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Books > Academic & Education > Professional & Technical > Neuroscience
Epilepsy, Part I, "Basic Principles and Diagnosis," Volume 107,
in the"Handbook of Clinical Neurology"series offers a comprehensive
review of our knowledge of the field today, including epidemiology,
basic mechanisms, animal models, and topics of increasing interest
such as the role of inflammation in epilepsy. It provides a
comprehensive approach to description of the clinical,
electrographic and imaging aspects of the epilepsies, with a clear
outline of contemporary classification and the role of modern
diagnostic techniques, as well as neuropsychological and
psychiatric aspects of epilepsy. Chapters are authored by
internationally respected neurologists with varied perspectives
insuring depth to the content. "Epilepsy, Part II," "Treatment, "
Volume 108, continues coverage of epilepsy with a focus on
treatment. The volumes will be a very important resource for basic
scientists, clinical investigators, and all health professionals
treating patients with epilepsy.
Epilepsy, Part II, "Treatment, " Volume 108, provides a full
description of epilepsy pathology and etiology, antiepileptic drug
treatment, the approach to surgical evaluation and alternative
procedures to be considered, in both children and adults, as well
as brain stimulation and diet treatment. Economic and psychosocial
issues such as stigma are fully covered. The special problems of
epilepsy treatment in the developing world are described. Chapters
are authored by internationally respected neurologists with varied
perspectives insuring depth to the content. "Epilepsy, Part I,"
"Basic Principles and Diagnosis," Volume 107, establishes the
scientific and practical diagnosis of epilepsy. The volumes will be
a very important resource for basic scientists, clinical
investigators, and all health professionals treating patients with
epilepsy.
Gap junctions between glial cells or neurons are ubiquitously
expressed in the mammalian brain and play a role in brain
development including cell differentiation, cell migration and
survival, and tissue homeostasis, as well as in human diseases
including hearing loss, neuropathies, epilepsy, brain trauma, and
cardiovascular disease. This volume provides neuroscience
researchers and students with a single source for information
covering the physiological, behavioral and pathophysiological roles
of gap junctions in the brain. In addition, the book also discusses
human disease conditions associated with mutations in single gap
junction connexion genes, making it applicable to clinicians doing
translational research. Finally, it includes reviews of
pharmacological studies with gap junction blockers and openers,
summarizing information obtained from phenotyping gap junctions
mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes. Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
The imaging of small cellular components requires powerful
instruments, and an entire family of equipment and techniques based
on the confocal principle has been developed over the past 30
years. Such methods are commonly used by neuroscience researchers,
but the majority of these users do not have a microscopy or a cell
biology backgrounds and do can encounter difficulties in obtaining
and interpreting results. This volume brings experts in
high-resolution optical microscopy applications in neuroscience and
cell biology together to document the state of the art. Outlining
what is currently possible, the volume also discusses promising
developments for the future and aids readers in selecting the most
scientifically meaningful approach to solve their questions. Each
chapter discusses instrumentation and technology in relationship to
application in research. All of the common and cutting edge trends
are covered - fluorescence / laser electron / nonlinear microscopy,
infrared fluorescence, multiphoton imaging, tomography, FRAP, live
imaging, STED, PALM/STORM, etc.
This new volume in the Handbook of Clinical Neurology presents a
comprehensive review of the fundamental science and clinical
treatment of psychiatric disorders. Advances in neuroscience have
allowed for dramatic advances in the understanding of psychiatric
disorders and treatment. Brain disorders, such as depression and
schizophrenia, are the leading cause of disability worldwide. It is
estimated that over 25% of the adult population in North America
are diagnosed yearly with at least one mental disorder and similar
results hold for Europe. Now that neurology and psychiatry agree
that all mental disorders are in fact, "brain diseases," this
volume provides a foundational introduction to the science defining
these disorders and details best practices for psychiatric
treatment.
Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are
starting to have impact on fields ranging from metabolism to
development to cardiology. The book contains a dozen chapters
written by world experts on these topics, half focusing on the
optogenetic molecular tools themselves, and half on the genetic and
hardware approaches that make them powerfully useful in intact
tissues and organisms.
This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system. Clinicians will find this handbook to be an invaluable resource
for summarizing the present state of scientific and clinical
knowledge in the field of neuro-oncology. In addition,
practitioners in the field will uncover new tactics and therapies
that will aid them in providing optimal neuro-oncological care for
their patients.
Handbook of Clinical Neurology: Neuro-Oncology, Part II provides an overview of the most recent developments in the field of neuro-oncology, including new diagnostic imaging techniques, along with immunology, molecular biology, and clinical aspects of different types of tumors. It also considers management and new therapeutic strategies for tumors, such as gene therapy, radiation therapy, and molecularly targeted treatments. Divided into five sections encompassing 33 chapters, the book begins with a description of specific tumor types such as low-grade gliomas, anaplastic astrocytomas, and medulloblastoma and primitive neuroectodermal tumors, along with rare brain tumors like neurofibromatosis and other genetic syndromes. It then discusses tumors at special sites, from brainstem tumors to peripheral nerve tumors, tumors of the meninges, and optic, hypothalamic, and thalamic tumors. It also explains the neurological complications of systemic cancer and the adverse effects of some treatments. Clinicians and neuroscientists, as well as researchers who read this book, will gain a better understanding of the clinical features and management of the neurological manifestations of tumors.
This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology. Written by internationally-renowned scientists, this timely
volume will be of wide interest to students, scholars, science
journalists, and a variety of experts who are interested in keeping
track of the discoveries that are rapidly emerging about the
evolution of the brain and cognition. Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.
One of the most pressing questions in neuroscience, psychology
and economics today is how does the brain generate preferences and
make choices? With a unique interdisciplinary approach, this volume
is among the first to explore the cognitive and neural mechanisms
mediating the generation of the preferences that guide choice. From
preferences determining mundane purchases, to social preferences
influencing mating choice, through to moral decisions, the authors
adopt diverse approaches to answer the question. Chapters explore
the instability of preferences and thecommon neural processes that
occur across preferences. Edited by one of the world s most
renowned cognitive neuroscientists, each chapter is authored by an
expert in the field, with a host of international
contributors.
Published since 1959, International Review of Neurobiology is a
well-known series appealing to neuroscientists, clinicians,
psychologists, physiologists, and pharmacologists. Led by an
internationally renowned editorial board, this important serial
publishes both eclectic volumes made up of timely reviews and
thematic volumes that focus on recent progress in a specific area
of neurobiology research. This volume reviews existing theories and
current research surrounding the movement disorder
Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Neuroendocrinology, the discipline concerned with how the
nervous system controls hormonal secretion and how hormones control
the brain, is pivotal to physiology and medicine.
Neuroendocrinology has disclosed and underpins fundamental
physiological, molecular biological and genetic principles such as
the regulation of gene transcription and translation, the
mechanisms of chemical neurotransmission and intracellular and
systemic feedback control systems. Reproduction, growth, stress,
aggression, metabolism, birth, feeding and drinking and blood
pressure are some of the bodily functions that are triggered and/or
controlled by neuroendocrine systems. In turn, neuroendocrine
dysfunction due to genetic or other deficits can lead, for example,
to infertility, impotence, precocious or delayed puberty, defective
or excessive growth, obesity and anorexia, Cushing s Syndrome,
hypertension or thyroid disorders. These as well as neuroendocrine
tumors are some of the themes covered in the 36 chapters of the
Handbook. Drafted by internationally acknowledged experts in the
field, the Handbook chapters feature detailed up-to-date
bibliographies as well as "how do we know?" call out sections that
highlight the experimental or technical foundations for major
concepts, principles, or methodological advances in each area.
Aimed at senior undergraduate and graduate students, post-doctoral
fellows and faculty in neuroscience, medicine, endocrinology,
psychiatry, psychology and cognate disciplines, the "Handbook of
Neuroendocrinology" satisfies an unmet need that will prove useful
at the laboratory bench as well as in the office.
This volume follows on from the symposium "Brain Machine
Interfaces - Implications for science, clinical practice and
society," held on August 26th-29th 2010 in Ystad, Sweden, and
features contributions from pioneers and leading scientists in the
field of BMI and motor systems physiology, including spinal cord,
basal ganglia and motor cortex. The wide range of topics covered
include implants for mind control of prostheses and in robotics,
clinical and experimental research on Deep Brain Stimulation (DBS)
for the treatment of Parkinson s disease, depression and Alzheimer
s disease, cochlear implants, retinal implants, novel flexible
micro- and nano-electrode implants, safety aspects including acute
and chronic tissue reactions to implants and on ethical issues in
DBS. Program and abstracts from the individual contributors can be
found on http: //www.med.lu.se/nrc/bmi_symposium.
This volume of "Progress in Brain Research" documents research
presented at the 26th International Summer School of Brain Research
(Amsterdam, Jun/Jul 2010) and looks at how the oscillations that
characterize brain activity vary between task performance - the EEG
power and performance modulations, rest - the MRI default mode and
other networks, and sleep - the cortical slow oscillations. Studies
over the past decade indicate that the study of these slow
oscillations is essential for our understanding of plasticity,
memory, brain structure from synapse to default mode network,
cognition, consciousness and ultimately for our understanding of
the mechanisms and functions of sleep and vigilance.
This volume of "Progess in Brain Research" follows on from the 32nd International Symposium of the Groupe de recherche sur le systeme nerveux central (GRSNC), May 2010, and aims to provide an overview of the various neural mechanisms that contribute to learning new motor and sensory skills, and to adapting to changed circumstances, including the use of devices and implants to substitute for lost sensory or motor abilities (brain machine interfaces). The focus is on recent developments covering five major themes: Mechanisms to improve motor performanceNeuro-rehabilitation of motor functionMechanisms to enhance sensory perceptionCross modal interationc for enhancing sensorimotor performanceAssistive technologies to enhance sensorimotor performance This volume focuses on the translation of scientific knowledge
into applications and strategies that can help restore lost
function following injury or disease including assistive
neuroprosthetic technologies to enhance sensorimotor performance
and neurorehabilitation.
This volume of "Progess in Brain Research" follows on from the
32nd International Symposium of the Groupe de recherche sur le
systeme nerveux central (GRSNC), May 2010, and aims to provide an
overview of the various neural mechanisms that contribute to
learning new motor and sensory skills, and to adapting to changed
circumstances, including the use of devices and implants to
substitute for lost sensory or motor abilities (brain machine
interfaces). The focus is on recent developments covering five
major themes: Mechanisms to improve motor
performanceNeuro-rehabilitation of motor functionMechanisms to
enhance sensory perceptionCross modal interationc for enhancing
sensorimotor performanceAssistive technologies to enhance
sensorimotor performance
This volume provides a comprehensive look into the innovative methods used to explore the visual system. From the way the brain processes vision, an imperative part of the human experience, to the role eye movement plays in a range of questions concerning visual perception, memory, attention, free will, and even topological diagnoses, this in-depth handbook gives neurologists, ophthalmologists, and neuro-ophthalmologists an invaluable tool to help them better understand the visual system. Disorders of the retinal and cerebral cortex, and those that affect control of eye and lid movements are thoroughly discussed, along with groundbreaking visual rehabilitative methods, and chapters on individual parts of the visual system. Practitioners will find a useful resource that lays out fundamental concepts, while seamlessly summarizing clinical and laboratory methods for neuro-ophthalmological evaluation. The material is perfect for early-stage physicians or long
practicing specialists who wish to learn the latest developments in
the field.
Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Suchneurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field. This volume emphasizes essential observations from all of the
important clinical phases involved in any neuromodulation:
targeting, intraoperative assessment, programming, complications,
and complication avoidance. There are commonalities to all
neuromodulation procedures that must be brought to the forefront to
form a cohesive presentation of neuromodulation, and such emphasis
will give readers a more solid grounding in the fundamentals needed
to embrace this field as a cohesive clinical entity.
This volume provides clinicians and scientists with the latest information concerning the muscular dystrophies, paying special attention to the way advancements in molecular and cell biology, biochemistry, and other biological sciences provide comprehensive insights into a group of disorders that have only been studied for the past two decades. Information on both pathogenesis and prospects for treatment are
covered, with an emphasis on clinical implications, both now and in
the foreseeable future. Clinical wisdom is combined with invaluable
perspectives from the most highly experienced physicians, experts,
and scientists to bring an authoritative and complete examination
of the muscular dystrophies, their diagnosis, and treatments
protocols. Insights from this handbook will both enhance and
forward efforts for practitioners who care for, and manage,
patients with this group of disorders.
The Handbook of Clinical Neurology Vol 100: Hyperkinetic Movement Disorders discusses hyperkinetic disorders related mainly to basal ganglia dysfunction and pathology. It contains 13 sections and 51 chapters written by authoritative and experienced investigators and clinicians in this extremely broad and diverse group of diseases and syndromes. The first section on choreoathetoid diseases and syndromes includes chapters on Huntington's disease and Huntington's disease look-alikes; spinocerebellar degenerations; neuroacanthocytosis; entatorubral-pallidoluysian atrophy; neuroferritinopathy; neurodegeneration with brain iron accumulation; mitochondrial disorders; acquired hepatocerebral degeneration; benign hereditary chorea; and "senile chorea." The remaining chapters focus on the abnormal involuntary movements associated with each disease or syndrome. These include immune-related chorea, vascular chorea, metabolic disturbances that can induce chorea, chorea in other medical settings (e.g., postpump chorea in children, cancer-related paraneoplastic syndromes), myoclonus, essential tremor, and dystonia, including dystonia plus syndromes. There are also chapters on tardive dyskinesia, unusual clinical syndromes, and tics and stereotyped movements in children. The text is a valuable resource for neurology and psychiatry residents, practicing neurologists and psychiatrists, and specialists in movement disorders.
This selection of articles from the Encyclopedia of the Eye
covering retina, optics/optic nerve and comparative topics
constitutes the first reference for scientists, post docs, and
graduate students with an interest beyond standard textbook
materials. It covers the full spectrum of research on the retina -
from the basic biochemistry of how nerve cells are created to
information on neurotransmitters, comparisons of the structure and
neuroscience of peripheral vision systems in different species, and
all the way through to injury repair and other clinical
applications. *The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of the retina *Chapters are carefully selected from the Encyclopedia of the Eye by one of the world's leading vision researchers *The best researchers in the field provide their conclusions in the context of the latest experimental results
The serotonin 5-HT6 receptor represents a novel pharmacological
target whose impact on physiopathology of CNS functions remains
undetermined. Some receptor antagonists have been synthesized and
they show a modulatory role in learning and memory processes and
food intake. The pharmacology of 5-HT6 receptor agonists is still
under evaluation. However, both 5-HT6 antagonists and agonists seem
to exert potential antidepressant activity. Recently, a second
messenger system has been discovered. 5-HT6 receptor function is
becoming more and more intriguing. Thus, the aim of the present
book is to try to clarify the pharmacology of 5-HT6
receptors. written by expert researchers covers all published literature to date in the field of 5-HT6 receptors
This volume explores sleep medicine, sleep science, and the sleep disorders that keep one-quarter of the U.S. population from getting this necessary component of normal cognitive functioning and survival. With an emphasis on diagnostic techniques, particularly imaging, this handbook shines newfound attention on the genetic and clinical aspects of sleep medicine. Advances in basic science are explored, including a better understanding of sleep-wakefulness and new models of rapid eye movement (REM) sleep mechanisms. Advancements in the understanding of sleep-wake-dependent genes, gene products, and the role of sleep duration in mortality and morbidity are also presented, along with fascinating noninvasive neuroimaging studies that demonstrate marked changes in function during different sleep states. Clinicians will gain new insights into the diagnosis of sleep
disorders and sleep science. In addition, researchers will have an
invaluable tool that will form a foundation for new approaches into
the ongoing study of sleep medicine.
With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases.
With recent advances of modern medicine more people reach the "elderly age" around the globe and the number of dementia cases are ever increasing. This book is about various aspects of dementia and provides its readers with a wide range of thought-provoking sub-topics in the field of dementia. The ultimate goal of this monograph is to stimulate other physicians' and neuroscientists' interest to carry out more research projects into pathogenesis of this devastating group of diseases. |
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