The most trusted book on multiple sclerosis, updated and revised with the latest research in combating the disease

Once known as the "crippler of young adults," now more than 75 percent of MS patients will never need a wheelchair. In "Multiple Sclerosis, " Dr. Louis J. Rosner and Shelley Ross explain that there genuinely is new hope, more than ever before, both for controlling the disease today and curing it tomorrow.

Updated with the latest research and terminology, this revised edition gets to the bottom of every treatment option from the tried-and-true to today's cutting-edge and experimental therapies. Its trusted advice covers every step of living with MS, what you need to know, and what you need to ask. Dr. Louis Rosner and Shelley Ross explain what the disease is, who gets it and why, and what people with MS can do to continue living happy and healthy lives. Whether you or your loved one has just been diagnosed with MS or has lived with it for a while, "Multiple Sclerosis" gives you the information you need to live well with the disease, including:

- The diagnosis: how to understand and identify MS as early as possible

- The varying symptoms and courses of the disease: how to recognize and treat them

- The emotional struggles that come with MS: where to turn for support

- The most current medical research and therapies available to MS patients: how to know if they are right for you

For decades, this trusted handbook has helped those with MS and their families and friends to treat and understand their disease. Research brings us closer to a cure every day, but until that day comes, patients have, in this book, the very best tool for beating MS -- the facts.

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre---mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--- coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi---directional transcription and production of repeat associated non---ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer's disease, Huntington's disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.

This volume introduces the concept of Perpetration-Induced Traumatic Stress (PITS), a form of PTSD symptoms caused not by traditionally expected roles, such as being a victim or rescuer in trauma, but by being an active participant in causing trauma. Sufferers of PITS may be in the roles of soldiers, executioners, or police officers, where it is socially acceptable or even expected for them to cause trauma, including death. Scattered evidence of PITS is consolidated, its implications are explored, and exciting potentials for future research are suggested.

Compared to the more widely understood PTSD, there appears to be greater severity and different symptom patterns for those affected by PITS. Obvious differences to be explored for those who kill include questions of context, guilt, meaning, content of dreams, and sociological questions, leading to special implications for therapy, research into the causality of PTSD, and violence prevention efforts. Disciplines including sociology, public policy, history, philosophy, and theology will also find applications for this groundbreaking material.

The book begins with a public health/epidemiologic examination of the situation, with a systematic view of the problem based on classic (infectious disease) epidemiologic principles applied to this behavioral health issue. This application is expanded to take into account the fact that unlike most epidemics in our species' history, a unique factor that must be accounted for in any public health analysis is that the host (opioid-dependent/misusing patient) is generally not under sufficiently strong motivation to avoid the disease. The introduction concludes with a survey of recent containment approaches, categorized epidemiologically by target (agent, vector, host.) The remainder of the book is organized according to this framework, addressing agent, vector/transmission and host, respectively. Sections Three and Four comprise the major focus of the book, and are dedicated primarily to practical education for primary care providers in preventing opioid use disorder, and overcoming it after the fact.

This handbook identifies the various social deficiencies widely associated with children and youth diagnosed with autism spectrum disorder (ASD). It discusses possible causes as well as the lifelong effects if these deficiencies are not addressed. The handbook presents current behavioral and curriculum-based methods for assessing social deficits. Chapters examine the various interventions that have been used to improve social skills and behavior, including video modeling, peer-mediated interventions, and script fading. Chapters also assess various interventions using empirically based procedures, evaluate the research of each of these procedures, provide guidelines for treatment planning, and offer clinical recommendations. The handbook concludes with future directions for the development of both social behavior and clinical social skills interventions. Topics featured in the Handbook include: Impairments in social behavior that may result in negative outcomes such as depression, loneliness, and suicide in individuals with ASD. Bullying among youth with ASD. Behavioral skills training to promote social behavior of individuals with ASD. The Early Start Denver Model approach to helping young children with ASD. The implementation of social skills groups for individuals diagnosed with ASD. The Handbook of Social Skills and Autism Spectrum Disorder is a must-have resource for researchers, clinicians/professionals, and graduate students in clinical child, school, and developmental psychology, behavioral therapy, and social work, as well as such interrelated disciplines as child and adolescent psychiatry, rehabilitation medicine/therapy, pediatrics, and special education/educational psychology.

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

Autism spectrum disorder (ASD) is a relatively new diagnostic label which reflects the variability and differentiation of symptomatology among children and youth commonly described as having autistic disorder, high-functioning autism (HFA), and Asperger's syndrome. Current best practices have emerged from decades of evidence-based research, research-to-practice translation of empirically supported procedures, and consensus-driven recommendations from multiple disciplines. As a result, practitioners have many educational and intervention choices for children and youth with ASD-what is critical is that these options are informed by empirical outcomes that have been replicated in experimental trials (group and single-case) and disseminated to professionals and researchers alike. Children and Youth with Autism Spectrum Disorder (ASD) is a state-of-the-art volume of 15 chapters across four thematic sections that reflect the current convention of viewing autism along a continuum of presenting symptoms. Skillfully edited by James K. Luiselli, sections cover diagnosis, assessment, and measurement; evidence-based practices; health and development; and additional topics such as mindful caregiving and support, CBT, and behavioral family intervention. Compiling the most up-to-date advances in approaches toward diagnosis, education, treatment, and program development, Children and Youth with Autism Spectrum Disorder (ASD) will be a valuable resource for professionals and trainees in the ASD field including psychologists, educators, therapists, behavior analysts, and similar practitioners. It is also appropriate for academic researchers and courses devoted to clinical psychology, special education, developmental disabilities, and special topics.

Dr. Leonard Swischuk, who is recognized for authoring several superb and widely read pediatric radiology textbooks, has produced yet another outstanding work on the important subject of imaging the cervical spine in children. A distinguished pediatric radiologist, he draws upon his extensive experience in the field and his gift for writing clear and readable text to provide practitioners with an insightful approach to pediatric cervical spine injuries. Those who work in trauma imaging will appreciate the wealth of practical guidelines contained in this thorough yet concise book. Dr. Swischuk's text is organized into six chapters. The first two discuss developmental anatomy and normal variants. Chapters three and four concentrate on congenital anomalies and on abnormalities of the dens. The final two chapters consider trauma and miscellaneous abnormalities of the cervical spine. The book has several notable strengths that are appealing to radiology residents, such as its succinct and well-organized overview of the topic. To help residents identify cases that they are likely to encounter during board exams and in practice, Dr. Swischuk selected excellent plain film examples from his personal collection that illustrate the conditions he discusses and reflect his emphasis on cervical radiography. The illustrated cases also include CT and MR images that clarify and qualify the plain film findings. Helpful reference lists complete each chapter and guide residents to resources for further reading. In addition, Dr. Swischuk 's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

The difference that being female makes to the diagnosis, life and experiences of an autistic person is hugely significant. In this widely expanded second edition, Sarah Hendrickx combines the latest research with personal stories from girls and women on the autism spectrum to present a picture of their feelings, thoughts and experiences at each stage of their lives.

Outlining the likely impact will be for autistic women and girls throughout their lifespan, Hendrickx surveys everything from diagnosis, childhood, education, adolescence, friendships and sexuality, to employment, pregnancy, parenting, and aging.

With up-to-date content on masking, diagnosis later in life, and a new focus on trans and non-binary voices, as well as a deeper dive into specific health and wellbeing implications including menopause, PCOS, Hypermobility/Ehlers-Danlos, autistic burnout, and alexithymia, this is an invaluable companion for professionals, as well as a guiding light for autistic women to understand and interpret their own experience in context.

The belief in my little angel has given me my greatest strength. Embrace all the mystery, wonder, and love your child has to offer. Nothing can take that away from you, not even autism. What you are about to read is a true story about my daughter and other angels in my life. They have given me the love, patience, and faith needed to survive in our new world together. This is not a cure-all book that debates or dictates which treatments or therapies are best for treating autism. However, this book meant to give others renewed strength and courage. Our story is not just about autism. It is meant to be shared by anyone who is struggling with any life challenge. More importantly, I am sending you this message... "You are not alone, you are never alone."

Naming Adult Autism is one of the first critiques of cultural and medical narratives of Autism to be authored by an adult diagnosed with this condition. Autism is a 'social disorder', defined by interactions and lifestyle. Yet, the expectations of normalcy against which Autism is defined have too rarely been questioned. This book demonstrates the value of the Humanities towards developing fuller understandings of Autistic adulthood, adapting theory from Adorno, Foucault and Butler. The chapters expose serious scientific limitations of medical assumptions that Autistic people are gifted at maths but indifferent to fiction. After interrogating such cliches in literature, cinema and television, James McGrath also explores more radical depictions of Autism via novels by Douglas Coupland, Margaret Atwood, Clare Morrall and Meg Wolitzer, plus poems by Les Murray and Joanne Limburg. Follow this link to see James McGrath in conversation with Kelly-Anne Watson at Leeds Beckett University: https://www.youtube.com/watch?v=xQOotRZRzv4 Follow this link to view a content breakdown of the above interview: https://www.academia.edu/36406389/Naming_Adult_Autism_A_Conversation_winter_2017_ Follow this link to read a 'Seeking Sara' blog interview with James: https://seekingsara174.wordpress.com/2018/08/19/639/

Although the history of epilepsy, one of the most common serious neurological disorders, can easily be traced back to ancient times, the modern understanding of the disease only began in the middle of the 19th century. This history of the first fifty years of modern epileptology reflects the thinking, accomplishments, and failures of physicians between 1865 and 1914. This epoch presented a very bleak clinical picture: diagnosis was difficult and often arbitrary; treatment was poor and, at times, worse than the disease; and patients, who were usually viewed as having a progressive dementing condition, were shunned by society.

Tradition, physicians' immaculate perceptions, their thinking in analogies, and the difficulty a doctor has in separating himself from his society are some of the important factors which led to a lack of clinical advancement during this time. Nevertheless, taking a longer view, a foundation was being established for understanding the physiology of the brain and how that might be related to epilepsy. This book should be of interest to any professional person concerned with or involved in exploring the neurophysiology of brain functions and its deviations, the care and treatment of patience with epilepsy, and the historical and social aspects of medicine.

Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

The purpose of this book is to contribute to basic and clinical medical research on cochlear implants for inner ear malformation and cochlear nerve deficiency. Cochlear implantation for children is performed worldwide, and the outcomes concerning speech and hearing acquisition are epoch-making. However, there are some difficulties associated with applying this operative treatment to patients who have complicated inner ear malformations or cochlear nerve deficiencies that have slowed the development of their speech, hearing, and/or sense of balance. The first part of the book outlines the fundamental aspects of inner ear maldevelopment to facilitate readers' understanding of cochlear implantation from the point of view of embryology, morphology, and genetics. In turn, the second part describes current clinical cases and presents successful clinical reports. The book offers a primary resource for otolaryngologists, neurologists, and pediatricians with an interest in this field.

Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies. The editors bring together contributions from internationally recognized workers in the field to provide an up to date account of how and why molecular and cellular neurobiology is such an important area for clinical neuroscience. Understanding the molecular aspects of a number of neurodegenerative conditions such as Parkinson's or Alzheimer's disease for the purpose of improving patient management remains a major challenge of neurobiology be it from the basic or clinical perspective. A strategic evaluation of research contributions and the power of modern methods will help advance knowledge over the next years.

Expanding on the critical contributions of previous editions, this updated and comprehensive resource covers the latest diagnostic criteria of insomnia. The book is thematically divided into two parts. The first section consists of chapters on nomenclature, epidemiology, pathophysiology, diagnosis and differential diagnosis, complications and prognosis and treatment both pharmacological and behavioral. The second features chapters on insomnia in special populations, including ones on children and adolescents, cancer sufferers and survivors, in pregnancy, in menopausal women and in patients with neurological disorders and those with psychiatric illnesses. This third edition fills an important niche in the medical literature by addressing insomnia in its multiple forms, summarizes the findings published in different medical journals, and presents these to the practicing health care provider in an easily accessible format.