Memory loss is not always viewed purely as a contingent neurobiological process present in an ageing population; rather, it is frequently related to larger societal issues and political debates. This edited volume examines how different media and genres - novels, auto/biographical writings, documentary as well as fictional films and graphic memoirs - represent dementia for the sake of critical explorations of memory, trauma and contested truths. In ten analytical chapters and one piece of graphic art, the contributors examine the ways in which what might seem to be the individual, ahistorical diseases of dementia are used in contemporary cultural texts to represent and respond to violent historical and political events - ranging from the Holocaust to postcolonial conditions - all of which can prove difficult to remember. Combining approaches from literary studies with insights from memory studies, trauma studies, anthropology, the critical medical humanities and media, film and comics studies, this volume explores the politics of dementia and incites new debates on cultures of remembrance, while remaining attentive to the lived reality of dementia.

This volume presents several machine intelligence technologies, developed over recent decades, and illustrates how they can be combined in application. One application, the detection of dementia from patterns in speech, is used throughout to illustrate these combinations. This application is a classic stationary pattern detection task, so readers may easily see how these combinations can be applied to other similar tasks. The expositions of the methods are supported by the basic theory they rest upon, and their application is clearly illustrated. The book's goal is to allow readers to select one or more of these methods to quickly apply to their own tasks. Includes a variety of machine intelligent technologies and illustrates how they can work together Shows evolutionary feature subset selection combined with support vector machines and multiple classifiers combined Includes a running case study on intelligent processing relating to Alzheimer's / dementia detection, in addition to several applications of the machine hybrid algorithms

This book takes an in depth and hard look at the current status and future direction of treatment predictive markers in Personalized Medicine for the brain from the perspectives of the researchers on the cutting edge and those involved in healthcare implementation. The contents provide a comprehensive text suitable as both a pithy introduction to and a clear summary of the "science to solutions" continuum in this developing field of Personalized Medicine and Integrative Neuroscience. The science includes both measures of genes using whole genome approaches and SNIPS as well as BRAINmarkers of direct brain function such as brain imaging, biophysical changes and objective cognitive and behavioral measurements. Personalized Medicine for Brain Disorders will soon be a reality using the comprehensive quantitative and standardized approaches to genomics, BRAINmarkers and cognitive function. Each chapter provides a review of recent relevant literature; show the solutions achieved through integrative neuroscience and applications in patient care thus providing a practical guide to the reader. The timeliness of this book's content is propitious providing bottom line information to educate practicing clinicians, health care workers and researchers, and also a pathway for undergraduate and graduates interested in further their understanding of and involvement in tailored personal solutions.

New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients.

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

People with neurological disorders may experience significant problems, isolation, detachment, and passivity while dealing with environmental requests. They constantly rely on caregivers and family assistance, which can create negative outcomes on their quality of life. An emerging way to overcome these issues is assistive technology-based interventions (AT). AT-based programs are designed to fill the gap between human/individual capacities or skills and environmental requests. These technologies can also bring about independence and self-determination and provide people with neurological disorders an active role, positive participation, and an enhanced status in being able to achieve functional daily activities by reducing the roles of their families and caregivers. The positive impacts of this technology are an important area of research, and its usage for neurological disorders is critical for the assessment and recovery of patients. Assistive Technologies for Assessment and Recovery of Neurological Impairments explores the use of AT-based programs for promoting independence and self-determination of individuals with neurological disorders. The chapters discuss AT-based interventions in detail with the specific technologies that are being used, the positive effects on patients, and evidence-based practices. This book also focuses on specific technologies such as virtual reality (VR) setups and augmented reality (AR) as valid ecological environments for patients that ensure methodological control and behavioral tracking for both assessment and rehabilitation purposes. This book is essential for occupational therapists, speech therapists, physiotherapists, neurologists, caregivers, psychologists, practitioners, medical professionals, medical technologists, IT consultants, academicians, and students interested in assistive technology interventions for people with neurological impairments.

While we now recognize that MS is a common neurological disease, as late as the early twentieth century it was considered a relatively rare condition in Europe and the United States. It was only in the late 1860s that MS came to be generally recognized as a distinct disease apart from other paraplegic maladies. One of the important historical questions about MS is whether it was a new disease of the nineteenth century or one that had simply gone unrecognized for a long time. Answering this question is complicated by the different frames or ways physicians understood and explained disease in previous centuries. The way we now conceive, categorize, and explain disease is a relatively recent formulation in the long view of medical history. This work aims to answer some of the fundamental questions of the history of MS. How and why did MS emerge when and where it did, first in a book of pathological anatomy in early nineteenth-century France, then as a distinct disease category in France by 1868? How and why did the perception of MS as a rare disease in the early twentieth century change so that by the middle of that century it was considered a common affliction of the nervous system? How did local conditions shape research on MS? Why did MS emerge as a popular crusade and research priority, rather suddenly, in the late 1940s and early 1950s? How has the experience of people with MS changed from the nineteenth to the twentieth centuries? Since there was no consensus about the merits of any treatment until very recently, how does one explain the sometimes aggressive treatment of disease from the late nineteenth century to the mid-twentieth century? This book focuses in part on howsociocultural factors allowed MS to emerge into medical awareness and later popular consciousness and how the different scientific and sociocultural frames of disease affected the experience of people with MS. These factors were important in particular ways because of the peculiar disease process of MS, especially its tendency to wax and wane in many patients and in clinical symptoms.

The diagnosis and treatment of disease is a primary concern for health professionals and individuals in society. Managing the treatment and controlling symptoms of diseases is imperative to patient longevity and quality of life. Effective Techniques for Managing Trigeminal Neuralgia is a critical scholarly resource that examines the monitoring, management, and treatment of trigeminal neuralgia. Featuring coverage on a broad range of topics such as vascular compression, medical management, and percutaneous technique, this book is geared towards medical professionals, researchers, students, and professionals seeking current research on various treatment options as well as future frontiers in diagnosis and treatment.

Patients with Parkinson's disease commonly struggle with sleep disorders that which negatively affect their quality of life. Sleep Considerations in the Management of Parkinson's Disease provides a comprehensive overview of common sleep issues and related topics in in this complex field. Each chapter begins with a case that describes a typical scenario related to a sleep problem in Parkinson's disease, followed by a discussion of both the sleep problem and the specifics of the case, providing practical, real-world information to help you provide better patient care. Includes concise chapters authored by Dr. Lana Chahine, each carefully reviewed and supplemented by expert contributors in the specific field. Addresses a wide variety of topics including sleep-onset insomnia, nocturnal manifestations of anxiety disorders, REM sleep behavior disorder, restless legs syndrome and periodic limb movements, and excessive daytime sleepiness. Consolidates today's available information and experience in this important area into one convenient resource.

Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology.

Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders.

This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

In this edited volume, experts on the treatment of dementia associated with Parkinson's Disease (PD) describe in detail the current status of knowledge in their respective area of expertise. The importance and clinical relevance of cognitive impairment and dementia in PD is emphasized, all relevant aspects including epidemiology, full and detailed spectrum of clinical features, current knowledge on pathology, neurochemistry and genetics, findings in auxillary investigations, relation to other neurodegenerative disorders, diagnostic process and management are described, rounded-up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and is heavily referenced thereby capturing all relevant literature.

This issue of Neurologic Clinics, guest edited by Dr. Phyllis C. Zee, with consulting editor Randolph W. Evans, will focus on Circadian Rhythm Disorders. Topics include, but are not limited to, Circadian biology, Genetic basis of circadian rhythms, Implication of circadian rhythm misalignment on sleep and health, Assessment of circadian rhythms, Circadian Rhythm sleep-wake phase disorders, Irregular sleep-wake rhythm sleep -wake disorder, Non-24 hour sleep-wake rhythm disorder, Shift Work Sleep Disorder, Challenging cases, and Future of circadian and sleep medicine.

As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases. This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

This comprehensive update offers practical advice for professionals working in neuropsychology with older adults. Focusing on fundamentals, common issues, special considerations, and late-life cognitive disorders, respected names in this critical specialty address a wide range of presenting problems and assessment, diagnostic, and treatment concerns. Th roughout, coverage pays keen attention to detail, bringing real-world nuance to large-scale concepts and breaking down complex processes into digestible steps. And like its predecessor, the new Handbook features recommendations for test batteries and ends each chapter by extracting its "clinical pearls." A sampling of the topics covered: * Assessment of depression and anxiety in older adults. * The assessment of change: serial assessments in dementia evaluations. * Elder abuse identifi cation in older adults. * Clinical assessment of postoperative cognitive decline. * Cognitive training and rehabilitation in aging and dementia. * Diff erentiating mild cognitive impairment and cognitive changes of normal aging. * Evaluating cognition in patients with chronic obstructive pulmonary disease. This Second Edition of the Handbook on the Neuropsychology of Aging and Dementia offers a wealth of expert knowledge and hands-on guidance for neuropsychologists, gerontologists, social workers, and other clinicians interested in aging. Th is can be a valuable reference for those studying for board certifi cation in neuropsychology as well as a resource for veteran practitioners brushing up on key concepts in neuropsychology of age related disorders.

Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.