The purpose of this book is to educate readers regarding the efficacy of cognitive rehabilitation across a variety of neurological conditions, with specific emphasis on rehabilitation-related change detectable via neuroimaging. For ease of reference, this information is divided into separate chapters by neurological condition, since the nature of cognitive impairment and mechanism of rehabilitation may differ across populations. Also included are discussions of the use of neuroimaging in cognitive rehabilitation trials, rigorous design of cognitive rehabilitation trials to have greater scientific impact (e.g., obtaining Class I evidence), and future directions for the field. As such, the book is designed to be useful to both clinicians and researchers involved in the rehabilitation of such conditions so that they can make informed decisions regarding evidence-based treatment to deploy in clinical settings or to further study in research endeavors.

This book explores how theatre and performance can change the way we think about dementia and some of the environments in which dementia care takes place. Drawing on the author's creative practice and other performance projects in the UK, it explores some of the challenges and opportunities of making performance in care homes. Rather than focusing on the transformative potential of the arts, it asks how artists can engage with the different types of relationships that exist in a care community. These include the relationships that residents and staff have with each other as well as relationships with care spaces. Exploring the intersection between participatory performance and the everyday creativity of a care home, it argues that the arts have a cultural role to play in supporting dementia care as a relational practice. Moreover, it celebrates the intrinsic creativity of caregiving and how principles and practices of care work can inform theatre and performance in diverse ways.

This book comprehensively examines chemotherapy-induced peripheral neuropathy (CIPN), a common dose-limiting condition that negatively affects both the quality of life of cancer patients and disease outcomes. CIPN remains a challenging area for both clinical care and research, as there are multiple unresolved issues. Written by leading international experts, the book discusses the natural history of CIPN, the latest predictors of toxicity, instruments for evaluating symptoms, and prevention/therapeutic strategies, as well as patients' experiences of this common clinical syndrome. Lastly it highlights avenues for future research to enhance our understanding of CIPN. Providing essential information on the management of CIPN and the latest research in the field, this book is a valuable resource for researchers and healthcare providers working with patients with various malignant diseases.

Neuroethics is concerned with the wide array of ethical, legal and social issues that are raised in research and practice. The field has grown rapidly over the last five years, becoming an active interdisciplinary research area involving a much larger set of academic fields and professions, including law, developmental psychology, neuropsychiatry, and the military.
Neuroethics and Practice helps to define and foster this emerging area at the intersection of neuroethics and clinical neuroscience, which includes neurology, neurosurgery, psychiatry and their pediatric subspecialties, as well as neurorehabiliation, clinical neuropsychology, clinical bioethics, and the myriad other clinical specialties (including nursing and geriatrics) in which practitioners grapple with issues of mind and brain. Chatterjee and Farah have brought together leading neuroethicists working in clinically relevant areas to contribute chapters on an intellectually fascinating and clinically important set of neuroethical topics, involving brain enhancements, brain imaging, competence and responsibility, severe brain damage, and consequences of new neurotechnologies. Although this book will be of direct interest to clinicians, as the first edited volume to provide an overall comprehensive perspective on neurethics across disciplines, it is also a unique and useful resource for a wide range of other scholars and students interested in ethics and neuroscience.

Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Alzheimer's is a devastating disease, robbing its victims of so much of themselves before the end. For caregivers facing this disease, a diagnosis of Alzheimer's disease can sound like the ultimate tragedy, the disease that will rob us of our loved one by inches. It doesn't have to be. While Alzheimer's and related dementias are serious and not easily understood diseases, a new guide can help families negotiate the difficult scientific, emotional, and practical issues of dealing with the disease. In a moving and easy to read format, Dr. Steinberg has laid out a true caregiver's guide to dealing with Alzheimer's disease, from the first signs to the final stages. Incorporating science, real-life case studies from his practice and from his extensive experience as a nationally recognized seminar speaker, as well as from his personal journey coping with his mother's illness, Dr. Steinberg leads the reader through a learning and healing process. In a candid and personal sharing of his experience, Dr. Steinberg helps the reader clearly understand what to expect, when to ask for help, how to cope with the changes and the inevitable pressures within the family, and how to continue to love as a loved one's disease threatens family stability and well-being. With his profound knowledge of the disease, its treatment and manifestations, and his great love and tenderness as the son of an Alzheimer's patient, Dr. Steinberg has created a truly memorable work.

Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more.

"Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases" is the second volume in the series, "Pharmaceutical Leads from Medicinal Plants." This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases.

This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development.
Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this areaContains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's diseaseEach plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Memory loss is not always viewed purely as a contingent neurobiological process present in an ageing population; rather, it is frequently related to larger societal issues and political debates. This edited volume examines how different media and genres - novels, auto/biographical writings, documentary as well as fictional films and graphic memoirs - represent dementia for the sake of critical explorations of memory, trauma and contested truths. In ten analytical chapters and one piece of graphic art, the contributors examine the ways in which what might seem to be the individual, ahistorical diseases of dementia are used in contemporary cultural texts to represent and respond to violent historical and political events - ranging from the Holocaust to postcolonial conditions - all of which can prove difficult to remember. Combining approaches from literary studies with insights from memory studies, trauma studies, anthropology, the critical medical humanities and media, film and comics studies, this volume explores the politics of dementia and incites new debates on cultures of remembrance, while remaining attentive to the lived reality of dementia.

In 1997, Vagus Nerve Stimulation (VNS) therapy (Cyberonics, Houston, Texas) was approved by the United States Food and Drug Administration for the treatment of epilepsy refractory to antiepileptic medications. In 2005, VNS received FDA approval for treatment-resistant depression refractory to antidepressants, and Cyberonics recently received FDA approval for the clinical study of VNS for rapid cycling bipolar depression. Many researchers continue to investigate the anxiolytic effects of VNS in human and non-human animal models. The author presents a study of VNS effects on anxiety and the capacity of atropine methyl nitrate to attenuate these effects. The results indicate that VNS decreases anxiety in the laboratory animals tested. These findings provide evidence to support the testing and subsequent use of VNS therapy for the treatment of clinical anxiety in humans. Because many therapies that are effective in the treatment of depression effectively treat anxiety, VNS therapy should be effective and approvable for clinical anxiety. This book can serve as a research tool, training mechanism, or surgical guide to the implantation of the vagus nerve stimulating electrode in the laboratory rat. Hopefully, this resource provides information that facilitates FDA approval of VNS for treatment-resistant anxiety, a chronic, devastating and often debilitating illness.

Research on autism has flourished in recent years. As a result, specialism has developed and lines of research have become specialized and isolated. This collection of research on autism spectrum disorders investigates and cross-references a wide range of neurocognitive, clinical, and interventionist perspectives on autistic spectrum disorders research - from functional Magnetic Resonance Imaging studies to naturalistic intervention.

Accessible to students, parents and practitioners, "Autism" provides an overview of high profile research
Features contributions from teams at the forefront of research output in the UK, Europe and the United States
Introductory and concluding chapters highlighting major research themes while exploring broader issues on the integration of autism research,

ABOUT THE BOOK: It seemed nothing Tracy did for her son would work-testing, counseling, medication, therapy-and violent meltdowns were a daily occurrence. She agonized over What is next? What is to become of my beautiful son? Tracy's struggles were long and hard, but with a mother's determination, a supportive family, and God's love and intervention, she found strength, endurance, and unexpected open doors. To the Land of the Lost is a mom's gripping, true story account of the trials faced while parenting a child who has Asperger's syndrome. The story is gut wrenching and heartbreaking, while at the same time loving, uplifting, encouraging, and inspirational. To the Land of the Lost is a must read for any parent, caregiver, teacher, or friend of someone living with an autism spectrum disorder. **** ABOUT THE AUTHOR: Tracy M. Maguire lives in Dublin, Ireland, with her three children: Graham, Sophie, and James. Her eldest son, Graham, now almost 19 years old, has Asperger's syndrome. Tracy is passionate about encouraging parents who are raising a child with Asperger's and giving them hope in what can often feel like a hopeless situation.

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer s disease, Parkinson s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters."

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.

What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal's decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.