Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress-from molecular biology to whole organs-relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.

Each day, novel neuroscientific findings show that researchers are focusing on developing advanced smart hardware designs and intelligent computational models to imitate the human brain's computational abilities. The advancements in smart materials provide a significant role in inventing intelligent bioelectronic device designs with smart features such as accuracy, low power consumption, and more. These advanced and intelligent computing models through machine and smart deep learning algorithms help to understand the information processing capabilities of the human brain with optimum accuracy. The Handbook of Research on Futuristic Design and Intelligent Computational Techniques in Neuroscience and Neuroengineering highlights advanced computational models and hardware designs in neurology and integration of mathematical physical, biological, chemical, and engineering models to mimic brain functions; discovers new technological diagnosis techniques; and achieves high accuracy in learning models to better understand the functioning of the human brain. Providing rich information on brain-computer interfacing, gamification in children, and vestibular rehabilitation, this text acts as an essential resource for experts in electrophysiological studies, neurologists, neuro-physiotherapists, neuro-radiologists, intelligent system developers, bio-software and hardware developers, neuro database collectors, electro-physiologists, professors associated with neurology, psychiatrists, engineers, scientists, and students from academia and industry involved in interdisciplinary approaches to neurology.

Given the evolution of cerebrospinal testing (CSF) testing methods, the near future is certain to see an explosion of new CSF analysis methodologies. Broad-based and extensively illustrated, Cerebrospinal Fluid in Clinical Practice provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. It examines the alterations of the composition of CSF in relation to diseases and disorders of the nervous system, emphasizing the findings that are useful in clinical practice. This expansive reference is perfect regardless of your level of experience in central nervous system diseases. Provides in-depth coverage of CSF examination and analysis, CSF physiology and pathophysiology, approach to diagnosis, and future directions in CSF analysis. Explores the gamut of all CNS infections for a broad but detailed review of the scope of neurological disease. Contains detailed discussion on the proper use of specific diagnostic screens on CSF, so you may gain knowledge on how new diagnostic methods impact clinical medicine. Incorporates extensive illustrations and tables, with visual emphasis on diagnostic, laboratory, and anatomic data.

This volume guides the practitioner in the current management of women with epilepsy, in a comprehensive and scientifically informed manner. Many chapters are devoted to the various aspects of pregnancy management for women with epilepsy, from reducing the risks of medication exposure to breast feeding. All female age groups are discussed and chapters on issues important for adolescents and the mature women are also included. The editors have included internationally recognized experts as contributors, to bring together a body of knowledge unparalleled in previous settings. This book should be a guide to management for women with epilepsy for years to come, due to its solid scientific basis and the comprehensive vision of the contributors.
* Features discussions on issues for women with epilepsy that span from the lab to the clinic
* Encompasses the current state of this evolving topic
* Organized in discreet clinical entities for easy reference with helpful tables and figures"

Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the potential impact of recent results of experiments in the laboratory. This book highlights the importance that original observations have in inspiring both new treatments and continued research.
* Presents unique and challenging case vignettes in epilepsy contributed by eminent physicians in the field
* Provides practicing physicians with examples of how baffling cases were handled and solved
* A new section provides a translational perspective, with basic scientists discussing the potential mechanisms underlying original clinical observations, and clinical scientists discussing the clinical implications of experiments in the epilepsy laboratory

This book covers the explosion of new information about the relationship between the brain and its blood supply since the first edition was published in 2009. With new knowledge and its impact on clinical care, neurovascular neuropsychology has become a recognized sub-specialty that has been integrated into health care systems in the US and abroad. The second edition brings to this larger audience the latest word on these matters, with new emphasis on women's issues, relevance to the pediatric population, insights from modern imaging, and advances in medical and surgical treatments such as heart transplantation, cardiovascular transarterial therapies, and noninvasive brain stimulation in connection with neurocognitive outcomes.

This edited reference addresses controversial clinical issues of the psychiatric aspects of epilepsy. The book explores the reasons behind the poor communication between psychiatrists and neurologists and suggests potential remedies to this important problem, and two chapters are devoted to examining whether psychiatrists and neurologists are properly trained to recognize and treat conditions that both disciplines commonly encounter in clinical practice. Identification of the causes behind the high rate of comorbidity between epilepsy and mood, anxiety, psychotic and attention deficit disorders is given high priority in the volume, and a specific review of the evidence of common pathogenic mechanisms that may be operant in epilepsy and these psychiatric disorders is included. Recently identified bidirectional relationship between mood disorders and epilepsy and its implication in the course and response to treatment of the seizure disorder are also explored. Several chapters are devoted to rectify common misunderstandings of the use of psychotropic drugs in patients with epilepsy, including the use of antidepressant and central nervous system stimulants. Finally, one chapter explores the possibility of organic causes of psychogenic non-epileptic seizures.
* Compiles into one source the important controversial issues of the psychiatric aspects of epilepsy, which have significant implications in clinical practice
* Authors are internationally recognized authorities in the field of psychiatric aspects of epilepsy

In 1997, Vagus Nerve Stimulation (VNS) therapy (Cyberonics, Houston, Texas) was approved by the United States Food and Drug Administration for the treatment of epilepsy refractory to antiepileptic medications. In 2005, VNS received FDA approval for treatment-resistant depression refractory to antidepressants, and Cyberonics recently received FDA approval for the clinical study of VNS for rapid cycling bipolar depression. Many researchers continue to investigate the anxiolytic effects of VNS in human and non-human animal models. The author presents a study of VNS effects on anxiety and the capacity of atropine methyl nitrate to attenuate these effects. The results indicate that VNS decreases anxiety in the laboratory animals tested. These findings provide evidence to support the testing and subsequent use of VNS therapy for the treatment of clinical anxiety in humans. Because many therapies that are effective in the treatment of depression effectively treat anxiety, VNS therapy should be effective and approvable for clinical anxiety. This book can serve as a research tool, training mechanism, or surgical guide to the implantation of the vagus nerve stimulating electrode in the laboratory rat. Hopefully, this resource provides information that facilitates FDA approval of VNS for treatment-resistant anxiety, a chronic, devastating and often debilitating illness.

Dysimmune Neuropathies provides readers with detailed, basic information that will enable users to recognize and differentiate each neuropathy to adequately guide an investigation and create a treatment plan. An overview of recent progress, avenues for future research, and the desired benefits are also covered. The book highlights the many developments in the field that have occurred in terms of pathophysiological mechanisms, particularly immunological, that have direct implications on treatment strategies. This book is a great reference for trainees, clinicians and researchers specializing in neurology, neuromuscular diseases and neurophysiology.

Alzheimer's is a devastating disease, robbing its victims of so much of themselves before the end. For caregivers facing this disease, a diagnosis of Alzheimer's disease can sound like the ultimate tragedy, the disease that will rob us of our loved one by inches. It doesn't have to be. While Alzheimer's and related dementias are serious and not easily understood diseases, a new guide can help families negotiate the difficult scientific, emotional, and practical issues of dealing with the disease. In a moving and easy to read format, Dr. Steinberg has laid out a true caregiver's guide to dealing with Alzheimer's disease, from the first signs to the final stages. Incorporating science, real-life case studies from his practice and from his extensive experience as a nationally recognized seminar speaker, as well as from his personal journey coping with his mother's illness, Dr. Steinberg leads the reader through a learning and healing process. In a candid and personal sharing of his experience, Dr. Steinberg helps the reader clearly understand what to expect, when to ask for help, how to cope with the changes and the inevitable pressures within the family, and how to continue to love as a loved one's disease threatens family stability and well-being. With his profound knowledge of the disease, its treatment and manifestations, and his great love and tenderness as the son of an Alzheimer's patient, Dr. Steinberg has created a truly memorable work.

Parkinson s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery.
* Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson s disease
* Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD
* Current overviews of current status of PD research and discovery from bench-to-bedside
* Provides novel insights and views on where the future of PD research may lead
* Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases"

This book presents cutting edge research on the basic neurobiology of parental behavior as it relates to behavioral disorders, including postpartum depression, anxiety, and inadequate parental bonding to infants. Internationally recognized basic and clinical researchers present new research findings in humans and animals that elucidate the roles of the brain, physiological state, genes and environment in maternal and paternal care. By bridging the gap between basic and clinical research, new understandings of how the biology of the brain and the reproductive state of the parent impact their mental health and the successful rearing of young emerge.
* Presents the neural network of motherhood based on fundamental and functional MRI studies of parental care - from rodents to humans
* Discusses the role of gene-environment interactions in parenting
* Offers parenting strategies and priorities in raising young
* Discusses maternal defense - the neurobiology of maternal protection
* Examines the significance and underlying causes of postpartum depression
* Discusses parenting and anxiety - neurobiological basis for reductions during the postpartum period
* Also includes the neurobiology of fatherhood - a fresh evolutionary and biological perspective on paternal behavior
* Presents information on maternal neuroplasticity - how reproductive history changes the maternal brain
* Translates research - internationally renowned researchers' insights into common factors that regulate mammalian parenting

Ethical Dimensions of Commercial and DIY Neurotechnologies Volume Three, the latest release in the Developments in Neuroethics and Bioethics series, highlights new advances in the field, with this new volume presenting interesting chapters on timely topics surrounding neuroethics and bioethics. Each chapter is written by an international board of authors.

ABOUT THE BOOK: It seemed nothing Tracy did for her son would work-testing, counseling, medication, therapy-and violent meltdowns were a daily occurrence. She agonized over What is next? What is to become of my beautiful son? Tracy's struggles were long and hard, but with a mother's determination, a supportive family, and God's love and intervention, she found strength, endurance, and unexpected open doors. To the Land of the Lost is a mom's gripping, true story account of the trials faced while parenting a child who has Asperger's syndrome. The story is gut wrenching and heartbreaking, while at the same time loving, uplifting, encouraging, and inspirational. To the Land of the Lost is a must read for any parent, caregiver, teacher, or friend of someone living with an autism spectrum disorder. **** ABOUT THE AUTHOR: Tracy M. Maguire lives in Dublin, Ireland, with her three children: Graham, Sophie, and James. Her eldest son, Graham, now almost 19 years old, has Asperger's syndrome. Tracy is passionate about encouraging parents who are raising a child with Asperger's and giving them hope in what can often feel like a hopeless situation.

Neuroethics is concerned with the wide array of ethical, legal and social issues that are raised in research and practice. The field has grown rapidly over the last five years, becoming an active interdisciplinary research area involving a much larger set of academic fields and professions, including law, developmental psychology, neuropsychiatry, and the military.
Neuroethics and Practice helps to define and foster this emerging area at the intersection of neuroethics and clinical neuroscience, which includes neurology, neurosurgery, psychiatry and their pediatric subspecialties, as well as neurorehabiliation, clinical neuropsychology, clinical bioethics, and the myriad other clinical specialties (including nursing and geriatrics) in which practitioners grapple with issues of mind and brain. Chatterjee and Farah have brought together leading neuroethicists working in clinically relevant areas to contribute chapters on an intellectually fascinating and clinically important set of neuroethical topics, involving brain enhancements, brain imaging, competence and responsibility, severe brain damage, and consequences of new neurotechnologies. Although this book will be of direct interest to clinicians, as the first edited volume to provide an overall comprehensive perspective on neurethics across disciplines, it is also a unique and useful resource for a wide range of other scholars and students interested in ethics and neuroscience.

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.

The purpose of this book is to educate readers regarding the efficacy of cognitive rehabilitation across a variety of neurological conditions, with specific emphasis on rehabilitation-related change detectable via neuroimaging. For ease of reference, this information is divided into separate chapters by neurological condition, since the nature of cognitive impairment and mechanism of rehabilitation may differ across populations. Also included are discussions of the use of neuroimaging in cognitive rehabilitation trials, rigorous design of cognitive rehabilitation trials to have greater scientific impact (e.g., obtaining Class I evidence), and future directions for the field. As such, the book is designed to be useful to both clinicians and researchers involved in the rehabilitation of such conditions so that they can make informed decisions regarding evidence-based treatment to deploy in clinical settings or to further study in research endeavors.

As people are living longer on average than ever before, the number of those with dementia will increase. Because many will live a considerable time at home with their diagnosis, we need to know more about the ways people can adapt to and learn to live with dementia in their everyday lives. Lars-Christer Hyden argues in this book that to do so will involve re-imagining what dementia really is and what it can mean to the afflicted and their loved ones. One of the most important everyday opportunities for sharing experiences is the simple act of storytelling. But when someone close to you gradually loses the ability to tell stories and cherish the shared history you have together, this is seen as a threat to the relationship, to the feeling of belonging together, and to the identity of the person diagnosed. Therefore, learning about how people with dementia can participate in storytelling along with their families and friends helps to sustain those relationships and identities. In Entangled Narratives, Hyden not only emphasizes the possibilities that are inherent in collaborative storytelling, but instructs professionals and otherwise healthy relatives to learn how to effectively listen and, ultimately, re-imagine their patients and loved ones as collaborative meaning-makers in their lives.

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). The book should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering.
* Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures
* Contributors are top experts at the forefront of computational epilepsy research
* Chapter contents are highly relevant to both basic and clinical epilepsy researchers