Topics include: Pediatric Stroke; Stroke Mimics; Intracranial Hemorrhage; Transient Ischemic Attack; Intensive Care Management of Acute Ischemic Stroke; Endovascular and Neurosurgical Management of Acute Ischemic Stroke; Intravenous Thrombolysis in Acute Ischemic Stroke; Vertigo, Vertebrobasilar Disease and Posterior Circulation Ischemic Stroke; and Neuroimaging in Acute Stroke.

"Overall, this text is excellent, beautifully formatted, and contains many chapters on mild traumatic brain injury that would prove helpful to professionals working in this field. While the text is probably most suited for a graduate level class in a university curriculum, I think it would be an excellent resource for the practicing professional's library--the forensic expert, the life care planner, or the rehabilitation counselor."--The Rehabilitation Professional

" This] book will provide a valuable resource to neuropsychologists and non-neuropsychologists alike for many years into the future as the primary, one-stop shopping bank vault of information relating to symptom validity assessment in the very specialized world of mild traumatic brain injury."--Psychological Injury and Law

"The book is well written, engaging, and easy to read. It goes well beyond simply reviewing validity test literature, as numerous clinical issues related to both mTBI and validity testing are discussed, validity assessment in multiple clinical and forensic settings is described, and up-to-date research findings are provided. I would recommend this book to any clinician (or clinician in training) who wants a practical guide specifically devoted to integrating validity assessment techniques and outcomes into clinical work."--Archives of Clinical Neuropsychology

"This edited book is clearly the best in the field among the several that have just come out on the topic. The chapter authors are leaders in the field, and touch all important areas. The chapters form a logical sequence that make learning about the field easier, are well-written, and are filled with up-to-date scientific findings that will help practitioners navigate well this difficult area of neuropsychological forensic practice. I recommend the book without reservation and am sure it will be useful in guiding neuropsychological assessments and preparations for court." Gerald Young, PhD, C. Psych.
York University

"This book provides an excellent, singular shelf reference on the influence of motivational factors and the importance of symptom validating testing in the neuropsychological assessment of mild traumatic brain injury It] marks an essential resource for those who see patients with mild traumatic brain injury." Michael McCrea, PhD, ABPP-CN
Medical College of Wisconsin

"This outstanding volume is a unique contribution to the neuropsychologist's library, bringing together two of our most important and timely topics in one text: MTBI and validity assessment for effort, response bias and malingered symptomology This will be an important resource for some time to come and deserves a prominent place in every neuropsychologist's library." Joel E. Morgan, PhD, ABPP-CN
New Jersey Medical School

This authoritative volume is the first book specifically devoted to symptom validity assessment with individuals with a known or suspected history of mild traumatic brain injury (MTBI). It brings together leading experts in MTBI, symptom validity assessment, and malingering to provide a thorough and practical guide to the challenging task of assessing the validity of patient presentations after an MTBI. The book describes techniques that can drastically alter case conceptualization, treatment, and equitable allocation of resources. In addition to covering the most important symptom validity assessment methods, this timely volume provides guidance to clinicians on professional and research issues, and information on symptom validity testing in varied populations.

The book covers MTBI assessment in such specific settings and populations as clinical, forensic, sports, children, gerontological, and military. It also addresses professional issues such as providing feedback to patients about symptom validity, ethical issues, and diagnostic schemas. "Mild Traumatic Brain Injury "will provide neuropsychologists, referring health care providers, courts, disability insurance companies, the military, and athletic teams/leagues with the in-depth, current information that is critical for the accurate and ethical evaluation of MTBI. Key Features:

Provides in-depth, expert coverage of one of the most critical topics for clinical neuropsychologists Includes contributions from the leading authorities on both MTBI/post-concussive syndrome and malingering/symptom validity Covers assessment in such contexts as civil forensics, sports, military/veterans, and gerontological settings

The New Edition of this respected reference delivers complete, practical guidance on current electrodiagnostic techniques and their clinical applications for investigating problems of both the central and peripheral nervous systems. Completely revised and updated, this 5th Edition provides state-of-the-art knowledge on electroencephalography, electromyography, nerve conduction studies, evoked potentials, polysomnography, and electronystagmography. Deepen your understanding of the principles, scope, limitations, diagnostic importance, prognostic relevance, and complications for each technique. Visually grasp the technical and practical aspects of electrodiagnostic tests with almost 800 charts, figures, and tables. Rely on the knowledge, experience, and perspective of renowned expert Dr. Michael J. Aminoff and an international team of contributors comprised of a virtual "who's who" of clinical neurophysiology. Keep up with developments in the field through significant updates, including new chapters on Artifacts and Normal Variants in the Electroencephalogram; Microneurography; Clinical Applications of Nerve Excitability Testing; Ultrasound of Muscle and Nerve; The Blink Reflex and Other Brainstem Reflexes; Visual Evoked Potentials,Electroretinography and Other Diagnostic Approaches to the Visual System; and Magnetic Stimulation in Clinical Practice and Research. Access information on the go from your laptop or mobile device via expertconsult.com, featuring fully searchable text, and links to PubMed. Meet regulatory and professional standards and apply best practices with state-of-the-art guidance (for both non-specialists and specialists) emphasizing the clinical applications of each electrodiagnostic technique. Get easily actionable information and avoid mistakes with electrophysiologic findings integrated into the clinical context in which they are obtained. You cannot practice clinical neurophysiology without Aminoff.

Manual of Pediatric Neurology is an easy-to-read and easy-to-access text based on clinical scenarios. Emphasis is placed on signs and symptoms, diagnostic tests as needed, and practical advice on treatment for childhood neurologic disorders. The book comprises a collection of chapters that address frequently encountered pediatric scenarios in all clinical settings. These include the management of seizures in the emergency department, treatment of epilepsy in the outpatient setting, acute management of headaches and many more. The book also covers topics juxtaposed to neurology such as neonatal neurology, neurogenetics, and the management of stroke in children. Special attention is placed on commonly encountered neurological conditions such as Tourette' syndrome, neuromuscular illnesses, and CNS infections. Interpretation of frequently used tests such as EEG, CSF analysis, and nerve conduction testing is also covered. Finally, one chapter is devoted to the care of child neurology patients at the end of life, i.e. palliative care.

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment.
*Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment
*Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders
*A must have reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain"

This volume covers what is known regarding the natural history, basic biology, and clinical aspects, including imaging and treatment, of CNS metastasis. Three chapters cover the biology of the brain and brain metastases: molecular biology, includes what is known about specific genes/proteins involved in the process of metastasis and model systems to study brain metastasis; brain microenvironment, focuses on the resident cells of the microenvironment and their role in CNS metastasis; and the blood- brain barrier, includes a discussion of permeability with respect to brain metastases. A discussion of experimental imaging covers both the biology of brain metastasis from an imaging perspective and the use of imaging techniques to study brain metastases. The three clinical chapters discuss treatment options of surgery, chemotherapy, and radiation. The potential for novel targeted therapies is also addressed. Because of the uniqueness of the disease, leptomeningeal metastasis is discussed separately. The last chapter is devoted to quality of life issues associated with CNS metastasis.

Electromyography remains a main diagnostic tool within neurology. This issue of Neurologic Clinics addresses the most recent developments in the clinical application of EMG. Articles in this issue include: Nerve conduction studies: Basic Concepts and Patterns of Abnormalities; Needle Electromyography-Basic Concepts andInterpretation of Recorded Potentials;Electrodiagnostic Evaluation of Carpal TunnelSyndrome;Electrodiagnostic Evaluation of Ulnar Neuropathyand Other Upper Extremity Mononeuropathy; Lower Extremity Mononeuropathies;Electrodiagnostic Evaluation of Brachial Plexopathies; Evaluation ofRadiculopathies;Electrodiagnostic Approach to Motor NeuronDiseases;Electrophysiologic Findings in PeripheralNeuropathies; Evaluation of Neuromuscular Junction Disorders in the EMGLaboratory;Electrodiagnostic Findings inMyopathy;Electrodiagnostic Approach to CranialNeuropathies; Technical Issues with Nerve Conduction Studies and Needle EMG;andCoding and Reimbursement of ElectrodiagnosticStudies.

This issue on Sleep Electroencephalography (EEG) gives an overview of Electrophysiological readings in sleep with such articles as "The Nuts and Bolts of EEG? and "How the Sleep/Wake EEG Changes Across the Lifespan.? Identifying abnormal EEG activity and patterns in the Electroencephalographic readings is also discussed.? The issue then further focuses in on Seizures and the EEG; specifically, how EEG can be used to diagnosis and identify seizure disorders and differentiate seizures from other paroxysmal nocturnal events, and to diagnose other primary sleep disorders in people with epilepsy.

The Guest Editors have assembled expert authors to cover the full clinical span of the topic autism and autism spectrum disorders. An historical perspective of the evolution of the disorder opens the issue. Next, comprehensive coverage is given to an article on the definitions, diagnostic criteria, and clinical features of autism spectrum disorders. Other articles in the issue cover the relevant topics like epidemiology, genetic syndromes and genetic testing, early diagnosis and diagnostic evaluation, and neuroimaging and neurochemistry of autism. Authors also present information on tsocial skills for the autistic child, behavioral interventions, and transitioning the autistic child into adulthood, to name a few. This issue should be very well received by pediatricians.

Sleep Loss and Obesity: Intersecting Epidemics represents a major contribution to the field of sleep medicine. It is a comprehensive review of the neurobiology of sleep, circadian timing and obesity, the deleterious effects of sleep loss and obesity on health, and the worrisome associated social and medical costs in a range of patient populations and overall to society. The number of individuals who are obese has reached alarming levels. As a result, the incidence of Type 2 diabetes, cardiovascular disorders, heart disease, and kidney failure have also increased. The surgeon general estimates that the total annual cost of obesity in the US is about $117 billion. This cost is expected to escalate significantly because the number of overweight and obese children is increasing rapidly. Indeed, the new generation is expected to have a shorter life-span then their parents. In addition, sleep loss is emerging as an important contributing factor to obesity. People who sleep less or are sleep deprived tend to eat more, especially carbohydrates, and have a higher body mass index. Increased weight restricts the upper airway, causing obstructive sleep apnea and further sleep loss. In the end there is a vicious cycle of weight gain and sleep loss. In the past few years there has been a tremendous growth in our understanding of brain mechanisms controlling energy metabolism. Interestingly the neurons regulating waking also regulate feeding. There is also a mechanism that regulates the timing of feeding and sleep. In shift-workers this system is likely to be disturbed, and this has an adverse impact on both feeding and sleep. Sleep Loss and Obesity: Intersecting Epidemics is the first title to clearly examine how obesity and sleep loss are interacting epidemics. This fascinating title makes the link between energy metabolism, sleep and circadian timing; identifies poor sleep as a risk-factor for obesity in children and adults and offers treatment strategies for obstructive sleep apnea and obesity. This book will be a vital source of information for all physicians interested in sleep disorders and obesity. It will also be of value to neuroscientists, health system administrators, and policy makers.

Rapidly growing knowledge in systems neuroscience may contribute to expand the range of activities in persons with disabilities, but in its practical application, cooperation between experts in different research fields is necessary. In this conference, the guest speakers and audiences will be from wide range of research fields; e.g., systems-neuroscience, neurology, engineering, psychology, and the attendees will discuss the possibilities.

Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.

Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology.

These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms.
Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future researchChapters are extensively referenced to provide readers with a comprehensive list of resources on the topics coveredAll chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

There are more than 100 billion brain cells in our heads, and every single one represents a fragment of thought and feeling. And yet each cell is a mystery of beauty, with branching, intricate patterns like shattered glass. Richard Wingate has been scrutinizing them for decades, yet he is still moved when he looks at one through a microscope and traces their shape by hand. With absorbing lyricism and clarity, Wingate shows how each type of cell possesses its own personality and history, illustrating a milestone of scientific discovery and exploring the stories of pioneering scientists like Ramon y Cajal and Francis Crick, and capturing their own fascinating shapes and patterns. Discover the ethereal world of the brain with this elegant little book - and find out how we all think and feel.

Topics include: Neoplastic Meningitis and Epidural Metastases: Evaluation and Management; Management of Brain Metastases: Surgery, Radiation, or Both?; Meningiomas/Nerve Sheath Tumors/Pituitary Tumors: Diagnosis and Treatment; Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors: The Uncommon but Potentially Curable Primary Brain Tumors; Primary CNS Lymphoma: Overview of Current Treatment Strategies; Anaplastic Gliomas: Radiation, Chemotherapy, or Both?; Low Grade Gliomas: When and How to Treat?; Glioblastoma Multiforme: Overview of Current Treatment and Future Perspectives.

This volume highlights recent developments in neuro-oncology that are not only increasing the survival rate of patients, but also improving their quality of life. Through an in-depth exploration of new therapies, including advanced diagnostic tools and a fresh perspective on molecular biology, immunology, and the clinical aspects of tumors, clinicians will gain a critical understanding of emerging therapies and techniques. Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments are also explored, providing clinicians with new tools and tactics they can use to treat tumors of the nervous system.

Clinicians will find this handbook to be an invaluable resource for summarizing the present state of scientific and clinical knowledge in the field of neuro-oncology. In addition, practitioners in the field will uncover new tactics and therapies that will aid them in providing optimal neuro-oncological care for their patients.
* An invaluable resource that includes critical, in-depth insights into recent developments in neuro-oncology
* A fresh perspective on molecular biology, immunology, and other clinical aspects of tumors of the nervous system
* Extensive coverage of tumor management and new therapeutic strategies, including gene therapy and molecularly targeted treatments
* New tactics and therapies that will aid clinicians in their quest to provide optimal care for their neuro-oncological patients

This text presents difficult management issues surrounding women with epilepsy in a unique format. The Editors provide several controversial cases in adolescence, pre-conception, pregnancy and menopause with invited experts offering their differing opinions. The Editors compare the clinical approaches and build a consensus based on the best available evidence. Professionals charged with managing this challenging patient group will be given insights on providing the best possible care based on current available data and expert opinion.

Parasomnias can be roughly divided into Non-REM disorders and REM disorders, and this issue covers much of what is known today on the diagnosis and treatment of various types of parasomnias.? Articles examine disorders such as sleepwalking, sleep sex, sleep violence, sleep eating, and diagnostic methods of these.? The issue also delves into forensic concerns, especially with regard to sleep violence.? Other? types of parasomnias discussed include sleep talking and sleep enuresis.

'Wise, timely and eloquent... A joy to read.' Guardian What does it mean to be well? Is it something in our body? Or, is it rather something subjective - something of the mind? In this profound collection of clinical stories, eminent psychiatrist Dr Alastair Santhouse draws on his experience of treating thousands of hospital patients to show how our emotions are inextricably linked to our physical wellbeing. Our minds shape the way we understand and react to symptoms that we develop, dictate the treatments we receive, and influence whether they work. They even influence whether we develop symptoms at all. Written with brutal honesty, deep compassion, and a wry sense of humour, Head First examines difficult cases that illuminate some of our most puzzling and controversial medical issues-from the tragedy of suicide, to the stigma surrounding obesity, to the ongoing misery of chronic fatigue. Ultimately he finds that our medical model has failed us by promoting specialization and overlooking perhaps the single most important component of our health: our state of mind.

Diseases once believed to be confined to the tropics, such as parasitic, mycobacterial, fungal, bacterial, and viral infections are still a major cause of mortality and moribidity in the tropics, yet can affect the developed world in an era of increased global travel and migration. Neuroimaging technique developments over the last several decades have helped clinicians better understand and diagnose these conditions. Experts from tropical countries share their experiences regarding tropical disorders, some of which are rare in the western world, but possible to appear in patients and not readily recognized by specialists not familiar with these diseases.

Topics in this issue include: Relevance of neuroimaging in the diagnosis and management of tropical neurologic disorders; Pathology of Tropical Diseases; Viral Infections of the Central Nervous System; Central Nervous System Tuberculosis; Parasitic diseases of nervous system; Neuroimaging in Post-infectious Demyelination and Nutritional Disorders of the Central Nervous System; CNS Fungal Infections in the Tropics; Neuroimaging Epilepsy in the Tropics; Neuroimaging in Cranio-Vertebral Anomalies as seen in Tropics; Vascular Brain Pathologies; Neurobrucellosis; Hirayama Disease; Transverse Myelitis; and Pyomyositis.

This issue of Neurologic Clinics addresses the neurologic consequences of exposure to environmental toxins.

In this issue of Neurosurgery Clinics, Drs. Chang and? Barbaro provide a thorough look at epilepsy, with sections focusing on devices in epilepsy surgery, open loop systems, closed loop systems, and non-stimulation. Topics in this issue include history and overview of stimulation for epilepsy, trigeminal nerve stimulation, anterior thalamus DBS, hippocampal stimulation, neuropace RNS, seizure detection/prediction algorithms, cooling, seizure prediction and its applications, stimulation paradigms, and experimental stimulation.