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Books > Academic & Education > Professional & Technical > Neuroscience
Among the most interesting fields in research are the emerging
possibilities to interface the human brain directly with machines,
e.g. with computers and robotic interfaces. The European Space
Agency's Advanced Concept team as a multidisciplinary team from
engineering, artificial intelligence, and neural engineering has
been working on the cutting edge of exploring brain machine
interfaces for application in space as solutions to limitations
astronauts face in space, and this book for the first time presents
the state-of-the-art-cohesively.
This textbook provides a thorough and comprehensive overview of the
human brain and spinal cord for medical and graduate students as
well as residents in the clinical neurosciences. Standing on the
shoulders of training from outstanding scientist-teacher mentors
and based on more than 30 years of experience teaching about the
brain and spinal cord to medical and graduate students, this single
authored text presents everything the reader would need as they
begin their study of the nervous system. At the same time the
experienced neuroscientist will find much useful and valuable
information in these pages that is based almost exclusively on
studies in experimental primates and observations in humans. Every
effort has been made to present the complexities of the nervous
system as simply and clearly as possible. The careful reader will
discover a clarity and depth of coverage that makes the reading
both instructional and enjoyable. Topics are presented logically
and the text in an easy-to-read style. The accompanying line
drawings emphasize important concepts in a clear and uncluttered
manner.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. In this volume, invited experts provide
authoritative reviews on various aspects of Monoamine Oxidase and
its Inhibitors.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. This volume reviews existing theories and
current research surrounding the movement disorder
Dyskinesia.
This book presents the essentials of behavioral test methodology needed for effective study planning and high quality behavioral data collection on laboratory mice. The broad scope of behavioral testing in relation to the neurosciences is discussed, as are thefine details of varioustest situations. Mistakes made in past research are scrutinized and lessons are drawn about how to avoid them in future work. Diverse factors that can influence the results of behavioral experiments are discussed, ranging from the specific parameters employed in a test to the laboratory environment outside the test situation itself. Throughout the book, emphasis is placed on special issues that arise when testing genetically different mice, including inbred strains and mice with targeted mutations. This knowledge will assist an investigator who lacks formal training in behavioral psychology to build a behavioral testing lab and insure that its output meets current standards of good practice in behavioral neuroscience research. The book will be a convenient manual of procedures for daily use
in studies of mouse behavior. It will be of interest even to
experienced behavioural researchers, but of particular value to
scientists just beginning work with mice, including undergraduate
and graduate students as well as postdoctoral investigators who
want to collect phenotypic data with knockout and other genetically
defined mice. Constructed from materials used in a long running
course on Advanced Animal Behavior at University of North
Carolina-Greensboro, the book is an ideal text for a course on
behavioral testing.
This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience. All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.
"Epigenetic Regulation in the Nervous System" addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winningvolume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this
book offers a comprehensive review of behavioral epigenetics and a
balanced treatment of the strengths and weaknesses in
experimentation in this area. Covering background material as well
as topics of current interest, it serves both as a cutting-edge
resource and a foundational reference. The book will benefit
neuroscience researchers and graduate students with an interest in
the links between gene regulation and behavior, as will clinicians
dealing with disorders such as addiction, depression, and
schizophrenia.
This well-established international series examines major areas of
basic and clinical research within neuroscience, as well as
emerging and promising subfields.This volume explores
interdisciplinary research on decision making taking a neural and
behavioural approach
This issue of International Review of Neurobiology is split over 2
volumes, bringing together cutting-edge research on Bioinformatics
of Behavior. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
Neurological Rehabilitation is the latest volume in the definitive
Handbook of Clinical Neurology series. It is the first time that
this increasing important subject has been included in the series
and this reflects the growing interest and quality of scientific
data on topics around neural recovery and the practical
applications of new research. The volume will appeal to clinicians
from both neurological and rehabilitation backgrounds and contains
topics of interest to all members of the multidisciplinary clinical
team as well as the neuroscience community. The volume is divided
into five key sections. The first is a summary of current research
on neural repair, recovery and plasticity. The authors have kept
the topics readable for a non-scientific audience and focused on
the aspects of basic neuroscience that should be most relevant to
clinical practice. The next section covers the basic principles of
neurorehabilitation, including excellent chapters on learning and
skill acquisition, outcome measurement and functional neuroimaging.
The key clinical section comes next and includes updates and
reviews on the management of the main neurological disabling
physical problems, such as spasticity, pain, sexual functioning and
dysphagia. Cognitive, emotional and behavioural problems are just
as important and are covered in the next section, with excellent
chapters, for example, on memory and management of executive
dysfunction. The final part draws the sections on symptom
management together by discussing the individual diseases that are
most commonly seen in neurorehabilitation and providing an overview
of the management of the disability associated with those
disorders. The volume is a definitive review of current
neurorehabilitation practice and will be valuable to a wide range
of clinicians and scientists working in this rapidly developing
field.
This issue of "Progress in Brain Research" is split over 2 volumes,
bringing together cutting-edge research on functional neural
transplantation. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
Epilepsy, Part I, "Basic Principles and Diagnosis," Volume 107,
in the"Handbook of Clinical Neurology"series offers a comprehensive
review of our knowledge of the field today, including epidemiology,
basic mechanisms, animal models, and topics of increasing interest
such as the role of inflammation in epilepsy. It provides a
comprehensive approach to description of the clinical,
electrographic and imaging aspects of the epilepsies, with a clear
outline of contemporary classification and the role of modern
diagnostic techniques, as well as neuropsychological and
psychiatric aspects of epilepsy. Chapters are authored by
internationally respected neurologists with varied perspectives
insuring depth to the content. "Epilepsy, Part II," "Treatment, "
Volume 108, continues coverage of epilepsy with a focus on
treatment. The volumes will be a very important resource for basic
scientists, clinical investigators, and all health professionals
treating patients with epilepsy.
Epilepsy, Part II, "Treatment, " Volume 108, provides a full
description of epilepsy pathology and etiology, antiepileptic drug
treatment, the approach to surgical evaluation and alternative
procedures to be considered, in both children and adults, as well
as brain stimulation and diet treatment. Economic and psychosocial
issues such as stigma are fully covered. The special problems of
epilepsy treatment in the developing world are described. Chapters
are authored by internationally respected neurologists with varied
perspectives insuring depth to the content. "Epilepsy, Part I,"
"Basic Principles and Diagnosis," Volume 107, establishes the
scientific and practical diagnosis of epilepsy. The volumes will be
a very important resource for basic scientists, clinical
investigators, and all health professionals treating patients with
epilepsy.
Gap junctions between glial cells or neurons are ubiquitously
expressed in the mammalian brain and play a role in brain
development including cell differentiation, cell migration and
survival, and tissue homeostasis, as well as in human diseases
including hearing loss, neuropathies, epilepsy, brain trauma, and
cardiovascular disease. This volume provides neuroscience
researchers and students with a single source for information
covering the physiological, behavioral and pathophysiological roles
of gap junctions in the brain. In addition, the book also discusses
human disease conditions associated with mutations in single gap
junction connexion genes, making it applicable to clinicians doing
translational research. Finally, it includes reviews of
pharmacological studies with gap junction blockers and openers,
summarizing information obtained from phenotyping gap junctions
mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes. Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
The imaging of small cellular components requires powerful
instruments, and an entire family of equipment and techniques based
on the confocal principle has been developed over the past 30
years. Such methods are commonly used by neuroscience researchers,
but the majority of these users do not have a microscopy or a cell
biology backgrounds and do can encounter difficulties in obtaining
and interpreting results. This volume brings experts in
high-resolution optical microscopy applications in neuroscience and
cell biology together to document the state of the art. Outlining
what is currently possible, the volume also discusses promising
developments for the future and aids readers in selecting the most
scientifically meaningful approach to solve their questions. Each
chapter discusses instrumentation and technology in relationship to
application in research. All of the common and cutting edge trends
are covered - fluorescence / laser electron / nonlinear microscopy,
infrared fluorescence, multiphoton imaging, tomography, FRAP, live
imaging, STED, PALM/STORM, etc.
This new volume in the Handbook of Clinical Neurology presents a
comprehensive review of the fundamental science and clinical
treatment of psychiatric disorders. Advances in neuroscience have
allowed for dramatic advances in the understanding of psychiatric
disorders and treatment. Brain disorders, such as depression and
schizophrenia, are the leading cause of disability worldwide. It is
estimated that over 25% of the adult population in North America
are diagnosed yearly with at least one mental disorder and similar
results hold for Europe. Now that neurology and psychiatry agree
that all mental disorders are in fact, "brain diseases," this
volume provides a foundational introduction to the science defining
these disorders and details best practices for psychiatric
treatment.
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are
starting to have impact on fields ranging from metabolism to
development to cardiology. The book contains a dozen chapters
written by world experts on these topics, half focusing on the
optogenetic molecular tools themselves, and half on the genetic and
hardware approaches that make them powerfully useful in intact
tissues and organisms.
This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system. Clinicians will find this handbook to be an invaluable resource
for summarizing the present state of scientific and clinical
knowledge in the field of neuro-oncology. In addition,
practitioners in the field will uncover new tactics and therapies
that will aid them in providing optimal neuro-oncological care for
their patients.
Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.
This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology. Written by internationally-renowned scientists, this timely
volume will be of wide interest to students, scholars, science
journalists, and a variety of experts who are interested in keeping
track of the discoveries that are rapidly emerging about the
evolution of the brain and cognition. Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.
This volume provides clinicians and scientists with the latest information concerning the muscular dystrophies, paying special attention to the way advancements in molecular and cell biology, biochemistry, and other biological sciences provide comprehensive insights into a group of disorders that have only been studied for the past two decades. Information on both pathogenesis and prospects for treatment are
covered, with an emphasis on clinical implications, both now and in
the foreseeable future. Clinical wisdom is combined with invaluable
perspectives from the most highly experienced physicians, experts,
and scientists to bring an authoritative and complete examination
of the muscular dystrophies, their diagnosis, and treatments
protocols. Insights from this handbook will both enhance and
forward efforts for practitioners who care for, and manage,
patients with this group of disorders.
The previous two editions of the "Human Nervous System "have
been the standard reference for the anatomy of the central and
peripheral nervous system of the human. The work has attracted
nearly 2,000 citations, demonstrating that it has a major influence
in the field of neuroscience. The 3e is a complete and updated
revision, with newchapters covering genes and anatomy, gene
expression studies, and glia cells. The book continues to be an
excellent companion to the "Atlas of the Human Brain," and a common
nomenclature throughout the book is enforced. Physiological data,
functional concepts, and correlates to the neuroanatomy of the
major model systems (rat and mouse) as well as brain function round
out the new edition.
Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field. This volume emphasizes essential observations from all of the
important clinical phases involved in any neuromodulation:
targeting, intraoperative assessment, programming, complications,
and complication avoidance. There are commonalities to all
neuromodulation procedures that must be brought to the forefront to
form a cohesive presentation of neuromodulation, and such emphasis
will give readers a more solid grounding in the fundamentals needed
to embrace this field as a cohesive clinical entity.
One of the most pressing questions in neuroscience, psychology
and economics today is how does the brain generate preferences and
make choices? With a unique interdisciplinary approach, this volume
is among the first to explore the cognitive and neural mechanisms
mediating the generation of the preferences that guide choice. From
preferences determining mundane purchases, to social preferences
influencing mating choice, through to moral decisions, the authors
adopt diverse approaches to answer the question. Chapters explore
the instability of preferences and thecommon neural processes that
occur across preferences. Edited by one of the world s most
renowned cognitive neuroscientists, each chapter is authored by an
expert in the field, with a host of international
contributors.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. This volume reviews existing theories and
current research surrounding the movement disorder
Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist |
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