"This volume, in my view, should prove to be a landmark publication. Farreras and her colleagues have thrown available light onto what will prove to be a rich field of historical research and historically informed science policy." - Wade E. Pickren, Journal of the History of the Behavioral Sciences This volume breaks new ground in assessing the intramural research conducted at the United States National Institute of Mental Health and the National Institute of Neurological Diseases and Blindness (today the National Institute of Neurological Disorders and Stroke) in the 1950s. The research conducted in these institutes was pioneering and laid the foundation for current neuroscience and behavioural research. Dr. Ingrid Farreras uses the records of the time and also oral histories conducted with retired institute scientists to present the institutional context in which the research was conducted. Topics in her discussion include the history of the United States Public Health Service, the creation of the two institutes at the National Institutes of Health, the organization of their extramural and intramural research programs, and brief summaries of the research that the fifteen laboratories and branches of both institutes conducted during the 1950s. Twelve noted scientists involved in neurological and mental health research then provide their unique, first-hand accounts of their experiences at the NIH. The volume also contains four appendices providing information about the organizational structure of the two institutes, the scientists who worked there, citations of illustrative landmark papers that were published based on their research, and selected primary and secondary resources related to the history of these institutes. The aim of the volume is to foster continuing additional descriptive and analytical research on the history of biomedical sciences in the areas of neurology and mental health in the mid twentieth century.

This book presents an international research-based framework that has empowered parents of children with autism spectrum disorder (ASD) to become critical decision makers to actively guide their child's learning and self-advocacy. Parents can use this framework to identify their child's vision and dreams, and to work with educators and service providers to establish specific learning goals and to implement effective interventions and programs that enable their child to achieve those goals and realise their vision for the future. The book begins by reviewing available research on evidence-based practice for children with ASD and outlining the Cycle of Learning decision-making framework for parents and professionals. Throughout the remainder of the book, case studies are presented to illustrate the ways in which different parents have successfully utilised this framework to develop effective plans for their child and to advocate for learning and education programs for both their child and other children with ASD in school and community settings. In addition, it highlights concrete examples of how parents have used the framework to empower their children with ASD to develop their self-awareness and self-determination, and to be able to self-advocate as they move through adolescence and into adult life.

This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer's disease (AD) is the leading cause of dementia and is present in 60%-70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

Focusing mainly on case studies from Australia and the United States of America, this book considers how people with dementia represent themselves and are represented in 'theatre of the real' productions and care home interventions, assessing the extent to which the 'right kind' of dementia story is being affirmed or challenged. It argues that this type of story - one of tragedy, loss of personhood, biomedical deficit, and socio-economic 'crisis - produces dementia and the people living with it, as much as biology does. It proposes two novel ideas. One is that the 'gaze' of theatre and performance offers a reframing of some of the behaviours and actions of people with dementia, through which deficit views can be changed to ones of possibility. The other is that, conversely, dementia offers productive perspectives on 'theatre of the real'. Scanning contemporary critical studies about and practices of 'theatre of the real' performances and applied theatre interventions, the book probes what it means when certain 'theatre of the real' practices (specifically verbatim and autobiographical) interact with storytellers considered, culturally, to be 'unreliable narrators'. It also explores whether autobiographical theatre is useful in reinforcing a sense of 'self' for those deemed no longer to have one. With a focus on the relationship between stories and selves, the book investigates how selves might be rethought so that they are not contingent on the production of lucid self-narratives, consistent language, and truthful memories.

"Wrestling With Ghosts" summarizes and updates a growing literature that includes traditional cultural accounts, scientific research, and subjective reports about the uncanny sleep disorder referred to as sleep paralysis (SP). The book serves as an important tool to normalize the sleep paralysis experience by attempting to remove its often-publicized mystical and supernatural aura. Specifically, the book is a serious contribution to the psychological and social scientific literature as an example of behavioral/social methodology in clarifying psychological phenomena that can be misinterpreted individually or by culture as "paranormal." However, the book does not refute the very real phenomenology of the experience and is intended as a practical guide for recognizing and managing the disorder in creative and self-enhancing ways. Moreover, this work reiterates the aesthetic and creative power of uncanny dreaming regardless of its origin. This aesthetic dimension of sleep paralysis and lucid dreaming is part of mythical, shamanic, creative, personal and scientific multidisciplinary approach to studying and describing dream phenomenology. Additionally, this work provides a retrospective look at the history of this uncanny disorder in human evolution, its recent western medical history and its most recent empirical descriptions as so-called alien abduction cases, including a presentation of Jungian and Freudian mythical perspectives. The empirical data is presented in balance with traditional cross-cultural and folklore accounts of the disorder as well as in the context of numerous recent cases researched in conjunction with the long-term study. Part of the data presented includes a proposalabout psycho-geographical and psycho-geomagnetic distributions of "ghost" stories, dream attacks, and other SP related phenomena. These geographical zones correlate with geodynamic areas such as the Pacific "Ring of Fire" region where an increased number of cultural name

Twenty years ago, the idea that Alzheimer's disease (AD) involved any sort of inflammatory or immune component seemed implausible. Now, there are hundreds of laboratories world-wide that are pursuing basic research in this area, and multi-site clinical trials are underway. How this dramatic sea-change came about is made clear in this book, both through overviews of the field and through focused papers on specific topics of recent interest. Complement, cytokines and the complex host of other acute phase reactants are covered, as are summaries of many epidemiologic and clinical-pathological findings. Written by established investigators who have led neuroinflammatory research for two decades, this volume particularly emphasizes correlations between inflammatory phenomena in the brains of AD patients with findings of the "classic" approach, such as pathophysiologic effects of amyloid b peptide. The book documents and synthesizes earlier and recent findings in AD to help a broad range of scientists in gaining a broader and more comprehensive knowledge of the complexities AD presents. In addition, many of the concepts and results that have emerged from AD inflammation research may have implications for other neurologic disorders that involve inflammatory components, including multiple sclerosis and stroke.

The endocannabinoid system consists of cannabinoid receptors, their endogenous lipid ligands (endocannabinoids) and the enzymatic machinery for their synthesis and degradation. In the brain, endocannabinoids regulate ion channel activity and neurotransmitter release and thereby contribute to various aspects of brain function, including memory, reward and emotions. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. Unprecedented advances have been made in the understanding of the role of endocannabinoids in the regulation of the emotional brain over the past few years. However, a comprehensive book encompassing all these aspects is still lacking. The book will provide an overview of the role played by the endocannabinoid system in the regulation of emotional processes with particular emphasis on the modulation of memory and reward for emotionally arousing events and for the regulation of motivational aspects in cannabis use.

Modern Electroencephalographic Assessment Techniques: Theory and Applications presents numerous signal processing and connectivity analysis methodologies addressing a wide variety of clinical applications including epilepsy, schizophrenia, Alzheimer's disease and even alcoholism. Among the different topics addressed, the neurophysiological basis of cognitive processes is also investigated. The goal is to provide a comprehensive overview of the most modern and widely established approaches mainly applied in, but not limited to, decomposing high resolution multichannel Electroencephalography (EEG) and Magnetoencephalography (MEG) signals into functional interconnected brain regions. Synergistic approaches linking both EEG/ MEG and functional Magnetic Resonance Imaging (fMRI) techniques are also discussed. In line with the popular Neuromethods series, chapters present the theoretical basis of each method along with prosperous application domains, in the form of a balanced mixture of theoretical tutorials, comprehensive reviews and original research. Emphasis is given to the underlying assumptions, to technical matters that greatly affect the outcome of each proposed method, to the ambitions and to the domain of application of each method. Furthermore, links to graph theory and visualization of connectivity motifs is also addressed in an attempt to better describe the functional characteristics of brain networks. Authoritative and practical, Modern Electroencephalographic Assessment Techniques: Theory and Applications touches upon both the biomedical and computational aspects of this exciting and rapidly evolving field and will allow for a more in-depth, vital understanding of the brain's complex underlying mechanisms.

These are short stories that I have written going on this long lonely journey of being a caregiver taking care of my husband Chuck. Try to imagine in your mind as you read these stories what I was going through each day. The Lord also blessed me with writing stories of my journey and poetry that has expressed my feeling as you read them throughout this book. I pray as you read these stories they will give you some insight, understanding and hope of what it's like for your loved one to has this disease, "Alzheimer's," and to not know you after being with them for so many years.

This volume explores the revolutionary fMRI field from basic principles to state-of-the-art research. It covers a broad spectrum of topics, including the history of fMRI's development using endogenous MR blood contrast, neurovascular coupling, pulse sequences for fMRI, quantitative fMRI; fMRI of the visual system, auditory cortex, and sensorimotor system; genetic imaging using fMRI, multimodal neuroimaging, brain bioenergetics and function and molecular-level fMRI. Comprehensive and intuitively structured, this book engages the reader with a first-person account of the development and history of the fMRI field by the authors. The subsequent sections examine the physiological basis of fMRI, the basic principles of fMRI and its applications and the latest advances of the technology, ending with a discussion of fMRI's future. fMRI: From Nuclear Spins to Brain Function, co-edited by leading and renowned fMRI researchers Kamil Ugurbil, Kamil Uludag and Lawrence Berliner, is an ideal resource for clinicians and researchers in the fields of neuroscience, psychology and MRI physics.

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

To foster a better understanding of dopamine receptor functionality, this detailed volume creates an interface between updated classical methods and new emerging technologies heretofore not available to new or seasoned researchers. Divided in five sections dedicated to experimental approaches investigating different facets of dopaminergic signal transduction, Dopamine Receptor Technologies covers epigenetic and post-transcriptional analysis, computational and biochemical techniques, visualization and imaging methods, molecular and cell biological tools, as well as behavioral assessment. The book, as a part of the popular Neuromethods series, provides insightful step-by-step protocols and methodological reviews that readers will find useful. Practical and versatile, Dopamine Receptor Technologies seeks to aid researchers in developing new pharmacological tools to improve our knowledge of in vivo roles played by each receptor subtype and the synthesis of prospective lead compounds for drug discovery.

This volume collects protocols and procedures utilizing cellular, tissue, and whole animal models that can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. It begins with chapters on the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia and glia-glia co-culture models, oligodendrocytes, and cell-based assays for the evaluation of cell vitality. This revised second edition expands to cover methodology encompassing site-specific direct labeling of neurotrophins and their receptors, angiogenesis assays, stem cells, pancreatic beta-cells, axonal transport, synapse biology, dendritic spine analysis, and brain endothelial cells. Subsequent chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides, as well as protocols describing nanofiber- and nanoparticle-based methods for brain delivery of neurotrophic agents. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neurotrophic Factors: Methods and Protocols, Second Edition is a valuable resource for a wide audience of readers as they explore nervous system function and pathology.

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

Silently orienting us to the world are traditions embedded in our language. These traditions shape how we understand the necessities and possibilities of life and truth. Dualism, a metaphysical theory, is such a tradition, and, in Keen's view, the separate discourses of science and morality create double meanings in our experience. Psychopharmacology is a critical intersection of these two worlds, where physical compounds are used to change mental life. Increasingly, the language of neurochemistry formulates that treatment. To control ennui with chemicals is to direct our attention away from what is wrong in our lives and to focus instead on what we can control easily, by taking a pill.

Mental life has become marginal in biologically reductionistic discourse. While the demystification of human consciousness is surely a cornerstone of modernity, in excess it indulges a world design where nothing is sacred and everything becomes just another phenomenon to which we owe nothing. Our practice of manipulating consciousness as an object surrenders the complex reflections of moral ambiguity and struggle. Following the example of our doctors, Keen asserts, we the population neglect what is wrong in our lives. Like the rest of nature, our minds become exploitable. And properties of consciousness become commodities sold by prescription in drug stores. A provocative analysis of psychopharmacology this will be of interest to treatment professionals, from psychologists, psychiatrists, and nurses to social workers, as well as the interested public.

This ground breaking title presents the many different neurologic syndromes and vastly expanding data in the brain sciences from an evolutionary, or neuro-archeological, perspective, as well as a clinical one. The neuro-archeological perspective offers a more thorough picture of the field - providing hindsight that leads to great insight and foresight. It thus provides the reader with the core foundational aspects of many perplexing neurologic syndromes. Authored by a noted authority in cognitive neurology and including ample tables, diagrams and images, the book covers the full range of behavioral neurological, psychological and neuropsychiatric syndromes, as well as their underlying disease states, relevant neuropsychological tests and contemporary neuroimaging, both structural and functional. The evolutionary approach offers a comprehensive, novel, and completely updated overview of each topic. An invaluable title unlike any other in the field, Cognitive, Conative and Behavioral Neurology: An Evolutionary Perspective is a landmark resource and will be of great interest to neurologists, psychiatrists, neuroscientists, and trainees in all fields.

The second edition of this successful book provides further and in-depth insight into theoretical models dealing with Internet addiction, as well as includes new therapeutical approaches. The editors also broach the emerging topic of smartphone addiction. This book combines a scholarly introduction with state-of-the-art research in the characterization of Internet addiction. It is intended for a broad audience including scientists, students and practitioners. The first part of the book contains an introduction to Internet addiction and their pathogenesis. The second part of the book is dedicated to an in-depth review of neuroscientific findings which cover studies using a variety of biological techniques including brain imaging and molecular genetics. The third part of the book focuses on therapeutic interventions for Internet addiction. The fourth part of the present book is an extension to the first edition and deals with a new emerging potential disorder related to Internet addiction - smartphone addiction. Moreover, in this second edition of the book new content has been added. Among others, the reader will find an overview of theoretical models dealing with Internet addiction, results from twin studies in the context of Internet addiction and additional insights into therapeutic approaches to Internet addiction.

The diagnosis of autism spectrum disorder (ASD) has evolved greatly since Asperger's day. And as our clinical understanding of this spectrum of disorders has grown, so has recognition of the connections between anxiety disorders and ASD a welcome development, but also a source of confusion for many in the field.

The "Handbook of Autism and Anxiety" brings together leading experts to explain this comorbidity, the diagnostic similarities and differences between the two disorders and the extent to which treatment for each can be coordinated for optimum results. Focusing on repetitive behaviors, social difficulties and fears as core components of anxiety disorders as well as ASD, contributors discuss specific symptoms in depth to aid in diagnosis. Assessment and treatment issues relevant to the autism-anxiety connection are considered in clinical and school contexts. And an especially timely conclusion details how key changes in the "DSM-5 "affect the diagnosis and conceptualization of each disorder.

Key topics addressed in the "Handbook "include: Phenotypic variability in ASD: clinical considerations.Etiologic factors and transdiagnostic processes.Social worries and difficulties: autism and/or social anxiety disorder?Implementing group CBT interventions for youth with ASD and anxiety in clinical practice.Autism and anxiety in school settings."DSM"-"5" and autism spectrum disorder.

The "Handbook of Autism and Anxiety" is an essential resource for researchers, clinicians/professionals and graduate students in child and school psychology, psychiatry, social work, education, clinical counseling and behavioral therapy."