The importance of chloride ions in cell physiology has not been
fully recognized until recently, in spite of the fact that chloride
(Cl-), together with bicarbonate, is the most abundant free anion
in animal cells, and performs or determines fundamental biological
functions in all tissues. For many years it was thought that Cl-
was distributed in thermodynamic equilibrium across the plasma
membrane of most cells. Research carried out during the last couple
of decades has led to a dramatic change in this simplistic view. We
now know that most animal cells, neurons included, exhibit a
non-equilibrium distribution of Cl- across their plasma membranes.
Over the last 10 to 15 years, with the growth of molecular biology
and the advent of new optical methods, an enormous amount of
exciting new information has become available on the molecular
structure and function of Cl- channels and carriers. In nerve
cells, Cl- channels and carriers play key functional roles in GABA-
and glycine-mediated synaptic inhibition, neuronal growth and
development, extracellular potassium scavenging,
sensory-transduction, neurotransmitter uptake and cell volume
control. Disruption of Cl- homeostasis in neurons underlies
pathological conditions such as epilepsy, deafness, imbalance,
brain edema and ischemia, pain and neurogenic inflammation. This
book is about how chloride ions are regulated and how they cross
the plasma membrane of neurons. It spans from molecular structure
and function of carriers and channels involved in Cl- transport to
their role in various diseases.
* The first comprehensive book on the structure, molecular biology,
cell physiology, and role in diseases of chloride transporters /
channels in the nervous system in almost 20 years
* Chloride is the most abundant free anion in animal cells. THis
book summarizes and integrates for the first time the important
research of the past two decades that has shown that Cl- channels
and carriers play key functional roles in GABA- and
glycine-mediated synaptic inhibition, neuronal growth and
development, extracellular potassium scavenging,
sensory-transduction, neurotransmitter uptake and cell volume
control.
* The first book that systematically discusses the result of
disruption of Cl- homeostasis in neurons which underlies
pathological conditions such as epilepsy, deafness, imbalance,
brain edema and ischemia, pain and neurogenic inflammation.
* Spanning topics from molecular structure and function of carriers
and channels involved in Cl- transport to their role in various
diseases.
* Involves all of the leading researchers in the field.
* INcludes an extensive introductory section that covers basic
thermodynamic and kinetics aspects of Cl- transport, as well as
current methods for studying Cl- regulation, spanning from
fluorescent dyes in single cells to knock-out models to make the
book available for a growing population of graduate students and
postdocs entering the field.
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