Mechanisms controlling aggressive behavior started to be identified from late 20's of the 20th century and subsequent research described such mechanisms in great detail. While the findings are of great relevance for the understanding of aggression per se, they provide limited insights into the mechanisms of abnormal aggression i.e. those mechanisms that underlie aggression-related psychopathologies. While basic phenomena and mechanism of aggression are presented, this book is the first that comprehensively describes ultimate and proximate mechanisms that transform normal (laboratory animals) or tolerable (humans) manifestations of aggressiveness into abnormal patterns in laboratory animals and aggression-related psychopathologies in humans. This book is written for behavioral neurobiologists and neuroscientists, interested in emotional control in general and aggression research in particular. The book will also offer important information to neurologists and psychiatrists dealing with aggressive behavior in the clinic and ultimately, may provide means to understand and on the long run to discover novel approaches to the treatment of abnormal human aggression.

This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

"Neurological Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer s disease, Parkinson s disease, Huntington disease, ALS, and the epilepsies. "Neurological Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the second volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
- Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process
- Critical evaluation of animal and translational models improving transition from drug discovery and clinical development
- Emphasis on what results mean to the overall drug discovery process
- Exploration of issues in clinical trial design and conductance in each therapeutic area"

This volume provides a vital and comprehensive resource on stroke, including research, diagnosis, prevention, and treatment modalities. Practitioners in these fields will find invaluable information in this handbook, from basic mechanisms of the disease, to enhanced diagnostic and therapeutic capabilities for patient care.

With the field of cerebrovascular disorders, including stroke, making rapid advancements, clinicians will find illuminating and insightful chapters on the pathophysiological basis of this disorder.

Advances in our understanding of the biochemical background of strokes, coupled with an examination of breakthroughs in epidemiology, genetics, neuroimaging, interventional radiology, surgery, and even clinical psychology are also explored, giving researchers and clinicians a profoundly altered way to approach stroke research, diagnosis, and patient treatment and care.
* A comprehensive resource on stroke, prevention techniques, diagnosis, and treatment modalities
* Illuminating and insightful information on the pathophysiological basis of stroke
* A thorough examination of the rapid advancements made in the field of cerebrovascular disorders and their applications to stroke

This volume provides a comprehensive guide to the manifestations and pathogenesis involved with stroke, including advancements in research and a newfound understanding of the biochemical background of this cerebrovascular disorder.

This intensive handbook is meant to give clinicians a source reference that will enable them to gain a thorough knowledge and understanding of the clinical features and management of the many neurological manifestations of stroke disorder.

In addition, practitioners, clinicians, and researchers will gain a better understanding of highly studied topics, including amongst others, the medical complications associated with stroke, chapters on anterior circulation and hemorrhagic stroke syndromes, stroke related psychiatric disorders, and other rare causes of stroke disorder.
* A comprehensive source that thoroughly examines the neurological manifestations of stroke
* A guide to highly studied topics, including stroke complications, syndromes, and stroke related psychiatric disorders
* A better understanding of the pathophysiological basis of strokes that will help practitioners better diagnose, prevent, and improve patient care

This volume provides a comprehensive exploration of stroke, from basic mechanisms of disease to enhanced diagnostic and therapeutic capabilities. The ongoing efforts within the neurological community are also highlighted, bringing a better understanding of the pathophysiological basis of this disorder.

Clinicians will find invaluable information that can be used to enhance the lives of an aging global population. Covered topics include the functional anatomy of the brain itself, as well as advancements in the understanding of the biochemical background of strokes.

Related fields and their dramatic impact on stroke research are also included, with findings in the fields of epidemiology, genetics, neuroimaging, and interventional radiology thoroughly explored. In addition, great attention is paid to therapeutic avenues, including investigation, prevention, and patient management.
* A comprehensive resource for information on diagnostic advancements, prevention, and treatment of strokes
* A clinical perspective on the ways related fields such as epidemiology, genetics, and neuroimaging, amongst others, are impacting new research in this disorder
* A foundation that will enable researchers to pursue new clinical investigations

DESCRIPTION:
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. Articles in this volume discuss ion transport;
ocular aquaporins and aqueous humor dynamics;
the role of Ggap junction channels in the ciliary body secretory epithelium; regional dependence of inflow; functional modulators linking Iinflow with outflow of aqueous humor; aqueous humor outflow resistance; aqueous humor dynamics; the effects of circulatory events on
aqueous humor inflow and intraocular pressure; retinal ganglion cells and glaucoma; what functional genomics is teaching us about intraocular pressure regulation and glaucoma;
molecular approaches to glaucoma; outflow signaling mechanisms and new therapeutic strategies for the control of intraocular pressure.
*Guest edited by cell membrane experts
*Dynamic and thorough coverage of all aspects of the aqueous humor from inflow to outflow
*Provides the latest teachings on genomics and glaucoma
*Highlights new therapeutic strategies for the control of intraocular pressure

This volume contains the papers presented at the 15th International Symposium on Hearing (ISH), which was held at the Hotel Regio, Santa Marta de Tormes, Salamanca, Spain, between 1st and 5th June 2009. Since its inception in 1969, this Symposium has been a forum of excellence for debating the neurophysiological basis of auditory perception, with computational models as tools to test and unify physiological and perceptual theories. Every paper in this symposium includes two of the following: auditory physiology, psychoph- ics or modeling. The topics range from cochlear physiology to auditory attention and learning. While the symposium is always hosted by European countries, p- ticipants come from all over the world and are among the leaders in their fields. The result is an outstanding symposium, which has been described by some as a "world summit of auditory research. " The current volume has a bottom-up structure from "simpler" physiological to more "complex" perceptual phenomena and follows the order of presentations at the meeting. Parts I to III are dedicated to information processing in the peripheral au- tory system and its implications for auditory masking, spectral processing, and c- ing. Part IV focuses on the physiological bases of pitch and timbre perception. Part V is dedicated to binaural hearing. Parts VI and VII cover recent advances in und- standing speech processing and perception and auditory scene analysis. Part VIII focuses on the neurophysiological bases of novelty detection, attention, and learning.

In this book, we approach neurophysiology at the interface of neurology and clinical neurophysiology. The medical disciplines of the nervous system, n- rology and clinical neurophysiology, rest heavily on other sciences, notably cellular biology, neuro-anatomy, neuro-physiology, applied physics and ma- ematical biology. Existing medical textbooks on neurophysiology, neurology and clinical neurophysiology are an excellent source of the phenomenology of various principles and diseases. Here, we choose to elucidate some of the under- ing physiological, physical processes and experimental methods, intended for a broad audience - medical residents and students, as well as students in the emerging area of medical technical sciences. We feel that a good understanding of fundamentals may signi?cantly - hance insight into various aspects of clinical neurology and clinical neu- physiology. This book, therefore, is focused on a selection of clinical signs and symptoms to highlight basic principles of neurology, (neuro-)physiology and neuroanatomy. While we believe this text to be of interest to medical students or residents in neurology or clinical neurophysiology, we speci?cally aim at students - terested in contributing to new developments and innovations in neurology and clinical neurophysiology. These students are involved with patients, even though they are not trained for routine patient care.

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous sub-disciplines and subspecialties. This volume pulls all of the critical information into one volume eliminating the need to search through numerous books and journals which can be exhaustive and demanding. It provides cardiovascular physiologists with an integrated, in-depth evaluation of the latest research developments and will aide in developing new pathways of research and scholarship.
Key Features
* Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship.
* Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume.

Although we no longer live in the relative simplicity of the Jurassic age, and even though we are not aware of them, primitive mammalian brain that developed in that era still live on inside our skulls and remain crucial to our daily functions. The challenges we face today in the information age--how to process the vastly greater, more varied and quickly changing inputs we receive--are very different from those that our ancestors faced during the Jurassic age. As we struggle to process overwhelming amounts of information, we may sometimes ask whether our brains can change to help us adapt. In fact, our brains have always changed gradually, so the questions we should ask are really how our brains will change, and whether we will be able to take full advantage of the changes, perhaps even enhance them, to help us keep up with the accelerating evolution of machines. To understand how our brains will change, we need to understand how they evolved in the first place, as well as how the interactions of the resulting brain structures, including the relics of primitive mammalian and even reptilian processes, influence how we think and act.
In Mind from Body, Don Tucker, one of the most original thinkers about organic information processing, provides a fascinating analysis of how our brains have become what they are today and speculates intriguingly about what they could be tomorrow. He presents important research that explains how personal experience creates the emotional and motivational bases of each of our thoughts, even though we are usually not aware that it is happening. Tucker shows that in exploring how these bodily thought processes still determine how we react to the world andmake decisions, we can become more rational in our actions, free ourselves from fruitless or even self-destructive patterns of behavior, become more efficient, and perhaps even wiser. By combining the most up-to-date scientific thought and hands-on experimental results, expressed clearly and compellingly, along with a story of hypothetical decision-making, Tucker explicates what is happening behind our thought processes as our minds struggle to maintain the pace of the information age.

This volume provides concise and comprehensive information on neuromuscular disorders, including rapid advancements in the understanding of the neurobiology of neuromuscular transmission. In addition, clinicians will find timely discussions on the various forms of these disorders that have been discovered due to increased study within the field.

New observations into the immunopathogenesis of myasthenia gravis, and the molecular mechanisms underlying the links between activity and patterns of gene expression, particularly in muscle, are also explored, along with novel information on the understanding of the pathophysiology of the heterogeneous group of peripheral nerve hyperexcitability syndromes.

Each of these valuable insights, and their accompanying explanations, provides a framework on which new therapeutic strategies can be built to aid in the enhancement and restoration of normal function in neuromuscular junction disorders.
* New insights into the study of neuromuscular junction disorders, including rapid advancements in the field
* Comprehensive information on the neuromuscular junction, and a detailed examination of myasthenia gravis and other disorders
* A new framework upon which to build therapeutic strategies that will enhance the restoration of normal function in neuromuscular disorders

This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.

Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

This volume surveys the recent advances and provide an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.

The proposed book will act as a guide for scientists and clinicians to the unique information that MRS can provide. It will be a comprehensive overview of clinical and pre-clinical MRS applications and potential clinical utility of MRS biomarkers in degenerative brain diseases from leading experts in the field. MRS has proven to be a powerful complementary tool to MRI for the diagnosis and monitoring of disease progression and response to treatment because it can detect changes in cell density, cell type, and biochemical composition, not just structural changes. As the population in the developed world continues to age, neuroimaging for diagnosis, prognosis, and therapy monitoring of neurodegenerative diseases becomes increasingly important and there has been a recent surge of clinical and pre-clinical applications of MRS indicating that this technique can provide robust and non-invasive biomarkers of degeneration.

Written specifically for the clinical neuropsychologist who does forensic consultations, the book is a comprehensive review by experts of the procedures available to evaluate malingered neuropsychological deficits. It discusses tools for detecting atypical patterns of performance on standard clinical tests as well as malingering on measures of perception and sensorimotor function, of attention, processing speed, and memory, and of executive function. The underpinnings of the forensic neuropsychology enterprise are presented in chapters on definitions of malingering, research designs for its evaluation, data on the frequency with which malingering occurs, diagnostic classification statistics, symptom validity tests that do not depend on forced choice testing, and those that do. Guidance on assessing exaggerated psychiatric symptoms; exaggerated medical symptoms and injuries; and detecting malingering during the neurological exam is also included. Of particular note is a chapter devoted to the topic of coaching. The book closes with a review of the diagnostic criteria for malingering and looks to the future with evidence-based proposals for improving the criteria.

Now in its sixth best-selling edition, The Human Nervous System: Structure and Function continues to combine clear prose with high quality tailor-made medical illustrations to achieve for neuroscientists and medical students a succinct explanation of the fundamental principles behind the organization, structure, and function of the human nervous system. The distinguished authors take advantage of the many recent advances in neurobiology and molecular biology to include new coverage of such critical discoveries as stem cells, apoptosis, the role of the amygdala in stress, and the significance of dendritic spines. Among the core topics given expanded treatments are pain and pain pathways, the visual system, development and growth of the nervous system, the chemical senses of smell and taste, and the limbic system. There is also fresh material on neuronal stem cells, the auditory and vestibular systems, neurotransmitters as the chemical messengers of certain brain circuits, the cerebellum, and lesions of the spinal nerves, spinal cord, and brainstem. The superb illustrations are designed to extract and visually highlight the essence of the neuroanatomical features embedded in the complexities of the nervous system, thereby allowing the reader to match the structures of the brain with conventional X-ray pictures, and CT, MRI, and PET scans.

The authors, specialists in the UK, draw on developmental theory to propose a model of practice specifically for dementia care. The number of people who suffer from dementia is increasing and in consequence the problems it presents are affecting a growing number of therapists and carers. Many of these problems are peculiar to dementia and the models of care used with other client groups have proved inadequate when dealing with the provision of quality of care to people who have dementia. This revised edition contains a new opening chapter which brings our understanding of dementia up-to-date. The book looks at the relationship between occupation, wellbeing and dementia and examines the critical role of the carer in developing therapeutic interventions.

The book summarises the current understanding of the Nervous -, Endocrine and Immune systems with emphasis on shared mediators and receptors and functional interaction. In addition to the fundamental physiological and pathophysiological mechanisms, which are presented in detail, some clinically relevant subjects are also presented, such as inflammation, asthma and allergy, autoimmune disease, immunodeficiency and the acute phase response.

- A comprehensive presentation of neuroimmune biology
- Introduces the subject matter to the uninformed reader
- Contains basic information, theoretical considerations and up-to-date clinical chapters
- The clinical chapters will be helpful to practising physicians

Since its first application, microdialysis has become incredibly popular to study brain function and has been applied with success in different fields from psychopharmacology, neurobiology, and physiology in animals and also humans. "Microdialysis Techniques in Neuroscience" focuses on the practical aspects of microdialysis in animal and human, highlighting current technical limitations and providing a vision of what is yet to come for the determination of the most disparate compounds in the brain. The book s contents range from new techniques for detection and quantifying the release of several different neurotransmitters in vitro and in vivo, even in freely moving animals, to sophisticated use of reverse dialysis and the application of microdialysis in pharmacokinetic studies. Each of the sixteen chapters, in fitting with the spirit of the "Neuromethods" series, contain an introduction that gives a broad overview of a focused topic, followed by an extensive protocol on how the experiments are performed along with invaluable practical advice.

Detailed and authoritative, "Microdialysis Techniques in Neuroscience" will be a valuable reference for students, neuroscientists, and physicians for the use of microdialysis in the study of brain functions and its clinical applications."