A trustworthy clinical companion, the textbook offers best practice and management strategies for these common joint diseases. Formerly published as Osteoarthritis, the extensively revised third edition of the Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides up-to-date and evidence-based guidance on how to assess, diagnose, and manage patients. A prestigious and international author team ensure information is expert and relevant-this is a practical tool for clinicians managing people with osteoarthritis, gout, and other crystal-associated arthritis. Confidently consider and chose the right blend of treatment for your patient, whether physical, pharmacological, surgical, or supportive. The Oxford Textbook of Osteoarthritis and Crystal Arthropathy provides full coverage of joint failure, and includes detailed sections on epidemiology, risk factors, clinical assessment, and investigations. This edition also now includes new sections on gout and other crystal arthropathies. Clinically relevant and easily understandable overviews of basic science, including pathology and pain physiology, along with critical appraisal of current guidelines, make this a highly valuable resource. Significant coverage is also given to patient education and the involvement of the patient in management planning. Also highly illustrated, the textbook is a strong reference tool with summary boxes and key points at the end of chapters making it easy to find information quickly and help you deliver the optimum patient outcome. The textbook equips rheumatologists and musculoskeletal health professionals with the knowledge to provide best possible patient care.

Pain is the most common reason people seek medical help. The treatment of chronic pain is a major unmet clinical need and its impact on health, well-being, society and the economy is immense. Pain is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience plays a key role in advancing our understanding of pain. This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. Behavioural approaches to the study of persistent or chronic pain in animal models or humans are at the core of the volume, but the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural alterations are also emphasized.

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Lipid Structure, Domains, and Proteins: Molecular Mechanisms of Ethanol and Anesthetic Actions (C.D. Stubbs, E. Rubin). Membrane Cholesterol and Ethanol (W.G. Wood et al.). The Effects of Ethanol on Polyunsaturated Fatty Acid Composition (N. Salem, Jr., G. Ward). Receptors and Ion Channels: Sensitivity of NMDA Receptors to Acute and in Utero Ethanol Exposure (S.W. Leslie, M.S. Weaver). Molecular Mechanisms of Alcohol Neurotoxicity (F.T. Crews et al.). Second Messenger Systems and Kinases: Nucleoside Transport and EthanolInduced Heterologous Desensitization (A. Gordon et al.). Ethanol and Phospholipid Dependent Signal Transduction (J.B. Hoek et al.). Gene Expression: Regulation of Neuronal Gene Transcription by Ethanol (M.F. Miles et al.). Effect of Acute and Chronic Administration of Ethanol on cfos Expression in Brain (F. Le et al.). 19 additional articles. Index.

I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland ("the stone of madness") as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of his scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in "La vie en rose", the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called "Ma vie en noir".

This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).

Of those which deal with sex and love addiction, this work is alone in that it examines adolescents as a specific population. The number of case histories presented in the text are a prominent feature. The work should be of interest to clinicians and clients both. The book addresses the case of adolescent sex and love addicts as was done with adolescent chemical dependents 20 years ago.

This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.

This broad and thought-provoking volume provides an overview of recent intellectual and scientific advances that bridge the gap between psychiatry and neuroscience, offering a wide range of penetrating insights in both disciplines. The third volume on the topic in the last several years from a varying panel of international experts, this title identifies the borders, trends and implications in both fields today and goes beyond that into related disciplines to seek out connections and influences. Similar to its two Update book predecessors, Psychiatry and Neuroscience - Volume III presents the current state-of-the-art in the main disciplines - psychiatry and neuroscience - and attempts to provide deeper comprehension or explication of the normal and diseased human mind, its biological correlates and its biographical and existential implications. This engaging volume continues the previous style of exploring different disciplines and trying to integrate disciplinary evidence from varying points of view in an organic manner. Developed for clinicians and researchers in the fields of medicine, psychiatry, psychology and biology, this third volume also will be of great interest to students and university professors of diverse disciplines.

This book presents a unique exploration of common myths about autism by examining these myths through the perspectives of autistic individuals. Examining the history of attitudes and beliefs about autism and autistic people, this book highlights the ways that these beliefs are continuing to impact autistic individuals and their families, and offers insights as to how viewing these myths from an autistic perspective can facilitate the transformation of these myths into a more positive direction. From 'savant syndrome' to the conception that people with autism lack empathy, each chapter examines a different social myth - tracing its origins, highlighting the implications it has had for autistic individuals and their families, debunking misconceptions and reconstructing the myth with recommendations for current and future practice. By offering an alternative view of autistic individuals as competent and capable of constructing their own futures, this book offers researchers, practitioners, individuals and families a deeper, more accurate, more comprehensive understanding of prevalent views about the abilities of autistic individuals as well as practical ways to re-shape these into more proactive and supportive practices.

This monograph offers a cross-system exchange and cross-modality investigation into brain-heart interplay. Brain-Heart Interplay (BHI) is a highly interdisciplinary scientific topic, which spreads from the physiology of the Central/Autonomous Nervous Systems, especially Central Autonomic Network, to advanced signal processing and modeling for its activity quantification. Motivated by clinical evidence and supported by recent findings in neurophysiology, this monograph first explores the definition of basic Brain-Heart Interplay quantifiers, and then moves onto advanced methods for the assessment of health and disease states. Non-invasive use of brain monitoring techniques, including electroencephalogram and function Magnetic Resonance Imaging, will be described together with heartbeat dynamics monitoring through pulseoximeter and ECG signals. The audience of this book comprises especially of biomedical engineers and medical doctors with expertise in statistics and/or signal processing. Researchers in the fields of cardiology, neurology, psychiatry, and neuroscience in general may be interested as well.

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as "oxidative stress," in the pathology of Alzheimer's disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer's Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer's Disease.

Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.

Surgical Techniques in Epilepsy Surgery presents the operative procedures used in the treatment of intractable epilepsy in a practical, clinically relevant manner. Founded by pioneering neurosurgeon Wilder Penfield, the Montreal Neurological Institute (MNI) is a leading global centre of epilepsy surgery and this volume reflects the Institute's approach, combining traditional techniques with modern neuronavigation based approaches. There is an emphasis on mastering the important trilogy of topographic, vascular and functional anatomy of the brain. The basic anatomical and physiological mechanisms underlying epilepsy are presented in a practical manner, along with the clinical seizure evaluation that leads to a surgical hypothesis. The consultation skills and investigations necessary for appropriate patient selection are discussed, as well as pitfalls and the avoidance of complications. This is an invaluable resource not only for neurosurgeons, neurosurgical residents and fellows in epilepsy surgery, but also for neurologists, and others who provide medical care for patients with intractable epilepsy.

Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease. Aminopeptidases in Biology and Disease will be a timely and useful source of information both for those immersed in the field of aminopeptidases and those just taking their first steps into this exciting and ever-expecting field of research. Each chapter starts with a brief abstract summarizing the content and biological reference. Aminopeptidases in Biology and Disease: - Provides an up-to-date presentation of the role of aminopeptidases in biological processes, Highlights the critical role played by aminopeptidases in various diseases, Provides backgroun

This book provides a concise overview of VR systems and their cybersickness effects, giving a description of possible reasons and existing solutions to reduce or avoid them. Moreover, the book explores the impact that understanding how efficiently our brains are producing a coherent and rich representation of the perceived outside world would have on helping VR technics to be more efficient and friendly to use. Getting Rid of Cybersickness will help readers to understand the underlying technics and social stakes involved, from engineering design to autonomous vehicle motion sickness to video games, with the hope of providing an insight of VR sickness induced by the emerging immersive technologies. This book will therefore be of interest to academics, researchers and designers within the field of VR, as well as industrial users of VR and driving simulators.

This new title in the Fast Facts series, full of up-to-date and authoritative information, is a critical resource for all health care professionals working with children and adolescents.Psychiatrists, prescribing psychologists, psychotherapists, pediatricians, family practice physicians, pediatric neurologists, nurse practitioners, allied mental health professionals, and trainees in these professions are provided with: General introductory reviews of the principles of pediatric psychopharmacology and related patient assessment issues; Detailed discussions of psychiatric medications organized by drug class; A comprehensive review of child and adolescent psychiatric disorders. Rich background information and clear explanations of clinical directions for the prescriber and nonprescriber alike.

Authored by two child and adolescent psychiatrists, Pediatric Psychopharmacology provides empirically-based, state-of-the-art knowledge as well as clear practical guidance regarding assessment, prescription, monitoring, and discontinuation of medications.