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Books > Academic & Education > Professional & Technical > Pharmacology

Histopathology of Preclinical Toxicity Studies - Interpretation and Relevance in Drug Safety Evaluation (Hardcover, 4th... Histopathology of Preclinical Toxicity Studies - Interpretation and Relevance in Drug Safety Evaluation (Hardcover, 4th edition)
Peter Greaves
R3,403 R3,125 Discovery Miles 31 250 Save R278 (8%) Shipped within 7 - 12 working days

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

NEW TO THE FOURTH EDITION:

*This edition is in full color and featuresnearly 200 high-quality images

*Provides extended commentary on the relevance of pathological findingsand features a fully updatedbibliography containing sources for further reading

*Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions. "

Meyler's Side Effects of Cardiovascular Drugs (Hardcover): Jeffrey K. Aronson Meyler's Side Effects of Cardiovascular Drugs (Hardcover)
Jeffrey K. Aronson
R1,297 R942 Discovery Miles 9 420 Save R355 (27%) Shipped within 7 - 12 working days

Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician.

Each year, heart disease kills more people than cancer. Patients are treated by a variety of specialists and primary care practitioners, depending on the organ system involved. This volume enables practitioners to assess the adverse effects of the complete range of drugs used in cardiovascular medicine, including antihypertensive drugs, and drugs used in the treatment of heart failure, angina, angina pectoris, and cardiac arrhythmia and enable practitioners to prescribe preventative treatments with medications such as blood pressure reducers, aspirin, and cholesterol-lowering drugs, as well as drugs used for more aggressive therapy.

The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler s Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.

This volume is critical for any health professional involved in the administration of cardiovascular mediations.
Surpasses the Physician s Desk Reference (c) by including clinical case studies and independent expert analysisComplete index of drug namesMost complete cross referencing of drug-drug interactions availableExtensive references to primary and secondary literatureAlso includes information on adverse effects in pregnancy

The book is divided into six sections:

Drugs used to treat hypertension, heart failure and angina pectorisDiuretics - a general introduction to their adverse effects, followed by monographs on individual drugsAntidysrhythmic drugs - a general introduction to their adverse effects, followed by monographs on individual drugsDrugs that act on the cerebral and peripheral circulationsAnticoagulants, thrombolytic agents, and anti-platelet drugsCardiovascular adverse effects of non-cardiovascular drugs "

PAKs, RAC/CDC42 (p21)-activated Kinases - Towards the Cure of Cancer and Other PAK-dependent Diseases (Hardcover, New): Hiroshi... PAKs, RAC/CDC42 (p21)-activated Kinases - Towards the Cure of Cancer and Other PAK-dependent Diseases (Hardcover, New)
Hiroshi Maruta
R1,555 R1,276 Discovery Miles 12 760 Save R279 (18%) Shipped within 7 - 12 working days

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.

This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.
This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect."

Meyler's Side Effects of Endocrine and Metabolic Drugs (Hardcover): Jeffrey K. Aronson Meyler's Side Effects of Endocrine and Metabolic Drugs (Hardcover)
Jeffrey K. Aronson
R1,601 R1,361 Discovery Miles 13 610 Save R240 (15%) Shipped within 7 - 12 working days

Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician.

Endocrine and metabolic diseases are common, includes diseases such as diabetes, thyroid disease, and obesity. Endocrinologists, including diabetes professionals, internal medicine and primary care practitioners, obstetricians and gynecologists, and others will find this book useful when treating endocrine or metabolic diseases.

The material is drawn from the 15th edition of the internationally renowned encyclopedia, Meyler s Side Effects of Drugs, and the latest volumes in the companion series, Side Effects of Drugs Annuals. Drug names have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN); when those are not available, clinical names have been used. In some cases, brand names have been used.

This volume is critical for any health professional involved in the administration of endocrine and metabolics mediations.
Surpasses the Physician s Desk Reference (c) by including clinical case studies and independent expert analysis

Complete index of drug names

Most complete cross referencing of drug-drug interactions available

Extensive references to primary and secondary literature

Also includes information on adverse effects in pregnancy

The book is divided into eight sections:

Corticosteroids and related drugs

Prostaglandins

Sex hormones and related drugs

Iodine and drugs that affect thyroid function

Insulin and other hypoglycemic drugs

Other hormones and related drugs

Lipid-regulated drugs

Endocrine and metabolic adverse effects of non-hormonal and non-metabolic drugs "

Principles of Clinical Pharmacology (Hardcover, 3rd edition): Arthur Atkinson Principles of Clinical Pharmacology (Hardcover, 3rd edition)
Arthur Atkinson
R2,702 Discovery Miles 27 020 Shipped within 7 - 11 working days

"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

Pharmacology - Principles and Practice (Hardcover): Miles P. Hacker, William S. Messer, Kenneth A. Bachmann Pharmacology - Principles and Practice (Hardcover)
Miles P. Hacker, William S. Messer, Kenneth A. Bachmann
R1,547 R1,323 Discovery Miles 13 230 Save R224 (14%) Shipped within 7 - 12 working days

This unique and much needed textbook will meet the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker, et al. to help train new drug researchers.
The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, Pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process.
*Uses individual drugs to explain molecular actions
*Full color art program explains molecular and chemical concepts graphically
*Logical structure reflecting the current state of pharmacology and translational research, starting with receptors and finishing with target molecules
*Covers such intricacies as drug resistance and cell death
*Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool

Controlled Release Veterinary Drug Delivery - Biological and Pharmaceutical Considerations (Hardcover): Michael J. Rathbone,... Controlled Release Veterinary Drug Delivery - Biological and Pharmaceutical Considerations (Hardcover)
Michael J. Rathbone, Robert Gurny
R6,476 Discovery Miles 64 760 Shipped within 7 - 11 working days

Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).


The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.


"Controlled Release Veterinary Drug Delivery" comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.


The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Organophosphates Chemistry, Fate, and Effects - Chemistry, Fate, and Effects (Hardcover): Janice E. Chambers, Patricia E. Levi Organophosphates Chemistry, Fate, and Effects - Chemistry, Fate, and Effects (Hardcover)
Janice E. Chambers, Patricia E. Levi
R1,561 Discovery Miles 15 610 Shipped within 7 - 11 working days

This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity.
Key Features
* Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms
* Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds
* Examines organophosphorus compound-induced toxicity mediated by mechanisms other than
inhibition of acetylcholinesterase
* Covers new research on differences in toxicity induced by the variety of organophosphorus
* Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity "in vivo"

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders (Hardcover): Robert A. McArthur, Franco Borsini Animal and Translational Models for CNS Drug Discovery: Neurological Disorders (Hardcover)
Robert A. McArthur, Franco Borsini
R1,371 Discovery Miles 13 710 Special order

"Neurological Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer s disease, Parkinson s disease, Huntington disease, ALS, and the epilepsies. "Neurological Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the second volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
- Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process
- Critical evaluation of animal and translational models improving transition from drug discovery and clinical development
- Emphasis on what results mean to the overall drug discovery process
- Exploration of issues in clinical trial design and conductance in each therapeutic area"

Approaches to Design and Synthesis of Antiparasitic Drugs, Volume 25 (Hardcover): N. Anand, S. Sharma Approaches to Design and Synthesis of Antiparasitic Drugs, Volume 25 (Hardcover)
N. Anand, S. Sharma
R4,709 Discovery Miles 47 090 Special order

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Advances in Atomic Spectroscopy, Volume 1 (Hardcover): Joseph Sneddon Advances in Atomic Spectroscopy, Volume 1 (Hardcover)
Joseph Sneddon
R2,109 Discovery Miles 21 090 Special order

This series describes selected advances in the area of atomic spectroscopy. It is promarily intended for the reader who has a background in atmoic spectroscopy; suitable to the novice and expert. Although a widely used and accepted method for metal and non-metal analysis in a variety of complex samples, "Advances in Atomic Spectroscopy" covers a wide range of materials. Each Chapter will completely cover an area of atomic spectroscopy where rapid development has occurred.

A Dictionary of Pharmacology and Allied Topics (Hardcover, 2nd edition): D.R. Laurence, J. R. Carpenter A Dictionary of Pharmacology and Allied Topics (Hardcover, 2nd edition)
D.R. Laurence, J. R. Carpenter
R4,358 Discovery Miles 43 580 Special order

This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for "reference" and for "browsing," and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.

Features of this dictionary:

- Provides definitions of terms in pharmacology, both basic and clinical

- Gives information on new medicine development and official regulations

- Covers allied topics, including statistics, ethics, scientific miscounduct, authorship, publication and law.

Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders (Hardcover, 3rd edition): Robert A. McArthur,... Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders (Hardcover, 3rd edition)
Robert A. McArthur, Franco Borsini
R1,537 Discovery Miles 15 370 Special order

"Reward Deficit Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. "Reward Deficit Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. "Reward Deficit Disorders" also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the third volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, which is also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaNeurological Disorders is available for purchase individually.

Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (Hardcover): Jeffrey K. Aronson Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (Hardcover)
Jeffrey K. Aronson
R1,233 Discovery Miles 12 330 Special order

Elsevier now offers a series of derivative works based on the acclaimed "Meyler s Side Effect of Drugs, 15th Edition." These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
Opioids and analgesics are members of a diverse group of drugs used to relieve pain. They are frequently used in combination with prescription and nonprescription pain relievers, and misuse is prevalent. Pain medicine specialists and physicians or surgeons will find this volume useful in prescribing the appropriate drugs for pain therapy and for preventing misuse of the medication.
* The only drug guide that includes clinical case studies and expert analysis
* "UNIQUE " Features not only analgesics and anti-inflammatory drugs, but also all other drugs that act in an analgesic or anti-inflammatory manner
* Most complete cross referencing of drug-drug interactions available
* Latest content from the most highly regarded compilation of drug side effects: "Side Effects of Drugs Annual" serial"

Target Validation in Drug Discovery (Hardcover, New): Brian W. Metcalf, Susan Dillon Target Validation in Drug Discovery (Hardcover, New)
Brian W. Metcalf, Susan Dillon
R1,713 Discovery Miles 17 130 Special order

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Side Effects of Drugs Annual, Volume 28 - A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions... Side Effects of Drugs Annual, Volume 28 - A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions (Paperback, 29 Ed)
Jeffrey K. Aronson
R5,711 Discovery Miles 57 110 Special order

Volume 28 in the series of Side Effects of Drugs Annuals (http: //www.elsevier.com/locate/series/seda) continues to serve its primary goal: to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has reviewed new data and trends by selecting from the year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is unproven or misleading. The use of the book is enhanced by separate indexes, allowing the reader to access the text via drug name, adverse effect, or drug interaction.
The current annual includes an essay by the editor, Dr Jeffrey Aronson, entitled 'Classifying Drug Adverse Reactions in the 21st Century.' In it he describes how the modern approach to classifying adverse drug reactions takes into account the dose that causes the reaction, the time-course of the reaction, and the susceptibility factors that increase the individual patient's risk, and shows how this analysis can facilitate regulatory decision making.
*Provides a critical yearly survey of new data and trends
*Includes an essay that describes the modern approach to classifying adverse drug reactions
*Special reviews in this Annual include, among other topics: Antipsychotic drugs and now-onset diabetes mellitus, Treating asthma during pregnancy, and MMR vaccine and autism

Elsevier's Dictionary of Vitamins and Pharmacochemistry (Hardcover): Henry Philippsborn Elsevier's Dictionary of Vitamins and Pharmacochemistry (Hardcover)
Henry Philippsborn
R3,574 Discovery Miles 35 740 Special order

The dictionary will contain terms covering the following fields and subfields: Vitamin Technology: Vitamin biochemistry / Physiology; Origin of vitamins: natural, synthetic; Fat-soluble vitamins; Water-soluble vitamins; Vitamins as antioxidants; Vitamin deficiencies / Hypervitaminosis - Enzymes/Proteins: Biotechnology as applied biological science aimed at industrial exploitation - Hormones: Biochemistry; Physiology - Pharmaceutical Chemistry / Pharmaceutical Technology / Pharmaceutical Processes: Conception of the active principles; Structural analysis; Antibiotics and their way of action; Biochemistry; The Drug / The Medicament: Definition, origin, way of action; Biochemistry - Medical Aspects in the languages English, German, French and Portuguese.
*An important resource for pharmacologists, pharmaceutists and medical doctors
*Includes definitions in several prominent languages (English, German, French, Portuguese)
*Covers subfields of Vitamin Technology, Enzymes/Proteins, Hormones, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Processes, and more

Biosensors: A Russian Perspective, Volume 3 (Hardcover): A.P.F. Turner, Reinhard Renneberg Biosensors: A Russian Perspective, Volume 3 (Hardcover)
A.P.F. Turner, Reinhard Renneberg
R1,354 Discovery Miles 13 540 Special order

Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

Clinical Pharmacology During Pregnancy (Hardcover, New): Clinical Pharmacology During Pregnancy (Hardcover, New)
R1,528 Discovery Miles 15 280 Special order

"Clinical Pharmacology During Pregnancy" is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.
Uses an evidence-based approach for therapeutics during pregnancyIncludes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indicationIncludes a companion website containing support materials for professional or continuing education courses in OB pharmacology

Pharmacogenomics - Challenges and Opportunities in Therapeutic Implementation (Hardcover): Yui-Wing Francis Lam, Larisa H.... Pharmacogenomics - Challenges and Opportunities in Therapeutic Implementation (Hardcover)
Yui-Wing Francis Lam, Larisa H. Cavallari
R1,935 Discovery Miles 19 350 Special order

"Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation" includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
Multi-contributed book and chapters are written by contributors who are experts in their fieldProvides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may beIncludes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applicationsChapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting

Bridging Hippocrates and Huang Ti, Volume 1 - A Comparative Thesaurus of Traditional Chinese and Western Urology, Andrology and... Bridging Hippocrates and Huang Ti, Volume 1 - A Comparative Thesaurus of Traditional Chinese and Western Urology, Andrology and Sexology (Hardcover, New)
P. Marandola, S. Musitelli, Wei Li Chen
R2,793 Discovery Miles 27 930 Special order

Western Medicine as seen today has a strong scientific basis in its development. The pathogenesis of most diseases and their symptomatology and physical signs are well studied and understood. The management of patients is based on firm understanding of these disease processes. In contrast, Traditional Chinese Medicine came about through the experience of many generations of practitioners over thousands of years. Undoubtedly, many of these treatments have proved to be effective in their own way, however, firm scientific basis is still lacking.


While most Western Medicine advocates control of disease by eradication of pathogens and surgical removal of diseased organs as in the case of cancer, Traditional Chinese Medicine seeks to improve resistance against disease. There is probably a great wealth of therapeutic value in Traditional Chinese Medicine, which has not been discovered or explored fully. By combining the knowledge of both Western and Traditional Chinese Medicine, one might be able to improve the results of efficacy of treatments and the survival of patients. The integration of Medicine from East and West will take time to evolve and will need interested physicians from different parts of the world to work closely together to realize such a possibility.


This book is an attempt to bridge the medical world of two great and ancient civilizations in their approach to the treatment of disease. It is informative with a detailed account of the history of medical development. It is highly recommended for those medical practitioners from both East and West who are interested to explore alternative medicine and research new areas of the medical frontier.

Pharmacological and Chemical Synonyms - A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical... Pharmacological and Chemical Synonyms - A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical Literature of the World (Hardcover, 10th edition)
E.E.J. Marler
R6,739 Discovery Miles 67 390 Special order

Now in its tenth edition, this famous compilation of synonyms for drugs, pesticides and other substances of pharmacological or biochemical interest has become even more international and comprehensive in its scope. Electronic storage of the data has ensured that the book is fully up to date, while the highest degree of cross referencing between entries is guaranteed. The types of names presented are: chemical names, abbreviated chemical names, source names, pharmacological names, pesticide names, names derived from places, plants or persons, research code numbers, and proprietary names (trademarks).

For people working in the fields of biochemistry, pharmacology, pharmaceutics, and toxicology, as well as for medical editors and drug regulatory officers, this work will prove to be an indispensable source of information.

Diuretic Agents - Clinical Physiology and Pharmacology (Hardcover): Donald W. Seldin, Gerhard H. Giebisch Diuretic Agents - Clinical Physiology and Pharmacology (Hardcover)
Donald W. Seldin, Gerhard H. Giebisch
R2,686 R2,547 Discovery Miles 25 470 Save R139 (5%) Special order

The only comprehensive work to cover all aspects of diuretic agents, the book discusses the pharmacology and toxicology of diuretic agents as well as the physiological effects. Experts in the field present the principles and experimental approaches for the study of interactions between pharmacologic compounds in relation to specific target organs. Diuretic Agents contains information on the mechanisms of action and application of diuretics, and details FDA regulations and pharmaceutical industry guidelines.
Key Features
* Written by experts in the field
* Covers all aspects of diuretic agents
* Includes information on the mechanisms of action and application of diuretics

A Manual of Adverse Drug Interactions (Hardcover, 5th edition): J.P. Griffin, P.F. D'Arcy A Manual of Adverse Drug Interactions (Hardcover, 5th edition)
J.P. Griffin, P.F. D'Arcy; Foreword by Rosalinde Hurley
R5,813 Discovery Miles 58 130 Special order

For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.

Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.

The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.

If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

Global Clinical Trials Playbook - Capacity and Capability Building (Hardcover): Menghis Bairu, Richard Chin Global Clinical Trials Playbook - Capacity and Capability Building (Hardcover)
Menghis Bairu, Richard Chin
R1,872 Discovery Miles 18 720 Special order

Pharmaceuticals companies, biotech companies, and CROs, regardless of size, all face the same challenge of managing costs and operational execution associated with bringing a valuable drugs and devicesto market. Because of timeline pressures and cost as well asthe growing interest in "neglected diseases" and diseases affecting the emerging nations, clinical trials are increasingly conducted in emerging markets and developing countries where infrastructure, leadership, skilled personnel and a governance are at a premium.

Working with academics, regulatory professionals, safety officers, experts from the pharma industry and CROs, the editors have put together thisup-to-date, step-by-step guide book tobuilding and enhancingglobal clinical trial capacity inemerging markets anddeveloping countries. This book covers the design, conduct, and tools to build and/or enhance human capacity to executesuch trials, appealing toindividuals in health ministries, pharmaceutical companies, world health organizations, academia, industry, and non-governmental organizations (NGOs) who are managing global clinical trials.

* Givesmedical professionals the businesstools needed to effectively execute clinical trials throughout the world

* Provides real world international examples which illustrate the practical translation of principles

* Includes forms, templates, and additional references for standardization in a number of global scenarios"

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