The most trusted book on multiple sclerosis, updated and revised with the latest research in combating the disease

Once known as the "crippler of young adults," now more than 75 percent of MS patients will never need a wheelchair. In "Multiple Sclerosis, " Dr. Louis J. Rosner and Shelley Ross explain that there genuinely is new hope, more than ever before, both for controlling the disease today and curing it tomorrow.

Updated with the latest research and terminology, this revised edition gets to the bottom of every treatment option from the tried-and-true to today's cutting-edge and experimental therapies. Its trusted advice covers every step of living with MS, what you need to know, and what you need to ask. Dr. Louis Rosner and Shelley Ross explain what the disease is, who gets it and why, and what people with MS can do to continue living happy and healthy lives. Whether you or your loved one has just been diagnosed with MS or has lived with it for a while, "Multiple Sclerosis" gives you the information you need to live well with the disease, including:

- The diagnosis: how to understand and identify MS as early as possible

- The varying symptoms and courses of the disease: how to recognize and treat them

- The emotional struggles that come with MS: where to turn for support

- The most current medical research and therapies available to MS patients: how to know if they are right for you

For decades, this trusted handbook has helped those with MS and their families and friends to treat and understand their disease. Research brings us closer to a cure every day, but until that day comes, patients have, in this book, the very best tool for beating MS -- the facts.

Amantadine is used to treat the symptoms of Parkinson's disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions. It is also used to control movement problems that are a side effect of certain medications used to treat Parkinson's disease (MedlinePlus). This book is a concise guide to the use of amantadine to treat Parkinson's disease. Divided into five sections, the text begins with an overview of the signs and symptoms of Parkinson's disease, followed by coverage of its pathophysiology and diagnosis. The next chapters discuss the role of amantadine in the treatment of the disease, as well as its clinical efficacy and safety. The book concludes with advice on dosage, adverse effects, and its interaction with other drugs. Tables and figures further enhance the text. Key points Concise guide to the use of amantadine to treat Parkinson's disease In depth coverage of signs and symptoms of the disease, its pathophysiology and diagnosis Discusses clinical efficacy, safety, dosage, side effects, and interaction with other drugs Includes tables and figures to further enhance learning

The book is a compendium of the aforementioned subclass of models of Basal Ganglia, which presents some the key existent theories of Basal Ganglia function. The book presents computational models of basal ganglia-related disorders, including Parkinson's disease, schizophrenia, and addiction. Importantly, it highlights the applications of understanding the role of the basal ganglia to treat neurological and psychiatric disorders. The purpose of the present book is to amend and expand on James Houk's book (MIT press; ASIN: B010BF4U9K) by providing a comprehensive overview on computational models of the basal ganglia. This book caters to researchers and academics from the area of computational cognitive neuroscience.

Asperger Syndrome now affects an estimated 10 million children and adults in the United States. Here, Lawton takes an evenhanded look at AS, its development and symptoms, the biological and potential genetic components, the associated physical complaints, and how natural medicine can help. She includes a history of early treatment and current drug and psychotherapy treatments, and explains how diet, blood sugar, and food sensitivities or allergies can play a role. She also looks at the controversy over vaccinations and explains blood tests that can pinpoint a rationale for herbal and homeopathic treatments. The book includes a chapter specifically addressing what is safe to do on your own and when you should seek the help of a medical practitioner. Resources include a listing of AS traits, books that are reliable sources of information, and authoritative Web sites. The spotlight on Asperger Syndrome has been widening with recent attention from mainstream media. This neurological condition, often misdiagnosed as Attention Deficit Disorder, Obsessive Compulsive Disorder, or high-functioning autism is increasingly being recognized, and now affects an estimated 10 million children and adults in the United States alone. Unlike autistic individuals, Asperger sufferers have normal or above normal language, intelligence and cognition, and are often seen as brilliant—verbose with formal speech patterns and superior memory—but they have odd interests, unusual reactions to the environment, inflexibility in routines, poor interaction with people, and inability to form age-appropriate relationships. There is no known cure, but as Suzanne Lawton explains in this work, there are approaches that can reduce or remove the symptoms. While traditional medications are the only option for some sufferers, there are those who can benefit from the natural treatments offered by herbal medicine, diet and nutrition, homeopathy, and amino acids. These drug-free approaches also reduce the physical problems common to Asperger suffers, including stomachaches and headaches and irritable bowel syndrome. says Lawton. Recent FDA warnings regarding the use of psychotropic medications with children (previous treatment has focused on anti-anxiety, anti-depressant, and mood-stabilizing drugs) have fueled the outcry of parents who want to get their children off drugs to avoid the side effects. Here, Lawton takes an evenhanded look at Asperger Syndrome, its development and symptoms, the biological and potential genetic components, the associated physical complaints, and how natural medicine can help. She includes a history of early treatment and current drug and psychotherapy treatments, and explains how diet, blood sugar, and food sensitivities or allergies can play a role. She also looks at the controversy over vaccinations and explains blood tests that can pinpoint a rationale for herbal and homeopathic treatments. Lawton includes a chapter specifically addressing what is safe to do on your own and when you should seek the help of a medical practitioner. Resources include a listing of AS traits, books that are reliable sources of information, and authoritative Web sites.

Have you, a friend or family member been living with undiagnosed autism?

For every visibly Autistic person you meet, there are countless 'masked' people who pass as neurotypical. They don't fit the stereotypical mould of Autism and are often forced by necessity to mask who they are, spending their entire lives trying to hide their Autistic traits. In particular, there is evidence that Autism remains significantly undiagnosed in women, people of colour, trans and gender non-conforming people, many of whom are only now starting to recognise those traits later in life.

Blending cutting-edge research, personal insights and practical exercises for self-expression, Dr Devon Price examines the phenomenon of 'masking', making a passionate argument for radical authenticity and non-conformity. A powerful call for change, Unmasking Autism gifts its readers with the tools to uncover their true selves and build a new society - one where everyone can thrive on their own terms.

The book begins with a public health/epidemiologic examination of the situation, with a systematic view of the problem based on classic (infectious disease) epidemiologic principles applied to this behavioral health issue. This application is expanded to take into account the fact that unlike most epidemics in our species' history, a unique factor that must be accounted for in any public health analysis is that the host (opioid-dependent/misusing patient) is generally not under sufficiently strong motivation to avoid the disease. The introduction concludes with a survey of recent containment approaches, categorized epidemiologically by target (agent, vector, host.) The remainder of the book is organized according to this framework, addressing agent, vector/transmission and host, respectively. Sections Three and Four comprise the major focus of the book, and are dedicated primarily to practical education for primary care providers in preventing opioid use disorder, and overcoming it after the fact.

Dr. Leonard Swischuk, who is recognized for authoring several superb and widely read pediatric radiology textbooks, has produced yet another outstanding work on the important subject of imaging the cervical spine in children. A distinguished pediatric radiologist, he draws upon his extensive experience in the field and his gift for writing clear and readable text to provide practitioners with an insightful approach to pediatric cervical spine injuries. Those who work in trauma imaging will appreciate the wealth of practical guidelines contained in this thorough yet concise book. Dr. Swischuk's text is organized into six chapters. The first two discuss developmental anatomy and normal variants. Chapters three and four concentrate on congenital anomalies and on abnormalities of the dens. The final two chapters consider trauma and miscellaneous abnormalities of the cervical spine. The book has several notable strengths that are appealing to radiology residents, such as its succinct and well-organized overview of the topic. To help residents identify cases that they are likely to encounter during board exams and in practice, Dr. Swischuk selected excellent plain film examples from his personal collection that illustrate the conditions he discusses and reflect his emphasis on cervical radiography. The illustrated cases also include CT and MR images that clarify and qualify the plain film findings. Helpful reference lists complete each chapter and guide residents to resources for further reading. In addition, Dr. Swischuk 's direct writing style makes the complex content highly accessible, providing imaging residents with an invaluable introduction to pediatric cervical spine radiology.

It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre---mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--- coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi---directional transcription and production of repeat associated non---ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer's disease, Huntington's disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.

The belief in my little angel has given me my greatest strength. Embrace all the mystery, wonder, and love your child has to offer. Nothing can take that away from you, not even autism. What you are about to read is a true story about my daughter and other angels in my life. They have given me the love, patience, and faith needed to survive in our new world together. This is not a cure-all book that debates or dictates which treatments or therapies are best for treating autism. However, this book meant to give others renewed strength and courage. Our story is not just about autism. It is meant to be shared by anyone who is struggling with any life challenge. More importantly, I am sending you this message... "You are not alone, you are never alone."

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book's final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Learn how to reduce the impact of environmental toxins on brain development, functioning, and health. The human brain is a marvelously complex organ that has evolved great new capabilities over the past 250,000 years. During most of that period, daily life was vastly different from our lives today. Exercise was not optional - one literally had to run for one's life, livelihood, and sustenance. The Stone Age diet was not a fad, but the only food available. Periods of fasting arose from food scarcity, and hence the earliest keto-diet was commonplace. Life changed greatly with the advent of agriculture and industry. Diseases that were previously unknown or uncommon began to surface as by-products of civilization's advance. Changes in our ways of living have altered the nature of illness as well as its diagnosis and treatment. From the 1970s to the present, tens of thousands of chemicals with applications in all aspects of our lives have grown more than 40-fold. Exposure to these new substances has impacted many aspects of our health, especially the delicate parts of the brain and nervous system. In parallel with the changes in our environment, we have seen the growth of brain disorders including Alzheimer's Disease and autism in previously unimaginable ways. Here, Arnold Eiser elucidates some features of diseases affecting the nervous system that are increasing in incidence with a focus on those disorders that appear related to environmental toxins that modern life has introduced. He takes readers behind the scenes of the science itself to discover the human stories involved in the discovery and management of these illnesses. Offering insights from a variety of scientific disciplines, Eiser clearly and succinctly illustrates the impact of toxins on our brains and how we might better protect ourselves from negative outcomes. With interviews from leading authorities in the field of neuroscience, environmental toxicology, integrative medicine, neurology, immunology, geriatrics, and microbiology (re the gut microbiome), this book offers a robust understanding of the complex threats to our brains, and the healthy brain's dependence upon many other systems within our bodies. This is a voyage of discovery into the science, history, and human struggle regarding disorders challenging the brain as well as their possible prevention.

This handbook identifies the various social deficiencies widely associated with children and youth diagnosed with autism spectrum disorder (ASD). It discusses possible causes as well as the lifelong effects if these deficiencies are not addressed. The handbook presents current behavioral and curriculum-based methods for assessing social deficits. Chapters examine the various interventions that have been used to improve social skills and behavior, including video modeling, peer-mediated interventions, and script fading. Chapters also assess various interventions using empirically based procedures, evaluate the research of each of these procedures, provide guidelines for treatment planning, and offer clinical recommendations. The handbook concludes with future directions for the development of both social behavior and clinical social skills interventions. Topics featured in the Handbook include: Impairments in social behavior that may result in negative outcomes such as depression, loneliness, and suicide in individuals with ASD. Bullying among youth with ASD. Behavioral skills training to promote social behavior of individuals with ASD. The Early Start Denver Model approach to helping young children with ASD. The implementation of social skills groups for individuals diagnosed with ASD. The Handbook of Social Skills and Autism Spectrum Disorder is a must-have resource for researchers, clinicians/professionals, and graduate students in clinical child, school, and developmental psychology, behavioral therapy, and social work, as well as such interrelated disciplines as child and adolescent psychiatry, rehabilitation medicine/therapy, pediatrics, and special education/educational psychology.

Headache medicine research is a rapidly expanding discipline and many important advances in headache management have developed over the last 20 years. However, the revolution and evolution in headache medicine has remained limited largely to the developed countries. Indeed, there is an enormous need for further quality and capacity of headache care in most parts of the world. Thankfully, efforts to bridge this gap have begun. To date, training of practitioners in headache medicine is improving in the developing countries, country-specific epidemiological research is increasing, and new therapies are trickling slowly to the developing world.
Part of the Frontiers in Headache Research series, this book brings the theme of a global campaign to the forefront. Researchers, scientists, and respected clinicians from around the world discuss aspects of access to care, individual and societal burden, and public health authorities address the problems of headache medicine as public health issues to hundreds of millions of headache sufferers worldwide.

Although the history of epilepsy, one of the most common serious neurological disorders, can easily be traced back to ancient times, the modern understanding of the disease only began in the middle of the 19th century. This history of the first fifty years of modern epileptology reflects the thinking, accomplishments, and failures of physicians between 1865 and 1914. This epoch presented a very bleak clinical picture: diagnosis was difficult and often arbitrary; treatment was poor and, at times, worse than the disease; and patients, who were usually viewed as having a progressive dementing condition, were shunned by society.

Tradition, physicians' immaculate perceptions, their thinking in analogies, and the difficulty a doctor has in separating himself from his society are some of the important factors which led to a lack of clinical advancement during this time. Nevertheless, taking a longer view, a foundation was being established for understanding the physiology of the brain and how that might be related to epilepsy. This book should be of interest to any professional person concerned with or involved in exploring the neurophysiology of brain functions and its deviations, the care and treatment of patience with epilepsy, and the historical and social aspects of medicine.

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

The purpose of this book is to contribute to basic and clinical medical research on cochlear implants for inner ear malformation and cochlear nerve deficiency. Cochlear implantation for children is performed worldwide, and the outcomes concerning speech and hearing acquisition are epoch-making. However, there are some difficulties associated with applying this operative treatment to patients who have complicated inner ear malformations or cochlear nerve deficiencies that have slowed the development of their speech, hearing, and/or sense of balance. The first part of the book outlines the fundamental aspects of inner ear maldevelopment to facilitate readers' understanding of cochlear implantation from the point of view of embryology, morphology, and genetics. In turn, the second part describes current clinical cases and presents successful clinical reports. The book offers a primary resource for otolaryngologists, neurologists, and pediatricians with an interest in this field.