Neuro-Oncology-a new title in the Blue Books of Practical Neurology series-is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist. Access comprehensive coverage of treatment for adult and pediatric conditions-including tumors of the spinal cord as well as the brain. Find coverage of recent advances easily thanks to the emphasis on the latest clinical and laboratory findings and their implications for clinical management and treatment. Apply the possibilities and outcomes of neuro-oncologic surgery within the context of neurologic practice. Address the neurologic complications of cancer and its treatment as well as of primary and secondary tumors. Tap into the global perspectives of experts from all around the world for a multi-disciplinary approach to practice.

This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed 'amyloid'. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer's disease-related dementia and Parkinson's disease, as well as other less prevalent conditions like Huntington's disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others. The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry.

The book is organized into four interconnected volumes: Neuropsychological Endophenotypes and Biomarkers (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers, Metabolic and Peripheral Biomarkers and Molecular Genetic and Genomic Markers . The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health. "

This book presents the neurobiology of orthodontics according to the most recently acquired knowledge on the interaction of the brain activity with the senses. In particular, it highlights the ability of orofacial sensory input to modulate and change the brain activity underlying functions of the stomatognathic system, such as chewing, biting, speech, and occlusal feedback. The approach adopted thereby represents a significant departure from traditional orthodontics, in which malocclusions of the teeth have been interpreted as deriving from DNA coding errors. The described new conceptualization of the etiology and diagnosis of malocclusions has profound implications for orthodontic therapy, as is clearly explained. Orthodontic therapy in turn has significant effects on the brain, which are documented in a chapter devoted to neuroimaging methods. By opening up new and creative pathways in the world of orthodontics, this book will hopefully both educate and excite the practitioner. It is recommended reading for all orthodontists.

Fibromyalgia is a syndrome of wide spread pain that is known from all parts of the world. An aspect of the syndrome of fibromyalgia is fluctuation as in onset of pain, variation in the level of symptoms, time off from pain and recovery from pain and other symptoms. The analysis of these fluctuations might create a basis for solid suggestions regarding the nature of the syn-drome itself. E.g. the pain level is well known to vary with mental and physical load including exposure to cold. Simultaneously, fibromyalgia has been found to mean an altered balance in the autonomic nervous system. In the first section of the book a developmental stage or life before fibromyalgia is covered. Intra- and interpersonal patterns based on narrations of the afflicted are pictured. Identified patterns are psychometrically examined and environmental as well as psychobiological patterns are accounted for. In the mid-section of the book life with fibromyalgia is scrutinized including biomarkers. Patterns regarding variation in the level of pain, gaps in fibromyalgia pain and environmental factors influencing these gaps are related. The effect on life, symptoms and defense measures is elucidated from the angle of mental load. The last sections portrait psychological and environmental influences concerning recovery, but especially the striking phenomenon of recovery being scarce. Special attention is paid to cognitive-emotional functioning, the need to target dissociation and environmental influences on maintenance.

In the fast-paced world of health care clinical effectiveness relies not only upon medical, but also administrative competence. This issue of Neurologic Clinics features 14 articles from experts in their respective areas of office management. Articles include practice and compensation models; negotiating with payers; using benchmarks; web based neurology resources (clinical); web based neurology resources (practice management); use of electronic health records in neurology practice; hot topics in risk management; HIPPA and other regulatory issues; ethical issues; new concepts in residency and fellowship training; using evidence based medicine; P4P and PQRI; patient education; and the future of neurology.

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Is a pear sweeter than a peach? Which of Mona Lisa's hands is crossed over the other? What would the Moonlight Sonata sound like played by a brass band? Although these are questions that appeal to mental imagery in a variety of sensory modalities, mental imagery research has been dominated by visual imagery. With the emergence of a well-established multisensory research community, however, it is time to look at mental imagery in a wider sensory context. Part I of this book provides overviews of unisensory imagery in each sensory modality, including motor imagery, together with discussions of multisensory and cross-modal interactions, synesthesia, imagery in the blind and following brain damage, and methodological considerations. Part II reviews the application of mental imagery research in a range of settings including individual differences, skilled performance such as sports and surgical training, psychopathology and therapy, through to stroke rehabilitation. This combination of comprehensive coverage of the senses with reviews from both theoretical and applied perspectives not only complements the growing multisensory literature but also responds to recent calls for translational research in the multisensory field.

From the award-winning author of "Angel of Death" comes a comprehensive and engaging narrative of mankind's battle against polio.
For much of the twentieth century, polio inspired terror as the 'morning paralysis' which could invade any home and disable or kill a previously healthy person. The cruelty of the disease is epitomised by the iconic images of the crippled child and the iron lung.
This is the story of mankind's struggle against polio, is compelling, exciting and full of twists and pardoxes. One of the grand challenges of modern medicine, it was a battleground between good and bad science. Some research won Nobel Prizes; other work was flawed or fraudulent, holding up progress and endangering patients' lives. Gareth Williams takes an original view of the journey to understanding and defeating polio, exploring the profoundly moving experiences of victims alongside the medical and scientific landmarks in the history of the disease.
Praise for "Angel of Death: "
'An engaging narrative, in which medical history is interweaved with social history and reflections on contemporary issues' "BBC History Magazine "
""
'Wonderful. Wonderfully-researched, vividly-written, an example of medical history at its absolute best."'" Michael Neve

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Guest Editor Adre du Plessis addresses Neonatal Neurology in this issue of Clinics in Perinatology, a companion to his September 2009 issue on Fetal Neurology. Mechanisms and management of acute brain injury is reviewed, including articles on Systemic and cerebral transitional hemodynamics in premature infants, Hypoxic-ischemic brain injury in the term infant, Neuroprotection in the newborn infant, Intracranial hemorrhage in the premature and term newborn, Infection-inflammatory mechanisms of brain injury in the newborn, Neonatal stroke, and Neonatal seizures. Next, Neurodiagnostic advances for the newborn infant is explored, with articles covering, Advanced brain MRI techniques, Advances in Near Infrared Spectroscopy, and Bedside electrocortical monitoring. The issue closes with a section devoted to Longterm neurologic outcome: Mechanisms of dysfunction and recovery, with articles on Longterm outcome in premature infants, Mechanisms of Cerebral Plasticity, The longterm effects of neonatal seizures, Constraint-induced therapy: Plasticity in practice, and Neonatal brain injury and autistic spectrum disorders in survivors.

Five-year-old Tommy killed himself at home, where he lived with parents who said he was unwanted and deficient. College student Jennifer committed suicide by swallowing a huge mixture of pills at a motel, miles from the house where she lived with an imposing, unemotional mother who'd long thought the girl a burden. Bob, a father of two and computer company manager, might have survived his attempt at suicide, but his wife did not call 911 for 10 minutes after she found him in his running car in the garage, so he died on the way to the hospital. All of these cases described in detail by author Mecke share a factor aside from the fatality. Each person was clearly motivated by an instigator: someone who provoked the suicide. Instigators create a crushing relationship with a potentially suicidal person that, as Mecke puts it, becomes a "fatal attachment." Mecke, with more than 40 years experience as clinical psychologist, believes instigators are responsible in a significant number of the more than 30,000 suicides that occur in the United States each year. Through vivid and compelling text, we understand the minds of suicide victims and their instigators, and also learn how early trauma associated with death or abandonment can make one become an instigator. Finally, Mecke shows us how we can intervene to try and break the instigator's grip, to foil the attachment. As she explains one of her primary points, relating to both the suicidal and their instigators, is that children require careful nurturing especially during their early lives. "And the bent their personalities take following a trauma places responsibility upon us all to watch, to explain, to care for them." In addition to tragicstories drawn from her practice, Mecke also describes the instigators in larger scale suicides and those of historical figures--from the cult suicide of hundreds moved by Jim Jones at Jamestown, and the suicide bombings motivated by Osama bin Laden, to the suicide of poet Sylvia Plath and the person who precipitated her death. Classical literature and Greek mythology is also used extensively to address the issue of what triggers suicide. The insights apply universally. This is a must-read for clinicians, counselors, and anyone interested in knowing about suicide and its causes.

Behavioral neuroscience encompasses the disciplines of neurobiology and psychology to study mechanisms of behavior. This volume provides a contemporary overview of the current state of how ethics informs behavioral neuroscience research. There is dual emphasis on ethical challenges in experimental animal approaches and in clinical and nonclinical research involving human participants.

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

With recent advancements in new knowledge, it has become evident that psychostimulants and related drugs of abuse are influencing our central nervous system (CNS) remarkably and could alter their function for a longtime. This volume is the first to focus on substance abuse induced brain pathology in the widest sense as it covers alterations in neuronal, glial and endothelial cell functions under the influence of acute or chronic usage of substance abuse.

Published since 1959, "International Review of Neurobiology" is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume is a collection of articles covering "Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. "Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.

This serial is firmly established as an extensive documentation of the advances in contemporary brain research. Each volume presents authoritative reviews and original articles by invited specialists. This volume concentrates on coma and consciousness science. presenting articles from leading figures in the area on the clinical and ethical implications of work in this field. The book provides a thorough review of the various aspects of coma science from a review of the concepts, questioning of recent advances, case studies, through to where research in the field is heading.

* Provides the reader with a unique overview of all aspects of new advances in coma science

* Broad focus with contributions by the top scientists worldwide in the respective disciplines

This fully revised 2e provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader s understanding.
More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
"

This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

Informed by the author's work in dementia care and palliative care as a psychodynamic psychotherapist, Holding Time contributes to an increasing recognition of the importance and value of relationship-centred care in this field. Most of the book is written ethnographically and unfolds as a narrative. It also includes the real words of staff and residents from the care homes in which she conducted observations. Holding Time explores how the relational investment in care is vital alongside a technical one. The book does this by detailing the micro-interactions of everyday care and concern and play before moving out on to a wider, organisational and macro stage. It addresses our fears about dependency on a societal level, and attempts to challenge the foregrounding of the independent, rational individual over all other experiences. The author's contribution is particular to the UK dementia care home setting, and offers a predominantly psychoanalytic take. It is a contemporary exploration of the dementia care field, and contributes to the general movement to improve care of those living (and working) with dementia.

This volume brings together noted scientists who study presbycusis from the perspective of complementary disciplines, for a review of the current state of knowledge on the aging auditory system. Age-related hearing loss (ARHL) is one of the top three most common chronic health conditions affecting individuals aged 65 years and older. The high prevalence of age-related hearing loss compels audiologists, otolaryngologists, and auditory neuroscientists alike to understand the neural, genetic and molecular mechanisms underlying this disorder. A comprehensive understanding of these factors is needed so that effective prevention, intervention, and rehabilitative strategies can be developed to ameliorate the myriad of behavioral manifestations.

The aim is to provide students and researchers in auditory science and aging with a understanding of the various effects of aging on the auditory system.

Contents:

• Introduction and Overview Sandra Gordon-Salant and Robert D. Frisina
• The Physiology of Cochlear Presbyacusis Richard A. Schmiedt
• The Cell Biology and Physiology of the Aging Central Auditory Pathway Barbara Canlon, Robert Benjamin Illing, and Joseph Walton
  
• Closing the Gap between Neurobiology and Human Presbycusis: Behavioral and Evoked Potential Studies of Age-related Hearing Loss in Animal Models and in Humans James R. Ison, Kelly L. Tremblay, and Paul D. Allen
• Behavioral Studies with Aging Humans: Hearing Sensitivity and Psychoacoustics Peter J. Fitzgibbons and Sandra Gordon-Salant.
• Binaural Processing and Auditory Asymmetries David A. Eddins and Joseph W. Hall III

• The Effects of Senescent Changes in Audition and Cognition on Spoken Language Comprehension Bruce A. Schneider, Kathy Pichora-Fuller, and Meredyth Daneman
• Factors Affecting Speech Understanding in Older Adults Larry E. Humes and Judy R. Dubno
• Epidemiology of Age-related Hearing Impairment Karen J. Cruickshanks, Weihai Zhan, and Wenjun Zhong
• Interventions and Future Therapies: Lessons from Animal Models James F. Willott and Jochen Schacht

Sandra Gordon-Salant is Professor and Director of the Doctoral Program in Clinical Audiology in the Department of Hearing and Speech Sciences at the University of Maryland, College Park. Robert D. Frisina is Professor of Otolaryngology, Neurobiology & Anatomy, and Biomedical Engineering, and Associate Chair of Otolaryngology at the University of Rochester Medical School. Arthur N. Popper is Professor in the Department of Biology and Co-Director of the Center for Comparative and Evolutionary Biology of Hearing at the University of Maryland, College Park. Richard R. Fay is Director of the Parmly Hearing Institute and Professor of Psychology at Loyola University of Chicago.

About the series:

The Springer Handbook of Auditory Research presents a series of synthetic reviews of fundamental topics dealing with auditory systems. Each volume is independent and authoritative; taken as a set, this series is the definitive resource in the field.

Interest in the study of peripheral nerve repair and regeneration has increased significantly over the last twenty yearsandtoday the number of nerve reconstructions performed is progressively increasing due to the continuous improvement in surgical technology and to the spread of microsurgical skills among surgeons worldwide.

This volume of "International Review of Neurobiology "providdes an overview of the state of the art knowledge in peripheral nerve repair and regeneration by bringing together a number of reviews that critically address some the most important issues in this biomedical field."

This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer's disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson's disease and Huntington's disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab. Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases.