Written to encourage defensive action, Levine's book is meant both as a guide and a reference to understanding and preventing dementia. It is intended for lay people interested in learning about dementia and the measures that can be taken to repel its onslaught, as well as for caregivers and family members of impaired patients. Defying Dementia is presented in two sections. First, Levine explains the various types of dementia, its increasing incidence and current treatments, and the treatments being tested and on the horizon. The role of physiology and fresh insights from the field of genetics are included. The second section focuses on methods that can be incorporated into a healthy lifestyle to help avoid dementia. How do we motivate individuals to take action or change behavior in response to a possible threat that has not yet materialized? When the threat is dementia, argues longtime neurologist Robert Levine, it is an issue of considerable importance. The earlier the campaign is initiated to defeat this lurking foe, the greater the chances the combatant will emerge victorious. Written to encourage such defensive action, Levine's book is meant both as a guide and a reference to understanding and preventing dementia. It is intended for lay people interested in learning about dementia and the measures that can be taken to repel its onslaught, as well as for caregivers and family members of impaired patients. Defying Dementia is presented in two sections. First, Levine explains the various types of dementia, its increasing incidence and current treatments, and the treatments being tested and on the horizon. The role of physiology and fresh insights from the field of genetics are included. The second section focuses on methods that can be incorporated into a healthy lifestyle to help avoid dementia. Vignettes illustrate how dementia in its many forms can be recognized as it emerges. With proper actions on our part, we can achieve mastery, Levine writes. The transformation may not be easy, but recognizing the scourge that dementia is, and the way it devours the humanity of its victims, may inspire us to move ahead. Preparation is the key word; building solid defenses over time. And while any moment is worthwhile to begin this task, the earlier the better.

Sturge-Weber syndrome is an enigmatic disorder, seldom difficult to diagnose but often difficult to treat. This book consolidates what is known about the Sturge-Weber syndrome in the hope that this information will be useful in the care of patients and serve as a stimulus to encourage research on some of the remaining questions about the syndrome.This book is the 2nd Edition. The 1st Edition was published in June 1999, ISBN-10: 0967048400; ISBN 13: 978-0967048406

Yet despite this awareness, many clinicians as well as the general public continue to under-appreciate the significance of ADHD as it manifests itself in adults. What happens to all these ADHD kids when they grow up? ADHD isn t like a cold or the flu it doesn t just go away all of the time. As a child grows and matures, it is possible that the symptoms lessen, and in some cases adults are able to overcome the disorder, but it doesn t usually just vanish on its own. At least 40-70% of those diagnosed with this disorder as kids will have it persist when they are adults; however, mental health professionals often overlook ADHD symptoms and continue calling their adult patients who suffer from it anxious or depressed, or diagnose them with a personality disorder. Family members may also consider adults with procrastination issues, inattentiveness, and distractibility lazy or malingering, when in fact they are suffering from ADHD. Here Joel Young MD, who has been treating and researching ADHD for more than15 years, takes a comprehensive look at ADHD in adults. As an accurate diagnosis is essential to a patient s successful treatment, the book begins by detailing how clinicians can provide the most accurate ADHD diagnosis. Once established, the basic diagnostic process begins. This includes obtaining a careful medical history to rule out medical problems that may mimic the symptoms of ADHD, taking a psychiatric history and carefully considering any family or genetic history of medical and psychiatric problems. Some helpful tools used to evaluate quickly and comprehensively distressed patients are presented. Comorbidities are extremely common among patients with ADHD. Emphasis in the book is placed on the most common ADHD comorbidities, including mood and anxiety disorders, bipolar disorder, oppositional defiant disorders, eating disorders and learning disabilities. The book also details the different types of ADHD that clinicians may encounter: ADHD (predominately hyperactive/impulsive subtype) is manifested in people who are hyperactive, and experience serious problems at work and at home. They are fidgety and impatient and may be the most commonly diagnosed adults. ADHD (predominately-inattentive subtype) manifests itself in patients who are typically, but not exclusively, female. As children, these women were inattentive and distractible, underperforming but not demonstrating overt behaviors typical of their hyperactive brethren. Their conditions may be complicated by factors like anxiety, depression, and fatigue. Even as adults, most clinicians overlook their symptoms. Other chapters focus on diagnostic and treatment issues in specific populations: adolescents and common adolescent mindsets; women with ADHD; substance abuse; psychotherapy and coaching as treatments and medications. The medications chapter will review the use of antidepressant and mood stabilizing medications taken in concert with stimulants or non-stimulants, and other medication combinations need for conditions comorbid with ADHD. Finally, the author concludes by presenting findings that self-referred patients with fibromyalgia and chronic fatigue syndrome have high rates of ADHD. Young proposes that extreme distractibility may intensify the patient s pain perception. Overall this book provides clinicians and family members with a concise yet comprehensive overview of the many issues associated with ADHD throughout adolescence and adulthood."

The Migraine Brain, edited by David Borsook, Arne May, Peter J. Goadsby, and Richard Hargreaves, makes a major contribution to the field, addressing the increasingly sophisticated neuroimaging techniques that have allowed researchers to begin to define functional and anatomical characteristics of migraine and other less-common types of headache. Of particular focus is how imaging is changing the way we understand migraine. This includes changes in function, structure and chemistry of the migraine brain. Included are sections that focus on particular aspects of migraine, for example the migraine aura: those symptoms that cause visual sensitivity (blinding white light), sensory difficulty (loud noises, painful touch, and hot/cold spells), slurred language, and motor dysfunction.
Extensively illustrated throughout, The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
A collation of the top thinkers in the field and the only book of its kind, The Migraine Brain is necessary reading for neurologists and neuroscientists.

This book reports on the latest technological and clinical advances in the field of neurorehabilitation. It is, however, much more than a conventional survey of the state-of-the-art in neurorehabilitation technologies and therapies. It was written on the basis of a week of lively discussions between PhD students and leading research experts during the Summer School on Neurorehabilitation (SSNR2014), held September 15-19 in Baiona, Spain. Its unconventional format makes it a perfect guide for all PhD students, researchers and professionals interested in gaining a multidisciplinary perspective on current and future neurorehabilitation scenarios. The book addresses various aspects of neurorehabilitation research and practice, including a selection of common impairments affecting CNS function, such as stroke and spinal cord injury, as well as cutting-edge rehabilitation and diagnostics technologies, including robotics, neuroprosthetics, brain-machine interfaces and neuromodulation.

Get the most comprehensive, up-to-date guidance available for exam prep with help from Neurology Self-Assessment. Written by Drs. Justin T. Jordan, David R. Mayans, and Michael J. Soileau, this companion volume to Bradley's Neurology in Clinical Practice thoroughly covers the core and subspecialty topics you'll encounter on your exam, along with detailed answer explanations and cross-references to Bradley's. With a focus on assessing subspecialty strengths and weaknesses, it's the ideal preparation for board certification, maintenance of certification, in-training examinations, and neurology examinations for medical students. Features six examinations of more than 100 questions each that follow the board exam blueprint. Contains challenging questions that fully prepare you for exams, with detailed answer explanations and references to Bradley's Neurology in Clinical Practice, 7th Edition. Covers basic neuroscience, behavioral neurology, and psychiatry; clinical neurology topics such as headache, cerebrovascular disease, and neuro-infectious disease; and increasingly tested areas such as ethics and interpersonal skills. Over a quarter of the questions include illustrations such as anatomy, imaging, histology slides, and clinical photos. Includes excellent coverage of key topics such as neurochemistry and neurophysiology, new immune-mediated therapies, child neurology, metabolic diseases, and much more. Offers unique, scorable tests online with subspecialty question divisions. Comes with a downloadable eBook and online access that allows you to test interactively and get immediate feedback and scores.

Neuroimaging, Part Two, a volume in The Handbook of Clinical Neurology series, illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This second volume covers imaging of the adult spine and peripheral nervous system, as well as pediatric neuroimaging. In addition, it provides an overview of the differential diagnosis of the most common imaging findings, such as ring enhancement on MRI, and a review of the indications for imaging in the most frequent neurological syndromes. The volume concludes with a review of neuroimaging in experimental animals and how it relates to neuropathology. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, with the entire field moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to the new horizon in the study of neurological disorders.

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

This volume describes the treatment of uniquely complex and profound sexual problems that the therapeutic community has been largely unsuccessful in treating. The reader is drawn to understand and even identify with the people experiencing sexual disturbance. This process of identification helps to mitigate the biases that we use to dehumanize the sexually disturbed.

This work is developed around a case study format, with chapters on specific psychosexual disturbances. All of these cases experienced early childhood sexual trauma or mislearning that interrupted the course of normal sexual development. Such victims then frequently repeat the learned behavior in later life, acting out the role of perpetrator. In addition to presenting the treatment process as it is formulated in the mind of the therapist, the author offers a blueprint for therapy that makes specific treatment possible for clients with similar disorders. Therapists are also guided in developing an effective clinical presence, covering such matters as initial contact, boundary setting, self awareness, dress, voice tone, and overall demeanor. Strategies for avoiding becoming enmeshed in psychological defenses are presented in detail.

Based upon two decades of research with patients who have experienced pathology in one hemisphere of the brain, this book deals with brain mechanisms in human communicative behaviour, and with related motor functions from a broadly biological point of view. The work discusses the possible evolutionary origins of human communication, the relation of brain mechanisms in communicative behaviour to analogous nonhuman behaviors, and the neural systems involved in various levels and kinds of communication. Noncommunicative mechanisms which parallel those used in communication are also outlined in detail. Individual differences in brain organization for some functions are also explored.

Much new data is presented along with the theoretical treatment of human communication which emphasizes a behavioral rather than a linguistic approach. The work will interest psycholinguists, cognitive psychologists, neurologists, clinical neuropsychologists, speech pathologists, and advanced students in these fields.

Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.

Few issues cause as much strife in contemporary society as does the cause and treatment of autism. Stories about the autism epidemic abound on talk shows and make headlines in newspapers and magazines. Celebrities and politicians express their personal opinions on the cause (or causes) of the increase in autism spectrum disorders (or ASDs), opinions often not shared by the conventional scientific community. Parents, family members, schools and government-funded agencies struggle to do the right thing for individuals with ASDs, This volume in the "Biographies of Disease" series provides an understandable, non-biased guide to the quagmire of information about ASDs. This foundation will enable readers to better understand the statements made by various authorities on ASDs. Autism covers all aspects of our historical and current understanding of autism spectrum disorders. The text starts with the recognition of autism in the forties and traces the development of ways to diagnose autism, explains why autism has been expanded to the autistic spectrum disorders. The author covers what is known and not known about the autism epidemic and the causes of ASDs. The critical importance of screening and early intervention is emphasized with respect to outcome for individuals with ASDs. Promising areas of research are highlighted. After reading this book, the reader will be able to place the latest breaking news about ASDs into perspective. While it is not yet possible to answer all of the questions about autism, this book allows the reader to follow along as the mystery is unraveled.

"Autism" covers all aspects of our historical and current understanding of autism spectrum disorders: The recognition of autism in the forties and the development of ways to diagnose autism; why autism has been expanded to the autistic spectrum disorders; what is known and not known about the autism epidemic and the causes of ASDs; the importance of screening and early intervention as well as information about outcome for individuals with ASDs; and promising areas of research.

After reading this book, the reader will be able to place the latest breaking news about ASDs into perspective. While it is not yet possible to answer all of the questions about autism, this book allows the reader to follow along as the mystery is unraveled.

CDC estimates reveal that 1.6 million to 3.8 million concussions occur each year. This issue will include topics such as pathophysiology, imagine, rturn to learn programs and long-term consequences of concussions.

Researchers' knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book's discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

This informative text details the many changes in everyday life as the result of injury, illness, or aging affecting the brain. Experts across brain-related fields trace mechanisms of conditions such as Parkinson's disease, TBI, and dementia as they impact regions of the brain, and resulting cognitive, emotional, sensory, and motor impairments as they contribute to deficits in personal and social functioning. In addition to symptoms and behaviors associated with insults to the brain (and the extent to which the brain can adapt or self-repair), chapters provide cogent examples of how societal and cultural expectations can shape the context and experience of disability. The book's focus on everyday activities brings new clarity to diverse links between symptoms and diagnosis, brain and behavior. Included in the coverage: *The aging brain and changes in daily function. *Stroke: impact on life and daily function. *Traumatic brain injury (TBI) and the impact on daily life. *Everyday life with cancer. *Real-world impact of HIV-associated neurocognitive impairment. *Disability and public policy in America. *Living after brain changes, from the patient's perspective. Rich in empirical data and human insight, Changes in the Brain gives neuropsychologists, clinical psychologists, clinical social workers, and rehabilitation nurses a robust new understanding of the daily lives of patients, both in theory and in the real world.

This common and very important disorder of Epilepsy is led by Dr. Steven Schachter in this issue of Neurologic Clinics. The majority of articles review methods for application of standards, guidelines, and consensus statement to clinical practice by Primary Care physicians and general Neurologists using validated and evidence-based tools such as screening instruments and algorithms for a number of critically important topics, ranging from initial evaluation to monitoring patients on treatment to counseling and educating patients on SUDEP and driving. Topics in this issue include: Guidelines and quality standards for adult epilepsy patients; Guidelines and quality standards in care of children with epilepsy; Initial evaluation of the patient with suspected epilepsy; Starting, choosing, changing, and discontinuing treatment; Methods for measuring seizure frequency and severity; Assessment of treatment side effects and quality of life; Screening for depression and anxiety; Counseling patients on driving and employment; Issues for women with epilepsy; Patient education (SUDEP - Sudden Unexpected Death in Epilepsy; Self-management; Adherence; Rescue medication); Optimizing the patient-physician therapeutic alliance.

This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.

Each issue of Orthopedic Clinics offers clinical review articles on the most cutting edge technologies, techniques, and more in the field. Major topic areas include: adult reconstruction, upper extremity, pediatrics, trauma, oncology, hand, foot & ankle, and sports medicine.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

This book offers a cross-cultural approach to cinematic representations of Alzheimer's disease in non-mainstream cinema. Even though Alzheimer's disease, the most common form of dementia, is a global health issue, it is not perceived or represented homogenously around the world. Contrary to very well-known mainstream films, the films discussed do not focus on the negative aspects normally associated with Alzheimer's disease, but on the importance of portraying the perspective of the persons living with Alzheimer's and their personhood. Similarly, this book analyses how the films use Alzheimer's as a trope to address issues relating to different areas of life and society such as, for example, family matters, intergenerational relationships, gender issues, national traditions versus global modernity, and caring for people with dementia. By examining an array of films, from crime fiction to documentary, that each present non-stigmatising representations of Alzheimer's disease, this in-depth study ultimately demonstrates the power of culture in shaping meaning.

This issue focuses on meningiomas and includes articles on Incidental Meningiomas: Management Strategies in the Modern Neuroimaging Era, Advanced Neuroimaging for Intracranial Meningiomas, Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas, Preoperative Embolization for Intracranial Meningiomas, Management of Spinal Meningiomas, Medical Management of Meningiomas: Current Status, Failed Treatments and Promising Horizons, and many more!

This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. This receptor, a member of the opioid receptor family, was traditionally thought to be primarily involved in pain modulation. Recent new findings have shown its unique role in neuroprotection and many other functions. Many scientists from a number of independent laboratories have now confirmed that DOR can provide neuroprotection against hypoxic/ischemic injuries. They have also found that it plays a role in a variety of physiological and pathophysiological events such as hypoxic encephalopathy, epilepsy, acupuncture, Parkinson's disease, etc. by regulating ionic homeostasis, glutamate transportation and signaling, and balancing intracellular survival/death signals. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.