Gap junctions between glial cells or neurons are ubiquitously
expressed in the mammalian brain and play a role in brain
development including cell differentiation, cell migration and
survival, and tissue homeostasis, as well as in human diseases
including hearing loss, neuropathies, epilepsy, brain trauma, and
cardiovascular disease. This volume provides neuroscience
researchers and students with a single source for information
covering the physiological, behavioral and pathophysiological roles
of gap junctions in the brain. In addition, the book also discusses
human disease conditions associated with mutations in single gap
junction connexion genes, making it applicable to clinicians doing
translational research. Finally, it includes reviews of
pharmacological studies with gap junction blockers and openers,
summarizing information obtained from phenotyping gap junctions
mouse mutants.
Serves as the most current and comprehensive reference available
covering the physiological, behavioral and pathophysiological roles
of gap junctions in the brain.
Chapters summarize knowledge of the basic physiology of gap
junctions in the brain, as well as of human disease conditions
associated with mutations in single gap junction connexin
genes.
Includes reviews of pharmacological studies with gap junction
blockers and openers, summarizing information obtained from
phenotyping gap junctions mouse mutants.
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