Patients with Parkinson's disease commonly struggle with sleep disorders that which negatively affect their quality of life. Sleep Considerations in the Management of Parkinson's Disease provides a comprehensive overview of common sleep issues and related topics in in this complex field. Each chapter begins with a case that describes a typical scenario related to a sleep problem in Parkinson's disease, followed by a discussion of both the sleep problem and the specifics of the case, providing practical, real-world information to help you provide better patient care. Includes concise chapters authored by Dr. Lana Chahine, each carefully reviewed and supplemented by expert contributors in the specific field. Addresses a wide variety of topics including sleep-onset insomnia, nocturnal manifestations of anxiety disorders, REM sleep behavior disorder, restless legs syndrome and periodic limb movements, and excessive daytime sleepiness. Consolidates today's available information and experience in this important area into one convenient resource.

Clinical Neurophysiology: Basis and Technical Aspects, the latest release in the Handbook of Clinical Neurology series, is organized into sections on basic physiological concepts, on the function and limitations of modern instrumentation, and on other fundamental or methodologic aspects related to the recording of various bioelectric signals from the nervous system for clinical or investigative purposes. There is discussion of the EEG, nerve conduction studies, needle electromyography, intra-operative clinical neurophysiology, sleep physiology and studies, the autonomic nervous system, various sensory evoked potentials, and cognitive neurophysiology.

Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation's science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders.

This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

In this edited volume, experts on the treatment of dementia associated with Parkinson's Disease (PD) describe in detail the current status of knowledge in their respective area of expertise. The importance and clinical relevance of cognitive impairment and dementia in PD is emphasized, all relevant aspects including epidemiology, full and detailed spectrum of clinical features, current knowledge on pathology, neurochemistry and genetics, findings in auxillary investigations, relation to other neurodegenerative disorders, diagnostic process and management are described, rounded-up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and is heavily referenced thereby capturing all relevant literature.

This issue of Neurologic Clinics, guest edited by Dr. Phyllis C. Zee, with consulting editor Randolph W. Evans, will focus on Circadian Rhythm Disorders. Topics include, but are not limited to, Circadian biology, Genetic basis of circadian rhythms, Implication of circadian rhythm misalignment on sleep and health, Assessment of circadian rhythms, Circadian Rhythm sleep-wake phase disorders, Irregular sleep-wake rhythm sleep -wake disorder, Non-24 hour sleep-wake rhythm disorder, Shift Work Sleep Disorder, Challenging cases, and Future of circadian and sleep medicine.

As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases. This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

This comprehensive update offers practical advice for professionals working in neuropsychology with older adults. Focusing on fundamentals, common issues, special considerations, and late-life cognitive disorders, respected names in this critical specialty address a wide range of presenting problems and assessment, diagnostic, and treatment concerns. Th roughout, coverage pays keen attention to detail, bringing real-world nuance to large-scale concepts and breaking down complex processes into digestible steps. And like its predecessor, the new Handbook features recommendations for test batteries and ends each chapter by extracting its "clinical pearls." A sampling of the topics covered: * Assessment of depression and anxiety in older adults. * The assessment of change: serial assessments in dementia evaluations. * Elder abuse identifi cation in older adults. * Clinical assessment of postoperative cognitive decline. * Cognitive training and rehabilitation in aging and dementia. * Diff erentiating mild cognitive impairment and cognitive changes of normal aging. * Evaluating cognition in patients with chronic obstructive pulmonary disease. This Second Edition of the Handbook on the Neuropsychology of Aging and Dementia offers a wealth of expert knowledge and hands-on guidance for neuropsychologists, gerontologists, social workers, and other clinicians interested in aging. Th is can be a valuable reference for those studying for board certifi cation in neuropsychology as well as a resource for veteran practitioners brushing up on key concepts in neuropsychology of age related disorders.

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.

This handbook provides a comprehensive and up-to-date survey of a wide range of developmental and clinical issues in pragmatics. Principally, the contributions to this volume deal with pragmatic competence in a native language, in a second or foreign language, and in a selection of language disorders. The topics which are covered explore questions of production and comprehension on the utterance and discourse level. Topics addressed concern the acquisition and learning, teaching and testing, assessment and treatment of various aspects of pragmatic ability, knowledge and use. These include, for example, the acquisition and development of speech acts, implicatures, irony, story-telling and interactional competence. Phenomena such as pragmatic awareness and pragmatic transfer are also addressed. The disorders considered include clinical conditions pertaining to children and to adults. Specifically, these are, among others, autism spectrum disorders, Down syndrome, and Alzheimer's disease.

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer's, Parkinson's, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients.

This volume has been compiled chiefly for the benefit of opium-eaters. Its subject is one indeed which might be made alike attractive to medical men who have a fancy for books that are professional only in an accidental way; to general readers who would like to see gathered into a single volume the scattered records of the consequences attendant upon the indulgence of a pernicious habit; and to moralists and philanthropists to whom its sad stories of infirmity and suffering might be suggestive of new themes and new objects upon which to bestow their reflections or their sympathies. But for none of these classes of readers has the book been prepared. In strictness of language little medical information is commu-nicated by it. Incidentally, indeed, facts are stated which a thoughtful physician may easily turn to professional account. The literary man will naturally feel how much more attractive the book might have been made had these separate and sometimes disjoined threads of mournful personal histories been woven into a more coherent whole; but the book has not been made or literary men.

Content covers all units for the Level 3 Award in Dementia Awareness and a mix of mandatory and optional units for the Level 3 Certificate in Dementia Care and the Dementia pathway of the Diploma. Content is matched exactly to the new specification for the Dementia units. Written by best-selling author Yvonne Nolan, so learners can be confident they have the expert support they need to succeed. A concise resource with five chapters, so you don't have to buy more than you need. Chapters combine relevant knowledge and competence units to assist transition from Award to Certificate or Diploma. A positive resource that will not only give learners the knowledge they need to complete the course, but also the skills to implement best practice in their setting Engaging case studies and real-life examples bring learning alive, helping candidates to apply their learning.

This issue of Neuroimaging Clinics of North America focuses on Headache and Chiari Malformation, and is edited by Dr. Noriko Salamon. Articles will include: Adult headache and neuroimaging: Indication of neuroimaging in general and economical overview; Headache caused by intracranial hypotension CSF leak; Headache caused by sinus disease; Headache and Chiari malformation; Headache and aneurysm; Treatment of headaches; Headache and neuroimaging: Indication and modality of choice in headaches in pediatrics; Headache and brain tumor; Headache and advanced neuroimaging: Understanding pain circuit and functional assessment of head pain; and more!

This issue of Neurologic Clinics, guest edited by Dr. David S. Younger, covers Vasculitis and the Nervous System. Topics include, but are not limited to, History and Background of Vasculitis, Overview of Primary and Secondary Vasculitis, Epidemiology of Primary Systemic Vasculitis, Comorbidity and Health Outcomes of Vasculitis, Experimental Autoimmune Vasculitis, Genetic Basis of Vasculitides, General Approach to the Patient with Vasculitis, ANCA-Associated Vasculitis, Polyarteritis Nodosa, Giant Cell Arteritis, Dermatologic Aspects of Vasculitides, Neuro-Ophthalmologic Aspects of Vasculitides, The Blood-Brain Barrier: Implications for Vasculitis, Adult Primary Angiitis of the Central Nervous System, Childhood Inflammatory Brain Diseases, Adult Vasculitic Stroke, Central Nervous System Vasculitis Due to Substance Abuse, Peripheral Nerve Vasculitis: Classification and Disease Associations, Hashimoto Encephalopathy: Autoimmune Encephalitis or Vasculitis, and Treatment of Primary Systemic and Nervous System Vasculitis.

This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington's diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.