Chronic Medical Disease and Cognitive Aging: Toward a Healthy Body and Brain explores the important and often overlooked connection between how chronic medical diseases of the body can affect cognitive function and brain health. As population demographics shift to that of an aging population it has become more important to understand and improve cognitive function in late life. Chronic medical diseases often increase the risk of cognitive impairment, and those with cognitive impairment may be less able to effectively manage their medical conditions, suggesting a reciprocal relationship may exist where medical disease impacts cognition that in turn may exacerbate physical health. Chronic Medical Disease and Cognitive Aging discusses current research on the association between a variety of chronic medical diseases and cognition and, where appropriate, promising interventions or accepted treatment strategies. While a cure for many diseases continues to be elusive, insights garnered from the interplay between diseases of the body and mind may help point the way to novel therapeutic strategies to improve cognitive function in late life.

This issue of Neuroimaging Clinics of North America focuses on Adult Brain Tumors, and is edited by Dr. Lara Brandao. Articles will include: Posterior Fossa Tumors in Adult Patients; Lymphomas and Adult Brain Tumors; Pre-Treatment Evaluation of Gliomas; Post Treatment Evaluation of Gliomas; Metastasis in Adult Brain Tumors; Extraparenchymal Lesions in Adult Brain Tumors; Interesting Case Studies in Adult Brain Tumors; Advanced MR Imaging Techniques in Daily Practice; and more!

This volume covers methodologies, ranging from the molecular level to the network level, used to study receptor-receptor interactions in heteroreceptor complexes inside the central nervous system. The chapters in this book cover topics such as biochemical binding techniques; receptor autoradiography; superfused synaptosome techniques; RTK-GPCR interaction; fluorescence and bioluminiscence energy transfer methods, Co-IP cytometry-based FRET; and novel bioinformatic approaches to understand membrane heteroreceptor complexes and the global panorama of their receptor-receptor interactions. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Receptor-Receptor Interactions in the Central Nervous System is a valuable resource for any scientist or researcher interested in this field of study.

Gut Microbiome and Behavior, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the gut microbiome on the brain and behavior, fully encapsulating the latest research in the field and defining the scope of this influence to outline potential mechanisms and possible implications.

Motivation: Theory, Neurobiology and Applications is inspired by a question central to health care professionals, teachers, parents, and coaches alike, "How can an individual be motivated to perform a given activity or training?" It presents novel measurements of motivation developed in psychology and economics, recent insights into the neurobiology of motivation, and current research on applications designed to boost motivation in neurorehabilitation, education, and sports. In addition, tactics on how to connect these different research and knowledge fields within a common (theoretical) framework of motivation is discussed. Thus, in short, the book provides an integrative, interdisciplinary, up-to-date accounting on the neurobiology of motivation and how it might be boosted.

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington's disease (HD); spinal-bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.

Dementia is a progressive neurodegenerative disease, of which Alzheimer s disease (AD) is the most frequent cause. AD is characterized by the progressive formation of insoluble amyloid plaques and vascular deposits of amyloid beta peptide in the brain. AD patients suffer from a loss of neurons and synapses in the cerebral cortex and certain sub-cortical regions. Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications provides a comprehensive collection for experts in the Neuroscience and Biomedical technology fields. Outlining various concepts from cognitive neuroscience and dementia to neural technology and rehabilitation; this book proves to bring together researchers and practitioners from diverse fields, in order to promote scientific research and industrial development in the field of early detection and rehabilitation technology of dementia.

"Walking In Their Shoes," is a sociological perspective on communicating with people diagnosed with moderate-severe Alzheimer's disease and where/how negative behaviors originate. This book includes true stories and illustrates how to successfully understand behaviors, resolve conflict, and redirect persons diagnosed with Alzheimer's disease. The Alzheimer Association estimates between the years 2010 and 2030, 17 million people will become at high risk to develop Alzheimer's disease. It is important that you see the faces and realities of these people, not just the numbers. My book is designed to assist you in exploring the reality, and face, of Alzheimer's disease by inviting you on a short journey into the world of Alzheimer's disease. "2010 Alzheimer's Disease Facts And Figures," Prevalence, pages 10-12: Alzheimer's Association.

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

Get the most comprehensive, up-to-date guidance available for exam prep with help from Neurology Self-Assessment. Written by Drs. Justin T. Jordan, David R. Mayans, and Michael J. Soileau, this companion volume to Bradley's Neurology in Clinical Practice thoroughly covers the core and subspecialty topics you'll encounter on your exam, along with detailed answer explanations and cross-references to Bradley's. With a focus on assessing subspecialty strengths and weaknesses, it's the ideal preparation for board certification, maintenance of certification, in-training examinations, and neurology examinations for medical students. Features six examinations of more than 100 questions each that follow the board exam blueprint. Contains challenging questions that fully prepare you for exams, with detailed answer explanations and references to Bradley's Neurology in Clinical Practice, 7th Edition. Covers basic neuroscience, behavioral neurology, and psychiatry; clinical neurology topics such as headache, cerebrovascular disease, and neuro-infectious disease; and increasingly tested areas such as ethics and interpersonal skills. Over a quarter of the questions include illustrations such as anatomy, imaging, histology slides, and clinical photos. Includes excellent coverage of key topics such as neurochemistry and neurophysiology, new immune-mediated therapies, child neurology, metabolic diseases, and much more. Offers unique, scorable tests online with subspecialty question divisions. Comes with a downloadable eBook and online access that allows you to test interactively and get immediate feedback and scores.

Neuroimaging, Part Two, a volume in The Handbook of Clinical Neurology series, illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This second volume covers imaging of the adult spine and peripheral nervous system, as well as pediatric neuroimaging. In addition, it provides an overview of the differential diagnosis of the most common imaging findings, such as ring enhancement on MRI, and a review of the indications for imaging in the most frequent neurological syndromes. The volume concludes with a review of neuroimaging in experimental animals and how it relates to neuropathology. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, with the entire field moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to the new horizon in the study of neurological disorders.

This book reports on the latest technological and clinical advances in the field of neurorehabilitation. It is, however, much more than a conventional survey of the state-of-the-art in neurorehabilitation technologies and therapies. It was written on the basis of a week of lively discussions between PhD students and leading research experts during the Summer School on Neurorehabilitation (SSNR2014), held September 15-19 in Baiona, Spain. Its unconventional format makes it a perfect guide for all PhD students, researchers and professionals interested in gaining a multidisciplinary perspective on current and future neurorehabilitation scenarios. The book addresses various aspects of neurorehabilitation research and practice, including a selection of common impairments affecting CNS function, such as stroke and spinal cord injury, as well as cutting-edge rehabilitation and diagnostics technologies, including robotics, neuroprosthetics, brain-machine interfaces and neuromodulation.

Sturge-Weber syndrome is an enigmatic disorder, seldom difficult to diagnose but often difficult to treat. This book consolidates what is known about the Sturge-Weber syndrome in the hope that this information will be useful in the care of patients and serve as a stimulus to encourage research on some of the remaining questions about the syndrome.This book is the 2nd Edition. The 1st Edition was published in June 1999, ISBN-10: 0967048400; ISBN 13: 978-0967048406

Written to encourage defensive action, Levine's book is meant both as a guide and a reference to understanding and preventing dementia. It is intended for lay people interested in learning about dementia and the measures that can be taken to repel its onslaught, as well as for caregivers and family members of impaired patients. Defying Dementia is presented in two sections. First, Levine explains the various types of dementia, its increasing incidence and current treatments, and the treatments being tested and on the horizon. The role of physiology and fresh insights from the field of genetics are included. The second section focuses on methods that can be incorporated into a healthy lifestyle to help avoid dementia. How do we motivate individuals to take action or change behavior in response to a possible threat that has not yet materialized? When the threat is dementia, argues longtime neurologist Robert Levine, it is an issue of considerable importance. The earlier the campaign is initiated to defeat this lurking foe, the greater the chances the combatant will emerge victorious. Written to encourage such defensive action, Levine's book is meant both as a guide and a reference to understanding and preventing dementia. It is intended for lay people interested in learning about dementia and the measures that can be taken to repel its onslaught, as well as for caregivers and family members of impaired patients. Defying Dementia is presented in two sections. First, Levine explains the various types of dementia, its increasing incidence and current treatments, and the treatments being tested and on the horizon. The role of physiology and fresh insights from the field of genetics are included. The second section focuses on methods that can be incorporated into a healthy lifestyle to help avoid dementia. Vignettes illustrate how dementia in its many forms can be recognized as it emerges. With proper actions on our part, we can achieve mastery, Levine writes. The transformation may not be easy, but recognizing the scourge that dementia is, and the way it devours the humanity of its victims, may inspire us to move ahead. Preparation is the key word; building solid defenses over time. And while any moment is worthwhile to begin this task, the earlier the better.

Yet despite this awareness, many clinicians as well as the general public continue to under-appreciate the significance of ADHD as it manifests itself in adults. What happens to all these ADHD kids when they grow up? ADHD isn t like a cold or the flu it doesn t just go away all of the time. As a child grows and matures, it is possible that the symptoms lessen, and in some cases adults are able to overcome the disorder, but it doesn t usually just vanish on its own. At least 40-70% of those diagnosed with this disorder as kids will have it persist when they are adults; however, mental health professionals often overlook ADHD symptoms and continue calling their adult patients who suffer from it anxious or depressed, or diagnose them with a personality disorder. Family members may also consider adults with procrastination issues, inattentiveness, and distractibility lazy or malingering, when in fact they are suffering from ADHD. Here Joel Young MD, who has been treating and researching ADHD for more than15 years, takes a comprehensive look at ADHD in adults. As an accurate diagnosis is essential to a patient s successful treatment, the book begins by detailing how clinicians can provide the most accurate ADHD diagnosis. Once established, the basic diagnostic process begins. This includes obtaining a careful medical history to rule out medical problems that may mimic the symptoms of ADHD, taking a psychiatric history and carefully considering any family or genetic history of medical and psychiatric problems. Some helpful tools used to evaluate quickly and comprehensively distressed patients are presented. Comorbidities are extremely common among patients with ADHD. Emphasis in the book is placed on the most common ADHD comorbidities, including mood and anxiety disorders, bipolar disorder, oppositional defiant disorders, eating disorders and learning disabilities. The book also details the different types of ADHD that clinicians may encounter: ADHD (predominately hyperactive/impulsive subtype) is manifested in people who are hyperactive, and experience serious problems at work and at home. They are fidgety and impatient and may be the most commonly diagnosed adults. ADHD (predominately-inattentive subtype) manifests itself in patients who are typically, but not exclusively, female. As children, these women were inattentive and distractible, underperforming but not demonstrating overt behaviors typical of their hyperactive brethren. Their conditions may be complicated by factors like anxiety, depression, and fatigue. Even as adults, most clinicians overlook their symptoms. Other chapters focus on diagnostic and treatment issues in specific populations: adolescents and common adolescent mindsets; women with ADHD; substance abuse; psychotherapy and coaching as treatments and medications. The medications chapter will review the use of antidepressant and mood stabilizing medications taken in concert with stimulants or non-stimulants, and other medication combinations need for conditions comorbid with ADHD. Finally, the author concludes by presenting findings that self-referred patients with fibromyalgia and chronic fatigue syndrome have high rates of ADHD. Young proposes that extreme distractibility may intensify the patient s pain perception. Overall this book provides clinicians and family members with a concise yet comprehensive overview of the many issues associated with ADHD throughout adolescence and adulthood."

An important new work establishing a foundation for future developments in neural engineering

The "Handbook of Neural Engineering" provides theoretical foundations in computational neural science and engineering and current applications in wearable and implantable neural sensors/probes. Inside, leading experts from diverse disciplinary groups representing academia, industry, and private and government organizations present peer-reviewed contributions on the brain-computer interface, nano-neural engineering, neural prostheses, imaging the brain, neural signal processing, the brain, and neurons.

The "Handbook of Neural Engineering" covers: Neural signal and image processing--the analysis and modeling of neural activity and EEG-related activities using the nonlinear and nonstationary analysis methods, including the chaos, fractal, and time-frequency and time-scale analysis methods--and how to measure functional, physiological, and metabolic activities in the human brain using current and emerging medical imaging technologies Neuro-nanotechnology, artificial implants, and neural prosthesis--the design of multi-electrode arrays to study how the neurons of human and animals encode stimuli, the evaluation of functional changes in neural networks after stroke and spinal cord injuries, and improvements in therapeutic applications using neural prostheses Neurorobotics and neural rehabilitation engineering--the recent developments in the areas of biorobotic system, biosonar head, limb kinematics, and robot-assisted activity to improve the treatment of elderly subjects at the hospital and home, as well as the interactions of the neuron chip, neural information processing, perception andneural dynamics, learning memory and behavior, biological neural networks, and neural control

Researchers' knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book's discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

CDC estimates reveal that 1.6 million to 3.8 million concussions occur each year. This issue will include topics such as pathophysiology, imagine, rturn to learn programs and long-term consequences of concussions.

This book offers a cross-cultural approach to cinematic representations of Alzheimer's disease in non-mainstream cinema. Even though Alzheimer's disease, the most common form of dementia, is a global health issue, it is not perceived or represented homogenously around the world. Contrary to very well-known mainstream films, the films discussed do not focus on the negative aspects normally associated with Alzheimer's disease, but on the importance of portraying the perspective of the persons living with Alzheimer's and their personhood. Similarly, this book analyses how the films use Alzheimer's as a trope to address issues relating to different areas of life and society such as, for example, family matters, intergenerational relationships, gender issues, national traditions versus global modernity, and caring for people with dementia. By examining an array of films, from crime fiction to documentary, that each present non-stigmatising representations of Alzheimer's disease, this in-depth study ultimately demonstrates the power of culture in shaping meaning.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.