This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for "reference" and for "browsing," and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.

Features of this dictionary:

- Provides definitions of terms in pharmacology, both basic and clinical

- Gives information on new medicine development and official regulations

- Covers allied topics, including statistics, ethics, scientific miscounduct, authorship, publication and law.

For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.

Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.

The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.

If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

Now in its tenth edition, this famous compilation of synonyms for drugs, pesticides and other substances of pharmacological or biochemical interest has become even more international and comprehensive in its scope. Electronic storage of the data has ensured that the book is fully up to date, while the highest degree of cross referencing between entries is guaranteed. The types of names presented are: chemical names, abbreviated chemical names, source names, pharmacological names, pesticide names, names derived from places, plants or persons, research code numbers, and proprietary names (trademarks).

For people working in the fields of biochemistry, pharmacology, pharmaceutics, and toxicology, as well as for medical editors and drug regulatory officers, this work will prove to be an indispensable source of information.

This text indicates those variables which in general may need a better control. Examples illustrate the impact that those variables may have on various characteristics. A series of representative studies are presented so that insight can be obtained about the effects of these parameters.

This series describes selected advances in the area of atomic spectroscopy. It is promarily intended for the reader who has a background in atmoic spectroscopy; suitable to the novice and expert. Although a widely used and accepted method for metal and non-metal analysis in a variety of complex samples, "Advances in Atomic Spectroscopy" covers a wide range of materials. Each Chapter will completely cover an area of atomic spectroscopy where rapid development has occurred.

This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors area pplicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series "Advances in Biosensors" presents a unique compendium of research papers, in which eminent authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possible scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.

This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.
This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect."

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).

The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.

"Controlled Release Veterinary Drug Delivery" comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.

The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity.
Key Features
* Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms
* Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds
* Examines organophosphorus compound-induced toxicity mediated by mechanisms other than
inhibition of acetylcholinesterase
* Covers new research on differences in toxicity induced by the variety of organophosphorus
* Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity "in vivo"