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Books > Academic & Education > Professional & Technical > Neuroscience

The Mouse Brain in Stereotaxic Coordinates, Compact - The Coronal Plates and Diagrams (Spiral bound, 3rd edition): George... The Mouse Brain in Stereotaxic Coordinates, Compact - The Coronal Plates and Diagrams (Spiral bound, 3rd edition)
George Paxinos, Keith B.J. Franklin
R2,148 R1,595 Discovery Miles 15 950 Save R553 (26%) Shipped within 7 - 12 working days

The Mouse Brain in Stereotaxic Coordinates is the most widely used and cited atlas of the mouse brain in print. It provides researchers and students with both accurate stereotaxic coordinates for laboratory use, and detailed delineations and indexing of structures for reference. The Compact 3rd edition is both a major revision and an expansion of previous compact editions. The 100 high resolution digital photographs of the coronal plane of section from the third full edition now complement the coronal drawings. The photographs of the sections and the intermediate sections are also provided on the accompanying CD. In addition, the compact version has a large introduction on stereotaxic surgery and the use of the atlas in the lab, as well as a number of panoramic simplified diagrams for student instruction. The Compact 3rd edition is in 8.5 x 11 format and is spiral bound suitable for positioning next to microscopes and cryotomes.
* Delineations of 100 coronal diagrams, as fully revised for the 3rd edition


* 100 coronal photographic plates produced from directly scanned very high resolution images of the biological sections (done at the Allen Institute)


* Beginner's guide with 25 pages on how to do stereotaxic surgery, how to use the atlas, including how to match experimental sections against the atlas plates (e.g. what features of the brain change gradually and can be used as guides to location)


* 3 sagittal, 5 coronal and 2 horizontal simplified overview diagrams for students


* Surface views of the brain with labels over the major structures


* Uses the best ontology tree (nomenclature based on the development of the brain) so farconstructed with universal application across mammals


* CD providing electronic versions of all diagrams and photographs in different resolutions for downloads

Atlas of the Spinal Cord - Mouse, Rat, Rhesus, Marmoset, and Human (Hardcover): Gulgun Sengul, Charles Watson, Ikuko Tanaka,... Atlas of the Spinal Cord - Mouse, Rat, Rhesus, Marmoset, and Human (Hardcover)
Gulgun Sengul, Charles Watson, Ikuko Tanaka, George Paxinos
R3,450 R2,589 Discovery Miles 25 890 Save R861 (25%) Shipped within 7 - 12 working days

The "Atlas of the Spinal Cord" is the first comprehensive atlas of rodent and primate spinal cords. This atlas features histological images and labeled drawings of every segment from rat, mouse, marmoset monkey, rhesus monkey, and human spinal cords. Nissl-stained section images and matching drawings for each segment are supplemented by up to four histochemical or immunohistochemical images on a facing page. The neuron groups supplying major limb muscles are identified in each species. Constructed by the established leaders in neuroanatomical atlas development, this new atlas will be the indispensible resource for scientists who work on rodent or primate spinal cord.
Full-color photographic images of Nissl-stained sections from every spinal cord segment in each of two rodent and three primate species over 160 Nissl platesComprehensively labeled diagrams to accompany each Nissl-stained section over 160 diagramsMore than 500 photographic images of sections stained for AChE, ChAT, parvalbumin, NADPH- diaphorase, calretinin, or other markers to supplement the Nissl-stained imagesDigital versions of diagrams are available to purchasers of this book via a website "

A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates (Hardcover, 2nd edition): Kadharbatcha... A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates (Hardcover, 2nd edition)
Kadharbatcha S. Saleem, Nikos K. Logothetis
R3,925 R3,295 Discovery Miles 32 950 Save R630 (16%) Shipped within 7 - 12 working days

The second edition of this atlas maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET.
The first rhesus monkey brain atlas with horizontal, coronal, and sagittal planes of sections, derived from the same animal.Shows the first detailed delineations of the cortical and subcortical areas in horizontal, coronal, and sagittal plane of sections in the same animal using different staining methods.Horizonal series illustrates the dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographic sections matched with 47 detailed diagrams (Chapter 3). Coronal series presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographic sections, with 76 corresponding drawings (Chapter 4).Sagittal series shows the complete mediolateral extent of the left hemisphere in 30 sagittal MRI sections, with 30 corresponding drawings (Chapter 5). The sagittal series also illustrates the location of different fiber tracts in the white matter."Individual variability" - provides selected cortical and subcortical areas in three-dimensional MRI (horizontal, coronal, and sagittal MRI planes). For comparison, it also provides similar areas in coronal MRI section in six other monkeys. (Chapter 6)"Vasculature" - indicates the corresponding location of all major blood vessels in horizontal, coronal, and sagittal series of sections. Provides updated information on the cortical and subcortical areas, such as architectonic areas and nomenclature, with references, in chapter 2.Provides the sterotaxic grid derived from the in-vivo MR image.

Basic Neurochemistry - Principles of Molecular, Cellular, and Medical Neurobiology (Hardcover, 8th edition): George J. Siegel,... Basic Neurochemistry - Principles of Molecular, Cellular, and Medical Neurobiology (Hardcover, 8th edition)
George J. Siegel, R. Wayne Albers, Donald Price, Scott Brady
R2,495 R2,137 Discovery Miles 21 370 Save R358 (14%) Shipped within 7 - 12 working days

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.

This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking;Stem cells, adult neurogenesis, regeneration;Lipid messengers;Expanded coverage of all major neurodegenerative and psychiatric disorders;Neurochemistry of addiction;Neurochemistry of pain;Neurochemistry of hearing and balance;Neurobiology of learning and memory;Sleep;Myelin structure, development, and disease;Autism; andNeuroimmunology.

The new edition features:

* Completely updated text with new authors and material, and many entirely new chapters * Over 400 fully revised figures in splendid color * 61 chapters covering the range of cellular, molecular and medical neuroscience * Translational science boxes emphasizing the connections between basic and clinical neuroscience * Companion website at http: //elsevierdirect.com/companions/9780123749475"

Ocular Periphery and Disorders (Hardcover): Darlene A. Dartt, Peter Bex, Patricia A. D'Amore, Reza Dana, Linda Mcloon, J y... Ocular Periphery and Disorders (Hardcover)
Darlene A. Dartt, Peter Bex, Patricia A. D'Amore, Reza Dana, Linda Mcloon, …
R2,384 R1,988 Discovery Miles 19 880 Save R396 (17%) Shipped within 7 - 12 working days

This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important diseases, including optic neuritis, thyroid eye disease, and strabismus. The volume offers a basic science background of these topics rather than a strictly clinical focus.

*The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the ocular periphery

*Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers

*The best researchers in the field provide their conclusions in the context of the latest experimental results

Quantum Magnetic Resonance Imaging Diagnostics of Human Brain Disorders (Hardcover, UK ed.): Madan M. Kaila, Rakhi Kaila Quantum Magnetic Resonance Imaging Diagnostics of Human Brain Disorders (Hardcover, UK ed.)
Madan M. Kaila, Rakhi Kaila
R2,434 R1,998 Discovery Miles 19 980 Save R436 (18%) Shipped within 7 - 12 working days

Magnetic resonance imaging (MRI) is a medical imaging technique used to visualize detailed internal structure of the body. This book discusses the recent developments in the field of MRI and its application to the diagnosis of human brain disorders. In addition, it reviews the newly emerging concepts and technology, based on the multi-coherence imaging (MQCI). It explains how computer packages can be used to generate images in diseased states and compare them to in vivo results. This will help improve the diagnosis of brain disorders based on the real-time events happening on atomic and molecular quantum levels. This is important since quantum-based MRI would enable clinicians to detect brain tumors at the very early stages.
Uses practical examples to explain the techniques - making it easier to understand the concepts
Uses diagrams to explain the physics behind the technique - avoiding the use of complicated mathematical formulae

Primer on the Autonomic Nervous System (Paperback, 3rd edition): Primer on the Autonomic Nervous System (Paperback, 3rd edition)
R1,694 R1,583 Discovery Miles 15 830 Save R111 (7%) Shipped within 7 - 12 working days

The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist s bookshelf
* Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience
* Provides key information about all aspects of autonomic physiology and pathology
* Discusses stress and how its effects on the body are mediated
* Compiles contributions by over 140 experts on the autonomic nervous system"

The Brain - An Introduction to Functional Neuroanatomy (Hardcover): Charles Watson, Matthew Kirkcaldie, George Paxinos The Brain - An Introduction to Functional Neuroanatomy (Hardcover)
Charles Watson, Matthew Kirkcaldie, George Paxinos
R1,019 R962 Discovery Miles 9 620 Save R57 (6%) Shipped within 7 - 12 working days

The authors of the most cited neuroscience publication, "The Rat Brain in Stereotaxic Coordinates," have written this introductory textbook for neuroscience students. The text is clear and concise, and offers an excellent introduction to the essential concepts of neuroscience.

Based on contemporary neuroscience research rather than old-style medical school neuroanatomy

Thorough treatment of motor and sensory systems

A detailed chapter on human cerebral cortex

The neuroscience of consciousness, memory, emotion, brain injury, and mental illness

A comprehensive chapter on brain development

A summary of the techniques of brain research

A detailed glossary of neuroscience terms

Illustrated with over 130 color photographs and diagrams

This book will inspire and inform students of neuroscience. It is designed for beginning students in the health sciences, including psychology, nursing, biology, and medicine.
Clearly and concisely written for easy comprehension by beginning students

Based on contemporary neuroscience research rather than the concepts of old-style medical school neuroanatomy

Thorough treatment of motor and sensory systems

A detailed chapter on human cerebral cortex

Discussion of the neuroscience of conscience, memory, cognitive function, brain injury, and mental illness

A comprehensive chapter on brain development

A summary of the techniques of brain research

A detailed glossary of neuroscience terms

Illustrated with over 100 color photographs and diagrams

Context Effects on Embodied Representation of Language Concepts (Paperback, New): Jie Yang Context Effects on Embodied Representation of Language Concepts (Paperback, New)
Jie Yang
R460 Discovery Miles 4 600 Shipped within 7 - 11 working days

Embodied theories claim that semantic representations are grounded in sensorimotor systems, but the contribution of sensorimotor brain areas in representing meaning is still controversial. One current debate is whether activity in sensorimotor areas during language comprehension is automatic. Numerous neuroimaging studies reveal activity in perception and action areas during semantic processing that is automatic and independent of context, but increasing findings show that involvement of sensorimotor areas and the connectivity between word-form areas and sensorimotor areas can be modulated by contextual information. "Context Effects on Embodied Representation of Language Concepts "focuses on these findings and discusses the influences from word, phrase, and sentential contexts that emphasize either dominant conceptual features or non-dominant conceptual features.
Reviews the findings about contextual modularityClarifies the invariant and flexible features of embodied lexical-semantic processing

The Human Nervous System (Hardcover, 3rd edition): Juergen K. Mai, George Paxinos The Human Nervous System (Hardcover, 3rd edition)
Juergen K. Mai, George Paxinos
R4,200 R3,529 Discovery Miles 35 290 Save R671 (16%) Shipped within 7 - 12 working days

The previous two editions of the "Human Nervous System "have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with newchapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the "Atlas of the Human Brain," and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.
Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. "Atlas of the Human Brain" (new edition in 2007)Full color throughout with many new and significantly enhanced illustrationsProvides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies"

Mouse Behavioral Testing - How to Use Mice in Behavioral Neuroscience (Hardcover): Douglas Wahlsten Mouse Behavioral Testing - How to Use Mice in Behavioral Neuroscience (Hardcover)
Douglas Wahlsten
R2,504 Discovery Miles 25 040 Shipped within 7 - 11 working days

This book presents the essentials of behavioral test methodology needed for effective study planning and high quality behavioral data collection on laboratory mice. The broad scope of behavioral testing in relation to the neurosciences is discussed, as are thefine details of varioustest situations. Mistakes made in past research are scrutinized and lessons are drawn about how to avoid them in future work. Diverse factors that can influence the results of behavioral experiments are discussed, ranging from the specific parameters employed in a test to the laboratory environment outside the test situation itself. Throughout the book, emphasis is placed on special issues that arise when testing genetically different mice, including inbred strains and mice with targeted mutations. This knowledge will assist an investigator who lacks formal training in behavioral psychology to build a behavioral testing lab and insure that its output meets current standards of good practice in behavioral neuroscience research.

The book will be a convenient manual of procedures for daily use in studies of mouse behavior. It will be of interest even to experienced behavioural researchers, but of particular value to scientists just beginning work with mice, including undergraduate and graduate students as well as postdoctoral investigators who want to collect phenotypic data with knockout and other genetically defined mice. Constructed from materials used in a long running course on Advanced Animal Behavior at University of North Carolina-Greensboro, the book is an ideal text for a course on behavioral testing.
A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific testDiagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicasProvides step-by-step instructions on planning and executing behavioral experiments in order to run them successfullyA companion website will provide access to statistical utilities in Excel and test protocols, examples of real documents used for published studies, and video clips of the mice behaviors resulting from various tests"

Headache: Handbook of Clinical Neurology Series 3 (Editors: Aminoff, Boller and Swaab) (Hardcover): Headache: Handbook of Clinical Neurology Series 3 (Editors: Aminoff, Boller and Swaab) (Hardcover)
R5,732 R5,355 Discovery Miles 53 550 Save R377 (7%) Shipped within 7 - 12 working days

This volume is about headache disorders, a universal problem for healthcare providers around the globe. It encompasses major developments, including the role of genetics and genomics in the emergence of new fields such as migraine genetics.

Clinicians will find an exhaustive, up-to-date accounting of cultural developments and the scientific advances that have revolutionized the medical community s understanding of all types of headaches. The value of evidence-based medicine and transitional research is highlighted, along with diagnostic tools that have proven effective in clinical settings.

This handbook provides a comprehensive explanation of the neurobiological aspects of the nervous system in health and disease, as well as the clinical aspects of neurological disease. In addition, the contributions made by the biological sciences to further an understanding of the pathophysiology of headaches are discussed, with critical information on primary and secondary headaches.
* A comprehensive guide to the advancements made in headache research and medicine, including the role of genetics and genomics
* An exhaustive accounting of cultural developments and scientific advances in headache medicine
* Critical information on primary and secondary headaches, including new therapies, prevention techniques, and management protocols"

Principles of Behavioral Genetics (Paperback, New): Robert R.H. Anholt, Trudy F.C. Mackay Principles of Behavioral Genetics (Paperback, New)
Robert R.H. Anholt, Trudy F.C. Mackay
R1,593 Discovery Miles 15 930 Shipped within 7 - 11 working days

How do genes determine behavior? How much of behavior is nature versus nurture? How do behaviors evolve? Anholt and Mackay, leading scholars in the field of behavioral genetics, address these questions and much more in this comprehensive textbook that defines the emerging field of behavioral genetics. The provides a range of examples, such as laboratory studies on flies and mice, field observations on species as diverse as butterflies and meerkats, and human behavioral disorders. The book blends classical and modern genetic principles with neurobiological and ecological perspectives to teach students how to find and map genes that affect behaviors, as well as how the coordinated expression of ensembles of these genes enables the nervous system to express complex behaviors in response to changes in the environment. Principles of Behavioral Genetics introduces us to the fascinating science that aims to understand how our genes determine what makes us tick.
Principles of Behavioral Genetics presents a comprehensive overview of the relationship between genes, brain and behavior. Introductory chapters provide clear explanations of basic processes of the nervous system and fundamental principles of genetics of complex traits without excessive statistical jargon. Individual chapters describe the genetics of social interactions, olfaction and taste, memory and learning, circadian behavior, locomotion, sleep, and addiction, as well as the evolution of behavior. Whereas the focus is on genetics, neurobiological and ecological aspects are also included to provide intellectual breadth. The book uses examples that span the gamut from classical model organisms to non-model systems and human biology, and include both laboratory and field studies. Samples of historical information accentuate the text to provide the reader with an appreciation of the history of the field. All chapters contain general overviews, concise summaries, study questions that promote not only memorization but also contemplation of the material, and recommendations for further in-depth reading. An extensive glossary that defines the terminology used in the book is included. This textbook encompasses a broad definition of the emerging science of behavioral genetics.
* Defines the emerging science of behavioral genetics
* Engagingly written by two leading experts in behavioral genetics
* Clear explanations of basic quantitative genetic, neurogenetic and genomic applications to the study of behavior
* Numerous examples ranging from model organisms to non-model systems and humans
* Concise overviews and summaries for each chapter

Principles of Hormone/Behavior Relations (Hardcover, New): Donald Pfaff Principles of Hormone/Behavior Relations (Hardcover, New)
Donald Pfaff
R1,531 Discovery Miles 15 310 Shipped within 7 - 11 working days

This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline.
* Uniform presentation of material across all chapter, with each chapter addressing a key principle, illustrated by basic experimental and clinical examples
* Includes user-friendly features such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations
* Illustrations highlight both the clinical and basic science information

Pathophysiology, Pharmacology and Biochemistry of Dyskinesia, Volume 98 (Hardcover, New): Jonathan Brotchie, Erwan Bezard,... Pathophysiology, Pharmacology and Biochemistry of Dyskinesia, Volume 98 (Hardcover, New)
Jonathan Brotchie, Erwan Bezard, Peter Jenner
R3,134 R2,914 Discovery Miles 29 140 Save R220 (7%) Shipped within 7 - 12 working days

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Pharmacology of 5-HT6 receptors, Part I, Volume 94 (Hardcover, 94th edition): Franco Borsini Pharmacology of 5-HT6 receptors, Part I, Volume 94 (Hardcover, 94th edition)
Franco Borsini
R2,956 R2,775 Discovery Miles 27 750 Save R181 (6%) Shipped within 7 - 12 working days

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes, and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.

written by expert researchers covers all published literature to date in the field of 5-HT6 receptors

Epigenetic Regulation in the Nervous System - Basic Mechanisms and Clinical Impact (Hardcover, New): J. David Sweatt, Michael... Epigenetic Regulation in the Nervous System - Basic Mechanisms and Clinical Impact (Hardcover, New)
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, Schahram Akbarian
R2,377 R1,924 Discovery Miles 19 240 Save R453 (19%) Shipped within 7 - 12 working days

"Epigenetic Regulation in the Nervous System" addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winningvolume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.
2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Sciencefrom the Association of American PublishersPresents a unified view of epigenetic mechanisms from behavior to genes and everything in betweenDiscusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientistsProvides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics"

Optogenetics, Volume 196 - Tools for Controlling and Monitoring Neuronal Activity (Hardcover): Thomas Knopfel, Edward S Boyden Optogenetics, Volume 196 - Tools for Controlling and Monitoring Neuronal Activity (Hardcover)
Thomas Knopfel, Edward S Boyden
R4,404 R4,136 Discovery Miles 41 360 Save R268 (6%) Shipped within 7 - 12 working days

Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology.

These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.
Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Handbook of Reward and Decision Making (Hardcover): Jean-Claude Dreher, Leon Tremblay Handbook of Reward and Decision Making (Hardcover)
Jean-Claude Dreher, Leon Tremblay
R2,948 R2,396 Discovery Miles 23 960 Save R552 (19%) Shipped within 7 - 12 working days

This book addresses a fundamental question about the nature of behavior: how does the brain process reward and makes decisions when facing multiple options? The book presents the most recent and compelling lesion, neuroimaging, electrophysiological and computational studies, in combination with hormonal and genetic studies, which have led to a clearer understanding of neural mechanisms behind reward and decision making. The neural bases of reward and decision making processes are of great interest to scientists because of the fundamental role of reward in a number of behavioral processes (such as motivation, learning and cognition) and because of their theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders (schizophrenia, Parkinson's disease, drug addiction, pathological gambling, ...).

* Comprehensive coverage of approaches to studying reward and decision making, including primate neurophysiology and brain imaging studies in healthy humans and in various disorders, genetic and hormonal influences on the reward system and computational models.

* Covers clinical implications of process dysfunction (e.g., schizophrenia, Parkinson's disease, eating disorders, drug addiction, pathological gambling)

* Uses multiple levels of analysis, from molecular mechanisms to neural systems dynamics and computational models.

" "This is a very interesting and authoritative handbook by some of the most outstanding investigators in the field of reward and decision making "," Professor Edmund T. Rolls, Oxford Center for Computational Neuroscience, UK

The Rat Brain in Stereotaxic Coordinates - Hard Cover Edition (Spiral bound, 6th edition): George Paxinos, Charles Watson The Rat Brain in Stereotaxic Coordinates - Hard Cover Edition (Spiral bound, 6th edition)
George Paxinos, Charles Watson
R3,783 R3,179 Discovery Miles 31 790 Save R604 (16%) Shipped within 7 - 12 working days

This completely revised edition of The Rat Brain in Stereotaxic Coordinates, the second most cited book in science, represents a dramatic update from the previous edition. Based on a single rat brain, this edition features an entirely new coronal set of tissue cut in regular 120 micron intervals with accompanying photographs and drawings of coronal, horizontal and sagittal sections of this new set. The use of the single brain allows for greater consistency between sections, while advances in histochemistry techniques provides increased refinement in the definition of brain areas, making this the most accurate and detailed stereotaxic rat atlas produced to date. The atlas will also include a CD-ROM featuring all of the graphics and text. Every lab working with the rat as an experimental animal model will want to use this book as their atlas of choice.
This book is also available in a softcover spiral binding at the same price.
* Includes twice as many coronal sections, nissl plates, and sagittal plates as the previous edition
* Uses a single rat brain allowing for better consistency and better delineations in the line drawings of structures
* Provides improved stereotaxic coordinates at a higher level of detail
* Accompanying CD-ROM features graphics and text
* Now available as hardcover version and softcover version with a spiral binding at the same price.

Neurobiology of Psychiatric Disorders, Volume 106 (Hardcover, 3rd ed.): Thomas E. Schlaepfer, Charles B. Nemeroff Neurobiology of Psychiatric Disorders, Volume 106 (Hardcover, 3rd ed.)
Thomas E. Schlaepfer, Charles B. Nemeroff; Series edited by Michael J. Aminoff, Fran cois Boller, Dick. F. Swaab
R4,377 R3,586 Discovery Miles 35 860 Save R791 (18%) Shipped within 7 - 12 working days

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.
*Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment
*Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders
*A must have reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain"

Slow Brain Oscillations of Sleep, Resting State and Vigilance, Volume 193 (Hardcover, New): E. J. Van Someren Slow Brain Oscillations of Sleep, Resting State and Vigilance, Volume 193 (Hardcover, New)
E. J. Van Someren
R4,763 R4,378 Discovery Miles 43 780 Save R385 (8%) Shipped within 7 - 12 working days

This volume of "Progress in Brain Research" documents research presented at the 26th International Summer School of Brain Research (Amsterdam, Jun/Jul 2010) and looks at how the oscillations that characterize brain activity vary between task performance - the EEG power and performance modulations, rest - the MRI default mode and other networks, and sleep - the cortical slow oscillations. Studies over the past decade indicate that the study of these slow oscillations is essential for our understanding of plasticity, memory, brain structure from synapse to default mode network, cognition, consciousness and ultimately for our understanding of the mechanisms and functions of sleep and vigilance.
Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Muscular Dystrophies, Volume 101 (Hardcover): Muscular Dystrophies, Volume 101 (Hardcover)
R3,337 R2,789 Discovery Miles 27 890 Save R548 (16%) Shipped within 7 - 11 working days

This volume provides clinicians and scientists with the latest information concerning the muscular dystrophies, paying special attention to the way advancements in molecular and cell biology, biochemistry, and other biological sciences provide comprehensive insights into a group of disorders that have only been studied for the past two decades.

Information on both pathogenesis and prospects for treatment are covered, with an emphasis on clinical implications, both now and in the foreseeable future. Clinical wisdom is combined with invaluable perspectives from the most highly experienced physicians, experts, and scientists to bring an authoritative and complete examination of the muscular dystrophies, their diagnosis, and treatments protocols. Insights from this handbook will both enhance and forward efforts for practitioners who care for, and manage, patients with this group of disorders.
* Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management
* A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies
* An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

Sleep Disorders Part II, Volume 99 (Hardcover, New): Pasquale Montagna, Sudhansu Chokroverty Sleep Disorders Part II, Volume 99 (Hardcover, New)
Pasquale Montagna, Sudhansu Chokroverty
R4,338 R3,646 Discovery Miles 36 460 Save R692 (16%) Shipped within 7 - 12 working days

This volume explores sleep medicine, sleep science, and the sleep disorders that keep one-quarter of the U.S. population from getting this necessary component of normal cognitive functioning and survival.

With an emphasis on diagnostic techniques, particularly imaging, this handbook shines newfound attention on the genetic and clinical aspects of sleep medicine. Advances in basic science are explored, including a better understanding of sleep-wakefulness and new models of rapid eye movement (REM) sleep mechanisms. Advancements in the understanding of sleep-wake-dependent genes, gene products, and the role of sleep duration in mortality and morbidity are also presented, along with fascinating noninvasive neuroimaging studies that demonstrate marked changes in function during different sleep states.

Clinicians will gain new insights into the diagnosis of sleep disorders and sleep science. In addition, researchers will have an invaluable tool that will form a foundation for new approaches into the ongoing study of sleep medicine.
* A comprehensive resource for the study of sleep science, sleep medicine, and sleep disorders
* Fascinating noninvasive neuroimaging studies that demonstrate marked changes during different sleep states
* A state-of-the-art reference that summarizes the clinical features and management of many of the neurological manifestations of sleep disorders

Neuroinflammation (Hardcover): Alireza Minagar Neuroinflammation (Hardcover)
Alireza Minagar
R2,500 R2,101 Discovery Miles 21 010 Save R399 (16%) Shipped within 7 - 12 working days

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair.

This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome.
Comprehensive review of the latest developments in neuroinflammation
Includes contributions from leading authorities

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