Ilana and Martin Gerschlowitz are an ordinary middle-class South African family – young, newly married with bright, promising futures. Ilana falls pregnant and gives birth to David, a happy, healthy baby boy. At 10 months old, David suffers recurring ear infections, and at 11 months old a terrible fever sends him to hospital. David’s behaviour abruptly changes – he no longer looks at his parents, his motor and budding language skills disappear, and the light in his eyes dims. It is the beginning of a journey with autism that few parents would ever want to encounter, and yet a staggering number of children are now diagnosed with autism, and the number of diagnoses rises every year.

Ilana and Martin work tirelessly to understand David’s autism diagnosis, and to search for ways to treat their son. The couple arrange an international autism conference, open a treatment centre for autistic children, and begin outreach programs for underprivileged families dealing with autism.

Ilana falls pregnant again and their third son, Aaron, develops normally. And then the unthinkable happens – at 16 months Aaron develops ear infections and they decide to insert grommets. Immediately after the procedure, they realise that Aaron is not behaving in his usual manner. Within days, it becomes clear that Aaron, too, has developed autism, and their journey begins afresh. Armed with the knowledge gained from years of treating David, the couple set about ensuring that Aaron’s condition is treated swiftly and carefully.

This outstanding text gives students a solid grounding in clinical and experimental neuropsychology. The author is a leading authority whose engaging writing style and thorough yet concise coverage of brain localization, anatomy, and their links to cognitive function make the book ideal for undergraduate or graduate use. It is illustrated with more than 60 figures, including six color plates.New to This Edition: *Incorporates more than two decades of major advances in the field--including developments in basic science, assessment, rehabilitation, and clinical research.*Coverage of neuroimaging.*Chapter on degenerative diseases and profound brain injury.

Artificial Intelligence for Neurological Disorders provides a comprehensive resource of state-of-the-art approaches for AI, big data analytics and machine learning-based neurological research. The book discusses many machine learning techniques to detect neurological diseases at the cellular level, as well as other applications such as image segmentation, classification and image indexing, neural networks and image processing methods. Chapters include AI techniques for the early detection of neurological disease and deep learning applications using brain imaging methods like EEG, MEG, fMRI, fNIRS and PET for seizure prediction or neuromuscular rehabilitation. The goal of this book is to provide readers with broad coverage of these methods to encourage an even wider adoption of AI, Machine Learning and Big Data Analytics for problem-solving and stimulating neurological research and therapy advances.

Introduction to Basic Aspects of the Autonomic Nervous System, Sixth Edition, Volume One is an all-encompassing reference on the autonomic nervous system's basic function, dysfunction and pathology. This volume describes the anatomy of the autonomic nervous system and its role in the regulation of blood pressure, body temperature, respiration, micturition, digestion and renal function. Additional chapters focus on the autonomic modulation of the neuroendocrine system, sexual function, and immunity. There is also a chapter on mummies and the autonomic nervous system. With these chapters, readers will gain extensive knowledge on the autonomic nervous system's anatomy, functional organization and neurochemistry, which is critical to care for patients with autonomic disorders and guide patient-oriented research.

Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing.

Genetic Models and Molecular Pathways Underlying Autism Spectrum Disorders, Volume 241 provides the most recent information on the animal model systems that are available to study different forms of autism spectrum disorders. In addition to genetically engineered animals that uniquely model genetic forms of ASD, this volume also provides detailed chapters on a variety of specific topics, including An overview of genetic models of ASDs, Phenotypic modeling of ASD symptoms, Molecular mechanisms of NF1 model of ASD symptoms, Ube3a gene dosage disorders: molecular and circuit mechanisms of ASD, Circuit dysfunctions in ASD models, ERK signaling in genetic models of ASD, and more.

Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more.

International Review of Research in Developmental Disabilities, Volume 55, provides a scholarly look at research on the causes, effects, classification systems and syndromes of developmental disabilities. Chapters in this new release include topics such as, Sensory Dysfunction Across Developmental Disabilities, The Role of natural communication partners in early communicate interventions for children with IDD, Adult employment in ID, The Future of Interventions to Foster Early Motor Development in Children with IDD, Developmental Perspectives of Problem Behaviors in DD. Contributors in this ongoing series come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

Imaging Methodology and Applications in Parkinson's Disease, Volume 141, provides an up-to-date and comprehensive textbook on the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools has played a pivotal role in expanding our understanding of disease etiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis, and in the identification of novel targets for therapeutic intervention. This book brings together lessons learned from neuroimaging tools in movement disorders, including chapters on Advances in PET Methodology, Advances in MRI Methodology, Advances in SPECT Methodology, Hybrid PET/MRI Methodology, and more.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Motor Biases, Volume 238, the latest release in the Progress in Brain Research series, discusses interdisciplinary research on the influence of cerebral lateralization on cognition within an evolutionary framework. Chapters of note in this release include Evolutionary Perspectives: Visual/Motor Biases and Cognition, Manual laterality and cognition through evolution: An archeological perspective, Laterality in insects, Motor asymmetries in fish, amphibians and reptiles, Visual biases and social cognition in animals, Mother and offspring lateralized social interaction across animal species, Manual bias, personality and cognition in common marmosets and other primates, and more.

Whereas most books about neurologic examinations are disease and anatomy oriented, The Neurologic Examination: Scientific Basis for Clinical Diagnosis focuses on a pathophysiological approach to the nervous system. The authors emphasize that the scientific interpretation of symptoms obtained from carefully taking the patient's history and noting signs found during physical examination are essential in the diagnosis of neurologic diseases, even if laboratory testing, such as electrophysiology and neuroimaging, are being more widely used. This book aims to provide a bridge from the basic sciences such as anatomy, physiology, pharmacology, and molecular biology to the neurologic symptoms. Neurologic examinations provide the foundation for the diagnosis, and only after a thorough and expertly executed examination can one begin to incorporate laboratory testing and treatment. The Neurologic Examination: Scientific Basis for Clinical Diagnosis, based on the widely successful Japanese book Diagnosis of Neurological Diseases (Igakushoin, Japan, second edition 2013) by Dr. Shibasaki, hopes to revitalize the use of neurologic examinations before jumping straight into laboratory testing. Doing so can help cut down on time, patient and physician anxiety, and unnecessary testing expenses. This book is a must-read for all practicing neurologists, residents, and medical students. Key Features Include * The chapters are arranged in order of the actual steps in a neurologic examination; * Highly illustrated with figures and tables indicative of the neurologic signs and symptoms that may appear during the given step; and * 99 discussion boxes are inserted throughout to provide a more in-depth look at particular topics without interrupting the reading flow of the text.

This issue of Neuroimaging Clinics of North America focuses on Pediatric Brain Tumors, and is edited by Dr. Lara A. Brandao. Articles will include: Posterior fossa tumors in pediatric patients; Supratentorial tumors in pediatric patients; Brain tumors in the neonate; Pineal region masses in pediatric patients; Sellar and suprasellar tumors in pediatric patients; Extraparenchymal lesions in pediatric patients; Tumor and tumor-like masses in pediatric patients that involve multiple spaces; Neuroimaging of innovative peptide base vaccine therapy in pediatric brain tumors; Advanced MRI in pediatric brain tumors: clinical applications; and much more!

This issue of Physical Medicine & Rehabilitation Clinics will focus on stroke rehabilitation and will include articles such as: Mechanisms of stroke recovery, Insights from basic sciences, Stroke recovery and predictors of rehabilitation outcomes, Upper limb motor impairments, Post-stroke spasticity, Communication disorders and dysphagia, Neuropharmacology of Recovery, Robotic therapy, and many more.

This issue provideds a comprehensive update to Sleep Medicine in the Intensive Care Unit, with editors Vipin Malik and Teofilo Lee-Chiong assembling a line-up of key topics such as:Sleep Neurobiology and Critical Care Illness,Obesity Hypoventilation Syndrome and Respiratory Failure,Obstructive Sleep Apnea,Non-Invasive Ventilation in Critically Ill Patients,Restless Leg Syndrome,Sleep and Endocrine System,Congestive Heart Failure and Central Sleep Apnea,Circadian Dysrhythmias,Neuromuscular Disorders and Sleep in Critically Ill Patients, Perioperative Issues and Sleep Disordered Breathing, Seizures, and more!

This book focuses on two fundamental aspects of brain-language relations: one concerns the neural organization of language in the healthy brain; the other challenges current approaches to treatment of aphasia and offers a new theory for recovery from aphasia. The essence of the book lies in the phrase neural multifunctionality: the constant and dynamic incorporation of non-linguistic functions into language models of the intact brain. The book makes the claim that language is a construction, created as we use it, and cannot be understood as being supported by neurally based linguistic networks only. Rather, language emerges from the constant and dynamic interaction among neural networks subserving cognitive, affective, and praxic functions with neural networks subserving lexical retrieval (naming), sentence processing (comprehension), and discourse (communication, conversation). In persons with stroke-induced aphasia, neural networks for executive system function, attention, memory, motor system function, visual system function, and emotion interact with neural networks for language to produce the aphasia profile and to influence recovery from aphasia. Consequently, neural multifunctionality in aphasia explains individual differences in the lesion-deficit model and continued recovery over time, redefining the concept of recovery from aphasia and offering new opportunities for treatment.

Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapid growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate most optimal regenerative strategies to treatments of human nervous system injuries. "

Neural Regeneration" provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including 1) neural regeneration in lower vertebrates, 2) neural regeneration in the peripheral nervous system, 3) neural regeneration in the central nervous system, 4) transplantation-mediated neural regeneration, and 5) clinical and translational research on neural regeneration. The contributors of this book are experts in each of their respective fields and are highly international including scientists working at different institutions in the United States, Canada, Australia and China.

This valuable reference book will be useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.
Provide an overview of cutting-edge knowledge on a broad spectrum of neural regeneration. Highly translational and clinically-relevanceInternational authors who are leaders in their respective fieldsVivid art work making the chapters easily understood

Genetic Patterns in Neuroimaging is explored in this important Neuroimaging Clinics issue. Articles include: Brain imaging and genetic risk of congenital malformations; Understanding genetics in neuroimaging; Influence of genetics in neuropathology; Building a bridge between genomics and neuroradiology; Systems genetics approaches to neuroimaging phenotypes; Imaging genetic predictions at an individual level; Brain imaging and genetic risk in the pediatric population; Imaging phenotypes in cognitive diseases; Molecular imaging in genetics; Imaging phenotypes in psychiatric disease; Genomics of brain tumor imaging; Neuroimaging and genetic influence in post-treatment brain neoplasms; Imaging phenotypes in multiple sclerosis; Genetic markers and influences in cerebrovascular malformations, and more.

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Cerebral Palsy in Infancy is a thought-provoking book which introduces a new way of thinking on the development and use of interventions. Relevant to current practice, it advocates early, targeted activity that is focused on increasing muscle activation, training basic actions and minimizing (or preventing) mal-adaptive changes to muscle morphology and function. The authors present recent scientific findings in brain science, movement sciences (developmental biomechanics, motor control mechanisms, motor learning, exercise science) and muscle biology. This knowledge provides the rationale for active intervention, underpinning the need for an early referral to appropriate services. The book features methods for promoting relatively intensive physical activity in young infants without placing a burden on parents which include assistive technologies such as robotics, electronic bilateral limb trainers and baby treadmills. Cerebral Palsy in Infancy begins by specifying the guidelines for training and exercise, outlining the rationale for such intervention. It goes on to cover the fundamentals of neuromotor plasticity and the development and negative effects of limited motor activity on brain organization and corticospinal tract development. Neuromuscular adaptations to impairments and inactivity are discussed along with the General Movement assessment that can provide early diagnosis and prognosis, facilitating very early referral from paediatric specialists to training programs. The book ends with a section featuring various methods of training with the emphasis on preventing/minimizing muscle contracture, stimulating biomechanically critical muscle activity and joint movement. An ideal clinical reference for those working to improve the lives of infants suffering from cerebral palsy. CONTRIBUTORS: Adel Abdullah Alhusaini (Saudi Arabia); David I. Anderson (USA); Nicolas Bayle (France); Roslyn Boyd (Australia); Giovanni Cioni (Italy); Diane L. Damiano (USA); Janet Eyre (UK); Linda Fetters (USA); Mary Galea (Australia); Andrew M Gordon (USA); Martin Gough (UK); Richard L Lieber (USA); Jens Bo Nielsen (Denmark); Micah Perez (Australia); Caroline Teulier (France). "This book provides a comprehensive overview of the challenges of motor development and the consequent impact of poor motor function in later childhood for infants with cerebral palsy (CP)." Reviewed by: Oxford Brookes University on behalf of the British Journal of Occupational Therapy, Dec 2014 conceived and edited by Roberta Shepherd with contributions from internationally renowned expert clinicians and researchers discusses new research and new evidence-based treatment interventions shows how to organize very early and intensive physical activity in young infants to stimulate motor development and growth therapies include the specificity of training and exercise, with emphasis on promoting muscle activity and preventing contracture by active instead of passive stretching methods include new interactive technologies in enhancing home-based training sessions carried out by the infant's family extensive referencing in each chapter for further study chapters feature "Annotations" which illustrate scientific findings

This issue of the Neurosurgery Clinics, Guest Edited by Drs. Jian, Ames, and Shaffrey, presents updates and state-of-the-art approaches to spinal deformity surgery. Spine surgery is a timely topics amongst neurosurgeons, and one that is continually evolving. Articles in this issue include Radiographic and Clinical Evaluation of Adult Spinal Deformity; Use of Surgimap in Osteotomy Planning, Correction Calculation, and Reciprocal Changes; Adolescent Scoliosis Classification and Treatment; Osteotomy for Rigid Deformity; Coronal Realignment, Reduction Techniques, and Complication Avoidance; Cervical Deformity; High Grade Sponylolisthesis; Proximal Junctional Kyphosis; and The Role of Minimally Invasive Techniques in the Treatment of Adult Spinal Deformity.

Headache: Through the Centuries illuminates the history of headaches with a particular interest in how the disorder has been understood and treated since the earliest recorded accounts, dating from around 4000 BC. Different types of headache were being recognized as early as the 2nd century AD. Over the years, though, the classification of types of headache has changed so that headache patterns described in the past are often difficult to relate to present-day types of headache. Since that time, a great deal of material on the topic has become available, the full gamut of manifestations of the disorder has been described, and considerable insight into its mechanisms has been obtained, though no completely satisfactory explanation of the disorder has yet become available. Providing an extensive history and the development of our understanding of headache over the course of six millennia, Headache: Through the Centuries is thought-provoking and relevant reading for neurologists, medical historians, and anyone interested in headaches.

Atlas of EEG, Seizure Semiology, & Management, Second Edition, is a richly-illustrated guide to the performance and interpretation of EEG and management of epilepsy. Revised and updated in its Second Edition, this new text features hundreds of detailed EEGs, and covers the science in extensive scope and detail, beginning with basic electronics and physiology and then moving through EEG interpretation, epilepsy diagnosis, and ultimately epilepsy management. The new edition also includes all basic classifications and definitions of seizures and epilepsy, making it the perfect clinical companion.
Atlas of EEG, Seizure Semiology, & Management utilizes full-color EEG presentations, alongside an easy-to-read synthesis of anatomy, physiology, and available treatment modalities. These detailed explanations of wave pattern, presentation, and treatment provide the student and practitioner with the most informed sense of clinical application and readiness. Atlas of EEG, Seizure Semiology, & Management covers every type of seizure, both epileptic and non-epileptic and divided into eight concise chapters. This unique atlas is necessary reading for all practicing neurologists, fellows, and residents.