This volume of Pharmacochemistry Library comprises the text of
invited lectures presented at the 11th Noordwijkerhout-Camerino
Symposium "Trends in Drug Research," held in Noordwijkerhout, The
Netherlands, from 11-15 May 1997.
In the programme attention has been given to the generation of
new biological target systems and the generation of new lead
molecules, with presentations on e.g. combinatorial chemistry,
compound libraries, database search, high throughput screening and
molecular biology.
Other topics discussed were the perspectives for new medicines
for the gastro-intestinal tract, the major developments in the
search for effective anti-HIV drugs and new aspects in synthetic
approaches. In a special session three topics which currently draw
much attention were discussed: How to deal with the major problem
of resistance against antimirobial agents? Can the apoptosis
mechanism be used as a drug target? Is the newly observed
phenomenon of inverse agonism a general principle and has it
consequences for drug development (and use?)
General
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