Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the
major excitatory neurotransmitter, and the serotonergic system is
one of the best studied and understood transmitter systems. It is
crucially involved in the organization of virtually all behaviours
and in the regulation of emotion and mood. Alterations in the
serotonergic system, induced by e.g. learning or pathological
processes, underlie behavioural plasticity and changes in mood,
which can finally results in abnormal behaviour and psychiatric
conditions. Not surprisingly, the serotonergic system and its
functional components appear to be targets for a multitude of
pharmacological treatments - examples of very successful drugs
targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded
our view on serotonin but also revealed in much more detail an
astonishing complexity of this system, which comprises a multitude
of receptors and signalling pathways. A detailed view on its role
in basal, but also complex, behaviours emerged, and, was presented
in a number of single review articles. Although much is known now,
the serotonergic system is still a fast growing field of research
contributing to our present understanding of the brains function
during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview
over the many facets of behavioural serotonin research. As such, it
will provide the most up to date and thorough reading concerning
the serotonergic systems control of behaviour and mood in animals
and humans. The goal is to create a systematic overview and first
hand reference that can be used by students and scholars alike in
the fields of genetics, anatomy, pharmacology, physiology,
behavioural neuroscience, pathology, and psychiatry. The chapters
in this book will be written by leading scientists in this field.
Most of them have already written excellent reviews in their field
of expertise.
The book is divided in 4 sections. After an historical
introduction, illustrating the growth of ideas about serotonin
function in behaviour of the last forty years, section A will focus
on the functional anatomy of the serotonergic system. Section B
provides a review of the neurophysiology of the serotonergic system
and its single components. In section C the involvement of
serotonin in behavioural organization will be discussed in great
detail, while section D deals with the role of serotonin in
behavioural pathologies and psychiatric disorders.
* The first handbook broadly discussing the behavioral neurobiology
of the serotonorgic transmitter system
* Co-edited by one of the pioneers and opinion leaders of the past
decades, Barry Jacobs (Princeton), with an international list (10
countries) of highly regarded contributors providing over 50
chapters, and including the leaders in the field in number of
articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier,
G.K. Aghajanian, E. C. Azmitia, and others
* The only integrated and complete resource on the market
containing the best information integrating international research,
providing a global perspective to an international community.
* Of great value not only for researchers and experts, but also for
students and clinicians as a background reference.
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