Contents:
OVERVIEW
Allen, A. and Hollander, E. 'Body Dysmorphic Disorder.' Psychiatric Clinic of North America 23 (2000).
Groopman, J. 'The Doubting Disease: When is Obsession a Sickness?' The New Yorker (April 10, 2000).

EPIDEMIOLOGY
Horwath, E. and Weissman, M.M. 'The Epidemiology and Cross-National Presentation of Obsessive-Compulsive Disorder.' Psychiatric Clinic of North America 23 (2000).
Kadesjo, B. and Gillberg, C. 'Tourette's Disorder: Epidemiology and Comorbidity in Primary School Children.' Journal of the American Academy of Child and Adolescent Psychiatry 39 (2000).

GENETICS
Pauls, D.L., Raymond, C.L., Stevenson, J.M., and Leckman, J.F. 'A Family Study of Gilles de la Tourette Syndrome.' American Journal of Human Genetics 48 (1991).
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O.J. 3rd, Liang, K.Y., LaBuda, M., Walkup, J., Grados, M., and Hoehn-Saric, R. 'A Family Study of Obsessive-Compulsive Disorder.' Archives of General Psychiatry 57 (2000).

NATURAL HISTORY
Phillips, K.A., McElroy, S.L., Keck, P.E., Pope, H.G., and Hudson, J.I. 'Body Dysmorphic Disorder: 30 Cases of Imagined Ugliness.' American Journal of Psychiatry 2 (1993).
Riddle, M. 'Obsessive-Compulsive Disorder in Children and Adolescents.' British Journal of Psychiatry 35 (1998).
Skoog, G. and Skoog, I. 'A 40-Year Follow-Up of Patients with Obsessive-Compulsive Disorder.' Archives of General Psychiatry 56 (1999).

NEUROBIOLOGY OF DISEASE
Graybiel, A.M., and Rauch, S.L. 'Toward a Neurobiology of Obsessive-Compulsive Disorder.' Neuron 28 (2000).
Leckman, J.F., and Riddle, M.A., 'Tourette's Syndrome. When Habit-Forming Systems Form Habits of Their Own?' Neuron 28 (2000).
Saxena, S. and Rauch, S.L. 'Functional Neuroimaging and the Neuroanatomy of Obsessive-Compulsive Disorder.' Psychiatric Clinic of North America 23 (2000).
Swedo, S.E., Leonard, H.L., Garvey, M., Mittleman, B., Allen, A.J., Perlmutter, S., Lougee, L., Dow, S., Zamkoff, J., and Dubbert, B.K. 'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: Clinical Description of the First 50 Cases.' American Journal of Psychiatry 155 (1998).
Kurlan, R. 'Tourette's Syndrome and 'PANDAS': Will the Relation Bear Out? Pediatric Autoimmune Neuropsychiatric Disorders Associated with with Streptococcal Infection.' Neurology 50 (1998).
Peterson, B.S., Skudlarski, P., Anderson, A.W., Zhang, H., Gatenby, J.C., Lacadie, C.M., Leckman, J.F., and Gore, J.C. 'A Functional Magnetic Resonance Imaging Study of Tic Supression in Tourette's Syndrome.' Archives of General Psychiatry 55 (1998).
Szeszko, P.R., Robinson, D., Alvir, J.M., Bilder, R.M., Lencz, T., Ashtari, M., Wu, H., and Bogerts, B. 'Orbital Frontal and Amygdala Volume Reductions in Obsessive-Compulsive Disorder.' Archives of General Psychiatry 56 (1999).
Wolf, S.S., Jones, D.W., Knable, M.B., Gorey, J.G., Lee, K.S., Hyde, T.M., Coppola, R., and Weinberger, D.R. 'Tourette's Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding.' Science 273 (1996).

Contents:
OVERVIEW
National Institutes of Health Concensus Development Conference Statement Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder (1998).
Swanson, J.M., Sergeant, J.A., Taylor, E., Sonuga-Barke, E.J., Jensen, P.S,, and Cartwell, D.P., 'Attention-Deficit Hyperactivity Disorder and Hyperkinetic Disorder,' Lancet 351 (1998).

GENETICS
Cook, E.H. 'Genetics of Attention-Deficit Hyperactivity Disorder.' Mental Retardation and Developmental Disabilities Research Reviews 5 (1999).
Eaves, L.J., Silberg, J.L., Meyer, J.M., Maes, H.H., Simonoff, E., Pickles, A., Rutter, M., Neale, M.C., Reynolds, C.A., Erikson, M.T., Heath, A.C., Loeber, R., Truett, K.R., and Hewitt, J.K. 'Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development.' Journal of Child Psychology and Psychiatry and Allied Disciplines 38 (1997).

NATURAL HISTORY
Biederman, J., Faraone, S., Milberger, S., Guite, J., Mick, E., Chen, L., Mennin, D., Marrs, A., Ouellette, C., Moore, P., Spencer, T., Norman, D., Wilens, T., Kraus, I., and Perrin, J. 'A Prospective 4-Year Follow-Up Study of Attention-Deficit Hyperactivity and Related Disorders.' Archives of General Psychiatry 53 (1996),
Faraone, S.V., Biederman, J., Spencer, T., Wilens, T., Seidman, L.J., Mick, E., and Doyle, A.E. 'Attention-Deficit/Hyperactivity Disorder in Adults: An Overview.' Biological Psychiatry 48 (2000).

EVOLUTION
Jensen, P.S., Mrazek, D., Knapp, P.K., Steinberg, L., Pfeffer, C., Schowalter, J., and Shapiro, T. 'Evolution and Revolution in Child Psychiatry: ADHD as a Disorder of Adaptation.' Journal of the American Academy of Child Adolescent Psychiatry 36 (1997).

NEUROBIOLOGY OF DISEASE
Castellanos, F.X., Giedd, J.N., Marsh, W.L., Hamburger, S.D., Vaituzis, A.C., Dickstein, D.P., Sarfatti, S.E., Vauss, Y.C., Snell, J.W., Lange, N., Kaysen, D., Krain, A.L., Ritchie, G.F., Rajapakse, J.C., and Rapoport, J.L. 'Quantitative Brain Magnetic Resonance Imaging in Attention-Deficit Hyperactivity Disorder.' Archive of General Psychiatry 53 (1996).
Peterson, B.S., Leckman, J.F., Tucker, D., Scahill, L., Staib, L., Zhang, H., King, R., Cohen, D.J., Gore, J.C., and Lombroso, P. 'Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive- Compulsive, and Attention Deficit/Hyperactivity Disorders.'Archives of General Psychiatry 57 (2000).
Swanson, J., Castellanos, F.X., Murias, M., LaHoste, G., and Kennedy, J. 'Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder and Hyperkinetic Disorder.' Current Opinions in Neurobiology 8 (1998).
Zhuang, X., Oosting, R.S., Jones, S.R., Gainetdinov, R.R., Miller, G.W., Caron, M.G., and Hen, R. 'Hyperactivity and Impaired Response Habituation in Hyperdopaminergic Mice.' Proceedings of the National Academy of Sciences of the USA 98 (2001).

TREATMENT
MTA Cooperative Group. 'Moderators and Mediators of Treatment Response for Children with Attention-Deficit/Hyperactivity Disorder: The Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder.' Archives of General Psychiatry 56 (1999)
MTA Cooperative Group. 'A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder.' Archives of General Psychiatry 56 (1999).
Safer, D.J. and Malever, M. 'Stimulant Treatment in Maryland Public Schools.' Pediatrics 106 (2000).
Zito, J.M., Safer, D.J., dosReis, S., Gardner, J.F., Boles, M., and Lynch, F. 'Trends in the Prescribing of Psychotropic Medications to Preschoolers.' Journal of the American Medical Association 283 (2000).

Contents:
EPIDEMIOLOGY
Warner, L.A., Kessler, R.C., Hughes, M., Anthony, J.C., and Nelson, C.B. 'Prevalence and Correlates of Drug Use and Dependence in the United States. Results from the National Comorbidity Survey.' Archives of General Pychiatry 52 (1995).

GENETICS
Sigvardsson, S., Bohman, M., and Cloninger, C.R., 'Replication of the Stockholm Adoption Study of Alcoholism Confirmatory Cross-Fostering Analysis.' Archives of General Psychology 53 (1996).
Merikangas, K.R., Stolar, M., Stevens, D.E., Goulet, J., Preisig, M.A., Fenton, B., Zhang, H., O'Malley, S.S., and Rounsaville, B.J. 'Familial Transmission of Substance Use Disorders.' Archives of General Psychiatry 55 (1998).

NATURAL HISTORY
McLellan, A.T., Lewis, D.C., O'Brien, C.P., and Kleber, H.D. 'Drug Dependence, a Chronic Mental Illness: Implications for Treatment, Insurance, and Outcomes Evaluation.' Journal of the American Medical Association 284 (2000).
Schuckit, M.A., and Smith, T.L. 'An 8-Year Follow-Up of 450 Sons of Alcoholic and Control Subjects.' Archives of General Psychiatry 53 (1996).
Vaillant, G.E. 'A Long-Term Follow-Up of Male Alcohol Abuse.' Archives of General Psychiatry 53 (1996)

EVOLUTION
Nesse, Randolph M. 'An Evolutionary Perspective on Substance Abuse.' Ethology and Sociobiology 15 (1994).

NEUROBIOLOGY OF DISEASE
Berke, J.D., and Hyman, S.E. 'Addiction, Dopamine, and the Molecular Mechanisms of Memory.' Neuron 25 (2000).
O'Brien, Charles P., Childress, Anna Rose, Ehrman, Ronald, and Robbins, Steven J. 'Conditioning Factors in Drug Abuse: Can they Explain Compulsion?' Journal of Psychopharmacology 12 (1998).
Robinson, T.E. and Berridge, K.C. 'The Neural Basis of Drug Craving: An Incentive-Sensitization Theory of Addiction.' Brain Research Reviews 18 (1993).
Tiffany, Stephen T. 'A Cognitive Model of Drug Urges and Drug-Use Behavior: Role of Automatic and Nonautomatic Processes.' Psychological Review 97 (1990).
Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gatley, S.J., Hitzemann, R., Chen, A.D., Dewey, S.L., and Pappas, N. 'Decreased Striatal Dopaminergic Responsiveness in Detoxified Cocaine-Dependent Subjects.' Nature 386 (1997).

The Science of Mental Health is a one-stop resource for major issues and classic controversies in mental health. To create this valuable collection, a leading expert in the field has reviewed thousands of articles in hundreds of scientific journals. The result is an authoritative selection that represents the most significant research worldwide and provides a uniquely balanced perspective on the field.

Contents:
OVERVIEW
McEwen, B.S., 'Allostasis and Allostatic Load: Implications for Neuropsychopharmacology.' Neuropsychopharmacology 22 (2000).

STRESS AND MEMORY
Cahill, L., Prins, B., Weber, M., and McGaugh, J.L. 'Beta-Adrenergic Activation and Memory for Emotional Events.' Nature 371 (1994).
de Quervain, D.J., Roozendaal, B., and McGaugh, J.L. 'Stress and Glucocorticoids Impair Retrieval of Long-Term Spatial Memory.' Nature 394 (1998).

STRESS, CHILD ABUSE, AND BRAIN DEVELOPMENT
Francis, D., Diorio, J., Liu, D., and Meaney, M.J., 'Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat.' Science 286 (1999).
Heim, C., Newport, D.J., Heit, S., Graham, Y.P., Wilcox, M., Bonsall, R., Miller, A.H., and Nemeroff, C.B. 'Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood.' Journal of American Medical Association 284 (2000).
Maccari, S., Piazza, P.V., Kabbaj, M., Barbazanges, A., Simon, H., and Le Moal, M. 'Adoption Reverses the Long-Term Impairment in Glucocorticoid Feedback Induced by Prenatal Stress.' Journal of Neuroscience 15 (1995).

DEGENERATION AND REGENERATION
Gould, E., Tanapat, P., McEwen, B.S., Flugge, G., and Fuchs, E. 'Proliferation of Granule Cell Precursors in the Dentate Gyrus of Adult Monkeys Is Diminished by Stress.' Proceedings of the National Academy of Sciences of the USA 95 (1998).
Sapolsky, R.M., Uno, H., Rebert, C.S., and Finch, C.E. 'Hippocampal Damage Associated with Prolonged Glucocorticoid Exposure in Primates.' Journal of Neuroscience 10 (1990).
Sapolsky, R.M. 'Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders.' Archive of General Psychiatry 57 (2000).

STRESS AND DRUG ADDICTION
Piazza, P.V. and Le Moal, M. 'The Role of Stress in Drug Self-Administration.' Trends in Pharmacological Sciences 19 (1998).

STRESS AND DEPRESSION
Wong, M.L., Kling, M.A., Munson, P.J., Listwak, S., Licinio, J., Prolo, P., Karp, B., McCutcheon, I.E., Geracioti, T.D., Jr., DeBellis, M.D., Rice, K.C., Goldstein, D.S., Veldhuis, J.D., Chrousos, G.P., Oldfield, E.H., McCann, S.M., and Gold, P.W. 'Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with Melancholic Features: Relation to Hypercortisolism and Corticotropin-Releasing Hormone.' Proceedings of the National Academy of Sciences of the USA 97 (2000).

STRESS AND HEALTH
Marmot, M.G., Smith, G.D., Stansfeld, S., Patel, C., North, F., Head, J., White, I., Brunner, E., and Feeney, A. 'Health Inequalities Among British Civil Servants: The Whitehall II Study.' Lancet 337 (1991).
Marmot, M.G., Bosma, H., Hemingway, H., Brunner, E., and Stansfeld, S. 'Contribution of Job Control and Other Risk Factors to Social Variations in Coronary Heart Disease Incidence.' Lancet 350 (1997).

INTERVENTIONS
Habib, K.E., Weld, K.P., Rice, K.C., Pushkas, J., Champoux, M., Listwak, S., Webster, E.L., Atkinson, A.J., Schulkin, J., Contoreggi, C., Chrousos, G.P., McCann, S.M., Suomi, S.J., Higley, J.D., and Gold, P.W. 'Oral Administration of a Corticotropin-Releasing Hormone Receptor Antagonist Significantly Attenuates Behavioral, Neuroendocrine, and Autonomic Responses to Stress in Primates.' Proceedings of the National Academy of Sciences of the USA 97 (2000).

Contents:
OVERVIEW
Liebowitz, M.R., Gorman, J.M., Fyer, A.J., and Klein, D.F. 'Social Phobia: Review of a Neglected Anxiety Disorder,' Archives of General Psychiatry 42 (1985).
Yonker, K.A., Warshaw, M.G., Massion, A.O., and Keller, M.D., 'Phenomenology and Course of Generalized Anxiety Disorder,' British Journal of Psychiatry 168 (1996).

EPIDEMIOLOGY
Kessler, R.C., DuPont, R.L., Berglund, P., and Wittchen, H.U., 'Impairment in Pure and Comorbid Generalized Anxiety Disorder and Major Depression 12 Months in two National Surveys.' American Journal of Psychiatry 156 (1999).
Weissman, M.M., Bland, R.C., Canino, G.J., Faravelli, C., Greenwald, S., Hwu, H.G., Joyce, P.R., Karam, E.G., Lee, C.K., Lellouch, J., Lepine, J.P., Newman, S.C., Oakley-Browne, M.A., Rubio-Stipec, M., Wells, J.E., Wickramaratne, P.J., Wittchen, H.U., and Yeh, E.K. 'The Cross-National Epidemiology of Panic Disorder.' Archives of General Psychiatry 54 (1997).

GENES AND ENVIRONMENT
Biederman, J., Faraone, S.V., Hirshfeld-Becker. D.R., Friedman, D., Robin, J.A., and Rosenbaum, J.F. 'Patterns of Psychopathology and Dysfunction in High-Risk Children of Parents with Panic Disorder and Major Depression.' American Journal of Psychiatry 158 (2001).
Finn, C.T., and Smoller, J.W. 'The Genetics of Panic Disorder.' Current Psychiatric Reports 3 (2001).
Merikangas, K.R., Avenevoli, S., Dierker, L., and Grillon, C. 'Vulnerability Factors Among Children at Risk for Anxiety Disorders.' Biological Psychiatry 1 (1999).

NATURAL HISTORY
Kagan, J. and Snidman, N. 'Early Childhood Predictors of Adult Anxiety Disorders.' Biological Psychiatry 46 (1999).
Katsching, H. and Amering, M. 'The Long-Term Course of Panic Disorder and its Predictors.' Journal of Clinical Psychopharmacology 18 (1998).
Shalev, A.Y., Freedman, S., Peri, T., Brandes, D., Sahar, T., Orr, S.P., and Pitman, R.K. 'Prospective Study of Posttraumatic Stress Disorder and Depression Following Trauma.' American Journal of Psychiatry 155 (1998).

CO-OCCURENCE OF ANXIETY DISORDERS AND OTHER ILLNESSES
Merikangas, K.R., Stevens, D.E., Fenton, B., Stolar, M., O'Malley, S., Woods, S.W., and Risch, N. 'Co-Morbidity and Familial Aggregation of Alcoholism and Anxiety Disorders.' Psychological Medicine 28 (1998).
Mineka, S., Watson, D., and Clark, L.A. 'Comorbidity of Anxiety and Unipolar Mood Disorders.' Annual Review of Psychology 49 (1998).
Regier, D.A., Rae, D.S., Narrow, W.E., Kaelber, C.R., and Schztzberg, A.F. 'Prevalence of Anxiety Disorders and Their Comorbidity with Mood and Addictive Disorders.' British Journal of Psychiatry 173 (1998).

EVOLUTION
Marks, I.M. and Nesse, R.M. 'Fear and Fitness: An Evolutionary Analysis of Anxiety Disorders.' Ethology and Sociobiology 15 (1994)

BRAIN AND BEHAVIOR
Bouton, M.E., Mineka, S., and Barlow, D.H., 'A Modern Learning Theory Perspective on the Etiology of the Panic Disorder.' Psychological Review 108 (2001).
Buchel, C., Morris, J., Dolan, R.J., and Friston, K.J. 'Brain Systems Mediating Aversive Conditioning: An Event-Related fMRI Study.' Neuron 20 (1998).
Cahill, L. and McGaugh, J.L. 'Mechanisms of Emotional Arousal and Lasting Declarative Memory.' Trends in Neuroscience 21 (1998).
Caldji, C., Francis, D., Sharma, S., Plotsky, P.M., and Meaney, M.J., 'The Effects of Early Rearing Environment on the Development of GABAA and Central Benzodiazephine Receptor Levels and Novelty-Induced Fearfulness in the Rat.' Neuropsychopharmacology 22 (2000).
Fendt, M. and Fanselow, M.S. 'The Neuroanatomical and Neurochemical Basis of Conditioned Fear.' Neuroscience and Biobehavioral Review 23 (1999).
Garcia, R., Vouimba, R-M., Baudry, M., and Thompson, R.F. 'The Amygdala Modulates Prefrontal Cortex Activity Relative to Conditioned Fear.' Nature 402 (1999).
Gorman, J.M., Kent, J.M.., Sullivan, G.M., and Coplan, J.D. 'Neuroanatomical Hypotheses of Panic Disorder, Revised.' American Journal of Psychiatry 157 (2000).
LeDoux, J.E. 'Emotion Circuits in the Brain.' Annual Review of Neuroscience 23 (2000).
Phelps, E.A., O'Connor, K.J., Gatenby, J.C., Gore, J.C., Grillon, C., and Davis, M. 'Activation of the Left Amygdala to a Cognitive Representation of Fear.' Nature Neuroscience 4 (2001).
Rauch, S.L., Whalen, P.J., Shin, L.M., McInerney, S.C., Macklin, M.L., Lasko, N.B., Orr, S.P., and Pitman, R.K. 'Exaggerated Amygdala Response to Masked Facial Stimuli in Posttraumatic Stress Disorder: A Functional MRI Study.' Biological Psychiatry 47 (2000).

TREATMENT
Barlow, D.H., Gorman, J.M., Shear, M.K., and Woods, S.W. 'Cognitive-Behavioral Therapy, Imipramine, or Their Combination for Panic Disorder: A Randomized Controlled Trial.' Journal of the American Medical Association 283 (2000).
Low, K., Crestani, F., Keist, R., Benke, D., Brunig, I., Benson, J.A., Fritschy, J.M., Rulicke, T., Bluethmann, H., Mohler, H., and Rudolph, U., 'Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety.' Science 6 (2000).

Contents:
OVERVIEW
Cloninger, C.R. 'A Systematic Method for the Clinical Description and Classification of Personality Variants.' Archives of General Psychiatry 44 (1987).
Costa, P.T. and McCrae, R.R. 'The Five-Factor Model of Personality and Its Relevance to Personality Disorders.' Journal of Personality Disorders 6 (1992).
Goldberg, L.R. 'An Alternative 'Description of Personality': The Big-Five Factor Structure.' Journal Personality and Social Psychology 59 (1990).
Mischel, W. and Shoda, Y. 'Reconciling Processing Dynamics and Personality Dispositions.' Annual Review of Psychology 49 (1998).
Widiger, T.A. and Costa, P.T.Jr. 'Personality and Personality Disorders.' Journal of Abnormal Psychology 103 (1994).

GENES AND ENVIRONMENT
Bouchard, T.J. Jr., Lykken, D.T., McGue, M., Segal, N.L., and Tellegen, A. 'Sources of Human Psychological Differences: The Minnesota Study of Twins Reared Apart.' Science 250 (1990).
Eaves, L., Heath, A., Martin, N., Maies, H., Neaale, M., Kendler, K., Kirk, K., and Corey, L. 'Comparing the Biological and Cultural Inheritance of Personality and Social Attitudes in the Virginia 30,000 Study of Twins and Their Relatives.' Twin Research 2 (1999).
Harris, J.R. 'Where Is the Child's Environment? A Group Socialization Theory Development.' Psychological Review 102 (1995).
Hewitt, J.K., Silberg, J.L., Rutter, M., Simonoff, E., Meyer, J.M., Maes, H., Pickles, A., Neale, M.C., loeber, R., Erickson, M.T., Kendler, K.S., Heath, A.C., Truett, K.R., Reynolds, C.A., and Eaves, L.J. 'Genetics and Developmental Psychopathology: 1. Phenotypic Assessment in the Virginia Twin Study of Adolescent Behavioural Development.' Journal of Child Psychology and Psychiatry and Allied Disciplines 38 (1997).
Johnson, J.G., Cohen, P., Brown, J., Smailes, E.M., and Bernstein, D.P. 'Childhood Maltreatment Increases Risk for Personality Disorders During Early Adulthood.' Archives of General Psychiatry 56 (1999).
Kendler, K.S., Neale, M.C., Kessler, R.C., Heath, A.C., and Eaves, L.J. 'A Test of the Equal-Environment Assumption in Twin Studies of Psychiatric Illness.' Behaviour Genetics 23 (1993).
Maccoby, E.E. 'Parenting and Its Effects on Children: On Reading and Misreading Behaviour Genetics.' Annual Review of Psychology 51 (2000).
Tellegen, A., Lykken, D.R., Bouchard, T.J., Wilcox, K.J., Segal, N.L., and Rich, S. 'Personality Similarity in Twins Reared Apart and Together.' Journal of Personality and Social Psychology 54 (1988).

NATURAL HISTORY
Moffitt, T.E. 'Adolescence-Limited and Life-Course Persistent Antisocial Behaviour. A Developmental Taxonomy.' Psychological Review 100 (1999).

NEUROBIOLOGY AND BEHAVIOUR
Anderson, S.W., Bechara, A., Damasio, H., Tranel, D., and Damasio, A.R., 'Impairment of Social and Moral Behaviour Related to Early Damage in Human Prefrontal Cortex.' Nature Neuroscience 2 (1999).
Damasio, A.R., Tranel, D., and Damsio, H., 'Individuals with Sociopathic Behaviour Caused by Frontal Damage Fail to Respond Autonomically to Social Stimuli.' Behavioral Brain Research 41 (1990).
Davidson, R.J., Putnam, K.M., and Larson, C.L. 'Dysfunction in the Neural Circuitry of Emotion Regulation-A Possible Prelude to Violence.' Science^M 289 (2000).

TREATMENT
Koerner, K., and Linehan, M.M. 'Research on Dialectical Behavior Therapy for Patients with Borderline Personality Disorder.' Psychiatric Clinic of North America (2000).

Contents:
OVERVIEW
Sachs, G.S. 'A 25-Year-Old Woman with Bipolar Disorder.' Journal of the American Medical Association 285 (2001).

EPIDEMIOLOGY
Kessler, R.C., Rubinow, D.R., Holmes, C., Abelson, J.M., and Zhao, S. 'The Epidemiology of DSM-III-R Bipolar Disorder in a General Population Survey.' Psychological Medicine 27 (1997)

Genetics
Craddock, N. and Jones, I. 'Genetics of Bipolar Disorder.' Journal of Medical Genetics 36 (1999).

NATURAL HISTORY
Angst, J. and Sellaro, R. 'Historical Perspectives and Natural History of Bipolar Disorder.' Biological Psychiatry 48 (2000).
Kilzieh, N. and Akiskal, H.S. 'Rapid-Cycling Bipolar Disorder. An Overview of Research and Clinical Experience.' Psychiatric Clinics of North America 22 (1999).
Jamison, K.R. 'Suicide and Bipolar Disorder.' Journal of Clinical Psychiatry 61 (2000).
Sanchez, L., Hagino, O., Weller, R. 'Bipolarity in Children.' Psychiatric Clinics of North America 22 (1999).

EVOLUTION
Wilson, D.R. 'Evolutionary Epidemiology and Manic Depression.' British Journal of Medical Psychology 71 (1998).

NEUROBIOLOGY OF DISEASE
Blumberg, H.P., Stern, E., Martinez, D., Ricketts, S., de Asis, J., White, T., Epstein, J., McBride, P.A., Eidelberg, D., Kocsis, J.H., and Silbersweig, D.A. 'Increased Anterior Cingulate and Caudate Activity in Bipolar Mania.' Biological Psychiatry 48 (2000).
Leibenluft, E., Albert, P.S., Rosenthal, N.E., and Wehr, T.A. 'Relationship Between Sleep and Mood in Patients with Rapid-Cycling Bipolar Disorder.' Psychiatry Research 31 (1996)
Ikonomov, O.C. and Manji, H.K. 'Molecular Mechanisms Underlying Mood Stabilization in Manic-Depressive Illness: The Phenotype Challenge.' American Journal of Psychiatry 156 (1999)
Manji, H.K. and Lenox, R,H. 'Signaling: Cellular Insights into the Pathophysiology of Bipolar Disorder.' Biological Psychiatry 48 (2000)

TREATMENT AND TREATMENT MECHANISMS
Frank, E., Swartz, H.A., and Kupfer, D.J. 'Interpersonal and Social Rhythm Therapy: Managing the Chaos of Bipolar Disorder.' Biological Psychiatry 48 (2000).
Berridge, M.J., Downes, C.P., and Hanley, M.R. 'Neural and Developmental Actions of Lithium: A Unifying Hypothesis.' Cell 59 (1989)
Klein, P.S. and Melton, D.A. 'A Molecular Mechanism for the Effect of Lithium on Development.' Proceedings of the National Academy of Sciences of the USA 93 (1996).
Schou, M. 'Forty Years of Lithium Treatment.' Archives of General Psychiatry 54 (1997).

From pediatric to the elderly, from contractible to refractive, this bestselling short text contains 110 cases covering all aspects of epilepsy. Each case follows the same format.

eBook available with sample pages: 0203213335

Providing key information and insight into the experiences of people living with a diagnosis of young onset dementia, this book will increase the knowledge and skills of health and social care professionals in the early recognition, diagnosis and support of young people with dementia and their families. The book explores the experiences of people living with a diagnosis of young onset dementia through detailed case studies, and gives learning points to implement in practice for the better provision of appropriate support and care. It explains the need for adapting services which are often designed for older people, and how the complicated diagnostic process can lead to misdiagnosis among younger people. Key issues are considered, including at-risk groups, work and dealing with potential loss of employment, changes in personal and family relationships, readjusting life expectations and plans, and social isolation.

The somatosensory system is unique in that it conveys information to the central nervous system (CNS) about both external and internal sensory environments. Recent technological and conceptual advances in the field have allowed great strides to be made in the description and understanding of how the CNS manages information about its own image. This knowledge, apart from its obvious scientific merit, is quickly leading to clinical applications in the realm of neurorehabilitation after the peripheral nerve injury and during recovery from stroke.

The Somatosensory System: Deciphering the Brain's Own Body Image presents both new and past research in the understanding of how the brain deals with its own body image. It provides a review of pertinent literature and offers comprehensive descriptions of state-of-the-art technical approaches. The material includes new frameworks for the conceptualization of the system's representations, scientific and clinical applications that stem from these approaches based on the new concepts, and a discussion of new directions and new tools for the study of the interface of the brain and the body.

In all industrialized countries, closed head injuries are responsible for vast numbers of hospital admissions and days of work lost. For instance, about 120,000 patients are admitted to hospital in the United Kingdom each year with a diagnosis that reflects closed head injury. Such injuries are a major cause of deaths following accidents, especially those that involve children and young people, and they are also a major cause of handicap and morbidity among the survivors. This clinical condition is intrinsically a neurological one, but its proper evaluation demands an understanding of the associated psychology and psychopathology. At the same time, a major neurological condition with such a high level of incidence ought to be extremely informative about the functioning of the human brain and hence provide a major focus for neuropsychological investigation.; In this book, the author seeks to integrate these two different perspectives by reviewing the clinical and neuropsychological aspects of closed head injury in a manner that is equally intelligible to researchers interested in the effects of brain damage upon human behaviour and to practitioners who are responsible for the assessm

Written by world experts in the field of neuronal chemoreception, Methods in Chemosensory Research describes new molecular, electrophysiological, genetic, behavioral, psychophysical, and imaging techniques that have recently been adapted to investigate the basic neuronal mechanisms underlying chemoreception: taste, olfaction and chemical-induced irritation. This unique book includes a wide variety of new and innovative imaging methods, electrophysiological methods, methods to investigate development, and various aspects of behavioral testing.

Covering the entire spectrum of chemoreception, each section not only describes what information can be obtained by using each method, but also shows how to apply each method to obtain reliable results. The book presents a comprehensive view of how the brain uses information about chemical stimuli that interact with receptors in the nose and tongue. Methods in Chemosensory Research gives you the new tools to learn how chemicals affect activity from the genetic to the behavioral levels.

Life at Home for People with a Dementia provides an evidence-based and readable account of improving life at home for people with a dementia and their families. There are estimated to be 47 million people with a dementia worldwide, the majority of whom will live, or want to live, in their own home. Yet there is a major shortcoming in available knowledge on what life is like for people with a dementia living at home. Most research focuses on care in hospitals or care homes, and takes a medical perspective. This book bridges this gap in knowledge by providing a comprehensive and critical overview of the best available evidence on enabling people with a dementia to live well at home from the viewpoint of those living with the condition, and in the context of global policy drivers on ageing and health, as well as technological advances. The book includes chapters on citizenships - that is, the diversity of people living with a dementia - enabling life at home, rethinking self-management, the ethics and care of people with a dementia at home, technological care and citizenship, and sharing responsibilities. It concludes with a care manifesto in which we set out a vision for improving life at home for people with a dementia that covers the areas of professional practice, education and care research. By covering a wide range of interrelated topics to advance understanding and practice as to how people with a dementia from diverse backgrounds can be supported to live well at home, this book provides a synthesised, critical and readable understanding of the complexities and risks involved.

This book presents the most comprehensive review of research regarding personality and motivational differences in persons with mental retardation. From the personal commentary of Edward Zigler, H. Carl Haywood, and Harvey N. Switzky, the book summarizes the classical work of the Yale and Peabody-Vanderbilt School over the last 40 years. A sampling of new directions in research is provided, including work on self-determination theory and practice; decision making; direct and indirect effects of genetic mental retardation syndromes on personality; personality and psychopathology in genetic mental retardation syndromes; a new theory of information processing linking cognition, motivation, and performance; and a sensitivity theory of motivation. This definitive work presents older and evolving newer models and applications to the field in order to demonstrate the power of motivational variables in understanding the behavior of persons with mental retardation. The purpose is to enhance the quality of life in persons with mental retardation and other developmental disabilities.

Neuroplasticity, Development, and Steroid Hormone Action explores the effects of steroid hormones on brain development, function, and aging and is a compilation of cutting-edge research of concern to the disciplines of neurobiology, neuroendocrinology, endocrinology, and developmental biology. The experimental approaches covered range from molecular to behavioral and endocrine to neurobiological. The authors are noted neurobiologists and active researchers from the United States, Japan, and the United Kingdom.

Divided into five sections and containing scientific photographs, line drawings, tables, color illustrations, and graphs, this interesting and timely text covers the neuroplastic effects of steroid hormones throughout the lifetime of various animal models, such as bees, fish, lizards, turtles, birds, mice, rats, and primates. These sections focus on:
Ÿ The development and differentiation of neuroendocrine systems
Ÿ Steroid dependent brain differentiation
Ÿ The central regulation of hormone secretion
Ÿ Steroid hormones and neuroplasticity in the mature brain
Ÿ Steroid mediated mechanisms of cell growth and survival

Traumatic injuries of the spinal cord continue to be the most common cause of permanent paralysis in young adults in the United States. New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves demonstrating that dendrites of injured motoneurons take on characteristics of axons. These and other new developments have helped to promote an exciting new era in the study of spinal cord neurobiology.

Motor Neurobiology of the Spinal Cord provides a description of the recent conceptual and technical advances in the field. It provides a description of the new experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture. It covers topics ranging from genetics to kinematics and examines cells, tissues, or whole animals in species ranging from fish to humans that are normal, injured, or diseased.

By integrating data derived from many new approaches, you'll learn about how spinal cord circuits operate under a variety conditions and about new and exciting inroads being made in motor neurobiology of the spinal cord. Motor Neurobiology of the Spinal Cord elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease.

The transition to secondary school can be a daunting time for parents of autistic youngsters, as well as children themselves. Have you selected the right place? What if staff don't really understand your child's needs? Will they adapt sufficiently - and if not, then what happens? The good news is that you have the ability as a parent or carer to address these concerns, rather than leaving it all to chance. This book will give you the tools to do just that. From choosing the right school for your child (and spotting the tell-tale signs of the wrong one), to preparing both your child and the new school for the transition, to overcoming barriers and building a positive, collaborative and effective relationship between home and school. Tackling key topics from the point of view of both parent and teacher and using examples of great practice, this contains everything you need to know in order to build a more positive secondary school experience for your child.

This book presents fifty neurological cases form on which consultant neurologists at the National Hospital for Neurology and Neurosurgery have provided their expert comments. Each case is presented with history, examination, investigations, diagnosis and comment by an expert.

This pocketbook catalogs the adverse effects of over 260 commonly prescribed and over-the-counter generic drugs and herbals used in neurology. It lists the generic drugs, herbals and supplements in alphabetical order and the adverse reactions that can arise from their use.

This volume contains a collection of papers written by former students, postdoctoral fellows, and colleagues of Richard Thompson and represent written versions of papers presented at the Festschrift symposium. The Festschrift provided an excellent opportunity for the participants to recount their memories and experiences of working with one of the leading figures in behavioral neuroscience, and to place their current research in the context of earlier research conducted in the Thompson laboratory.
As a Festschrift volume, the various chapters contain numerous and sometimes very personal references to Richard Thompson's influence on the careers of the authors, as well as summaries of past and present work being conducted in the authors' laboratories. Part I includes studies of spinal cord plasticity and the involvement of the hippocampus and related structure in classical eyeblink conditioning. Part II explores the critical role of the cerebellum and associated areas in classical eyeblink conditioning. Part III focuses on a continued exploration of the involvement of the cerebellum in classical eyeblink conditioning using standard procedures as well as innovative molecular biology and genetic techniques. It also includes studies aimed at delineating modulatory influences on learning such as stress and hormonal factors.
The incredible influence that Richard Thompson has had on the fields of experimental psychology and neuroscience should be evident on reading the contributions made by the various authors to this volume. The research conducted in Thompson's laboratory over the years has been cutting-edge, comprehensive, and influential. Therefore, this volume is dedicated to Richard F. Thompson a productive, innovative scientist and outstanding mentor.

This book is the first attempt at bringing together a volume of work from a range of professionals with an interest in spasticity. The framework for the definition was developed in part by the authors contributing chapters that make up this volume. The book represents the current "state-of-the-art" regarding definition, measurement, pathophysiology (all state-of-the-art summaries) and simultaneously gives clinicians guidance on clinical management. This work combines coverage of both spasticity and contractures as these two phenomena are often closely interrelated. Current researchers do not differentiate between these individual impairments and, as such, there is significant confusion in the literature. This book discusses both conditions and then separates them into their respective components. If these two conditions co-exist (which is generally the case), then the management of a patient will need to be customized to individual clinical presentation. The clinical sections of the book are all written by currently practicing, and research active, clinicians, and the earlier chapters are written by researchers currently working on spasticity. In summary, this book: Provides information that is clinically relevant and strongly researched Includes clinical studies covering both spasticity and contractures, which is unique Presents editors and contributors that are world-class experts Takes a cookbook approach to measurements in clinical studies and research Contains extensive references that are included at the end of each chapter

Cognitive Stimulation Therapy (CST) has made a huge global, clinical impact since its inception, and this landmark book is the first to draw all the published research together in one place. Edited by experts in the intervention, including members of the workgroup who initially developed the therapy, Cognitive Stimulation Therapy for Dementia features contributions from authors across the globe, providing a broad overview of the entire research programme. The book demonstrates how CST can significantly improve cognition and quality of life for people with dementia, and offers insight on the theory and mechanisms of change, as well as discussion of the practical implementation of CST in a range of clinical settings. Drawing from several research studies, the book also includes a section on culturally adapting and translating CST, with case studies from countries such as Japan, New Zealand and Sub-Saharan Africa. Cognitive Stimulation Therapy for Dementia will be essential reading for academics, researchers and postgraduate students involved in the study of dementia, gerontology and cognitive rehabilitation. It will also be of interest to health professionals, including psychologists, psychiatrists, occupational therapists, nurses and social workers.

This book provides insight and information to physicians, nurses, therapists, and administrators for the stroke center who are planning and evolving the programs necessary to organize care for better outcomes, regardless of the size of the hospital or available workforce.

Dr. Jose A. Valciukas, in Foundations of Environmental and Occupational Neurotoxicology, has written a thorough, lively, and educational study on toxic substances and their effects. Written in a manner that is accessible to both professionals and non-professionals, Dr. Valciukas explains how health and human behavior may be adversely affected by neurotoxins. He introduces his study with a history of environmental and occupational neurotoxicology.