"Neurological Disorders" is written for researchers in both
academia and the pharmaceutical industry who use animal models in
research and development of drugs for neurological disorders such
as neurofibromatosis, Alzheimer s disease, Parkinson s disease,
Huntington disease, ALS, and the epilepsies. "Neurological
Disorders "has introductory chapters expressing the view of the
role and relevance of animal models for drug discovery and
development for the treatment of psychiatric disorders from the
perspective of (a) academic basic neuroscientific research, (b)
applied pharmaceutical drug discovery and development, and (c)
issues of clinical trial design and regulatory agencies
limitations. Each volume examines the rationale, use, robustness
and limitations of animal models in each therapeutic area covered
and discuss the use of animal models for target identification and
validation. The clinical relevance of animal models is discussed in
terms of major limitations in cross-species comparisons, clinical
trial design of drug candidates, and how clinical trial endpoints
could be improved. The aim of this series of volumes on "Animal and
Translational Models for CNS Drug Discovery" is to identify and
provide common endpoints between species that can serve to inform
both the clinic and the bench with the information needed to
accelerate clinically-effective CNS drug discovery.
This is the second volume in the three volume-set, "Animal and
Translational Models for CNS Drug Discovery" 978-0-12-373861-5,
which is also available for purchase individually.
- Clinical, academic, government and industry perspectives
fostering integrated communication between principle participants
at all stages of the drug discovery process
- Critical evaluation of animal and translational models improving
transition from drug discovery and clinical development
- Emphasis on what results mean to the overall drug discovery
process
- Exploration of issues in clinical trial design and conductance in
each therapeutic area"
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