This common and very important disorder of Epilepsy is led by Dr. Steven Schachter in this issue of Neurologic Clinics. The majority of articles review methods for application of standards, guidelines, and consensus statement to clinical practice by Primary Care physicians and general Neurologists using validated and evidence-based tools such as screening instruments and algorithms for a number of critically important topics, ranging from initial evaluation to monitoring patients on treatment to counseling and educating patients on SUDEP and driving. Topics in this issue include: Guidelines and quality standards for adult epilepsy patients; Guidelines and quality standards in care of children with epilepsy; Initial evaluation of the patient with suspected epilepsy; Starting, choosing, changing, and discontinuing treatment; Methods for measuring seizure frequency and severity; Assessment of treatment side effects and quality of life; Screening for depression and anxiety; Counseling patients on driving and employment; Issues for women with epilepsy; Patient education (SUDEP - Sudden Unexpected Death in Epilepsy; Self-management; Adherence; Rescue medication); Optimizing the patient-physician therapeutic alliance.

Duchenne Muscular Dystrophy, an inherited and progressive muscle wasting disease, is one of the most common single gene disorders found in the developed world. In this fourth edition of the classic monograph on the topic, Alan Emery and Francesco Muntoni are joined by Rosaline Quinlivan, Consultant in Neuromuscular Disorders, to provide a thorough update on all aspects of the disorder. Recent understanding of the nature of the genetic defect responsible for Duchenne Muscular Dystrophy and isolation of the protein dystrophin has led to the development of new theories for the disease's pathogenesis. This new edition incorporates these advances from the field of molecular biology, and describes the resultant opportunities for screening, prenatal diagnosis, genetic counselling and from recent pioneering work with anti-sense oligonucleotides, the possibility of effective RNA therapy. Although there is still no cure for the disorder, there have been significant developments concerning the gene basis, publication of standards of care guidelines, and improvements in management leading to significantly longer survival, particularly with cardio-pulmonary care. The authors also investigate other forms of pharmacological, cellular and gene therapies. Duchenne Muscular Dystrophy will be essential reading not only for scientists and clinicians, but will also appeal to therapists and other professionals involved in the care of patients with muscular dystrophy.

This book reviews recent knowledge of the role of gut microbiome in health and disease. It covers extensive topics for several diseases, including metabolic-related diseases, allergies, gastrointestinal diseases, psychiatric diseases, and cancer, while also discussing therapeutic approaches by microbiota modification. Comprehensive and cutting-edge, Gut Microbiome-Related Diseases and Therapies deepens a reader's theoretical expertise in gut microbiome. Graduate and postdoctoral students, medical doctors, and biomedical researchers will benefit from this book.

This informative text details the many changes in everyday life as the result of injury, illness, or aging affecting the brain. Experts across brain-related fields trace mechanisms of conditions such as Parkinson's disease, TBI, and dementia as they impact regions of the brain, and resulting cognitive, emotional, sensory, and motor impairments as they contribute to deficits in personal and social functioning. In addition to symptoms and behaviors associated with insults to the brain (and the extent to which the brain can adapt or self-repair), chapters provide cogent examples of how societal and cultural expectations can shape the context and experience of disability. The book's focus on everyday activities brings new clarity to diverse links between symptoms and diagnosis, brain and behavior. Included in the coverage: *The aging brain and changes in daily function. *Stroke: impact on life and daily function. *Traumatic brain injury (TBI) and the impact on daily life. *Everyday life with cancer. *Real-world impact of HIV-associated neurocognitive impairment. *Disability and public policy in America. *Living after brain changes, from the patient's perspective. Rich in empirical data and human insight, Changes in the Brain gives neuropsychologists, clinical psychologists, clinical social workers, and rehabilitation nurses a robust new understanding of the daily lives of patients, both in theory and in the real world.

Each issue of Orthopedic Clinics offers clinical review articles on the most cutting edge technologies, techniques, and more in the field. Major topic areas include: adult reconstruction, upper extremity, pediatrics, trauma, oncology, hand, foot & ankle, and sports medicine.

This volume describes the treatment of uniquely complex and profound sexual problems that the therapeutic community has been largely unsuccessful in treating. The reader is drawn to understand and even identify with the people experiencing sexual disturbance. This process of identification helps to mitigate the biases that we use to dehumanize the sexually disturbed.

This work is developed around a case study format, with chapters on specific psychosexual disturbances. All of these cases experienced early childhood sexual trauma or mislearning that interrupted the course of normal sexual development. Such victims then frequently repeat the learned behavior in later life, acting out the role of perpetrator. In addition to presenting the treatment process as it is formulated in the mind of the therapist, the author offers a blueprint for therapy that makes specific treatment possible for clients with similar disorders. Therapists are also guided in developing an effective clinical presence, covering such matters as initial contact, boundary setting, self awareness, dress, voice tone, and overall demeanor. Strategies for avoiding becoming enmeshed in psychological defenses are presented in detail.

This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author's 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery.

This detailed volume collects protocols for experimentation into how neurons connect to produce the extraordinary functionalities of the nervous system. Contributed by experts and pioneers in their respective techniques, the book covers synapses in the brain and in culture, their constituents, their structures, their dynamics, and the assemblies they form, all in the structure of a laboratory guide. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synapse Development: Methods and Protocols serves as an ideal guide to minimizing the barrier to entry for the integration of new approaches with existing expertise, producing syntheses that will foster novel perspectives on the many ways in which synapses form, transform, and transmit.

This issue focuses on meningiomas and includes articles on Incidental Meningiomas: Management Strategies in the Modern Neuroimaging Era, Advanced Neuroimaging for Intracranial Meningiomas, Endoscopic Endonasal and Keyhole Surgery for the Management of Skull Base Meningiomas, Preoperative Embolization for Intracranial Meningiomas, Management of Spinal Meningiomas, Medical Management of Meningiomas: Current Status, Failed Treatments and Promising Horizons, and many more!

The purpose of this work is to review recent findings highlighting the mechanisms and functions of the neuronal oscillations that structure brain activity across the sleep-wake cycle. An increasing number of studies conducted in humans and animals, and using a variety of techniques ranging from intracellular recording to functional neuroimaging, has provided important insight into the mechanisms and functional properties of these brain rhythms. Studies of these rhythms are fundamental not only for basic neuroscience, but also for clinical neuroscience. At the basic science level, neuronal oscillations shape the interactions between different areas of the brain and profoundly impact neural responses to the environment, thereby mediating the processing of information in the brain. At the clinical level, brain oscillations are affected in numerous neurological conditions and might provide useful biomarkers that inform about patients' evolution and vulnerability. During sleep, these brain rhythms could provide functional support to internal states that govern the basic maintenance of local circuit and systemic interactions. During wake, the rhythmicity of cortical and subcortical circuits have been linked with sensory processing, cognitive operations, and preparation for action. This book will attempt to link together these sleep and wake functional roles at the level of neuroimaging and electroencephalographic measures, local field potentials, and even at the cellular level.

Few issues cause as much strife in contemporary society as does the cause and treatment of autism. Stories about the autism epidemic abound on talk shows and make headlines in newspapers and magazines. Celebrities and politicians express their personal opinions on the cause (or causes) of the increase in autism spectrum disorders (or ASDs), opinions often not shared by the conventional scientific community. Parents, family members, schools and government-funded agencies struggle to do the right thing for individuals with ASDs, This volume in the "Biographies of Disease" series provides an understandable, non-biased guide to the quagmire of information about ASDs. This foundation will enable readers to better understand the statements made by various authorities on ASDs. Autism covers all aspects of our historical and current understanding of autism spectrum disorders. The text starts with the recognition of autism in the forties and traces the development of ways to diagnose autism, explains why autism has been expanded to the autistic spectrum disorders. The author covers what is known and not known about the autism epidemic and the causes of ASDs. The critical importance of screening and early intervention is emphasized with respect to outcome for individuals with ASDs. Promising areas of research are highlighted. After reading this book, the reader will be able to place the latest breaking news about ASDs into perspective. While it is not yet possible to answer all of the questions about autism, this book allows the reader to follow along as the mystery is unraveled.

"Autism" covers all aspects of our historical and current understanding of autism spectrum disorders: The recognition of autism in the forties and the development of ways to diagnose autism; why autism has been expanded to the autistic spectrum disorders; what is known and not known about the autism epidemic and the causes of ASDs; the importance of screening and early intervention as well as information about outcome for individuals with ASDs; and promising areas of research.

After reading this book, the reader will be able to place the latest breaking news about ASDs into perspective. While it is not yet possible to answer all of the questions about autism, this book allows the reader to follow along as the mystery is unraveled.

Based upon two decades of research with patients who have experienced pathology in one hemisphere of the brain, this book deals with brain mechanisms in human communicative behaviour, and with related motor functions from a broadly biological point of view. The work discusses the possible evolutionary origins of human communication, the relation of brain mechanisms in communicative behaviour to analogous nonhuman behaviors, and the neural systems involved in various levels and kinds of communication. Noncommunicative mechanisms which parallel those used in communication are also outlined in detail. Individual differences in brain organization for some functions are also explored.

Much new data is presented along with the theoretical treatment of human communication which emphasizes a behavioral rather than a linguistic approach. The work will interest psycholinguists, cognitive psychologists, neurologists, clinical neuropsychologists, speech pathologists, and advanced students in these fields.

Autoimmune neurologic disease results when the immune response to the body s own organs run wild and causes the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years significant advances in our understanding of the pathophysiology of autoimmune disorders including biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include, dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists and neuroscientists, and any medical professional working with autoimmune disease and disorders.

*Comprehensive coverage of autoimmune neurology *Details the latest techniques for the study, diagnosis and treatment of diseases and disorders including dementia, neuromuscular disease, epilepsy, sleep disorders *A focused reference for clinical practitioners and the clinical neurology and neurology research communities"

The field of neuropsychology has grown rapidly in recently years. New developments have been of interest across disciplines to cognitive, clinical, and experimental psychologists as well as neuroscientists.
Neuropsychology presents a comprehensive overview of where the field stands now relative to all these disciplines. Representing the critical areas in human neuropsychology, this book begins with the history and development of the field and proceeds to discuss brain structure and function with regard to attention, perception, emotion, language, and movement.
Key Features
* Provides a comprehensive literature review
* Chapters represent the critical areas in human neuropsychology
* Organized for ease of use and reference
* Contributors from medicine, experimental, cognitive, and clinical psychology

Anomia is the inability to access spoken names for objects, most often associated with the elderly or those with brain damage to the left hemisphere. Anomia offers the state-of-the-art review of disorders of naming, written by acknowledged experts from around the world, approached from both clinical and theoretical viewpoints. Goodglass, known around the world for his research in aphasia and speech pathology, edits this first book devoted exclusively to naming and its disorders. Wingfield is known for his classic studies of lexical processing in aphasic and normal speakers. The book includes comprehensive literature reviews, a summary of relevant research data, as well as astudy of recent advances in cognitive analysis and anatomic findings. Anomia is an immensely useful work for all those involved in the study of language, particularly those in cognitive neuroscience, neurology, speech pathology, and linguistics.
Key Features
* Devoted entirely to naming and its disorders
* Includes up-to-date descriptions of advances in cognitive analysis
* Contains approaches from both clinical and theoretical viewpoints
* Brings together the top researchers from the U.S., England, and Italy

Dr. Flavia B. Consens has assembled an expert team of authors on the topic of Sleep in Medical and Neurologic Disorders. Articles include: Sleep and pulmonary disease, Sleep and Pain, Sleep and Neurodegenerative Disorders, Sleep and Stroke, Sleep in the pediatric population, Sleep and cancer, Narcolepsy and excessive daytime sleepiness, Sleep in the hospitalized patient, Sleep and psychiatric disorders, Occupational sleep medicine, and more!

This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. This receptor, a member of the opioid receptor family, was traditionally thought to be primarily involved in pain modulation. Recent new findings have shown its unique role in neuroprotection and many other functions. Many scientists from a number of independent laboratories have now confirmed that DOR can provide neuroprotection against hypoxic/ischemic injuries. They have also found that it plays a role in a variety of physiological and pathophysiological events such as hypoxic encephalopathy, epilepsy, acupuncture, Parkinson's disease, etc. by regulating ionic homeostasis, glutamate transportation and signaling, and balancing intracellular survival/death signals. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

Aimed at both beginners and experienced researchers unfamiliar with the technique, this book provides a concise and easy-to-understand guide to using immunohistochemistry. It identifies the proper place and purpose of each component of immunohistochemistry, emphasizes the components that are of critical importance, and explains the logistics of experimental approaches. Understanding the principles of immunohistochemistry allows for the identification and localization of protein targets and is of crucial use in the following experiments: * producing transgenic animals * studying the effects of drug treatments * electrophysiological studies * animal surgery * isolating and differentiating stem cells * super-resolution microscopy Immunohistochemistry for the Non-Expert is aimed at a wide audience, including molecular biologists, pharmacologists, immunologists, chemists, cell biologists, physiologists, and researchers involved with animal anatomy studies.

This important subject of Diagnosis of and Treatment for Neurobehavioral manifestations of neurologic disease is directed by three leaders of this field - Dr. Alizeza Minagar, Dr. Glen Finney, and Dr. Kenneth Heilman. Topics include: Neurobehavioral testing for mental status; Behavioral neurology of vascular neurology; Alzheimer's disease; Frontotemporal dementia; Traumatic brain injury; Parkinsonian Syndromes (e.g., Parkinson's disease, Lewy body dementia, progressive supranuclear palsy, corticobasal disease, multisystem atrophy); Behavioral neurology of multiple sclerosis and autoimmune encephalopathies; Infectious Diseases (Neuro-AIDS, Neurosyphilis, HSV); Neurobehavioral aspects of systemic disease; Neurobehavioral aspects of epilepsy; Behavioral neurology aspects of nutritional deficiencies; Neurobehavioral aspects of mitochondrial disease; and Medicinal-induced behavioral disorders.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging.

Handbook of Pain and Palliative Care:Biobehavioral Approaches for the Life Course Rhonda J. Moore, editor This book takes both a biobehavioral and a lifespan approach to understanding long-term and chronic pain, and intervening to optimize patients' functioning. Rich in clinical diversity, chapters explore emerging areas of interest (computer-based interventions, fibromyalgia, stress), ongoing concerns (cancer pain, low back pain), and special populations (pediatric, elderly, military). This coverage provides readers with a knowledge base in assessment, treatment, and management that is up to date, practice strengthening, and forward looking. Subject areas featured in the Handbook include: Patient-practitioner communication Assessment tools and strategies Common pain conditions across the lifespan Biobehavioral mechanisms of chronic pain Pharmaceutical, neurological, and rehabilitative interventions Psychosocial, complementary/alternative, narrative, and spiritual approaches Ethical issue and future directions With the rise of integrative perspective and the emphasis on overall quality of life rather than discrete symptoms, pain management is gaining importance across medical disciplines. Handbook of Pain and Palliative Care stands out as a one-stop reference for a range of professionals, including health practitioners specializing in pain management or palliative care, clinical and health psychologists, public health professionals, and clinicians and administrators in long-term care and hospice.

Occupational Neurology a volume in the Handbook of Clinical Neurology Series, provides a comprehensive overview of the science, clinical diagnosis, and treatment for neurotoxin related neurological and psychiatric disorders. This timely collection provides not only a complete scientific reference on the chemical origin of this class of neurological and psychiatric disorders, but also a practical guide to diagnosis and treatment challenges and best practices. Handbook of Clinical Neurology Series The first volume of the Handbook of Clinical Neurology under the editorship of George Bruyn and Pierre Vinken was published in 1968. In 1982, the series was brought to an interim conclusion with the publication of the cumulative index volume (Volume 44). By that stage, the Handbook had come to represent one of the largest scientific works ever published. It enjoys a high reputation in specialist media circles throughout the world. After the series was concluded in 1982, it was realized that an update of the material was imperative. Accordingly, a revised series was planned and published over the following years, concluding with the publication of another cumulative index to both series (Volume 76-78) in 2002. Since then, George Bruyn has passed away and Pierre Vinken has retired, but the need for a further new series, incorporating advances in the field, again become necessary. Professors Michael J. Aminoff, Francois Boller and Dick F. Swaab have with enthusiasm taken on the responsibility of supervising the preparation of a third series, the first volumes of which were published in 2003. Now, more than 130 volumes after the first published, the Handbook of Clinical Neurology series continues to have an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology.