This vivid memoir presents adventures from the life of Barbara A. Wilson, an internationally honoured scientist who played an influential role in the development of neuropsychological rehabilitation at a time when the scientific field was dominated by men. As a follow-up to the highly successful Story of a Clinical Neuropsychologist, this book includes a host of memories, both personal and professional, which focus on Barbara's development of her career as a woman in science. From childhood recollections and travels in Africa, to lifetime achievement awards and the restrictions of global pandemics, Barbara tells the story of her full and varied life and her unparalleled career in neuropsychological rehabilitation. Her book indicates that one can lead a meaningful and full life even after one of the most awful of losses, the death of a child, and also emphasizes the need to stick to one's principles in trying times. The result is an unparalleled insight into the life of a clinical neuropsychologist, which can encourage the next generation of professionals who are trying to balance career, international travel and family, as well as inspire any girls interested in entering the world of science.

Serotonin and Melatonin: Their Functional Role in Plants, Food, Phytomedicine, and Human Health highlights the significance of the plant sources of serotonin and melatonin in the fields of medicine, agriculture, and food science. Over the last few decades, an enormous amount of research data has been generated on these two neurotransmitters/plant signalers. This book covers topics regarding the occurrence of serotonin and melatonin in medicinal plants and food value plants with their implications for human health, the role of serotonin and melatonin in plant growth development, functions of melatonin and serotonin in the environmental adaptation of plants, and the implications of these molecules in human disorders and treatments. This volume should appeal to scientists and other professionals engaged in basic and applied research on the relevance of serotonin and melatonin to plants, animals, and humans. Features Reviews the global scientific literature and the experimental data of the authors on the occurrence of serotonin and melatonin in medicinal and food value plants and its implications for human health Explains in detail the role of serotonin and melatonin in plant growth development Helps in understanding the complex functions of melatonin and serotonin in the environmental adaptation in plants Discusses the importance of the development of transgenic plants with high amounts of serotonin and melatonin. Describes the current understanding of serotonin and melatonin in human disorders, and also their relevance in the treatment of specific health conditions. Written by acknowledged experts from across the world

A fun and fact-filled A-Z treasury for anyone with a head on their shoulders Neuropedia journeys into the mysteries and marvels of the three pounds of tissue between your ears-the brain. Eric Chudler takes you on a breathtaking tour of the nervous system with dozens of entries that explore the structure and function of the brain and cover topics such as the spinal cord and nerve cells, the methods of neuroscientific research, and the visionary scientists who have dedicated their lives to understanding what makes each of us who we are. The brain has fascinated and puzzled researchers, physicians, and philosophers for thousands of years and captivated us with each new discovery. This compendium of neuroscientific wonders is brimming with facts and insights, helping us to make sense of our current understanding of the nervous system while identifying the frontiers in our knowledge that remain unexplored. Chudler guides readers through a variety of rare and common neurological disorders such as alien hand disorder, Capgras syndrome, Alzheimer's disease, Parkinson's disease, and stroke, and discusses the latest brain-imaging methods used to diagnose them. He discusses neurochemicals, neurotoxins, and lifesaving drugs, and offers bold perspectives on human consciousness that enable us to better appreciate our place in nature. With marvelous illustrations by Kelly Chudler, Neuropedia is an informative and entertaining trip into the inner world of the brain.

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classification System and Risk Factor Cluster ID method will help to address gaps in our knowledge about the causes and possible prevention of this tragic complication. Exploring the interactions among the central and peripheral autonomic nervous systems and the cardiopulmonary systems, the book includes case studies of SUDEP, definite or probable, as well as near miss cases. It discusses how neurologists, emergency room physicians, and attending physicians can identify individuals at possible risk for SUDEP and lessen the chance of occurrence. Top medical professionals in the field detail the development of an international database of human cases and animal models of SUDEP and suggest how medical examiner and coroner offices can strengthen the database by providing information about incidences of SUDEP. In addition, the book describes related clinical and animal studies needed to classify risk factors for SUDEP victims. Understanding the risk factors and mechanisms underlying SUDEP will facilitate collaborative research in the laboratory, hospital, and clinic and lead to improved effectiveness of SUDEP prevention strategies.

This title includes a number of Open Access chapters. The rate of identification of children with neurobiological disabilities has been on the increase in recent years. Millions of dollars in research are being spent to understand the factors influencing these increases. The articles within this compendium shed vital light on this issue, confirming that various "ordinary" chemical hazards-of the sort encountered by countless children in their everyday lives-are having serious impacts on development. This volume investigates the impact of exposure to tobacco smoke, household chemicals, lead, agricultural toxins, and flame retardants.

There were an estimated 50 million people worldwide living with dementia in 2017 and this number will almost double every 20 years, reaching 82 million in 2030. Design has significant potential to contribute to managing this global concern. This book is the first to synthesise the considerable research and projects in dementia and design. Design interactions is a new way of considering how we can improve the relationship between people, products, places and services and of course technology trends, such as the 'internet of things', offer great opportunities in providing new ways to connect people with services and products that can contribute to healthier lifestyles and mechanisms to support people with acute and chronic conditions. In light of this, the book explores the contribution and future potential of design for dementia through the lens of design interactions, such as people, contexts, material and things. Design for People Living with Dementia is a guide to this innovative and cutting-edge field in healthcare. This book is essential reading for healthcare managers working to provide products, services and care to people with dementia, as well as design researchers and students. .

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico-in vitro-in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

This book will support researchers in the field of education disability by outlining inclusive research approaches and their challenges, outcomes, and impact. Each chapter reports on school/university-based research supporting inclusion for young people on the autism spectrum. This research has been developed in Australian schools with students, families, teachers, and specialists. The intent of this approach is to mobilise new knowledge to the benefit of all students, including students on the autism spectrum, their families, teachers, and school communities. This book showcases how research can be more inclusive with a move to collaborative, participatory, and co-produced research that will impact on young people, families, and educators. The authors highlight the complex challenges and the positive outcomes of conducting research in inclusive ways and provide detailed practical strategies for researchers. Inclusive education is socially, emotionally, and academically beneficial for all students and positively impacts on respectful attitudes to difference. This book provides a groundbreaking approach to research that by design is inclusive and therefore provides an invaluable opportunity for building the foundations of an inclusive society for all. This book will be invaluable to researchers, educators, and professional learning in schools.

The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Psychotherapists who have been trained in models of psychodynamic, psychoanalytic, or cognitive therapeutic approaches are skilled at listening to the language and affect of the client. They track the clients' associations, fantasies, and signs of psychic conflict, distress, and defenses. Yet while the majority of therapists are trained to notice the appearance and even the movements of the client's body, thoughtful engagement with the client's embodied experience has remained peripheral to traditional therapeutic interventions. Trauma and the Body is a detailed review of research in neuroscience, trauma, dissociation, and attachment theory that points to the need for an integrative mind-body approach to trauma. The premise of this book is that, by adding body-oriented interventions to their repertoire, traditionally trained therapists can increase the depth and efficacy of their clinical work. Sensorimotor psychotherapy is an approach that builds on traditional psychotherapeutic understanding but includes the body as central in the therapeutic field of awareness, using observational skills, theories, and interventions not usually practiced in psychodynamic psychotherapy. By synthesizing bottom-up and top down interventions, the authors combine the best of both worlds to help chronically traumatized clients find resolution and meaning in their lives and develop a new, somatically integrated sense of self. Topics addressed include: Cognitive, emotional, and sensorimotor dimensions of information processing * modulating arousal * dyadic regulation and the body * the orienting response * defensive subsystems * adaptation and action systems * treatment principles * skills for working with the body in present time * developing somatic resources for stabilization * processing

Autism: The Movement Sensing Perspective is the result of a collaborative effort by parents, therapists, clinicians, and researchers from all disciplines in science including physics, engineering, and applied mathematics. This book poses questions regarding the current conceptualization and approach to the study of autism, providing an alternative unifying data-driven framework grounded in physiological factors. This book reaches beyond subjective descriptions of autistic phenomena and embraces a new era of objective measurements, analyses, and statistical inferences. The authors harness activities from the nervous systems across the brain and body (often in tandem), and introduce a platform for the comprehensive personalized phenotyping of individuals with autism. The impact of this approach is discussed to advance the development of tailored treatments options, enhance the ability to longitudinally track symptomatology, and to fundamentally empower affected individuals and their families. This book encompasses a new era for autism research and treatments, and our continuous effort to collectively empower and embrace the autistic community.

This third edition of a trusted resource brings together the latest literature across multiple fields to facilitate the understanding and prevention of falls in older adults. Thoroughly revised by a multidisciplinary team of authors, it features a new three-part structure covering epidemiology and risk factors for falls, strategies for prevention and implications for practice. The book reviews and incorporates new research in an additional thirteen chapters covering the biomechanics of balance and falling, fall risk screening and assessment with new technologies, volitional and reactive step training, cognitive-motor interventions, fall injury prevention, promoting uptake and adherence to fall prevention programs and translating fall prevention research into practice. This edition is an invaluable update for clinicians, physiotherapists, occupational therapists, nurses, researchers, and all those working in community, hospital and residential or rehabilitation aged care settings.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

It is important to understand the relationship between the brain, cognition and behavior when providing care to the elderly. Behavioral Neurology in the Elderly provides a comprehensive overview of this significant relationship, one of the most important topics concerning medical and behavioral gerontology today. It provides insight into how the aging brain affects memory and language, as well as motor, emotional, and executive functioning. Beginning with a historical view of aging and healthy living, this practical and informative book describes the most important neurobehavioral issues such as information processing, motor function, language and communication. It also provides essential information on neurobehavioral disorders such as depression, sleep disorders, epilepsy, apraxia, dementia and stroke. Furthermore, it offers an ultimate guide to medical and neuropsychological geriatric assessment and evaluation. A resource for all professionals working with elderly people, Behavioral Neurology in the Elderly points out new directions in research methods for assessment, diagnosis, and treatment.

1. Cutting-edge synthesis of key areas in substance use and misuse, which sets it apart from competing biopsychology textbooks 2. Each chapter is written by leading experts on the topic in question, recruited from research teams around the world (including UK, US, Europe, New Zealand, Canada, Asia), who have a detailed knowledge of the relevant literature. 3. Important methodological and ethical issues are explored, with reference to various cultural contexts.

Non-motor Parkinson's Disease is a burgeoning area of the movement disorders field, as patients increasingly live longer and encounter more late-stage symptoms. The spectrum of non-motor manifestations spans much of the body, with non-motor features occurring in all stages of the disease. Identification of symptoms is key for preserving quality of life and successful treatment. This is a practical manual on all aspects of pre-motor and non-motor manifestations of Parkinson's. The genetic causes of non-motor symptoms are detailed and methods of patient evaluation summarized. Topics such as autonomic and sexual dysfunction, mood disorders, and drug-induced symptoms of non-motor Parkinson's are covered in depth. This is an essential resource for movement disorder specialists, neurologists and other clinicians involved in caring for those with Parkinson's disease.

This guide is structured to assist physicians in the management of those hypertensive patients who present with specific comorbidities, such as diabetes, systolic dysfunction, obesity, renal disease, or previous cardiac events, often associated with hypertension. The clinical cases contained in this book have been selected to provide a paradigmatic set of scenarios frequently encountered in daily clinical practice, and will serve as an easy-to-access tool in applying general guidelines to individual patients, particularly in the choice of the most appropriate antihypertensive therapy. Treatment of hypertension with associated clinical conditions require specific therapies and combinations of drugs, which are necessarily different from one comorbidity to another. By discussing exemplary cases that may better represent clinical practice in a "real world" setting, and analyzing step by step the diagnostic and therapeutic process, this book will assist cardiologists and physicians in selecting the diagnostic tools and forms of treatment best suited to the individual patient and the particular cardiovascular risk profile.

'A beautiful memoir in which Oliver Sacks comes wonderfully to life ... Exquisitely wrought, heartrending and joyous' Joyce Carol Oates

Bill Hayes came to New York in 2009 with a one-way ticket and only the vaguest idea of how he would get by. But, at forty-eight years old, having spent decades in San Francisco, he craved change. Grieving over the death of his partner, he quickly discovered the profound consolations of the city's incessant rhythms, the sight of the Empire State Building against the night sky, and New Yorkers themselves, kindred souls that Hayes, a lifelong insomniac, encountered on late-night strolls with his camera.

And he unexpectedly fell in love again, with his friend and neighbor, the writer and neurologist Oliver Sacks, whose exuberance is captured in funny and touching vignettes throughout. What emerges is a portrait of Sacks at his most personal and endearing, from falling in love for the first time at age seventy-five to facing illness and death (Sacks died of cancer in August 2015). Insomniac City is both a meditation on grief and a celebration of life. Filled with Hayes's distinctive street photos of everyday New Yorkers, the book is a love song to the city and to all who have felt the particular magic and solace it offers.

There's no such thing as a perfect family. A perfect life. A perfect man. Frank is proof of this. He's everyman and yet as unique as a fingerprint. With a wonderful wife and children who are the loves of his lives, he couldn't ask for anything more. But time and time again he keeps risking it all. In snapshots through time, 'Only About Love' takes a sweeping loop around Frank's life as he navigates courtship, marriage, fatherhood and illness. Told through the perspective of Frank and his family, this story is one of intense honesty about the things we do to those closest to us.

Your hands-on guide to dealing with dementia within the UK healthcare system If a loved one has recently been diagnosed with dementia, Dementia For Dummies, UK Edition provides trusted, no-nonsense guidance on what this may mean for you and your family. You'll get an understanding of the symptoms of dementia, make sense of the stages of the illness and grasp the differences between the various types of dementia, including Alzheimer's disease and vascular dementia. Dementia is an increasingly common condition that can have a significant impact on family life. Each person diagnosed is unique, and your loved one's symptoms can range from loss of memory to mood changes to communication problems and beyond. This sensitive, authoritative guide walks you through the different scenarios you may encounter as a family member or carer and explains step-by-step how you can keep your loved one as safe and as comfortable as possible--no matter how severe their symptoms are. Gives you the straight facts on dementia Covers the symptoms, causes and risk factors of dementia Helps identify and address the fears as you face a diagnosis Provides carers and family members with the information needed to help manage the illness If you're looking for support as you adjust to caring for a loved one with dementia, Dementia For Dummies helps make it easier.

This innovative book places the sensory experiences of autistic individuals within a sociological framework. It instigates new discussions around sensory experience, autism and how disability and ability can be reconceived. Autism is commonly understood to involve social and communication difficulties. Less commented upon is the sensory challenges faced by those with autism. Sociology is no different, focusing on communication and neglecting the sensory dimensions of experience. Sensory experiences and relations are central to how we understand and navigate through the natural and social worlds, and mediate our interactions with other people, objects and spaces. In this book, the author explores how these processes are affected by the favourite activities of autistic people. With real-life case studies and cutting-edge research, this book will be useful to students, autistic people, advocates and carers, disability studies researchers and sociologies of disability and the senses.

AutPlay (R) Therapy Play and Social Skills Groups provides practitioners with a step-by-step guide for implementing a social skills group to help children and adolescents with autism improve on their play and social skills deficits in a fun and engaging way. This unique 10-session group model incorporates the AutPlay Therapy approach focused on relational and behavioral methods. Group setup, protocol, and structured play therapy interventions are presented and explained for easy implementation by professionals. Also included are parent implemented interventions that allow parents and/or caregivers to become co-change agents in the group process and learn how to successfully implement AutPlay groups. Any practitioner or professional who works with children and adolescents with autism spectrum disorder will find this resource to be a unique and valuable guide to effectively implementing social skills groups.

This book is rather unique in its approach and coverage. The approach is essentially that of an engineering textbook, emphasizing the quantitative aspects and highlighting the fundamentals and basic concepts involved. The coverage progresses in a logical and systematic manner from the subcellular, starting with the electrophysiology of the cell membrane, then proceeding to synapses, neurons, and muscle, before considering neuronal motor ensembles and the neuromuscular system as a whole. Simple, clear, and comprehensive explanations are given throughout. After an introductory chapter on some background material in biology, biophysics, and chemical kinetics, a substantial part of the book (Chapters 2-8) necessarily covers in considerable detail the basic components and processes that underlie the electrical and associated activities of the nervous system. The remaining chapters of the book (Chapters 9-13) focus on the neuromuscular system, starting with the structure of muscle cells, the generation of force by muscular contraction, and muscle receptors. The last chapter examines aspects of the control of movement, motor learning and memory, the maintenance of posture, and locomotion, and critically examines some of the theories that have been advanced to explain how movement is controlled. The book is intended for undergraduate or graduate students in the natural sciences, mathematics, or engineering who seek a deeper understanding of the fundamentals of neuroscience and the somatomotor system, in accordance with the aforementioned objectives. The book can serve as a textbook for a one-semester course on the neuromuscular system or as a reference in a more general course on neuroscience. Provides a thorough analytical treatment of membrane electrophysiology, starting from the first principles Emphasizes strongly the basic and fundamental concepts throughout Discusses thoroughly the essential features and properties of the basic constituents of the nervous system, that is, neurons and synapses, including the neuromuscular junction Explains the main aspects of posture, locomotion, and control of movement Includes practice problems throughout the text and a solutions manual will be available for adopting professors Nassir Sabah is professor of biomedical engineering in the electrical and computer engineering department at the American University of Beirut, Lebanon. He received his B.Sc. (Hons. Class I) and his M.Sc. in electrical engineering from the University of Birmingham, U.K., and his Ph.D. in biophysical sciences from the State University of New York (SUNY/Buffalo). He has served as Chairman of the Electrical Engineering Department, Director of the Institute of Computer Studies, and Dean of the Faculty of Engineering and Architecture at the American University of Beirut. In these capacities, he was responsible for the development of programs, curricula, and courses in electrical, biomedical, communications, and computer engineering. Professor Sabah has extensive professional experience in the fields of electrical engineering, electronics, and computer systems, with more than 35 years' teaching experience in neuroengineering, biomedical engineering, electronics, and electric circuits. He has over 100 technical publications, mainly in neurophysiology, biophysics, and biomedical instrumentation. He has served on numerous committees and panels in Lebanon and the region. He is a Fellow of the Institution of Engineering and Technology (IET, U.K.), a member of the American Association for the Advancement of Science (AAAS), and a member of the American Society for Engineering Education (ASEE).