Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders

This volume describes the treatment of uniquely complex and profound sexual problems that the therapeutic community has been largely unsuccessful in treating. The reader is drawn to understand and even identify with the people experiencing sexual disturbance. This process of identification helps to mitigate the biases that we use to dehumanize the sexually disturbed.

This work is developed around a case study format, with chapters on specific psychosexual disturbances. All of these cases experienced early childhood sexual trauma or mislearning that interrupted the course of normal sexual development. Such victims then frequently repeat the learned behavior in later life, acting out the role of perpetrator. In addition to presenting the treatment process as it is formulated in the mind of the therapist, the author offers a blueprint for therapy that makes specific treatment possible for clients with similar disorders. Therapists are also guided in developing an effective clinical presence, covering such matters as initial contact, boundary setting, self awareness, dress, voice tone, and overall demeanor. Strategies for avoiding becoming enmeshed in psychological defenses are presented in detail.

Researchers' knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book's discussion of imaging modalities extends beyond advances in anatomical imaging to include metabolic and physiological studies. This work provides thorough discussion of the clinical view of tumors, ranging from the presentation of the patient to surgical management, and covers all therapeutic options for patient care, including chemotherapy, targeted molecular therapies, immunotherapies, and even personalized approaches to impact the set of lesions. Additionally, the book discusses radiotherapy with regard to the many options available to treat patients using myriad fractionated techniques with various sources. Finally, Gliomas reviews issues specific to the quality of life for patients, and techniques for maximizing the effect of caregivers. Edited and authored by premier researchers from around the world, Gliomas is a comprehensive reference for clinicians and researchers seeking the most up-to-date information on gliomas, and a guide to the best ways to effectively manage glioma patients and their care.

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.

This informative text details the many changes in everyday life as the result of injury, illness, or aging affecting the brain. Experts across brain-related fields trace mechanisms of conditions such as Parkinson's disease, TBI, and dementia as they impact regions of the brain, and resulting cognitive, emotional, sensory, and motor impairments as they contribute to deficits in personal and social functioning. In addition to symptoms and behaviors associated with insults to the brain (and the extent to which the brain can adapt or self-repair), chapters provide cogent examples of how societal and cultural expectations can shape the context and experience of disability. The book's focus on everyday activities brings new clarity to diverse links between symptoms and diagnosis, brain and behavior. Included in the coverage: *The aging brain and changes in daily function. *Stroke: impact on life and daily function. *Traumatic brain injury (TBI) and the impact on daily life. *Everyday life with cancer. *Real-world impact of HIV-associated neurocognitive impairment. *Disability and public policy in America. *Living after brain changes, from the patient's perspective. Rich in empirical data and human insight, Changes in the Brain gives neuropsychologists, clinical psychologists, clinical social workers, and rehabilitation nurses a robust new understanding of the daily lives of patients, both in theory and in the real world.

This common and very important disorder of Epilepsy is led by Dr. Steven Schachter in this issue of Neurologic Clinics. The majority of articles review methods for application of standards, guidelines, and consensus statement to clinical practice by Primary Care physicians and general Neurologists using validated and evidence-based tools such as screening instruments and algorithms for a number of critically important topics, ranging from initial evaluation to monitoring patients on treatment to counseling and educating patients on SUDEP and driving. Topics in this issue include: Guidelines and quality standards for adult epilepsy patients; Guidelines and quality standards in care of children with epilepsy; Initial evaluation of the patient with suspected epilepsy; Starting, choosing, changing, and discontinuing treatment; Methods for measuring seizure frequency and severity; Assessment of treatment side effects and quality of life; Screening for depression and anxiety; Counseling patients on driving and employment; Issues for women with epilepsy; Patient education (SUDEP - Sudden Unexpected Death in Epilepsy; Self-management; Adherence; Rescue medication); Optimizing the patient-physician therapeutic alliance.

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

Get the most comprehensive, up-to-date guidance available for exam prep with help from Neurology Self-Assessment. Written by Drs. Justin T. Jordan, David R. Mayans, and Michael J. Soileau, this companion volume to Bradley's Neurology in Clinical Practice thoroughly covers the core and subspecialty topics you'll encounter on your exam, along with detailed answer explanations and cross-references to Bradley's. With a focus on assessing subspecialty strengths and weaknesses, it's the ideal preparation for board certification, maintenance of certification, in-training examinations, and neurology examinations for medical students. Features six examinations of more than 100 questions each that follow the board exam blueprint. Contains challenging questions that fully prepare you for exams, with detailed answer explanations and references to Bradley's Neurology in Clinical Practice, 7th Edition. Covers basic neuroscience, behavioral neurology, and psychiatry; clinical neurology topics such as headache, cerebrovascular disease, and neuro-infectious disease; and increasingly tested areas such as ethics and interpersonal skills. Over a quarter of the questions include illustrations such as anatomy, imaging, histology slides, and clinical photos. Includes excellent coverage of key topics such as neurochemistry and neurophysiology, new immune-mediated therapies, child neurology, metabolic diseases, and much more. Offers unique, scorable tests online with subspecialty question divisions. Comes with a downloadable eBook and online access that allows you to test interactively and get immediate feedback and scores.

Dr. Flavia B. Consens has assembled an expert team of authors on the topic of Sleep in Medical and Neurologic Disorders. Articles include: Sleep and pulmonary disease, Sleep and Pain, Sleep and Neurodegenerative Disorders, Sleep and Stroke, Sleep in the pediatric population, Sleep and cancer, Narcolepsy and excessive daytime sleepiness, Sleep in the hospitalized patient, Sleep and psychiatric disorders, Occupational sleep medicine, and more!

CDC estimates reveal that 1.6 million to 3.8 million concussions occur each year. This issue will include topics such as pathophysiology, imagine, rturn to learn programs and long-term consequences of concussions.

Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

Each issue of Orthopedic Clinics offers clinical review articles on the most cutting edge technologies, techniques, and more in the field. Major topic areas include: adult reconstruction, upper extremity, pediatrics, trauma, oncology, hand, foot & ankle, and sports medicine.

This book offers a comprehensive and readable account of theoretical aspects of the origins of normal development of handedness and its relationship to cerebral lateralization and intellectual function. Later chapters review the evidence for links between non-right-handedness and various developmental disorders: mental impairment, autism, epilepsy, and disorders of spoken and written langauge. The emphasis is on understanding the range of underlying mechanisms that might lead to associations between handedness and disorder, and on identifying assessment procedures that can distinguish between different explanations.

Autoimmune neurologic disease results when the immune response to the body s own organs run wild and causes the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years significant advances in our understanding of the pathophysiology of autoimmune disorders including biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include, dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists and neuroscientists, and any medical professional working with autoimmune disease and disorders.

*Comprehensive coverage of autoimmune neurology *Details the latest techniques for the study, diagnosis and treatment of diseases and disorders including dementia, neuromuscular disease, epilepsy, sleep disorders *A focused reference for clinical practitioners and the clinical neurology and neurology research communities"

This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.

Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease & clinical diagnosis of sporadic ALS; Potential environmental factors in ALS; Neuropathology; Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS; Symptoms management and end of life care; Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data; Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?; Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience.