This book gathers revised and selected contributions to the 5th Dementia Lab Conference, D-Lab 2021, organized online on January 18-28, 2021, from the Emily Carr University of Art + Design, Vancouver, Canada. It describes original strategies in which design or creative methods have been shown to uncover, support and enhance the abilities of people living with dementia. Papers report on new ideas and findings relating to three main themes: engagement, empowerment and identity. They cover: ethics of inclusion and solutions for shifting the culture of care to be focused on both personal independence and reconnecting with the community; new ways of designing with people living with dementia; strategies for breaking negative stereotypes and preconceived opinions; and approaches to retaining personhood and dignity. Offering a timely source of information on new design and creative methods to a broad community of industrial, communication, interactive and inclusive designers, this book is also meant to address and inspire various stakeholders and organizations in dementia care.

This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.

With a focus on the practical, day-to-day tools needed by neurologists, psychiatrists, geriatricians, and others who work with the elderly, Memory Loss, Alzheimer's Disease and Dementia, 3rd Edition, is an indispensable, easy-to-read resource in this growing area. Clinical experts Drs. Andrew Budson and Paul Solomon cover the essentials of physical and cognitive examinations and laboratory and imaging studies for dementia and related illnesses, giving you the guidance you need to make accurate diagnosis and treatment decisions with confidence. Provides in-depth coverage of clinically useful diagnostic tests and the latest research findings and treatment approaches. Incorporates real-world case studies that facilitate the management of both common and uncommon conditions. Contains new chapters on Alzheimer's look-alikes and posterior cortical atrophy. Covers key topics such as chronic traumatic encephalopathy, primary age-related tauopathy (PART) and limbic-predominant, age-related TDP-43 encephalopathy (LATE), in addition to new criteria for dementia with Lewy bodies and posterior cortical atrophy. Includes current National Institute on Aging-Alzheimer's Association and DSM-5 criteria for Alzheimer's disease and mild cognitive impairment. Demonstrates how to use diagnostic tests such as the amyloid imaging scans florbetapir (Amyvid), flutemetamol (Vizamyl), and florbetaben (Neuraceq), which can display amyloid plaques in the living brains of patients, as well as the new tau scans. Includes access to more than two dozen videos that illustrate common tests, clinical signs, and diagnostic features. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

Asperger Syndrome now affects an estimated 10 million children and adults in the United States. Here, Lawton takes an evenhanded look at AS, its development and symptoms, the biological and potential genetic components, the associated physical complaints, and how natural medicine can help. She includes a history of early treatment and current drug and psychotherapy treatments, and explains how diet, blood sugar, and food sensitivities or allergies can play a role. She also looks at the controversy over vaccinations and explains blood tests that can pinpoint a rationale for herbal and homeopathic treatments. The book includes a chapter specifically addressing what is safe to do on your own and when you should seek the help of a medical practitioner. Resources include a listing of AS traits, books that are reliable sources of information, and authoritative Web sites. The spotlight on Asperger Syndrome has been widening with recent attention from mainstream media. This neurological condition, often misdiagnosed as Attention Deficit Disorder, Obsessive Compulsive Disorder, or high-functioning autism is increasingly being recognized, and now affects an estimated 10 million children and adults in the United States alone. Unlike autistic individuals, Asperger sufferers have normal or above normal language, intelligence and cognition, and are often seen as brilliant—verbose with formal speech patterns and superior memory—but they have odd interests, unusual reactions to the environment, inflexibility in routines, poor interaction with people, and inability to form age-appropriate relationships. There is no known cure, but as Suzanne Lawton explains in this work, there are approaches that can reduce or remove the symptoms. While traditional medications are the only option for some sufferers, there are those who can benefit from the natural treatments offered by herbal medicine, diet and nutrition, homeopathy, and amino acids. These drug-free approaches also reduce the physical problems common to Asperger suffers, including stomachaches and headaches and irritable bowel syndrome. says Lawton. Recent FDA warnings regarding the use of psychotropic medications with children (previous treatment has focused on anti-anxiety, anti-depressant, and mood-stabilizing drugs) have fueled the outcry of parents who want to get their children off drugs to avoid the side effects. Here, Lawton takes an evenhanded look at Asperger Syndrome, its development and symptoms, the biological and potential genetic components, the associated physical complaints, and how natural medicine can help. She includes a history of early treatment and current drug and psychotherapy treatments, and explains how diet, blood sugar, and food sensitivities or allergies can play a role. She also looks at the controversy over vaccinations and explains blood tests that can pinpoint a rationale for herbal and homeopathic treatments. Lawton includes a chapter specifically addressing what is safe to do on your own and when you should seek the help of a medical practitioner. Resources include a listing of AS traits, books that are reliable sources of information, and authoritative Web sites.

This book explores a study of how and under what circumstances children's ideas about the body change over the period of two school years, Primary 1 and 2 (6 and 7 years old), in a ""normal"" classroom setting in an Icelandic primary school. The focus is on children's ideas about the structure, location and function of bones and other organs and how changes in pupils' ideas are affected by the curriculum, teaching methods, teaching materials and teacher/pupil and peer interactions. Special attention is given to the differences between quiet children and more open children in respect to these issues. Result from the study shows that the children were generally more aware of the structures, locations and functions of the various organs than they were of processes and how the organs were interrelated and they were also more aware of the digestive system than other organ systems.

A provocative and fascinating look at new discoveries about the brain that challenge our ethics

The rapid advance of scientific knowledge has raised ethical dilemmas that humankind has never before had to address. Questions about the moment when life technically begins and ends or about the morality of genetically designing babies are now relevant and timely. Our ever-increasing knowledge of the workings of the human brain can guide us in the formation of new moral principles in the twenty-first century. In The Ethical Brain, preeminent neuroscientist Michael S. Gazzaniga presents the emerging social and ethical issues arising out of modern-day brain science and challenges the way we look at them. Courageous and thought-provoking -- a work of enormous intelligence, insight, and importance -- this book explores the hitherto uncharted landscape where science and society intersect.

This is the first book on X and Y chromosomal disorders to address these common but rarely diagnosed conditions. This book seeks to present the latest in research and clinical care addressing neuroimaging, the interaction between hormones, brain development, and neurodevelopmental progression. This book will primarily focus on 47, XXY (Klinefelter syndrome, or KS), 47, XYY (Jacobs' syndrome), and 47, XXX (Triple X). More variant disorders such as 48, XXXX, 48, XXXY and 49, XXXXY will be discussed. Topics of interest include neurological functioning, neuroimaging, social language, and the evolving perspectives of these XY chromosomal disorders. The effects of testosterone supplementation in males with 47, XXY will also be examined.

Food and water are necessary for survival, but can only be obtained via ingestive behavior (feeding, drinking, and moving). Survival thus depends on the ability of the brain to coordinate the need for water and energy with appropriate behaviors to modify their intake as necessary for homeostasis. However, the balance of these behaviors also inherently determines body weight, and imbalances contribute to the development of weight disorders, such as obesity and anorexia nervosa. The lateral hypothalamic area (LHA) of the brain is anatomically positioned to coordinate the sensation of osmotic and energy status with goal-directed ingestive behaviors necessary to maintain homeostasis and body weight, and, hence, may hold insight into the potential treatment for energy balance disorders. This volume reviews the essential role of the LHA for the control of body weight, from its historical description as a ""feeding center"" to the current view of this LHA as a cellularly heterogeneous hub that regulates multiple aspects of physiology to influence body weight. Furthermore, we evaluate how specific LHA populations coordinate certain metabolic cues and behaviors, which may guide the development of pathway-specific interventions to improve the treatment of energy balance disorders.