Many studies of the neural bases of language processes are now conducted with functional and structural neuroimaging. Research is often compromised because of difficulties in identifying the core structures in the face of the complex morphology of these regions of the brain. Although there are many books on the cognitive aspects of language and also on neurolinguistics and aphasiology, "Neuroanatomy of Language Regions of the Human Brain" is the first anatomical atlas that focuses on the core regions of the cerebral cortex involved in language processing. This atlas is a richly illustrated guide for scientists interested in the gross morphology of the sulci and gyri of the core language regions, in the cytoarchitecture of the relevant cortical areas, and in the connectivity of these areas.

Data from diffusion MRI and resting-state connectivity are integrated iwth critical experimental anatomical data about homologous areas in the macaque monkey to provide the latest information on the connectivity of the language-relevant cortical areas of the brain. Although the anatomical connectivity data from studies on the macaque monkey provide the most detailed information, they are often neglected because of difficulties in interpreting the terminology used and in making the monkey-to-human comparison. This atlas helps investigators interpret this important source of information. "Neuroanatomy of Language Regions of the Human Brain" will assist investigators of the neural bases of language in increasing the anatomical sophistication of their research adn in evaluating studies of language and the brain.
Abundantly illustrated with photographs, 3-D MRI reconstructions, and sections to represent the morphology of the sulci and gyri in the frontal, temporal, and parietal regions involved in language processingPhotomicrographs showing the cytoarchitecture of cortical areas involved in language processingSeries of coronal, sagittal, and horizontal sections identifying the sulci and gyri to assist language investigators using structural and functional neuroimaging techniquesAll images accompanied by brief commentaries to help users navigate the complexities of the anatomyIntegration of data from diffusion MRI and resting-state connectivity with critical experimental anatomical data on the connectivity of homologous areas in the macaque monkey

The 8th edition of Wolff's Headache and Other Head Pain remains the definitive reference text in the field. Our knowledge and understanding of headache and its management have changed significantly in the twenty-first century. A new international headache classification has been adopted; headache pathophysiology and genetics have advanced; and epidemiologic studies have burgeoned. We have greater insights into the diagnosis and treatment of the secondary headaches. New treatments are available for primary headache disorders, including migraine, cluster, and chronic daily headache, and our understanding and knowledge are increasing by means of ongoing trials. The 8th edition encompasses all of this new material, with all chapters updated and many new authors added.

This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding the role of aging on the endocrine system. Guest edited by Anne Cappola, the topics covered include reproductive aging in women, thyroid disorders, testosterone administration, osteoporosis in older adults, hormonal therapeutics and more.

The Year Book of Neurology and Neurosurgery brings you abstracts of the articles that reported the year's breakthrough developments in neurology and neurosurgery, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Readers will find information on a range of topics, including Movement Disorders, Infectious Diseases of the Nervous System, Neoplastic Disease, Pediatric Neurology and Neurosurgery, Cerebrovascular, Neuro-oncology, and Spine. The Year Book of Neurology and Neurosurgery is published annually in June.

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

*Covers both hereditary and cryptogenic neurologic disorders

*Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology

*Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Reflecting a vast amount of new information concerning the functional characteristics of the various 5-HT receptor subtypes and the Na+-dependent serotonin transporter (SERT), this volume provides state of the art methodologies currently applied in serotonin research from leading experts in the field. Serotonin Receptor Technologies describes approaches that vary from molecular biological and biochemical techniques (e.g., regarding receptor dimerization), fluorescence microscopy and imaging applications, flow cytometry, the use of organotypic slice and cell cultures to the generation of genetically modified animal models and the development of sophisticated behavioral tests, thus covering a wide spectrum of techniques to study serotonergic signaling in detail. Written for the popular Neuromethods series, chapters include the kind of detail and practical advice that ensures successful results in the lab. Authoritative and convenient, Serotonin Receptor Technologies serves to foster both basic and translational research aiming to further deepen our understanding of the various facets of aminergic systems, as well as to aid research on similar problems with related GPCRs and neurotransmitter transporters.

The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology - not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults.

Just as pediatric neurology evolved as an identified specialtyas the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into somany subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertisethus is provided to some traineesthrough fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research.

Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed - brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care."

Cell Adhesion Molecules: Implications in Neurological Diseases contains review articles on recent developments in the field of neural cell adhesion molecules (CAMs). The main focus is on the role of cell adhesion molecules in various neurological and neurodegenerative diseases. This perspective has been essentially overlooked in recently published books on neural CAMs. In addition, the contributors cover many newly identified cell adhesion molecules and some that have not received much attention in recent years. This books fills an important gap in the currently available literature.

Dating Neurological Injury: A Forensic Guide for Radiologists, Other Expert Medical Witnesses, and Attorneys presents a unique way to approach the dating of neurological injury as imaged by modern computed tomography (CT), magnetic resonance (MR) and ultrasound (US). Chapters are presented in a logical progression beginning with the general appearance of normal brain and progressing to the way abnormalities manifest themselves. The emphasis in these discussions is on the appearance of edema and of hemorrhage, as these two findings are the brain's most common response to injury. This volume presents in a systematic fashion the principles involved in the interpretation of images of the central nervous system specifically in a medical-legal setting where concern exists about the occurrence and timing of an injury. Dating Neurological Injury: A Forensic Guide for Radiologists, Other Expert Medical Witnesses, and Attorneys is a welcome addition to institutional, medical, and legal libraries, and to the personal libraries of malpractice defense and plaintiff lawyers and physicians in the neurosciences (neurosurgery, neurology, neuropathology, and neuroradiology) involved in medical-legal issues.

This book provides a comprehensive, rigorous review of the long-term outcome literature in epilepsy surgery in both adults and children. Each chapter examines the long-term outcome literature in a separate domain; covering seizure control, social, vocational/educational and psychiatric outcomes. Behavior and cognition are also discussed. The clinical predictors of good and bad outcomes in each domain are described and the gaps in current knowledge are highlighted. Separate chapters examine the methodological challenges associated with long-term outcome studies and the special considerations associated with informed consent in this population. Long-Term Outcomes of Epilepsy Surgery in Adults and Children is essential reading for all members of multidisciplinary epilepsy surgery teams, including neurosurgeons, neurologists and neuropsychologists; it will enable these teams to counsel patients and parents who are considering epilepsy surgery as a therapeutic option.

Edited by leaders of the field, Rathan Subramaniam from Johns Hopkins and Jorge Barrio from UCLA, this issue of PET Clinics focuses on the evolving role of novel imaging techniques in negenerative and movement disorders common in the aged population.

Changes in the focus of neurological practice worldwide have led to the need for new standard texts that reflect the current state of this expanding area of clinical expertise. The second edition of the Handbook of Neurological Rehabilitation is a major reference source that fulfils this need, providing an invaluable resource for all professions that work with patients suffering from neurological disorders. It brings restorative neurology to the bedside and shows how a reiterative, goal-oriented, problem-solving training programme can benefit patients, sometimes on a scale not achieved by pharmacological or surgical interventions. The book is divided into three sections all of which have been updated. Section One explores the clinical and biological principles underpinning rehabilitation practice in the context of neurological disablement. Section Two describes the assessment, treatment, and management of the major physical, cognitive and behavioural impairments, and the resulting functional deficits that may follow or accompany neurological disease. The final section explores in more detail these problems and their management in relation to the more common specific disorders of the nervous system. The text emphasises the fact that rehabilitation is an ongoing process involving multidisciplinary problem-solving, goal-setting and education; in which organised care is more effective than unorganised care; and the breakdown of professional barriers within rehabilitation, to facilitate the use of combined treatment techniques, improves outcome. It describes the contribution made by neural reorganisation and compensatory mechanisms to recovery of function, focuses on the avoidance of secondary deficit, and explores the physical, cognitive, affective and behavioural problems that may occur after neurological damage. At a time when new medical technologies threaten to fragment the integrity of medical care at individual and societal levels, it is crucial that all those involved in the management of chronic neurological disease have a working knowledge of the contents of this book. Their perspective on clinical practice will then be truly integrated and holistic and their patients will benefit accordingly.

This issue of Physical Medicine and Rehabilitation Clinics, Guest Edited by Dr. Francois Bethoux, is devoted to the topic of Ambulation in Adults with Central Neurologic Disorders. Ambulation, or the restoration thereof, is an extremely important part of recovery from any number of ailments or surgeries, from stroke to hip replacements. This issue will focus on the restoration of ambulation in adults suffering from central neurologic disorders, which is a major area for physiatrists. It will include articles on MS, stroke, Parkinson's disease, and spinal cord injuries. It will also offer information on how to measure and analyze ambulation in recovery, and medical treatments to improve ambulation.

Borderline personality disorder is a diagnosis often given to those who have serious problems with self-image and mood, as well as with interpersonal relations. This text presents a journal of a 15-month course of therapy with a classic splitting borderline patient, followed by an in-depth analysis of the case from three very different, but ultimately converging, perspectives. While there is a large and growing literature on borderline personality disorder, Anatomy of a Splitting Borderline is the first book-length study of a borderline patient, expressly revealing facets of this mental illness and its therapeutic challenge that could only be summarized in previous, briefer case histories. Psychiatrists, psychoanalysts, psychologists, social workers, and those in training in these professions are the audience for this ground-breaking book.

This book explores and evaluates accounts and models of autistic reasoning and cognition from a computational standpoint. The author investigates the limitations and peculiarities of autistic reasoning and sets out a remediation strategy to be used by a wide range of psychologists and rehabilitation personnel and will also be appreciated by computer scientists who are interested in the practical implementation of reasoning. The author subjects the Theory of Mind (ToM) model to a formal analysis to investigate the limitations of autistic reasoning and proposes a formal model regarding mental attitudes and proposes a method to help those with autism navigate everyday living. Based on the concept of playing with computer based mental simulators, the NL_MAMS, is examined to see whether it is capable of modeling mental and emotional states of the real world to aid the emotional development of autistic children. Multiple autistic theories and strategies are also examined for possible computational cross-overs, providing researchers with a wide range of examples, tools and detailed case studies to work from. Computational Autism will be an essential read to behavioral specialists, researcher's, developers and designers who are interested in understanding and tackling the increasing prevalence of autism within modern society today.

It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), " "list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.
Philosophical and social concepts of pain; testimonials of chronic-pain patientsClinical data from pain patients brainsAdvances in noninvasive brain imaging for pain patientsCombining theoretical and empirical approaches to the analysis of pain-related brain functionManipulation of brain function in animal models Emerging neurotechnology principles for pain diagnostics and therapeutics"

Neurology abounds with eponyms--Babinski's sign, Guillian-Barre' sundrome, Alzheimer's disease, etc. Neurologists and neuroscientists, however, are often hazy about the origin of these terms. This book brings together 55 of the most common eponyms related to the neurological examination, neuroanatomy, and neurological diseases. The chapters have a uniform structure: a short biography, a discussion of and a quotation from the original publication, and a discussion of the subsequent evolution and significance of the eponym. Photographs of all but one of the eponymists have been included. The material is organized into sections on anatomy and pathology, symptoms and signs, reflexes and tests, clinical syndromes, and diseases and defects. The selection of eponyms was based on the frequency of use, familiarity of clinical neurologists with the concept, and the significance within neurology of the individual who coined the eponym. This volume covers some of the classic ideas in the history of clinical neurology. It will be of interest to neurologists, neuroscientists, medical historians, and their students and trainees.

The development of treatment strategies that can help patients with spinal cord injury to regain lost functions and an improved quality of life is a major medical challenge, and experimental spinal cord research has to meet these challenges by resolving fundamental problems, establishing a basis for possible novel treatment strategies of spinal cord injury, and motivating their clinical translation. In "Animal Models of Spinal Cord Repair," expert researchers examine a broad range of experimental models for research on spinal cord injury, how they have contributed to our current state of knowledge, and what their advantages are in the further advancement of spinal cord repair. With models from simple lamprey to non-human primates, the information presented is intended to guide the implementation of animal models for spinal cord repair as well as to raise the awareness of the relevance of experimental models which may not be in the current mainstream of this research. As a part of the "Neuromethods" series, this work contains the kind of detailed description and implementation advice to guarantee successful results in the laboratory.

Comprehensive and cutting-edge, "Animal Models of Spinal Cord Repair" presents the background information and hands-on methods descriptions, as well as the basic and clinical issues, needed to stimulate and guide researchers with different backgrounds towards the development of improved strategies for functionally relevant repair of the injured human spinal cord."

The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology - not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults.

Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into somany subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research.

Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed - brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care."

The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology - not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults.

Just as pediatric neurology evolved as an identified specialtyas the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into somany subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertisethus is provided to some traineesthrough fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research.

Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed - brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.
*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care."

Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.