history of the Lysenko controversy, while exploring in greater depth the background of D. Lysenko's career and influence in the USSR. By presenting the rise and fall of T.D. Lysenko in a variety of aspects-his influence upon art, unrecognized predecessors, and the extent to which genetics continued in the USSR even while he was in power, and the revival of his reputation today-the authors provide a fresh perspective on one of the most notorious episodes in the history of science.

A global synthesis of the impacts of wildfires and controlled burning on insects, bringing together much hitherto scattered information to provide a guide to improved conservation management practice. The great variety of responses by insect species and assemblages demonstrates the often subtle balance between fire being a severe threat and a vital management component. Examples from many parts of the world and from diverse biotopes and production systems display the increasingly detailed appreciation of fire impacts on insects in terrestrial and freshwater environments and the ways in which prescribed burning may be tailored to reduce harmful ecological impacts and incorporated into protocols for threatened species and wider insect conservation benefits.

Since its discovery in 1998, RNA interference (RNAi) has heralded the advent of novel tools for biological research and drug discovery. This exciting new technology is emerging as a powerful modality for battling some of the most notoriously challenging viral clinical targets, such as the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV). However, several critical issues associated with this novel technology must be resolved before it can progress to testing in human clinical trials, and these have been the target of intensive research in recent years. In this book, expert RNAi specialists from around the world have teamed up to produce a timely and thought-provoking review of the area. The two central themes are: 1) the latest findings on RNAi-virus interactions and 2) progress in the development of RNAi-based antiviral therapeutics. A number of chapters explain general concepts concerned with the role of RNAi in natural antiviral defense mechanisms. Other chapters discuss how to improve the efficacy and safety of RNAi-based antiviral drugs, as well as describe how this technology is being developed as a new therapeutic tool for fighting specific viruses, including HIV, HCV, and respiratory viruses. The book also outlines potential new avenues for research. RNA Interference and Viruses is essential reading for researchers involved in RNAi or antiviral research and is a recommended text for all virology laboratories.

This is a fascinating encyclopedia comparing the most important adaptations and evolutions in the natural world with the most important discoveries and inventions of human history. Welcome to the amazing world of adaptations, where species-including humans-develop fascinating new capabilities to ensure a competitive edge in their environment, or in some cases, survival itself. Encyclopedia of Adaptations in the Natural World is a wide-ranging catalog of the most important of those adaptations-from photosynthesis to the the peculiar "vampire"-like behavior of the tiny life form called the prion. The seven chapters in the Encyclopedia cover the key survival challenges all organisms face. Entries within those chapters cover specific adaptations from all forms of life, including animals, plants, bacteria, algae, fungi, and viruses. For each adaptation, the book also describes a related technological breakthrough in the human world, showing how engineers today study natural processes to help them develop new inventions. Provides diagrams of the process of photosynthesis, the functional areas of the human brain, and the bluefin tuna Includes 58 photographs and electron microscope images illustrating the adaptations in the book Presents bibliographic listings of key reference books, internet resources, and academic papers for further reading

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

Our understanding of human color vision has advanced tremendously in recent years, helped along by many new discoveries, ideas, and achievements. It is therefore timely that these new developments are brought together in a book, assembled specifically to include new research and insight from the leaders in the field. Although intentionally not exhaustive, many aspects of color vision are discussed in this Springer Series in Vision Research book including: the genetics of the photopigments; the anatomy and physiology of photoreceptors, retinal and cortical pathways; color perception; the effects of disorders; theories on neuronal processes and the evolution of human color vision. Several of the chapters describe new, state-of-the-art methods within genetics, morphology, imaging techniques, electrophysiology, psychophysics, and computational neuroscience. The book gives a comprehensive overview of the different disciplines in human color vision in a way that makes it accessible to specialists and non-specialist scientists alike. About the Series: The Springer Series in Vision Research is a comprehensive update and overview of cutting edge vision research, exploring, in depth, current breakthroughs at a conceptual level. It details the whole visual system, from molecular processes to anatomy, physiology and behavior and covers both invertebrate and vertebrate organisms from terrestrial and aquatic habitats. Each book in the Series is aimed at all individuals with interests in vision including advanced graduate students, post-doctoral researchers, established vision scientists and clinical investigators. The series editors are N. Justin Marshall, Queensland Brain Institute, The University of Queensland, Australia and Shaun P. Collin, Neuroecology Group within the School of Animal Biology and the Oceans Institute at the University of Western Australia.

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

This book takes the reader on a journey, navigating the enigmatic aspects of cooperation; a journey that starts inside the body and continues via our thoughts to the human super-organism. Cooperation is one of life's fundamental principles. We are all made of parts - genes, cells, organs, neurons, but also of ideas, or 'memes'. Our societies too are made of parts - us humans. Is all this cooperation fundamentally the same process? From the smallest component parts of our bodies and minds to our complicated societies, everywhere cooperation is the organizing principle. Often this cooperation has emerged because the constituting parts have benefited from the interactions, but not seldom the cooperating units appear to lose on the interaction. How then to explain cooperation? How can we understand our intricate societies where we regularly provide small and large favors for people we are unrelated to, know, or even never expect to meet again? Where does the idea come from that it is right to risk one's life for country, religion or freedom? The answers seem to reside in the two processes that have shaped humanity: biological and cultural evolution.

In its first English-language edition, this book introduces the many-faceted interactions of animal populations with their habitats. From soil fauna, ants and termites to small and large herbivores, burrowing mammals and birds, the author presents a comprehensive analysis of animals and ecosystems that is as broad and varied as all nature. Chapter 2 addresses the functional role of animals in landscape ecosystems, emphasizing fluxes of energy and matter within and between ecosystems, and the effects of animals on qualitative and structural habitat change. Discussion includes chapters on the role of animal population density and the impacts of native herbivores on vegetation and habitats from the tropics to the polar regions. Cyclic mass outbreaks of species such as the larch bud moth in Switzerland, the mountain pine beetle and the African red-billed weaver bird are described and analyzed. Other chapters discuss Zoochory - the dispersal of seeds by ants, mammals and birds - and the influence of burrowing animals on soil development and geomorphology. Consideration extends to the impact of feral domestic animals. Chapter 5 focuses on problems resulting from introduction of alien animals and from re-introduction of animal species to their original habitats, discusses the effects on ecosystems of burrowing, digging and trampling by animals. The author also addresses keystone species such as kangaroo rats, termites and beavers. Chapter 6 addresses the role of animals in landscape management and nature conservation, with chapters on the impact of newcomer species such as animals introduced into Australia, New Zealand and Europe, and the consequences of reintroduction of species to original habitat. It also discusses the carrying capacity of natural habit, public attitudes toward conversation and more. The final section ponders the effects of climate on interactions between animals and their habitats.

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

ATP acts as main energy source and is pivotal for numerous signaling cascades both inside the cells (by fuelling various transport systems and donating phosphate groups) and between the cells (by chemical transmission). Similarly glutamate acts as an important molecule for both intercellular signaling though glutamatergic transmission and cell energetics by contributing to ATP production. In this collection of chapters, written by the leading experts in the field of cell metabolism and energetics, intracellular signaling and neurotransmission we covered various aspects of the interfacing between these two fundamental molecules. This book will be particularly useful for researchers, students, physicians and psychotherapists working in the field of neurobiology, neurology and psychiatry.

This book examines the academic discussion on climate engineering as an instance of politicization - as a subject of deliberation and decision-making. It traces legitimizing and delegitimizing frames applied to discuss both Carbon Dioxide Removal and Solar Radiation Management approaches in academic publications, and their implications for political decision-making. Moreover, it offers insights into how academic discourse on climate technology can influence political decision-making - especially at a technological stage where a socio-technical system with a high degree of inertia does not (yet) exist. The high degree of diversity of frames in the academic discussion is understood as an opportunity for deliberate decision-making concerning the future roles of these approaches in global climate policy. This book demonstrates how insights from science and technology studies can be operationalized in empirical political analysis. It appeals to scholars in both political science and environmental science who are interested in climate change policy-making and the science-policy nexus.

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components - Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists' focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Humans have changed ecosystems more rapidly and extensively in the last 50 years than in any comparable period of human history. We have done this to meet the growing demands for food, fresh water, timber, fiber, and fuel. While changes to ecosystems have enhanced the well-being of billions of people, they have also caused a substantial and largely irreversible loss in diversity of life on Earth, and have strained the capacity of ecosystems to continue providing critical services.
Among the findings:
Approximately 60% of the services that support life on Earth are being degraded or used unsustainably. The harmful consequences of this degradation could grow significantly worse in the next 50 years.
Only four ecosystem services have been enhanced in the last 50 years: crops, livestock, aquaculture, and the sequestration of carbon.
The capacity of ecosystems to neutralize pollutants, protect us from natural disasters, and control the outbreaks of pests and diseases is declining significantly.
Terrestrial and freshwater systems are reaching the limits of their ability to absorb nitrogen.
Harvesting of fish and other resources from coastal and marine systems is compromising their ability to deliver food in the future.
Richly illustrated with maps and graphs, Current State and Trends presents an assessment of Earth's ability to provide twenty-four distinct services essential to human well-being. These include food, fiber, and other materials; the regulation of the climate and fresh water systems; underlying support systems such as nutrient cycling; and the fulfillment of cultural, spiritual, and aesthetic values. The volume pays particular attention to the current healthof key ecosystems, including inland waters, forests, oceans, croplands, and dryland systems, among others. It will be an indispensable reference for scientists, environmentalists, agency professionals, and students.

The book focuses on four broad topics related to trapping of agriculturally important tephritid fruit flies, namely i) lures and traps, ii) invasion biology and detection of infestations, iii) attract and kill systems, and iv) trade regulations and risk assessment. This comprehensive structure progresses from the biological interaction between insect and lures/traps to the area-wide use of trapping systems to the utilization and impact of trapping data on international trade. The chapters include accounts of earlier research but are not simply compendia and instead evaluate past and current work as a tool for critical analysis and proposal of productive avenues for future work. At present there is no book available that deals with fruit fly trapping in such a broad context. Our book fills this gap and serves as a global reference for both those interested in fruit flies specifically as well as anyone dealing with the threat of invasive agricultural insects in general.

This volume presents the current state of laser-assisted bioprinting, a cutting edge tissue engineering technology. Nineteen chapters discuss the most recent developments in using this technology for engineering different types of tissue. Beginning with an overview, the discussion covers bioprinting in cell viability and pattern viability, tissue microfabrication to study cell proliferation, microenvironment for controlling stem cell fate, cell differentiation, zigzag cellular tubes, cartilage tissue engineering, osteogenesis, vessel substitutes, skin tissue and much more. Because bioprinting is on its way to becoming a dominant technology in tissue-engineering, Bioprinting in Regenerative Medicine is essential reading for those researching or working in regenerative medicine, tissue engineering or translational research. Those studying or working with stem cells who are interested in the development of the field will also find the information invaluable.

This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.