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Books > Academic & Education > Professional & Technical > Neuroscience

Statistics in Industry, Volume 22 (Hardcover, illustrated edition): Rao Khattree Statistics in Industry, Volume 22 (Hardcover, illustrated edition)
Rao Khattree
R2,976 R2,823 Discovery Miles 28 230 Save R153 (5%) Out of stock

The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.

This volume presents a state of the art exposition of topics in the field of industrial statistics. It serves as an invaluable reference for the researchers in industrial statistics/industrial engineering and an up to date source of information for practicing statisticians/industrial engineers. A variety of topics in the areas of industrial process monitoring, industrial experimentation, industrial modelling and data analysis are covered and are authored by leading researchers or practitioners in the particular specialized topic. Targeting the audiences of researchers in academia as well as practitioners and consultants in industry, the book provides comprehensive accounts of the relevant topics. In addition, whenever applicable ample data analytic illustrations are provided with the help of real world data.

The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans (Hardcover): Caleb E. Finch The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans (Hardcover)
Caleb E. Finch
R1,476 Discovery Miles 14 760 Out of stock

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle.
* Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists
* Provides a novel synthesis of existing ideas about the biology of longevity and aging
* Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Stress Consequences - Mental, Neuropsychological and Socioeconomic (Hardcover, New): George Fink Stress Consequences - Mental, Neuropsychological and Socioeconomic (Hardcover, New)
George Fink
R2,313 Discovery Miles 23 130 Out of stock

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that focuses on the physical and psychological consequences of stress for individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing s Syndrome: Addison s Disease) and the adverse impact of stress on human physical and mental health. Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer s disease and Parkinson s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries.
Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated in full color with over 200 figures Articles carefully selected by one of the world s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"

Time Series in the Frequency Domain, Volume 3 (Hardcover): P.R. Krishnaiah# Time Series in the Frequency Domain, Volume 3 (Hardcover)
P.R. Krishnaiah#; Volume editing by D.R. Brillinger
R3,981 Discovery Miles 39 810 Out of stock

Hardbound. This volume of the Handbook is concerned particularly with the frequency side, or spectrum, approach to time series analysis. This approach involves essential use of sinusoids and bands of (angular) frequency, with Fourier transforms playing an important role. A principal activity is thinking of systems, their inputs, outputs, and behavior in sinusoidal terms. In many cases, the frequency side approach turns out to be simpler with respect to computational, mathematical, and statistical aspects. In the frequency approach, an assumption of stationarity is commonly made. However, the essential roles played by the techniques of complex demodulation and seasonal adjustment show that stationarity is far from being a necessary condition. Assumptions of Gaussianity and linearity are also commonly made and yet, as a variety of the papers illustrate, these assumptions are not necessary. This volume complements Handbook of Statistics 5: Time Series in the

Bioactive Natural Products (Part E), Volume 15 - V15 (Hardcover): Atta-ur Rahman Bioactive Natural Products (Part E), Volume 15 - V15 (Hardcover)
Atta-ur Rahman
R10,348 Discovery Miles 103 480 Out of stock

Natural product chemistry covers a fascinating area of organic chemistry and its study has enriched organic chemistry in a myriad of different ways. In recent years the thrust has been in three major directions: advances in stereoselective synthesis of bioactive natural products, developments in structure elucidation of complex natural products through the applications of multidimensional NMR and mass spectroscopy, and the integration of bioassay procedures with the isolation processes leading to the isolation of active principles from the extracts. The present volume reflects these developments, and the growing emphasis on bioactive natural products, chemical constituents of echinoderms, diterpenoids from Rabdosia and Eremophila sp., structural studies on saponins, marine sesquiterpene quinones and antimicrobial activity of amphibian venoms. The reviews on bioactive metabolites of Phomophis, cardenolide detection by ELISA, xenocoumacins and bioactive dihydroisocoumarins, CD studies of carbohydrate-molybdate complexes, oncogene function inhibitors from microbial secondary metabolites and Gelsemium and Lupin alkaloids present frontier developments in several areas of natural product chemistry. It is hoped that the present volume, which contains articles by eminent authorities in each field, will be received with the same enthusiasm as the previous volumes of this series.

Nitric Oxide in the Nervous System, Volume - (Hardcover): Peter Jenner Nitric Oxide in the Nervous System, Volume - (Hardcover)
Peter Jenner; Volume editing by Stephen R. Vincent
R3,303 Discovery Miles 33 030 Out of stock

The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.
This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO.
Key Features
* Describes how and why NO is produced in the nervous system
* Examines all that is known of NOs role as a neurotransmitter
* Explores cellular actions and physiological roles in the brain and peripheral nervous system
Covers NOs molecular synthesis to its role in neuropathology

Bioinformatics of Behavior: Part 1, Volume 103 (Hardcover, New): Hans-Peter Hartung Bioinformatics of Behavior: Part 1, Volume 103 (Hardcover, New)
Hans-Peter Hartung
R3,617 Discovery Miles 36 170 Out of stock

This issue of International Review of Neurobiology is split over 2 volumes, bringing together cutting-edge research on Bioinformatics of Behavior. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Neuroscience of Preference and Choice - Cognitive and Neural Mechanisms (Hardcover): Raymond J. Dolan, Tali Sharot Neuroscience of Preference and Choice - Cognitive and Neural Mechanisms (Hardcover)
Raymond J. Dolan, Tali Sharot
R1,253 Discovery Miles 12 530 Out of stock

One of the most pressing questions in neuroscience, psychology and economics today is how does the brain generate preferences and make choices? With a unique interdisciplinary approach, this volume is among the first to explore the cognitive and neural mechanisms mediating the generation of the preferences that guide choice. From preferences determining mundane purchases, to social preferences influencing mating choice, through to moral decisions, the authors adopt diverse approaches to answer the question. Chapters explore the instability of preferences and thecommon neural processes that occur across preferences. Edited by one of the world s most renowned cognitive neuroscientists, each chapter is authored by an expert in the field, with a host of international contributors.
Emphasis on common process underlying preference generation makes material applicable to a variety of disciplines - neuroscience, psychology, economics, law, philosophy, etc.Offers specific focus on how preferences are generated to guide decision making, carefully examining one aspect of the broad field of neuroeconomics and complementing existing volumesFeatures outstanding, international scholarship, with chapters written by an expert in the topic area"

Febrile Seizures (Hardcover): Tallie Z. Baram, Shlomo Shinnar Febrile Seizures (Hardcover)
Tallie Z. Baram, Shlomo Shinnar
R3,047 Discovery Miles 30 470 Out of stock

Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following:
* New imaging tools and emerging data, visualizing effects of febrile seizures on the brain
* New genetic methodologies
* The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure.

Key Features
* First book on febrile seizures in over 20 years
* Broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods
* Comprehensive update of the topic, written by world leaders in the field
* Novel and newly discovered information based on up-to the minute methods
* Engaging style, accessible to the clinician, researcher, and educated parent

Maternal Substance Abuse and the Developing Nervous System (Hardcover): Ian S. Zagon, Theodore A. Slotkin Maternal Substance Abuse and the Developing Nervous System (Hardcover)
Ian S. Zagon, Theodore A. Slotkin
R1,207 Discovery Miles 12 070 Out of stock

The purpose of this book is to review the basic science and clinical findings concerning maternal substance abuse and the developing nervous system of unborn children. The short-term but vitally significant repercussions of such exposure on biological development, with particular reference to the nervous system, are discussed. The book also discusses the profound influence of maternal substance abuse on behavior in adulthood, which is caused by subtle changes in the chemistry or structure of the developing nervous system. The subject will not only be of interest to clinical and basic science researchers and teachers in the field of maternal substance abuse, but also to individuals in psychology, social work, cellular and molecular biolgoy, embryology, neuroscience, pharmacology, and in clinical professions such as pediatrics, neonatology, and obstetrics. The breadth of topics covered includes alcohol, cocaine, opiates, nicotine, benzodiazepines, marijuana, and the role of stress and hormones. Emphasis is placed on the relationship of the effects of substance abuse on neurotrophic factors and receptors.
Key Features
* Shows how abused substances act directly or indirectly to mimic or influence the action of neurotrophic factors
* Explains that the transient expression of peptides, neurotransmitters, and receptors can be markedly disturbed by drugs
* Demonstrates that animal and tissue culture studies are consistent with clinical observations and important in understanding and ameliorating adverse actions of drugs in early life

Temporal Lobe Epilepsy and the Mind-Brain Relationship: A New Perspective, Volume 76 (Hardcover, New): Shirley Ferguson Temporal Lobe Epilepsy and the Mind-Brain Relationship: A New Perspective, Volume 76 (Hardcover, New)
Shirley Ferguson
R4,129 Discovery Miles 41 290 Out of stock

This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research - here, conducted in the course of the diagnosis and surgical treatment of epilepsy - in helping to elucidate the relationship between brain and mind.

Sleep Disorders Part I, Volume 98 (Hardcover): Pasquale Montagna, Sudhansu Chokroverty Sleep Disorders Part I, Volume 98 (Hardcover)
Pasquale Montagna, Sudhansu Chokroverty
R4,605 R4,350 Discovery Miles 43 500 Save R255 (6%) Out of stock

Since the late 90 s, a renewed interest in the neurobiology of sleep has provided new advancements in the understanding of basic sleep science and the clinical aspects of sleep disorders, with particular interest given to the role of genetics.

From laboratory techniques and therapies, groundbreaking research in sleep-wakefulness, new models of rapid eye movement (REM) sleep mechanisms, to bright light therapy for circadian rhythm sleep disorders, this handbook will provide clinicians and researchers with a state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of sleep disorders.

Practitioners will find invaluable research, information, and laboratory techniques on such topics as sleep-wake-dependent genes, the role of sleep duration in mortality and morbidity, and advancements in the understanding of the neurobiology of sleep disorders, including narcolepsy-cataplexy, restless legs syndrome, REM behavior disorders, fatal familiar insomnia, sleep apnea and heart failure, and nocturnal paroxysmal dystonia, amongst others. In addition, significant advancements in therapies and drug protocols are presented.
* Clinical data on groundbreaking advancements in the understanding of basic sleep science
* Invaluable information on new therapies and drug protocols for sleep disorders
* A state-of-the-art reference that includes the role of genetics in sleep medicine"

The Pharmacology of Neurogenesis and Neuroenhancement, Volume 77 (Hardcover, 77th edition): Donard Dwyer The Pharmacology of Neurogenesis and Neuroenhancement, Volume 77 (Hardcover, 77th edition)
Donard Dwyer
R3,827 Discovery Miles 38 270 Out of stock

Currently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders. Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints. This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection. A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues. This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume. Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well. The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research. Consequently, this will be an indispensable resource for many years to come.
* Provides state-of-the-art reviews spanning significant emerging fields
* Discusses future directions and questions for future studies
* Includes informative illustrations

Numerical Methods for Solids (Part 3) Numerical Methods for Fluids (Part 1), Volume 6 (Hardcover, 1990-<2002): P.G. Ciarlet Numerical Methods for Solids (Part 3) Numerical Methods for Fluids (Part 1), Volume 6 (Hardcover, 1990-<2002)
P.G. Ciarlet; Edited by J.L. Lions
R3,096 Discovery Miles 30 960 Out of stock
Neuro-Oncology Part I, Volume 104 (Hardcover): Wolfgang Grisold, Riccardo Soffietti Neuro-Oncology Part I, Volume 104 (Hardcover)
Wolfgang Grisold, Riccardo Soffietti 1
R3,705 Discovery Miles 37 050 Out of stock

This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system.

Clinicians will find this handbook to be an invaluable resource for summarizing the present state of scientific and clinical knowledge in the field of neuro-oncology. In addition, practitioners in the field will uncover new tactics and therapies that will aid them in providing optimal neuro-oncological care for their patients.
* An invaluable resource that includes critical, in-depth insights into recent developments in neuro-oncology
* A fresh perspective on molecular biology, immunology, and other clinical aspects of tumors of the nervous system
* Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments
* New tactics and therapies that will aid clinicians in their quest to provide optimal care for their neuro-oncological patients

Functional Plasticity and Genetic Variation, Volume 91 - Insights into the Neurobiology of Alcoholism (Hardcover): Functional Plasticity and Genetic Variation, Volume 91 - Insights into the Neurobiology of Alcoholism (Hardcover)
R3,909 Discovery Miles 39 090 Out of stock

With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.

The Bilingual Brain - Neuropsychological and Neurolinguistic Aspects of Bilingualism (Hardcover): Martin L. Albert, Loraine K.... The Bilingual Brain - Neuropsychological and Neurolinguistic Aspects of Bilingualism (Hardcover)
Martin L. Albert, Loraine K. Obler
R1,089 Discovery Miles 10 890 Out of stock
Fundamental Neuroscience (Hardcover, 4th edition): Larry R. Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh,... Fundamental Neuroscience (Hardcover, 4th edition)
Larry R. Squire, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, …
R1,880 Discovery Miles 18 800 Out of stock

The fourth edition of "Fundamental Neuroscience" reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.

The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover.
Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries30% new material including new chapters on dendritic development and spine morphogenesis, chemical senses, cerebellum, eye movements, circadian timing, sleep and dreaming, and consciousnessAccompanying website for students and instructorsAdditional text boxes describing key experiments, disorders, methods, and conceptsMore than 650 four-color illustrations, micrographs, and neuroimages Multiple model system coverage beyond rats, mice, and monkeysExtensively expanded index for easier referencing

The Neuromodulators, Volume 64 (Hardcover): Ronald J. Bradley, R. Adron Harris, Peter Jenner The Neuromodulators, Volume 64 (Hardcover)
Ronald J. Bradley, R. Adron Harris, Peter Jenner; Volume editing by John R Smythies
R3,818 Discovery Miles 38 180 Out of stock

Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

Stroke, Volume 94 - Stroke, Part III: Investigation and management Investigation and Management: Part III (Hardcover): Marc... Stroke, Volume 94 - Stroke, Part III: Investigation and management Investigation and Management: Part III (Hardcover)
Marc Fisher
R4,560 R4,305 Discovery Miles 43 050 Save R255 (6%) Out of stock

This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.

Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.

Related fields and their dramatic impact on stroke research are also included, with findings in the fields of epidemiology, genetics, neuroimaging, and interventional radiology thoroughly explored. In addition, great attention is paid to therapeutic avenues, including investigation, prevention, and patient management.
* A comprehensive resource for information on diagnostic advancements, prevention, and treatment of strokes
* A clinical perspective on the ways related fields such as epidemiology, genetics, and neuroimaging, amongst others, are impacting new research in this disorder
* A foundation that will enable researchers to pursue new clinical investigations

New Concepts of Psychostimulants Induced Neurotoxicity, Volume 88 (Hardcover, 89th edition): Hari Shanker Sharma New Concepts of Psychostimulants Induced Neurotoxicity, Volume 88 (Hardcover, 89th edition)
Hari Shanker Sharma
R3,914 Discovery Miles 39 140 Out of stock

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

The Limits of Dream - A Scientific Exploration of the Mind / Brain Interface (Hardcover): J. F. Pagel The Limits of Dream - A Scientific Exploration of the Mind / Brain Interface (Hardcover)
J. F. Pagel
R459 Discovery Miles 4 590 Out of stock

The Limits of Dream focuses on what we currently know of the human central nervous system (CNS), examining the basic sciences of neurochemisty, neuroanatomy, and CNS electrophysiology as these sciences apply to dream, then reaching beyond basic science to examine the cognitive science of dreaming including the processes of memory, the perceptual interface, and visual imagery. Building on what is known of intrapersonal CNS processing, the book steps outside the physical body to explore artificially created dreams and their use in filmmaking, art and story, as well as the role of dreaming in creative process and creative madness. The limits of our scientific knowledge of dream frame this window that can be used to explore the border between body and mind. What is known scientifically of the cognitive process of dreaming will lead the neuroscientist, the student of cognitive science, and the general reader down different paths than expected into an exploration of the fuzzy and complex horizon between mind and brain.
* The clearest presentation of research and philosophy currently available relating to the mind/brain interface
* Discusses the cognitive processes of dreaming utilized in film and artificial intelligence
* Describes the functioning of dream in the creative process"

Neuro-Oncology, Part II, Volume 105 (Hardcover): Wolfgang Grisold, Riccardo Soffietti Neuro-Oncology, Part II, Volume 105 (Hardcover)
Wolfgang Grisold, Riccardo Soffietti
R4,698 Discovery Miles 46 980 Out of stock

Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment (Paperback): Scott D... Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment (Paperback)
Scott D Mendelson
R1,861 Discovery Miles 18 610 Out of stock

Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome).
This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome.
The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise.
The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications.
Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

* Provides an understanding of Metabolic Syndrome and how this syndrome is a major risk factor in depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, and other illnesses of psychiatric significance.
* Places specific emphasis on the connection of Metabolic Syndrome with Psychiatric illnesses, and how these conditions exacerbate each other.
* Discusses the actual mechanisms by which Metabolic Syndrome progresses and causes damage to the body.
* Explores the relationship between Major Depression, Heart Disease and Metabolic Syndrome.
* Includes supplementary section which discusses and critiques many current dietary supplements that are thought to be helpful for Metabolic Syndrome.
* Discusses the roles of diet, genetics and supplements in managing Metabolic Syndrome.

Protein Trafficking in Neurons (Hardcover): Andrew J. Bean Protein Trafficking in Neurons (Hardcover)
Andrew J. Bean
R2,243 Discovery Miles 22 430 Out of stock

The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases.
- Provides a comprehensive examination of membrane/protein movement in neuronal function.
- Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease
- Includes a focus on Molecular Mechanisms
- Illustrated with color summary pictures
- The only book examining protein trafficking and its functional implications, written by leaders in the field

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