Most people find colorful brain scans highly compelling-and yet, many experts don't. This discrepancy begs the question: What can we learn from neuroimaging? Is brain information useful in fields such as psychiatry, law, or education? How do neuroscientists create brain activation maps and why do we admire them? Casting Light on The Dark Side of Brain Imaging tackles these questions through a critical and constructive lens-separating fruitful science from misleading neuro-babble. In a breezy writing style accessible to a wide readership, experts from across the brain sciences offer their uncensored thoughts to help advance brain research and debunk the craze for reductionist, headline-grabbing neuroscience. This collection of short, enlightening essays is suitable for anyone interested in brain science, from students to professionals. Together, we take a hard look at the science behind brain imaging and outline why this technique remains promising despite its seldom-discussed shortcomings.

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

Thermoregulation, Part II: From Basic Neuroscience to Clinical Neurology, Volume 155, not only reviews how body temperature regulation changes in neurological diseases, but also how this aspect affects the course and outcomes of each disease. Other sections of the volume review three therapeutic approaches that are aimed at manipulating body temperature, including induced hypothermia, induced hyperthermia and antipyretic therapy. The book is comprised of nine sections across two volumes, five dealing with the basic aspects of body temperature regulation and four dealing with the clinical aspects. Basic sections cover the Thermoregulation system, Thermoreceptors, Thermoeffectors, Neural pathways, and Thermoregulation as a homeostatic function. In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.

One who Forgets and

One who is Forgotten

One in eight over the age of sixty-five and one in three over the age of eighty will be diagnosed with Alzheimer's Disease. In her memoir, author Joan Sutton narrates a moving account of her years as caregiver to her husband, noting that "Alzheimer's is a disease of the brain that is paid for with the currency of the heart."

A member of the board of overseers of The Alzheimer's Drug Discovery Foundation, she stresses the need to develop more effective treatment for the eight million Americans currently diagnosed with this incurable disease, pointing out that for every patient there is a large circle of others also affected.

Sutton offers practical advice for the care of the caregiver and the patient, and shares the pain that came as she watched pieces of her husband's self disappear. Following his death, after what Nancy Reagan described as "the long goodbye," she writes candidly about coping with her new status as a widow and the aching loneliness of the heart that is the price paid for having known a great love.

All profits from the sale of this book will benefit The Alzheimer's Drug Discovery Foundation/Canada.

Cover design by John R. Lewis

Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders provides a comprehensive overview of neurotechnological devices as potential treatments for psychiatric and neurodevelopmental disorders in children and adolescents. Many neuropsychiatric disorders are covered such as Autism Spectrum Disorder, ADHD, Depression, Tourette's Syndrome, and OCD. Different device-based treatments are discussed such as Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, Deep Brain Stimulation, Chronotherapy, and Neurofeedback.

The importance of facial expressions has led to a steadily growing body of empirical findings and theoretical analyses. Every decade has seen work that extends or challenges previous thinking on facial expression. The Science of Facial Expression provides an updated review of the current psychology of facial expression . This book summarizes current conclusions and conceptual frameworks from leading figures who have shaped the field in their various subfields, and will therefore be of interest to practitioners, students, and researchers of emotion in cognitive psychology, neuroscience, biology, anthropology, linguistics, affective computing, and homeland security. Organized in eleven thematic sections, The Science of Facial Expression offers a broad perspective of the "geography" of the science of facial expression. It reviews the scientific history of emotion perception and the evolutionary origins and functions of facial expression. It includes an updated compilation on the great debate around Basic Emotion Theory versus Behavioral Ecology and Psychological constructionism. The developmental psychology and social psychology of facial expressions is explored in the role of facial expressions in child development, social interactions, and culture. The book also covers appraisal theory, concepts, neural and behavioral processes, and lesser-known facial behaviors such as yawing, vocal crying, and vomiting. In addition, the book reflects that research on the "expression of emotion" is moving towards a significance of context in the production and interpretation of facial expression The authors expose various fundamental questions and controversies yet to be resolved, but in doing so, open many sources of inspiration to pursue in the scientific study of facial expression.

Imaging in Movement Disorders: Imaging in Other Movement Disorders and Dementia, Volume 143 provides an up-to-date textbook on the use of imaging modalities across the spectrum of movement disorders and dementias. The book brings together lessons learned from neuroimaging tools in the content of movement disorders, including idiopathic and sporadic forms of Parkinson's disease, Huntington's disease, Atypical Parkinsonism, Dystonia, Essential Tremor, and more. Specific chapters cover Neuroimaging Applications in Dystonia, Neuroimaging Applications in Essential Tremor, Neuroimaging applications in Restless Leg Syndrome, Neuroimaging Application in Tourette's Syndrome and TIC Disorders, Neuroimaging Applications in Functional Movement Disorders, and Neuroimaging Applications in Cerebellar Disorders. Addition sections cover Molecular Imaging of Parkinson's Disease Cognitive Impairment, Structural MRI in Parkinson's Disease Cognitive Impairment, Functional MRI in Parkinson's Disease Cognitive Impairment, Molecular Imaging of Dementia with Lewy Bodies, Structural and Functional MRI of Dementia with Lewy Bodies, Transcranial Sonography in Movement Disorders, Imaging transplantation in Movement Disorders, Hybrid PET-MRI Applications in Movement Disorders, amongst other topics.

This exciting collection tours virtual reality in both its current therapeutic forms and its potential to transform a wide range of medical and mental health-related fields. Extensive findings track the contributions of VR devices, systems, and methods to accurate assessment, evidence-based and client-centered treatment methods, and-as described in a stimulating discussion of virtual patient technologies-innovative clinical training. Immersive digital technologies are shown enhancing opportunities for patients to react to situations, therapists to process patients' physiological responses, and scientists to have greater control over test conditions and access to results. Expert coverage details leading-edge applications of VR across a broad spectrum of psychological and neurocognitive conditions, including: Treating anxiety disorders and PTSD. Treating developmental and learning disorders, including Autism Spectrum Disorder, Assessment of and rehabilitation from stroke and traumatic brain injuries. Assessment and treatment of substance abuse. Assessment of deviant sexual interests. Treating obsessive-compulsive and related disorders. Augmenting learning skills for blind persons. Readable and relevant, Virtual Reality for Psychological and Neurocognitive Interventions is an essential idea book for neuropsychologists, rehabilitation specialists (including physical, speech, vocational, and occupational therapists), and neurologists. Researchers across the behavioral and social sciences will find it a roadmap toward new and emerging areas of study.

This book provides medical professionals and researchers with a comprehensive overview of fundamental concepts and recent advances in neurochemistry, and offers new perspectives for all those involved with research in related disciplines. As drug discovery for neurodegenerative diseases is one of the largest subspecialties in the field of medicine, the book addresses topics that transcend the borders between disciplines, and presents a wealth of investigations into and discussions on critical questions relevant to the entire field of CNS drug research. It summarizes the available data on the fundamentals of neurotransmitters, treatment of and advanced care for neurodegenerative diseases; and outlines current and future research directions in this field. Combining both conventional and innovative approaches to the topic, the book offers a valuable guide for readers working in medicinal chemistry, the life sciences and allied fields.

Research on cognitive disorders is challenging due to the complexity of functions and numerous variables involved. The main purpose of this book is to effectively address the methodological issues and controversies in cognitive disorders research. First, it reviews the concept of human cognition as a complex activity involving interconnected mental and cerebral processes (its systemic structure), which represent the natural and social-cultural world by means of signs (its mediated, semiotic nature) and result from the internalization (or appropriation by the individual) of external actions and relations with things and persons (its cultural-historical origin). Subsequently, methodological issues are examined, including the use of the systemic and network approach in neuropsychological research, the concepts of single and double dissociation, single-case versus group studies, problems of brain-behavioral correlations using the lesion method and functional neuroimaging, the influence of task-relevant variables (confounders) related to the patient (e.g., age, education), to the lesion (size, etiology), and to the tests and testing conditions (ecological validity, examiners experience). Finally, readers are given the fundamentals of statistics applied to biomedical and psychological research, with illustrative examples of how to calculate Z score, effect size, 2 test, t test, Pearsons correlation coefficient, and simple linear regression. Methodological problems in current cognitive research on early multiple sclerosis, medial temporal lobe epilepsy, mild cognitive impairment and dementia are examined in detail.

Autism is a complex phenomenon that is both individual and social. Showing both robust similarities and intriguing differences across cultural contexts, the autism spectrum raises innumerable questions about self, subjectivity, and society in a globalized world. Yet it is often misrepresented as a problem of broken bodies and disordered brains. So, in 2015, a group of interdisciplinary scholars gathered in Rio de Janeiro, Brazil for an intellectual experiment: a workshop that joined approaches from psychological anthropology to the South American tradition of Collective Health in order to consider autism within social, historical, and political settings. This book is the product of the ongoing conversation emerging from this event. It contains a series of comparative histories of autism policy in Italy, Brazil, and the United States; focuses on issues of voice, narrative, and representation in autism; and examines how the concept of autism shapes both individual lives and broader social and economic systems. Featuring contributions from: Michael Bakan Benilton Bezerra Pamela Block M. Ariel Cascio Jurandir Freire Costa Barbara Costa Andrada Cassandra Evans Elizabeth Fein Clara Feldman Roy Richard Grinker Rossano Lima Francisco Ortega Dawn Prince-Hughes Clarice Rios Laura Sterponi Thomas S. Weisner Enrico Valtellina

For many researchers virtual reality (VR) is first of all a technology. This vision is also well reflected in the growing research work concerned with virtual environments: most of it has addressed more the development of new rendering technologies rather than the highly interactive and dynamic nature of user-system interaction that VR supports. However, this focus on technology is disappointing for developers and researchers. To overcome this limitation, the book describes VR as an advanced communication tool: a communication interface in single-user VR, and a communication medium in the case of multi-user VR. This book is part of a general inquiry into the implications of new technologies like VR. The shifting structures of communication systems present historic opportunities and challenges for communication researchers and that these require multidisciplinary approaches to communication research. Virtual reality may become the ship that helps us sail the vast oceans of cyberspace. This book is our attempt to construct a paper telescope to scan the horizon for signs of communication (and life) in the age of virtual reality.

Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. The current edition begins with an overview of the anatomy and molecular architecture of the neuromuscular junction and the electrophysiologic diagnosis of its disorders. The introductory chapters are followed by a detailed exposition of the pathogenesis, natural history, diagnosis and therapy of the autoimmune myasthenias, the Lambert-Eaton myasthenic syndrome, and the increasingly complex and fascinating diseases collectively referred to as congenital myasthenic syndromes. The acetylcholine receptor is a major target of both autoimmune and inherited myasthenias and a separate chapter reviews its structural and functional properties. The book also describes disorders that often target terminal nerve segment near the neuromuscular junction-- the syndrome of peripheral nerve hyperexcitability and the Guillain-Barr syndrome.
Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.

Animal Models for Examining Social Influences on Drug Addiction, Volume 140 in the International Review of Neurobiology series, provides insights on social factors that mediate drug addiction. This book discusses current research and projects, with specific chapters focusing on Social Influences on Nicotine-related Behaviors in Rodents, Models of Alcohol Intake in Social Contexts, Social Factors in Ethanol Sensitization, Social Modulation of Heroin Intake, Amphetamines and Social Aspects of Addiction, Amphetamines and Social Aspects of Addiction, Social Models of Cannabis Use, Oxytocin and Rodent Models of Addiction, Social Place Preference and Reward, Social Defeat Stress, and more.

Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.

This issue of Physical Medicine and Rehabilitation Clinics, guest edited by Dr. Miriam Segal, will cover the important topic of Muscle Overactivity in Upper Motor Neuron Syndrome, including assessment and problem-solving for complex cases. Topics discussed in the volume will include: Functional/problem based assessment in patients with spinal cord injury; Special considerations in pediatric assessment; Special considerations and assessment of spasticity and multiple sclerosis; Pharmacologic treatment tools; Peripheral neurolysis; The role of physical and occupational therapy; Neurosurgical approaches; The neuro-orthopedic approach; Upper extremity problem-solving: Challenging cases; Lower extremity problem-solving: Challenging cases; and Emerging therapies.

Neurobiology of the Placebo Effect, Part II, Volume 139, the latest release in the International Review of Neurobiology series, is the second part of a two-volume set that provides the latest placebo studies in clinically relevant models. Specific chapters cover the History of placebo effects in medicine, Lumping or Splitting: Towards a taxonomy of placebo and related effects, Theories and brain mechanisms of placebo analgesia, Pain Modulation: From CPM to placebo and nocebo effects in experimental and clinical pain, Modulation of the motor system by placebo and nocebo effects, and the role of sleep in learning placebo effects, amongst other topics.

The field of interventional neuroradiology has expanded greatly in recent years, shifting emphasis onto neuroendovascular methods that, increasingly, have become the standard in modern treatment. This shift has placed a demand on hospitals to provide a standard of care for which many busy clinicians have not been trained. Dr. Pearse Morris has written a timely and comprehensive reference for those who are interested in expanding their knowledge of neuroendovascular procedures, but have not had a specialized neuroradiology fellowship. The emphasis throughout is on patient safety and the outcome of various treatments. Topics covered in this volume include: Platelets and coagulation basic techniques, devices, and arterioty closure aneurysms extracranial angioplasty and stenting endovascular treatment of vasospasm dural arteriovenous malformations carotid cavernous fistulas balloon test occlusion and post-occlusion patient care spine and vertebroplasty tumor embolization thrombolysis and treatment of acute stroke venous thrombotic disease arteriovenous malformations of the brain Neuroradiologists, neurosurgeons, and neurologists will find this reference a much needed and practical asset to both their education and updating their practices.

The difference that being female makes to the diagnosis, life and experiences of an autistic person is hugely significant. In this widely expanded second edition, Sarah Hendrickx combines the latest research with personal stories from girls and women on the autism spectrum to present a picture of their feelings, thoughts and experiences at each stage of their lives.

Outlining the likely impact will be for autistic women and girls throughout their lifespan, Hendrickx surveys everything from diagnosis, childhood, education, adolescence, friendships and sexuality, to employment, pregnancy, parenting, and aging.

With up-to-date content on masking, diagnosis later in life, and a new focus on trans and non-binary voices, as well as a deeper dive into specific health and wellbeing implications including menopause, PCOS, Hypermobility/Ehlers-Danlos, autistic burnout, and alexithymia, this is an invaluable companion for professionals, as well as a guiding light for autistic women to understand and interpret their own experience in context.

Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics. Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.

Amantadine is used to treat the symptoms of Parkinson's disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions. It is also used to control movement problems that are a side effect of certain medications used to treat Parkinson's disease (MedlinePlus). This book is a concise guide to the use of amantadine to treat Parkinson's disease. Divided into five sections, the text begins with an overview of the signs and symptoms of Parkinson's disease, followed by coverage of its pathophysiology and diagnosis. The next chapters discuss the role of amantadine in the treatment of the disease, as well as its clinical efficacy and safety. The book concludes with advice on dosage, adverse effects, and its interaction with other drugs. Tables and figures further enhance the text. Key points Concise guide to the use of amantadine to treat Parkinson's disease In depth coverage of signs and symptoms of the disease, its pathophysiology and diagnosis Discusses clinical efficacy, safety, dosage, side effects, and interaction with other drugs Includes tables and figures to further enhance learning