This volume has been compiled chiefly for the benefit of opium-eaters. Its subject is one indeed which might be made alike attractive to medical men who have a fancy for books that are professional only in an accidental way; to general readers who would like to see gathered into a single volume the scattered records of the consequences attendant upon the indulgence of a pernicious habit; and to moralists and philanthropists to whom its sad stories of infirmity and suffering might be suggestive of new themes and new objects upon which to bestow their reflections or their sympathies. But for none of these classes of readers has the book been prepared. In strictness of language little medical information is commu-nicated by it. Incidentally, indeed, facts are stated which a thoughtful physician may easily turn to professional account. The literary man will naturally feel how much more attractive the book might have been made had these separate and sometimes disjoined threads of mournful personal histories been woven into a more coherent whole; but the book has not been made or literary men.

Content covers all units for the Level 3 Award in Dementia Awareness and a mix of mandatory and optional units for the Level 3 Certificate in Dementia Care and the Dementia pathway of the Diploma. Content is matched exactly to the new specification for the Dementia units. Written by best-selling author Yvonne Nolan, so learners can be confident they have the expert support they need to succeed. A concise resource with five chapters, so you don't have to buy more than you need. Chapters combine relevant knowledge and competence units to assist transition from Award to Certificate or Diploma. A positive resource that will not only give learners the knowledge they need to complete the course, but also the skills to implement best practice in their setting Engaging case studies and real-life examples bring learning alive, helping candidates to apply their learning.

Aimed at starting researchers in the field, Realizability gives a rigorous, yet reasonable introduction to the basic concepts of a field which has passed several successive phases of abstraction. Material from previously unpublished sources such as Ph.D. theses, unpublished papers, etc. has been molded into one comprehensive presentation of the subject area.
- The first book to date on this subject area
- Provides an clear introduction to Realizability with a comprehensive bibliography
- Easy to read and mathematically rigorous
- Written by an expert in the field

Growth in the incidence of dementia presents major challenges to global healthcare systems. As the burden of dementia in non-Western cultures grows, developing nations are expected to overtake developed nations in terms of dementia prevalence. Insights from developing nations and transcultural considerations are, nevertheless, neglected in the published literature. Dementia: A Global Approach fills this gap by integrating contemporary cross-cultural knowledge about dementia. Each section reviews the literature from the published, predominantly Western, perspective, contrasting it with empirical knowledge from non-Western cultures. Covering major clinical, epidemiological and scientific areas of interest, detailed consideration is also given to care-giving models across the world and management of patients who have migrated between regions. Enriched with personal insights from clinical experts across the globe, this is a key text for neurologists, geriatricians, psychiatrists, psychologists, epidemiologists and all those responsible for managing provisions of dementia services.

This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington's diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e, g., Bram Stoker's "Dracula"). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines.

This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights.

This volume contains selected and edited papers from the 7th European Conference on Eye Movements (ECEM 7) held in Durham, UK on August 31-September 3 1993. The volume is organized as follows: - Invited Lectures, Pursuit and Co-Ordination, Saccade and Fixation Control, Oculomotor Physiology, Clinical and Medical Aspects of Eye Movements, Eye Movements and Cognition, Eye Movements and Language and finally, Displays and Applications

One who Forgets and

One who is Forgotten

One in eight over the age of sixty-five and one in three over the age of eighty will be diagnosed with Alzheimer's Disease. In her memoir, author Joan Sutton narrates a moving account of her years as caregiver to her husband, noting that "Alzheimer's is a disease of the brain that is paid for with the currency of the heart."

A member of the board of overseers of The Alzheimer's Drug Discovery Foundation, she stresses the need to develop more effective treatment for the eight million Americans currently diagnosed with this incurable disease, pointing out that for every patient there is a large circle of others also affected.

Sutton offers practical advice for the care of the caregiver and the patient, and shares the pain that came as she watched pieces of her husband's self disappear. Following his death, after what Nancy Reagan described as "the long goodbye," she writes candidly about coping with her new status as a widow and the aching loneliness of the heart that is the price paid for having known a great love.

All profits from the sale of this book will benefit The Alzheimer's Drug Discovery Foundation/Canada.

Cover design by John R. Lewis

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research. It summarizes the available data on the fundamentals of neurotransmitters, treatment of and advanced care for neurodegenerative diseases; and outlines current and future research directions in this field. Combining both conventional and innovative approaches to the topic, the book offers a valuable guide for readers working in medicinal chemistry, the life sciences and allied fields.

This exciting collection tours virtual reality in both its current therapeutic forms and its potential to transform a wide range of medical and mental health-related fields. Extensive findings track the contributions of VR devices, systems, and methods to accurate assessment, evidence-based and client-centered treatment methods, and-as described in a stimulating discussion of virtual patient technologies-innovative clinical training. Immersive digital technologies are shown enhancing opportunities for patients to react to situations, therapists to process patients' physiological responses, and scientists to have greater control over test conditions and access to results. Expert coverage details leading-edge applications of VR across a broad spectrum of psychological and neurocognitive conditions, including: Treating anxiety disorders and PTSD. Treating developmental and learning disorders, including Autism Spectrum Disorder, Assessment of and rehabilitation from stroke and traumatic brain injuries. Assessment and treatment of substance abuse. Assessment of deviant sexual interests. Treating obsessive-compulsive and related disorders. Augmenting learning skills for blind persons. Readable and relevant, Virtual Reality for Psychological and Neurocognitive Interventions is an essential idea book for neuropsychologists, rehabilitation specialists (including physical, speech, vocational, and occupational therapists), and neurologists. Researchers across the behavioral and social sciences will find it a roadmap toward new and emerging areas of study.

Research on cognitive disorders is challenging due to the complexity of functions and numerous variables involved. The main purpose of this book is to effectively address the methodological issues and controversies in cognitive disorders research. First, it reviews the concept of human cognition as a complex activity involving interconnected mental and cerebral processes (its systemic structure), which represent the natural and social-cultural world by means of signs (its mediated, semiotic nature) and result from the internalization (or appropriation by the individual) of external actions and relations with things and persons (its cultural-historical origin). Subsequently, methodological issues are examined, including the use of the systemic and network approach in neuropsychological research, the concepts of single and double dissociation, single-case versus group studies, problems of brain-behavioral correlations using the lesion method and functional neuroimaging, the influence of task-relevant variables (confounders) related to the patient (e.g., age, education), to the lesion (size, etiology), and to the tests and testing conditions (ecological validity, examiners experience). Finally, readers are given the fundamentals of statistics applied to biomedical and psychological research, with illustrative examples of how to calculate Z score, effect size, 2 test, t test, Pearsons correlation coefficient, and simple linear regression. Methodological problems in current cognitive research on early multiple sclerosis, medial temporal lobe epilepsy, mild cognitive impairment and dementia are examined in detail.

Autism is a complex phenomenon that is both individual and social. Showing both robust similarities and intriguing differences across cultural contexts, the autism spectrum raises innumerable questions about self, subjectivity, and society in a globalized world. Yet it is often misrepresented as a problem of broken bodies and disordered brains. So, in 2015, a group of interdisciplinary scholars gathered in Rio de Janeiro, Brazil for an intellectual experiment: a workshop that joined approaches from psychological anthropology to the South American tradition of Collective Health in order to consider autism within social, historical, and political settings. This book is the product of the ongoing conversation emerging from this event. It contains a series of comparative histories of autism policy in Italy, Brazil, and the United States; focuses on issues of voice, narrative, and representation in autism; and examines how the concept of autism shapes both individual lives and broader social and economic systems. Featuring contributions from: Michael Bakan Benilton Bezerra Pamela Block M. Ariel Cascio Jurandir Freire Costa Barbara Costa Andrada Cassandra Evans Elizabeth Fein Clara Feldman Roy Richard Grinker Rossano Lima Francisco Ortega Dawn Prince-Hughes Clarice Rios Laura Sterponi Thomas S. Weisner Enrico Valtellina

The field of interventional neuroradiology has expanded greatly in recent years, shifting emphasis onto neuroendovascular methods that, increasingly, have become the standard in modern treatment. This shift has placed a demand on hospitals to provide a standard of care for which many busy clinicians have not been trained. Dr. Pearse Morris has written a timely and comprehensive reference for those who are interested in expanding their knowledge of neuroendovascular procedures, but have not had a specialized neuroradiology fellowship. The emphasis throughout is on patient safety and the outcome of various treatments. Topics covered in this volume include: Platelets and coagulation basic techniques, devices, and arterioty closure aneurysms extracranial angioplasty and stenting endovascular treatment of vasospasm dural arteriovenous malformations carotid cavernous fistulas balloon test occlusion and post-occlusion patient care spine and vertebroplasty tumor embolization thrombolysis and treatment of acute stroke venous thrombotic disease arteriovenous malformations of the brain Neuroradiologists, neurosurgeons, and neurologists will find this reference a much needed and practical asset to both their education and updating their practices.

For those fascinated by neurology and for fans of The Man Who Mistook His Wife for a Hat comes a powerful exploration of the mind during night time. Here are the mysteries of sleep, explained - from known conditions to the extreme. 'The Secret World of Sleep interweaves bizarre real life stories with cutting edge neurological science in the true tradition of Oliver Sacks. A fascinating read.' Martha Kearney, BBC Radio 4 World-renowned neurologist and sleep expert, Doctor Guy Leschziner, takes you through various sleep conditions and how they arise and affect people. Insomnia, narcolepsy, night terrors and apnoea are just some of the conditions afflicting those struggling with sleep. Then there are the extreme cases. The people frighten into paralysis by hallucinations. The woman in a state of deep sleep who gets dressed and goes for a drive. The teenager with 'Sleeping Beauty Syndrome', stuck in a cycle of excessive unconsciousness. The man who cleans out kitchens while 'sleep-eating'. With compassionate stories of his patients and their conditions, Leschziner illustrates the neuroscience behind our sleeping minds, revealing the many biological and psychological factors necessary in getting the rest needed for health and happiness. Pick of the Best Paperbacks - Sunday Times Best January Paperbacks - The Times Must Read Brain Books 2019 - Forbes Magazine The Best Neuroscience Books of 2019 - The Scientist Magazine The Best Books of 2019 - New Zealand Herald Best 100 Summer Reads 2019 - Sunday Times Week's best Science Picks - Nature Books of the Year 2019 - Irish Independent

This volume introduces the concept of Perpetration-Induced Traumatic Stress (PITS), a form of PTSD symptoms caused not by traditionally expected roles, such as being a victim or rescuer in trauma, but by being an active participant in causing trauma. Sufferers of PITS may be in the roles of soldiers, executioners, or police officers, where it is socially acceptable or even expected for them to cause trauma, including death. Scattered evidence of PITS is consolidated, its implications are explored, and exciting potentials for future research are suggested.

Compared to the more widely understood PTSD, there appears to be greater severity and different symptom patterns for those affected by PITS. Obvious differences to be explored for those who kill include questions of context, guilt, meaning, content of dreams, and sociological questions, leading to special implications for therapy, research into the causality of PTSD, and violence prevention efforts. Disciplines including sociology, public policy, history, philosophy, and theology will also find applications for this groundbreaking material.