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The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.
This volume presents a state of the art exposition of topics in the field of industrial statistics. It serves as an invaluable reference for the researchers in industrial statistics/industrial engineering and an up to date source of information for practicing statisticians/industrial engineers. A variety of topics in the areas of industrial process monitoring, industrial experimentation, industrial modelling and data analysis are covered and are authored by leading researchers or practitioners in the particular specialized topic. Targeting the audiences of researchers in academia as well as practitioners and consultants in industry, the book provides comprehensive accounts of the relevant topics. In addition, whenever applicable ample data analytic illustrations are provided with the help of real world data.
Written by Caleb Finch, one of the leading scientists of our time,
The Biology of Human Longevity - Inflammation, Nutrition, and Aging
in the Evolution of Lifespans synthesizes several decades of top
research on the topic of human aging and longevity particularly on
the recent theories of inflammation and its effects on human
health. The book expands a number of existing major theories,
including the Barker theory of fetal origins of adult disease to
consider the role of inflammation and Harmon's free radical theory
of aging to include inflammatory damage. Future increases in
lifespan are challenged by the obesity epidemic and spreading
global infections which may reverse the gains made in lowering
inflammatory exposure. This timely and topical book will be of
interest to anyone studying aging from any scientific angle.
Stress is a universal phenomenon that impacts adversely on most
people. This volume provides a readily accessible compendium that
focuses on the physical and psychological consequences of stress
for individuals and society. Clinical attention focuses on
disorders of the stress control system (e.g. Cushing s Syndrome:
Addison s Disease) and the adverse impact of stress on human
physical and mental health. Detailed reviews address disorders such
as PTSD, anxiety, major depression, psychoses and related disorders
such as combat fatigue and burnout. The work covers interactions
between stress and neurodegenerative disorders, such as Alzheimer s
disease and Parkinson s disease, as well as
stress-immune-inflammatory interactions in relation to cancer and
autoimmune and viral diseases. Emphasis is also placed on the role
of stress in obesity, hypertension, diabetes type II and other
features of the metabolic syndrome which has now reached epidemic
proportions in the USA and other countries.
Hardbound. This volume of the Handbook is concerned particularly with the frequency side, or spectrum, approach to time series analysis. This approach involves essential use of sinusoids and bands of (angular) frequency, with Fourier transforms playing an important role. A principal activity is thinking of systems, their inputs, outputs, and behavior in sinusoidal terms. In many cases, the frequency side approach turns out to be simpler with respect to computational, mathematical, and statistical aspects. In the frequency approach, an assumption of stationarity is commonly made. However, the essential roles played by the techniques of complex demodulation and seasonal adjustment show that stationarity is far from being a necessary condition. Assumptions of Gaussianity and linearity are also commonly made and yet, as a variety of the papers illustrate, these assumptions are not necessary. This volume complements Handbook of Statistics 5: Time Series in the
Natural product chemistry covers a fascinating area of organic chemistry and its study has enriched organic chemistry in a myriad of different ways. In recent years the thrust has been in three major directions: advances in stereoselective synthesis of bioactive natural products, developments in structure elucidation of complex natural products through the applications of multidimensional NMR and mass spectroscopy, and the integration of bioassay procedures with the isolation processes leading to the isolation of active principles from the extracts. The present volume reflects these developments, and the growing emphasis on bioactive natural products, chemical constituents of echinoderms, diterpenoids from Rabdosia and Eremophila sp., structural studies on saponins, marine sesquiterpene quinones and antimicrobial activity of amphibian venoms. The reviews on bioactive metabolites of Phomophis, cardenolide detection by ELISA, xenocoumacins and bioactive dihydroisocoumarins, CD studies of carbohydrate-molybdate complexes, oncogene function inhibitors from microbial secondary metabolites and Gelsemium and Lupin alkaloids present frontier developments in several areas of natural product chemistry. It is hoped that the present volume, which contains articles by eminent authorities in each field, will be received with the same enthusiasm as the previous volumes of this series.
The gas nitric oxide (NO) has burst upon neuroscience only
recently, and yet it has permeated into almost every avenue of
current research. The unique properties of this novel messenger
have revolutionized our way ofthinking about neurotransmission.
These special properties have also lead neuroscientists to invoke
NO to explain many previously unexplained phenomena in
neurobiology. Fortunately, the development of numerous
pharmacological agents is now allowing thesehypotheses to be
This issue of International Review of Neurobiology is split over 2
volumes, bringing together cutting-edge research on Bioinformatics
of Behavior. The 2 volumes review current knowledge and
understanding, provide a starting point for researchers and
practitioners entering the field, and build a platform for further
research and discovery.
One of the most pressing questions in neuroscience, psychology
and economics today is how does the brain generate preferences and
make choices? With a unique interdisciplinary approach, this volume
is among the first to explore the cognitive and neural mechanisms
mediating the generation of the preferences that guide choice. From
preferences determining mundane purchases, to social preferences
influencing mating choice, through to moral decisions, the authors
adopt diverse approaches to answer the question. Chapters explore
the instability of preferences and thecommon neural processes that
occur across preferences. Edited by one of the world s most
renowned cognitive neuroscientists, each chapter is authored by an
expert in the field, with a host of international
Febrile Seizures is written by the most active researchers and
clinicians in epilepsy research today. This book presents the
latest developments in this field as well as the current state of
knowledge in the following:
The purpose of this book is to review the basic science and
clinical findings concerning maternal substance abuse and the
developing nervous system of unborn children. The short-term but
vitally significant repercussions of such exposure on biological
development, with particular reference to the nervous system, are
discussed. The book also discusses the profound influence of
maternal substance abuse on behavior in adulthood, which is caused
by subtle changes in the chemistry or structure of the developing
nervous system. The subject will not only be of interest to
clinical and basic science researchers and teachers in the field of
maternal substance abuse, but also to individuals in psychology,
social work, cellular and molecular biolgoy, embryology,
neuroscience, pharmacology, and in clinical professions such as
pediatrics, neonatology, and obstetrics. The breadth of topics
covered includes alcohol, cocaine, opiates, nicotine,
benzodiazepines, marijuana, and the role of stress and hormones.
Emphasis is placed on the relationship of the effects of substance
abuse on neurotrophic factors and receptors.
This book is devoted to the surgical treatment of epilepsy and its consequences, and provides an extraordinary perspective on the fascinating question of the relationship between brain and mind. Contrary to the current emphasis on statistics and objectivity, this book is dedicated to understanding the whole person, the life and experiences of the individual. It reports on cutting-edge technical skills provided with a human touch. This book reflects the understanding that the temporolimbic seizure originates in tissue providing the substrate for the emotional life and memory. Finally, it emphasizes the value of clinical research - here, conducted in the course of the diagnosis and surgical treatment of epilepsy - in helping to elucidate the relationship between brain and mind.
Since the late 90 s, a renewed interest in the neurobiology of sleep has provided new advancements in the understanding of basic sleep science and the clinical aspects of sleep disorders, with particular interest given to the role of genetics.
From laboratory techniques and therapies, groundbreaking research in sleep-wakefulness, new models of rapid eye movement (REM) sleep mechanisms, to bright light therapy for circadian rhythm sleep disorders, this handbook will provide clinicians and researchers with a state-of-the-art reference that summarizes the clinical features and management of the many neurological manifestations of sleep disorders.
Practitioners will find invaluable research, information, and
laboratory techniques on such topics as sleep-wake-dependent genes,
the role of sleep duration in mortality and morbidity, and
advancements in the understanding of the neurobiology of sleep
disorders, including narcolepsy-cataplexy, restless legs syndrome,
REM behavior disorders, fatal familiar insomnia, sleep apnea and
heart failure, and nocturnal paroxysmal dystonia, amongst others.
In addition, significant advancements in therapies and drug
protocols are presented.
Currently, few drugs are available for the effective treatment of
neurodegenerative diseases and neurodevelopmental disorders. Recent
advances in neuroscience research offer hope that future strategies
for treating these brain disorders will include neurogenesis and
neuroenhancement as therapeutic endpoints. This volume reviews
cutting-edge findings related to the pharmacological aspects of
neurogenesis and neuroprotection. A broad range of topics are
covered from basic lab bench research to drug discovery efforts and
important clinical issues. This collection of reviews is a perfect
way to become acquainted with these exciting new fields in the
space of a single volume. Chapters are written with a general
audience in mind, but with enough high-level discussion to appeal
to specialists and experts as well. The authors have done an
excellent job of challenging current paradigms and pushing the
boundaries of exploration in keeping with the pioneering spirit
that gave rise to these emerging areas of research. Consequently,
this will be an indispensable resource for many years to come.
This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system.
Clinicians will find this handbook to be an invaluable resource
for summarizing the present state of scientific and clinical
knowledge in the field of neuro-oncology. In addition,
practitioners in the field will uncover new tactics and therapies
that will aid them in providing optimal neuro-oncological care for
With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.
The fourth edition of "Fundamental Neuroscience" reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.
The chapters include more than 100 boxes describing clinical
conditions, techniques, and other special topics. Each chapter went
through a thorough review process, giving the book an evenness of
tone. The chapters are authored by outstanding working scientists
who are experts on the topics they cover.
Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.
This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.
Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.
Related fields and their dramatic impact on stroke research are
also included, with findings in the fields of epidemiology,
genetics, neuroimaging, and interventional radiology thoroughly
explored. In addition, great attention is paid to therapeutic
avenues, including investigation, prevention, and patient
Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.
The Limits of Dream focuses on what we currently know of the human
central nervous system (CNS), examining the basic sciences of
neurochemisty, neuroanatomy, and CNS electrophysiology as these
sciences apply to dream, then reaching beyond basic science to
examine the cognitive science of dreaming including the processes
of memory, the perceptual interface, and visual imagery. Building
on what is known of intrapersonal CNS processing, the book steps
outside the physical body to explore artificially created dreams
and their use in filmmaking, art and story, as well as the role of
dreaming in creative process and creative madness. The limits of
our scientific knowledge of dream frame this window that can be
used to explore the border between body and mind. What is known
scientifically of the cognitive process of dreaming will lead the
neuroscientist, the student of cognitive science, and the general
reader down different paths than expected into an exploration of
the fuzzy and complex horizon between mind and brain.
Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.
Metabolic syndrome is a set of risk factors that includes:
abdominal obesity, a decreased ability to process glucose (insulin
resistance), dyslipidemia (unhealthy lipid levels), and
hypertension. Patients who have this syndrome have been shown to be
at an increased risk of developing cardiovascular disease and/or
type 2 diabetes. Metabolic syndrome is a common condition that goes
by many names (dysmetabolic syndrome, syndrome X, insulin
resistance syndrome, obesity syndrome, and Reaven's syndrome).
The efficient delivery of cellular constituents to their proper
location is of fundamental importance for all cells and is of
particular interest to neuroscientists, because of the unique
functions and complex architecture of neurons. Protein Trafficking
in Neurons examines mechanisms of protein trafficking and the role
of trafficking in neuronal functioning from development to
plasticity to disease. The book is divided into seven sections that
review mechanisms of protein transport, the role of protein
trafficking in synapse formation, exo- and endocytosis, transport
of receptors, trafficking of ion channels and transporters,
comparison of trafficking mechanisms in neuronal vs. non-neuronal
cell types, and the relationship between trafficking and neuronal
diseases such as Alzheimer's, Huntington's and Prion Diseases.
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