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This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology.
Written by internationally-renowned scientists, this timely
volume will be of wide interest to students, scholars, science
journalists, and a variety of experts who are interested in keeping
track of the discoveries that are rapidly emerging about the
evolution of the brain and cognition.
Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.
Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.
Edited by two leaders in the field, this volume offers a current
survey and synthesis of the most important findings of the
neuroscience behind autism of the past 20 years. With chapters
authored by experts in each topic, the volume explores etiology,
neuropathology, imaging, and pathways/models. Offering a broad
background of ASDs with a unique focus on neurobiology, the volume
offers more than the others on the market with a strictly clinical
focus or a single authored perspective that fails to offer expert,
comprehensive coverage. Researchers and graduate students alike
with an interest in developmental disorders and autism will
benefit, as will autism specialists across psychology and medicine
looking to expand their expertise.
Written by Caleb Finch, one of the leading scientists of our time,
The Biology of Human Longevity - Inflammation, Nutrition, and Aging
in the Evolution of Lifespans synthesizes several decades of top
research on the topic of human aging and longevity particularly on
the recent theories of inflammation and its effects on human
health. The book expands a number of existing major theories,
including the Barker theory of fetal origins of adult disease to
consider the role of inflammation and Harmon's free radical theory
of aging to include inflammatory damage. Future increases in
lifespan are challenged by the obesity epidemic and spreading
global infections which may reverse the gains made in lowering
inflammatory exposure. This timely and topical book will be of
interest to anyone studying aging from any scientific angle.
This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system.
Clinicians will find this handbook to be an invaluable resource
for summarizing the present state of scientific and clinical
knowledge in the field of neuro-oncology. In addition,
practitioners in the field will uncover new tactics and therapies
that will aid them in providing optimal neuro-oncological care for
This book explores the full consequences of the dissociation
between sexual behaviors and reproduction. Among the themes covered
is the difference between the stereotyped sexual behaviors in
non-human mammals and the astounding variety of human sexual
behaviors. The role of learning in shaping sexual behaviors is
explained, and it is shown how particular sexual experiences may be
at the origin of common human sexual dysfunctions. Chapters on
sexual incentives and a summary of the endocrine and central
nervous control of sexual behaviors are included.
Volume 42 presents an in-depth review on Alzheimer's Disease as
well as a look at several transcription factors.
Some well-known age-related neurological diseases include
Parkinson's disease, Alzheimer's disease, deafness, and blindness.
Even more common are the problems of aging which are not due to
disease but to more subtle impairments in neurobiological systems,
including impairments in vision, memory loss, muscle weakening, and
loss of reproductive functions, changes in body weight, and
sleeplessness. As the average age of our society increases,
diseases of aging continue to become more common, and conditions
associated with aging need more attention by doctors and
researchers. In 1991, patients over the age of 65 saw their doctors
an average of eight times per year. Research funding is provided by
the Neuroscience and Neuropsychology of Aging (NNA) Program, which
is run by the National Institute on Aging. This book offers a
comprehensive overview of all topics related to functional
impairments which are related to the aging brain and nervous
system. It is organized according to four general functions:
movement, senses, memory, and neuroendocrine regulation. Written by
the leading researchers in the field, this comprehensive work
addresses both impairments associated with diseases and not
associated with diseases, making it easier to understand the
mechanisms involved. Functional Neurobiology of Aging is an
important reference for professionals and students involved in
aging research, as well as physicians who need to recognize and
understand age-related impairments.
For over two decades, Paxinos and Watson's The Rat Brain in
Stereotaxic Coordinates, now in its 6th edition, and Franklin and
Paxinos' The Mouse Brain in Stereotaxic Coordinates, now in its 3rd
edition, have been the most used neuroanatomy references for
neuroscientists. Both the illustrations and nomenclature of the
atlas have become standard tools used by almost all research
neuroscientists who deal with anatomy, physiology, or
MRI Atlas of Human White Matter remains the only atlas to
provide detailed anatomy of human brain white matter. Knowledge of
this anatomy via diffusion tensor imaging (DTI )greatly enhances
our understanding of brain function and neural connectivity. These
advances promise to be particularly helpful with neurological
diseases, such asAlzheimer's. The second edition offers an
introduction to and description of the methodology, the 3D anatomy
of individual tracts, and a series of color-coded orientation maps
to delineate white matter anatomy in a slice-by-slice manner.
Improvements over the 1st edition include: full segmentation of up
to 176 regions of the brain, added definitions of gray matter to
further understanding between white and gray matter structures,
andthe addition of standardized stereotaxic coordinates. The
atlasserves as avaluable resource for clinicians, researchers and
graduate students in neuroscience, neurology, neurosurgery and
This book provides a comprehensive description of how human sensory
systems function, with comparisons of the five senses and detailed
descriptions of the functions of each of them. In addition to
describing anatomy and function, the book also provides insight as
to how sensory information is processed in the brain to provide the
basis for communication and for our perception of our surroundings.
The study of mathematical cognition and the ways in which the
ideas of space, time and number are encoded in brain circuitry has
become a fundamental issue for neuroscience. How such encoding
differs across cultures and educational level is of further
interest in education and neuropsychology. This rapidly expanding
field of research is overdue for an interdisciplinary volume such
as this, which deals with the neurological and psychological
foundations of human numeric capacity. A uniquely integrative work,
this volume provides a much needed compilation of primary source
material to researchers from basic neuroscience, psychology,
developmental science, neuroimaging, neuropsychology and
Among the most interesting fields in research are the emerging
possibilities to interface the human brain directly with machines,
e.g. with computers and robotic interfaces. The European Space
Agency's Advanced Concept team as a multidisciplinary team from
engineering, artificial intelligence, and neural engineering has
been working on the cutting edge of exploring brain machine
interfaces for application in space as solutions to limitations
astronauts face in space, and this book for the first time presents
General Description of Series
The imaging of small cellular components requires powerful
instruments, and an entire family of equipment and techniques based
on the confocal principle has been developed over the past 30
years. Such methods are commonly used by neuroscience researchers,
but the majority of these users do not have a microscopy or a cell
biology backgrounds and do can encounter difficulties in obtaining
and interpreting results. This volume brings experts in
high-resolution optical microscopy applications in neuroscience and
cell biology together to document the state of the art. Outlining
what is currently possible, the volume also discusses promising
developments for the future and aids readers in selecting the most
scientifically meaningful approach to solve their questions. Each
chapter discusses instrumentation and technology in relationship to
application in research. All of the common and cutting edge trends
are covered - fluorescence / laser electron / nonlinear microscopy,
infrared fluorescence, multiphoton imaging, tomography, FRAP, live
imaging, STED, PALM/STORM, etc.
Hardbound. In this volume prominent workers in the field discuss various time series methods in the time domain. The topics included are autoregressive-moving average models, control, estimation, identification, model selection, non-linear time series, non-stationary time series, prediction, robustness, sampling designs, signal attenuation, and speech recognition. This volume complements Handbook of Statistics 3: Time Series in the Frequency Domain.
This is a well-established international series that examines major areas of basic and clinical research within neuroscience (as well as emerging and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, neurobehavior. This volume provides a thorough treatment of gene models of schizophrenia, presenting articles from leading contributors in this important area.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research.
Epilepsy, Part I, "Basic Principles and Diagnosis," Volume 107,
in the"Handbook of Clinical Neurology"series offers a comprehensive
review of our knowledge of the field today, including epidemiology,
basic mechanisms, animal models, and topics of increasing interest
such as the role of inflammation in epilepsy. It provides a
comprehensive approach to description of the clinical,
electrographic and imaging aspects of the epilepsies, with a clear
outline of contemporary classification and the role of modern
diagnostic techniques, as well as neuropsychological and
psychiatric aspects of epilepsy. Chapters are authored by
internationally respected neurologists with varied perspectives
insuring depth to the content. "Epilepsy, Part II," "Treatment, "
Volume 108, continues coverage of epilepsy with a focus on
treatment. The volumes will be a very important resource for basic
scientists, clinical investigators, and all health professionals
treating patients with epilepsy.
Currently, few drugs are available for the effective treatment of
neurodegenerative diseases and neurodevelopmental disorders. Recent
advances in neuroscience research offer hope that future strategies
for treating these brain disorders will include neurogenesis and
neuroenhancement as therapeutic endpoints. This volume reviews
cutting-edge findings related to the pharmacological aspects of
neurogenesis and neuroprotection. A broad range of topics are
covered from basic lab bench research to drug discovery efforts and
important clinical issues. This collection of reviews is a perfect
way to become acquainted with these exciting new fields in the
space of a single volume. Chapters are written with a general
audience in mind, but with enough high-level discussion to appeal
to specialists and experts as well. The authors have done an
excellent job of challenging current paradigms and pushing the
boundaries of exploration in keeping with the pioneering spirit
that gave rise to these emerging areas of research. Consequently,
this will be an indispensable resource for many years to come.
This issue of International Review of Neurobiology is split over 2
volumes, bringing together cutting-edge research on Bioinformatics
of Behavior. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
This volume investigates the implications of how our brain directs our movements on decision-making. An extensive body of knowledge in chapters from international experts is presented as well as integrative group reports discussing new directions for future research.
The understanding of how people make decisions is of central
interest to experts working in fields such as psychology,
economics, movement science, cognitive neuroscience,
neuroinformatics, robotics, and sport science. For the first time
the current volume provides a multidisciplinary overview of how
action and cognition are integrated in the planning of and
decisions about action.
Theoretical Mechanics of Biological Neural Networks develops an engineering science for the description of neuroclectric signalling of biological neural networks in terms of the underlying neurobiological mechanisms. The primary theoretical contribution of the book is to show how to describe the co-ordinated electrical activity of arbitrarily complex neural networks in terms of a single governing principle ' for each significant component in the same way that Newton's formulation of classical mechanics allows one to express force-motion relationships for arbitrarily complex mechanical systems in terms of one fundamental principle of motion for each constituent element.;Practically, the book shows how to generate mathematical and computational representations Of' the co-ordinated electrical activity of neural networks, ranging from individual neurons to composite systems of interconnected networks. Complete listings of several general purpose computer programs embodying the theory are included in the book.
This book examines the role that dopamine plays in schizophrenia,
examining its role in not only the symptoms of the disease but also
in its treatment. It also reviews all neurotransmitters that have
been implicated in schizophrenia, exploring the genetic data,
clinical data implicating the transmitter, and the preclinical data
exploring how a transmitter may interact with dopamine and
contribute to the dopaminergic phenotype observed in the illness.
This book will serve as an educational tool for instructors, a
guide for clinicians, and be of interest to researchers. It is a
good reference for researchers specialized in one particular area
and interested in learning about other areas of pathology in
schizophrenia and how they may all feed into each other. The book
concludes with an overall integrative model assembling as many of
these elements as possible.
This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.
This volume explores interdisciplinary research on Attention and interaction of Attention with other cognitive processes including perception, learning, and memory. The papers cover major research on attention in Cognitive Neuroscience and Cognitive Psychology. The volume presents recent advances on attention including binding, dynamics of attention, attention and perceptual organization, attention and consciousness, emotion and attention, development of attention, crossmodal attention, computational modeling of attention, control of actions, attention and memory, and meditation.
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