This issue of Neurologic Clinics, guest edited by Dr. Devon I. Rubin, will cover key topics in Electromyography. This issue is one of four selected each year by our series consulting editor, Dr. Randolph W. Evans. Topics discussed in this issue will include: Nerve Conduction Studies, Needle EMG, Electrodiagnostic Assessment of Uncommon Mononeuropathies, EDX Assessment of Uncommon Mononeuropathies, Electrodiagnostic Assessment of Radiculopathies, Electrodiagnostic Assessment of Plexopathies, Electrodiagnostic Assessment of Polyneuropathy, Electrodiagnostic Assessment of Myopathy, Electrodiagnostic Assessment of Neuromuscular Junction Disorders, Electrodiagnostic Assessment of Motor Neuron Diseases, Electrodiagnostic Assessment of Hyperexcitable Nerve Disorders, and EMG Case Examples. Provides in-depth, clinical reviews on the latest updates in Electromyography, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

A REVISED AND EXPANDED EDITION Winner of the Autism Society of America's Dr Temple Grandin Award Autism is a different way of being human. By understanding autistic behaviours as strategies to cope with a world that feels chaotic and overwhelming, Barry Prizant seeks to enhance abilities, to teach new skills, help individuals build on their strengths and develop coping strategies to achieve a better quality of life. Revised and updated with new material on identity and intersectionality and a chapter on autistic advocacy, Uniquely Human offers a compassionate and insightful perspective that could be life-changing. With a wealth of inspiring stories and practical advice from thousands of autistic people and their families this is a ground-breaking book by one of the world's leading experts - essential reading for anyone who cares for people on the autism spectrum. 'Common sense practical advice based on a forty-year career' Temple Grandin, author of The Autistic Brain 'Will change our perception and understanding of autism ... I strongly recommend this book to parents and professionals' Tony Attwood, author of The Complete Guide to Asperger's Syndrome

Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer's disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer's disease families, in the frame of a precision medicine approach to Alzheimer's disease. This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer's disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer's a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer's disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer's disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer's disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel

Dr. Natasha Campbell-McBride set up The Cambridge Nutrition Clinic in 1998. As a parent of a child diagnosed with learning disabilities, she is acutely aware of the difficulties facing other parents like her, and she has devoted much of her time to helping these families. She realized that nutrition played a critical role in helping children and adults to overcome their disabilities, and has pioneered the use of probiotics in this field. Her willingness to share her knowledge has resulted in her contributing to many publications, as well as presenting at numerous seminars and conferences on the subjects of learning disabilities and digestive disorders. Her book Gut and Psychology Syndrome captures her experience and knowledge, incorporating her most recent work. She believes that the link between learning disabilities, the food and drink that we take, and the condition of our digestive system is absolute, and the results of her work have supported her position on this subject. In her clinic, parents discuss all aspects of their child's condition, confident in the knowledge that they are not only talking to a professional but to a parent who has lived their experience. Her deep understanding of the challenges they face puts her advice in a class of its own.

This book focuses on the role of the endocannabinoid system in local and systemic inflammation, with individual chapters written by experts in the field of cannabinoid research and medicine. The topics explore the actions of the endocannabinoid system on the immune system, including neuroinflammation in autoimmune disorders such as multiple sclerosis, and in neurodegenerative disorders such as Huntington's and Alzheimer's, as well as local and systemic inflammatory conditions affecting organs including the eye (uveitis and corneal inflammation), the bladder (interstitial cystitis), pancreas (diabetes), cardiovascular system (stroke), joints (arthritis), and sepsis. The objective of this book is to provide knowledge transfer on the use of cannabinoids in inflammatory disease by critically examining preclinical and clinical research on the immunomodulatory actions of the endocannabinoid system, with specific emphasis on the actions of cannabinoids in diseases where inflammation is a prominent component. By drawing these results together, we seek to provide further understanding of the complexities of endocannabinoid system modulation of immune function and identify potential uses and limitations for cannabinoid-based therapeutics.

A provocative and fascinating look at new discoveries about the brain that challenge our ethics

The rapid advance of scientific knowledge has raised ethical dilemmas that humankind has never before had to address. Questions about the moment when life technically begins and ends or about the morality of genetically designing babies are now relevant and timely. Our ever-increasing knowledge of the workings of the human brain can guide us in the formation of new moral principles in the twenty-first century. In The Ethical Brain, preeminent neuroscientist Michael S. Gazzaniga presents the emerging social and ethical issues arising out of modern-day brain science and challenges the way we look at them. Courageous and thought-provoking -- a work of enormous intelligence, insight, and importance -- this book explores the hitherto uncharted landscape where science and society intersect.

This issue of Neurologic Clinics, guest edited by Drs. Gary D. Clark and James J. Riviello, will cover key topics in Pediatric Neurology. This issue is one of four selected each year by our series consulting editor, Dr. Randolph W. Evans. Topics discussed in this issue will include: The State of Child Neurology; The Financial Power of Neurology in a Major Children's Hospital; Neurology in a Pandemic; Education: Training the Next Generation of Child Neurologists and Neurodevelopmental Disability Doctors, Student Education and Recruitment; Genetic Testing and Counseling in Child Neurology; Novel Treatments and Clinical Research in Child Neurology; Epilepsy: Novel Surgical Techniques and Monitoring; Epilepsy: Genetics; Epilepsy: Treatment of Epileptic Syndromes; Neuromodulation for Pediatric Epilepsy; Inflammatory Diseases of the Nervous System; Neurooncology; Neurocritical Care and Brain Monitoring; The Brain and Heart Disease in Children; Neurology of Sleep; and Evidence Based Protocols.

Traumatic Brain Injury (TBI) can occur through road traffic incidents, falls, or violence, and is therefore an extremely prevalent type of injury, constituting a significant burden on health care around the world. As more people are able to recover physically from TBI, it is important to consider how to help repair the cognitive functions of the brain. The cognitive functions could be greatly maximized by appropriate Neuropsychological rehabilitation, which occurs within months of the damage. This book discusses both the theoretical and practical applications of Neuropsychological rehabilitation techniques, offering a comprehensive overview of the process. Using several case studies from India, gained over years of clinical practice, research and academic teaching, this book offers an excellent guide to the procedures and tasks needed to respond effectively to patients with TBI. Although focused on the Indian context, this book will appeal to students and practitioners around the world as a useful resource on Neuropsychological rehabilitation techniques in India.

As humans interact more often and more intimately with computers, and as computational systems become an ever more important element of our society, playing roles in education, the production of culture and goods, and management, it is inevitable that we should seek to interact with these systems in ways that take advantage of our powerful emotional capabilities. Creating Synthetic Emotions through Technological and Robotic Advancements compiles progressive research in the emerging and groundbreaking fields of artificial emotions, affective computing, and sociable robotics that allow humans to begin the once impossible-seeming task of interacting with robots, systems, devices, and agents. This landmark volume brings together expert international researchers to expound upon these topics as synthetic emotions move toward becoming a daily reality.

Regular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting "physical health," but also for the central nervous system believed to promote "brain health." Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a "multimodal imaging" perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.

A prominent geriatric psychiatrist details the good, the bad, and the ugly aspects of places where those with dementia are treated-from emergency rooms and psychiatric hospitals to assisted living facilities and nursing homes. The Harsh Realities of Alzheimer's Care: An Insider's View of How People with Dementia Are Treated in Institutions is the first book of its kind. Written by an eminent geriatric psychiatrist who has worked with dementia patients in more than 70 facilities, the book distills all he has learned about dementia care, for better and, more often, for worse. Both a shocking expose and a practical guide, the book takes readers into nursing homes, assisted living facilities, and hospitals. It reveals the inadequacies and dangers of these institutions, detailing issues that result in poor care including federal standards for minimum staff training that are, in some cases, lower than those established for dog groomers. The author cites improvements that must be made in emergency rooms and inpatient psychiatric facilities treating victims of dementia, and he documents the downside of memory clinics. But there are steps caregivers can take to protect their loved ones-and themselves. Each chapter concludes with "reality lessons" that offer practical, affordable strategies for coping with dementia's many challenges. Vignettes and experiences from author's practice illustrate strategies that will improve quality of life for caregivers and their loved ones

This issue of Clinics in Geriatric Medicine, guested edited by Peter Jin, focuses on Peripheral Nerve Disease in the Geriatric Population. Topics include, but are not limited to: A clinical approach to diseases of peripheral nerve, Electrodiagnostic testing for disorders of peripheral nerves, The role of imaging for disorders of peripheral nerve, Common compression mononeuropathies, Diabetes and Peripheral Nerve Disease, When is it not just diabetic polyneuropathy? Findings in atypical polyneuropathies, Small Fiber Neuropathy in the Elderly, Cancer and peripheral nerve disease, Paraproteinemias and Peripheral Nerve Disease, Guillain-Barre Syndrome and other acute polyneuropathies, Chronic Immune-mediated Polyneuropathies, Immunotherapy for Peripheral Nerve Disorders, Management of Neuropathic Pain in the Geriatric Population, and more.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.
Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist