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This book systematically reviews sensory and motor nerve conduction studies on the ulnar nerve, from pilot human studies of peripheral nerve conduction in the 1950s through to the most recent scientific evidence. Precise descriptions are provided of approx. 70 nerve conduction techniques that were reproduced in the laboratory, with organization of the techniques according to practical criteria for ease of reference. Particular attention is devoted to those techniques that have shown higher sensitivity and specificity in diagnosis of compressive mononeuropathies, such as ulnar neuropathy at the elbow or wrist. Normal and pathological values derived from the original articles and the subsequent literature are presented, and the wealth of illustrative material facilitates comprehension and reproduction of each technique. The volume is completed by a detailed, well-illustrated glossary explaining the more commonly used terms in electrodiagnostic medicine. This book will appeal to novice and experienced neurologists, students, clinical neurophysiology technicians, and rehabilitation physicians. It represents a logical extension of the volumes on the median nerve recently published by Springer.
This engaging book covers a multitude of topics related to heart rhythm disorders (HRDs) and uniquely familiarizes readers with the development of treatment modalities over the past several decades, including the evolution of anti-arrhythmic drugs, pacemakers, defibrillators, and catheter ablation. Organized in ten sections, this title serves as both an archival and a contemporary resource for clinicians. The first section describes the discovery of the circulatory system by William Harvey in 1628 and outlines the development and understanding of HRD since the advent of intra-cardiac electrophysiology. Subsequent sections discuss the historical evolution of abnormal heart rhythms, such as supra and ventricular rhythms and sudden cardiac death, their treatment with drugs, surgery, pacemakers, implantable defibrillators and catheter ablation. Section nine offers a fascinating narration of the clinical evolution of overcoming heart attacks and its impact on HRDs. The final section explores potential new frontiers in HRD and the factors that may contribute to the prospective rise of cardiovascular diseases. A ground-breaking and invaluable addition to the clinical literature, Heart Rhythm Disorders: History, Mechanisms and Management Perspectives details the pervasive nature of cardiovascular diseases in human history, their ramifications, and their projected effects on at-risk demographic populations and human health in general.
As the number of children diagnosed with autism spectrum disorders grows each year, new discoveries and controversies arise. Andrew Wakefield explores many of these in his thorough investigation of the recent trial case of the "Arizona 5," which destroyed an Arizona family. Two parents, with five children on the spectrum, were accused of Munchausen syndrome by proxy a rare form of child abuse and were ganged up on by physicians, child protective services, and the courts, who alleged that the parents fabricated medical symptoms in all five children. However, Wakefield now presents ample evidence that was disregarded and that would have proven the parents' innocence. Families affected by autism suffer great hardship and prejudice, particularly as they navigate the uncertain waters of diagnosis, treatment, and education. The shocking story of the Arizona 5 family delves into the tremendous challenges some parents have to face, especially if their views on how to treat the syndrome don't align with the medical world's standards. Wakefield also includes numerous studies and research trials that support the controversial yet significant roles that vaccines and diet play in autism, factors many medical professionals wrongfully dismiss.
This book covers all aspects of the diagnosis and treatment of tumors of the jugular foramen - cranial base lesions that present particular diagnostic and management difficulties and remain challenging to remove despite advances in surgery and interventional neuroradiology. The authors have developed novel concepts and surgical techniques relating to management of the facial nerve, reconstruction of the cranial base, and resection of large tumors with intra- and extracranial extension. These techniques, as well as anatomic studies in cadavers, are presented by means of surgical photographs, illustrations, and videos. Tumors of the Jugular Foramen will be of interest to all specialists involved in the management of these challenging tumors, including neurosurgeons, ENT surgeons, neuroradiologists, neurologists, neurointensivists, radiotherapists, oncologists, and physiotherapists.
This book presents fifty clinical cases in neuro-ophthalmology, some of which are common and some of which are rare. Each case is presented as a diagnostic and management challenge as found in clinical practice. High quality clinical photographs and images bring the cases to life alongside the diagnostic process and management decisions of an experienced specialist. A short summary of important aspects of the pathogenesis and treatment of each disease finishes each case. Neuro-Ophthalmology: Illustrated Case Studies entertains and instructs the reader and is ideal reading for doctors in training in this area, as well as general consultant neurologists and ophthalmologists.
Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration. Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
This book provides clear guidance as to which neuroradiological findings in ill or injured patients should be immediately communicated by radiologists and trainees to the emergency room and referring physicians in order to facilitate key decisions and eliminate preventable errors. It offers a practical and illustrative approach that identifies what to look for and how to report it and describes the required follow-up and the most common differential diagnoses of the main critical findings in neuroradiology. The book is distinctive in being written from a "critical findings perspective", which makes its content more practical and memorable than that of a standard Emergency Neuroradiology textbook. It also illustrates the value of developing algorithmic approaches to report and communicate critical findings based on lists. While the book will appeal to a broad and variable audience, it is especially addressed to radiology training programs and will be a "must read" for residents and fellows in training.
This concise, thoroughly updated text provides a comprehensive, state-of-the art review of neurology and will serve as a highly practical resource for neurology residents and medical students. Emphasizing a practical approach to common neurologic disorders, the author blends chapters that cover the evaluation of specific complaints (confusion, dizziness and vertigo, visual loss, headache and facial pain) with others that focus on particular disorders (Parkinsonism, multiple sclerosis, dementia). Noting the core practice of neurology is largely unchanged from years ago and still largely done at the bedside, the author emphasizes the importance of acquiring expertise in the time-tested, classical techniques of history taking, directed examination, and localization. Toward that, the author encourages a focus on the key clinical pathways for diagnosis and management. A wide range of clinical pearls are provided and the diagrams and illustrations are well-designed and comprehensible, as are the clinical images (EEGs, CT, MRI) which provide excellent examples of a variety of neurologic disorders. The discussions and algorithms offered are evidence-based and state-of-the-art. Importantly, the author discusses a range of new, powerful treatments available for various disorders, including stroke, epilepsy, and multiple sclerosis. Concise and well-written, Neurology: A Clinician's Approach, 2nd Edition is an invaluable resource that will again serve as a very useful, gold-standard resource for trainees.
This innovative book examines what can be learnt about the brain mechanisms underlying religious belief and practice from studying people with neurological disorders, such as stroke, epilepsy and Parkinson's disease. Using a clinical case study approach, the book analyses the interaction of social influences, religious upbringing and neurological disorders on lived religious experience in a number of different religions. The interdisciplinary contributors to the book ensure a variety of perspectives to help understand how the religious life is affected when different cognitive functions are impaired; how faith modifies the effects of neurological disorders; and how awareness of faith practices may assist in the treatment of these conditions.
This book deals with neuroimaging of the brain, head, neck, and spine. During the last few years, there have been considerable advances in this subject, driven by clinical as well as technological developments. The authors, internationally renowned experts in their field, have contributed chapters that are disease-oriented and cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As a result, this book offers a comprehensive review of the state of the art in neuroimaging. It is particularly relevant for general radiologists, radiology residents, neurologists, neurosurgeons, and other clinicians wishing to update their knowledge in this discipline.
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact.
Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS.
A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding
Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.
In this book, the four leading experts on the ACE inhibitors donepezil, galantamine, and rivastigmine and the NMDA receptor antagonist memantine explain the practical pharmacology of these symptomatic drugs with the aim of providing a sound basis for their clinical use in patients with Alzheimer's disease. In addition, an introductory chapter considers the basic theory of pharmacology for Alzheimer's disease and the book closes with an overview of the ways in which symptomatic drugs for dementia are used. The wide acceptance of the amyloid cascade hypothesis has led to vigorous development of disease-modifying drugs for Alzheimer's disease, such as amyloid vaccinations and gamma- or beta-secretase inhibitors. The failure of clinical trials of these drugs to yield satisfactory results has, however, meant that for the time being patients continue to be treated only with symptomatic drugs. There is accordingly a need to become more proficient in the use of symptomatic medicines, and it is against the background of this quest that Practical Pharmacology for Alzheimer's Disease will be of wide interest.
Epilepsy is a common chronic neurological disorder characterised by recurrent unprovoked seizures, and affects 50 million people worldwide. Approximately 30% of these do not have seizure control even with the best available medications, hence renewed and increasing interest in the use of dietary treatments to treat epilepsy. These treatments include the traditional ketogenic diets but also the newer modified Atkins diet and low glycaemic index treatment.
The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat refractory epilepsy in children, and requires the dedicated support of a multi-disciplinary team including doctors and dietitians. "Dietary Treatment of Epilepsy: Practical Implementation of Ketogenic Therapy" provides comprehensive and practical training on all aspects of implementing and managing dietary treatments for epilepsy, with key chapters on assessment, calculations, implementation, monitoring and complications.
Edited by a highly respected expert in the field supported by a strong team of contributors, this is a must-have resource for paediatric dietitians and other members of the therapy team.
A wonderfully bittersweet, funnystrange account of living unwittingly with Asperger's syndrome. It is only after a crack-up, at the age of 55, that Tom Cutler gets the diagnosis that allows him to make sense of everything that's come before, including his weird obsessions with road-sign design, magic tricks, spinning tops, and Sherlock Holmes. The final realization that he has Asperger's allows a light to dawn on the riddles of his life: his accidental rudeness, maladroitness, Pan Am smile, and other social impediments. But, like many with Asperger's, Tom possesses great facility with words, and this shines through this exceptionally warm, bright, and moving memoir, which is alternately strikingly revealing, laugh-out-loud funny, and achingly sad. Tom explores his eccentric behavior from boyhood to manhood, examines the role of autism in his strange family, and investigates the scientific explanations for the condition. He recounts his anxiety and bewilderment in social situations, his sensory overload, his strange way of dressing, and his particular trouble with girls. He shares his autistic adventures in offices, toyshops, backstage in theaters, and in book and magazine publishing houses, as well as on--or more often off--roads.
In this book, recognized anesthesiology experts present the latest findings on anesthesia for electro-convulsive therapy (ECT). With the development of modified electroconvulsive therapy (m-ECT) and devices to provide brief-pulse stimulation, ECT is currently being re-evaluated as an important procedure in psychiatric disorder therapy and is increasingly being used worldwide to treat several psychiatric conditions. This trend is due to the social phenomenon of the growing number of patients for whom ECT is applicable. Since the new approach is more safe and effective than the original method without anesthesia, m-ECT is currently applied under general anesthesia in most advanced countries. This book provides an overview and practice of total anesthesia management in the perioperative period of ECT. It offers an indispensable resource not only for professional anesthesiologists but also healthcare professionals who use this therapy.
Shakespeare and Cognition examines the essential relationship between vision, knowledge, and memory in Renaissance models of cognition as seen in Shakespeare's plays. Drawing on both Aristotle's Metaphysics and contemporary cognitive literary theory, Arthur F. Kinney explores five key objects/images in Shakespeare's plays a " crowns, bells, rings, graves and ghosts a " that are not actually seen (or, in the case of the latter, not meant to be seen), but are central to the imagination of both the playwright and the playgoers.
This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.
This comprehensive title covers all of the broad aspects of stiff-person spectrum disorders (SPSD), ranging from clinical features and laboratory investigations to the basic scientific roles of neuroimmunology and genetics that aid clinicians in understanding the pathogenesis of this disorder. Organized across 15 chapters, this highly practical book begins with a thorough account of the history and clinical phenomenology of SPSD. Subsequent chapters then delve into the differential diagnoses of the disorder, as well as its electrophysiology, immunopathogenesis, and neurochemistry. Following this is an analysis of each subtype of SPSD including classic stiff-person syndrome and its variants, correlations between clinical phenotypes and antibodies, as well as SPSD in the pediatric population. Finally, the book concludes with an examination of the various SPSD diagnostic approaches, treatments, and potential emergencies seen in clinical practice. Developed by a renowned multidisciplinary authorship, Stiff-Person Syndrome and Related Disorders is an indispensable contribution to the clinical literature and will be of great interest to both clinicians and basic science researchers.
To foster a better understanding of dopamine receptor functionality, this detailed volume creates an interface between updated classical methods and new emerging technologies heretofore not available to new or seasoned researchers. Divided in five sections dedicated to experimental approaches investigating different facets of dopaminergic signal transduction, Dopamine Receptor Technologies covers epigenetic and post-transcriptional analysis, computational and biochemical techniques, visualization and imaging methods, molecular and cell biological tools, as well as behavioral assessment. The book, as a part of the popular Neuromethods series, provides insightful step-by-step protocols and methodological reviews that readers will find useful. Practical and versatile, Dopamine Receptor Technologies seeks to aid researchers in developing new pharmacological tools to improve our knowledge of in vivo roles played by each receptor subtype and the synthesis of prospective lead compounds for drug discovery.
Slavoj Zizek is perhaps the most important, original and enigmatic
philosophers writing today. Many readers both inside and outside of
the academy have been intrigued by both the man and his writing
yet, given the density of his prose and the radical views he often
espouses, they have struggled to get a handle on his basic
positions. He draws upon and makes continual reference to the
challenging concepts of Kant, Hegel, Marx, Lacan, and Badiou. His
prose is dense and frenetic and his dialectical twists and turns
seem to make it impossible to attribute to him any specific
position: he celebrates St. Paul and orthodox Christians even as he
engages in a spirited defense of Lenin.
This overview of autonomic pharmacology describes the anatomy, physiology and pharmacology of the autonomic (involuntary) nervous system. Covering the diverse group of drugs acting on the autonomous nervous system, their actions are reviewed together with their clinical uses, side effects, interactions and subcellular mechanisms of action. Information is organized in a logical flow, bringing together the latest advances in an integrated form on topics usually found only in a fragmented form. This work is intended for all those researching in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry and molecular biology.
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