What happens when the physical body and the subjective sense of self part company? How do we explain phantom limbs and alien abduction? What are the cognitive, neurobiological mechanisms that support such phenomena? In this special issue of Cognitive Neuropsychiatry, Spence and Halligan explore all these issues and more, with contributions drawn from an internationally renowned panel of authors, most of whom contributed to a symposium held in Sheffield, England in June 2001 ('The Neuropsychiatry of the Body in Space'). That meeting was primarily concerned with those bizarre and disturbing syndromes that arise when 'body' and 'self', soma and psyche are dissociated from each other, within or beyond the body's surface. Some disorders constrain the space of the body (as in neglect and dissociation syndromes), others seem to extend the boundaries (as with phantom limbs and autoscopy). Still others suggest a permeability of those boundaries (as in alien control and thought insertion, each occurring in schizophrenia). Finally, the body may itself be perceived as having passed into space, the most extreme exemplar being 'alien abduction'. Each paper contains a description of disturbed phenomenology and an account and critique of current cognitive neuropsychiatric findings.

Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.

* Includes chapters on sleep phase disorders, sleep apnea, periodic limb movements, narcolepsy, limit setting disorders in children, enuresis, and night terrors.
* Provides a unique, behavioral approach to sleep medicine.

There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.

"This is an important book that no suicidologist should be without. In it, the author, Edwin S. Shneidman, brings together work he undertook and completed between 1971 and 1993. This work includes an empirical study, some single case studies, some theoretical think pieces, and some suggestions for psychotherapy. In this volume, Suicide as Psychache: A Clinical Approach to Self-Destructive Behavior, Shneidman introduces the concept of psychache, adding to the existing vocabulary on suicide to which he has contributed so generously. Shneidman defines psychache as the hurt, anguish, soreness, aching, psychological pain in the mind. Suicide occurs, he says, when the person experiencing the psychache deems the pain unbearable, suicide having to do with differences in individual thresholds for enduring psychological pain. Other concepts that bear Shneidman's imprint include suicidology, psychological autopsy, postvention, subintentional death, and postself. In the language of Suicide as Psychache, the growing numbers of people committing suicide in the United States give testimony to the growing prevalence of psychache in the U. S. population. Like all of Shneidman's work, this book goes well beyond its primary intent in that it is much more than a book about suicide. It is a theoretical book about the psychology of human behavior as reflected in suicide and about creative ways of investigating and responding to suicide phenomena. The book is divided into four parts: Foundations, Analyses, Response, and Follow-Up. This review, being a review, cannot possibly do justice to Shneidman's Suicide as Psychache: A Clinical Approach to Self-Destructive Behavior. It contains so many rich insights coupled with interesting literary references that help to enlarge readers' understanding and knowledge that persons are advised to read the book for themselves. By bringing together his earlier work and building on it, Shneidman allows readers to witness the evolution in his thinking about life and human behavior a

The therapeutic options for the treatment of multiple sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. , have undergone enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the in?ammatory process (MS) and cl- sical neuroprotection (stroke, AD), therapeutic approaches focussing on active remyelinization and neuronal regeneration have become incre- ingly important. Based on current concepts, this book summarizes new therapeutic approaches. Although it was once thought that the central nervous system (CNS) of mammals was incapable of substantial recovery from injury, it is now clear that the adult CNS remains responsive to various substances that can promote cell survival and stimulate axonal growth. Among these substances are growth factors, including the neurotrophins and cytokines. Stem cell therapies for the induction of remyelinization and neuroregeneration are reviewed. The potential role of a protective - munity in the induction of remyelination and neuroregeneration is also discussed. Different gene therapy approaches for the treatment of MS VI Preface and other neurodegenerative diseases such as Alzheimer's disease and spinal cord injury, etc. , are also summarized.

This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer 's disease and Parkinson 's disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, which covering topics from immunology, neuroscience, and pharmacology to genetics and molecular biology. Possible future developments in the treatment of Alzheimer 's and Parkinson 's Diseases are also covered.

This book provides a bi-national portrait of dementia in the rapidly aging Mexican-origin population in Mexico and the United States. It provides a comprehensive overview of critical conceptual and methodological issues in the study of cognitive aging and related mental and physical conditions. The book examines the sources of vulnerability and their consequences for Mexican-origin and for "aging in place". By providing a combination of new knowledge, empirical evidence, and fresh approaches of dementia support in later life, this book will contribute to moving the field of Mexican-origin aging and health forward. By focusing on the serious challenges in old-age support for older people with dementia and neurocognitive disorders in two different contexts, this book will deepen academics, researchers, students and young investigators understanding of what is necessary to achieve optional care.

International Review of Neurobiology, Volume 46 presents in-depth reviews on such ground-breaking topics as assembly and intracellular trafficking of GABA A receptors, D-1 dopamine receptors, and Alzheimer's disease. This series offers the most comprehensive and up-to-date information available and is a must for anyone in the field.
Includes a historical overview of neurosteroid research
Contains a chapter on neurosteroid biosynthesis and regulation
Presents current methods of neurosteroid measurement and analysis
Discusses neurosteroid function in both the normal and the pathological brain
Chapters address the function of neurosteroid in:
Stress
Receptor plasticity and function
Learning and Memory
Alcohol use
Depression

The isolation of leptin in 1994 and its characterization as a factor influencing appetite, energy balance, and adiposity, immediately thrust the polypeptide into the rapidly growing body of literature centered on the physiology of obesity. The growing clinical awareness of obesity as a major health risk in developed societies dovetailed perfectly with any of a number of roles that leptin might play in this abenant physiological condition. Almost unnoticed amidst the excitement generated by early leptin publications was the suggestion that the "fat hormone" might also regulate a wide range of systems and events important to reproduction, including pubertal development, gonadal endocrinology, fettility, and pregnancy. Recognizing this potential, a relatively small cadre of researchers began to examine leptin specifically as a reproductive hormone, thus creating a new and fertile field of investigation. Interest in this area has since gained momentum and an increased number of participants have now made significant contributions to our understanding of many leptin-related mechanisms that are relevant to reproductive biology. Leptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. Preeminent researchers ti'om many of the subdisciplines working within this area present a welcomed compendium of the wealth of related literature and voice novel interpretations of cun'ent advances.

The role of experience is crucial in the development of the nervous system. The definition of experience includes neural activity, hormonal environment, and social interactions, as well as exposure to sensory stimuli. There are a variety of organism-environment interactions that guide the development of the nervous system. There is evidence that early sensory experiences enhance brain development and make for a more intelligent adult. A common theme throughout the book is the biological mechanism of early experiential influences in neural development. The book covers three stages of development: (1) embryonic or perinatal manipulations; (2) manipulations early after birth or hatching; (3) major periods of transformation in the organism's life. The first stimuli felt by an organism is at the embryonic stage. For example, the expression of prenatal reflexes and movements regulates the life and death of developing neurons and is necessary for the normal development of the nervous system. Another example is the sensory system, the development of which starts before the organism has any sensory input. Furthermore, interactions between a pregnant or nursing female and her environment can influence the environment experienced by her offspring. As regards the organism's development right after birth, evidence suggests that sensory deprivation of a particular system may lead to the death of its neurons. Experiments have been conducted on the olfactory bulb in the rodent and chick auditory systems. The major periods of transformation refer to clear changes in neural structure and function. One of the most extraordinary transformations observed in developing organisms is metamorphosis. During thisstage, some neurons may die, others alter their anatomy, take on a new function, and die at a later time. In some organisms, an entirely new sensory epithelium is formed, while in others, learned behavioral changes become biologically possible due to growth of cells that comprise a neural circuit.

The field of behavioral neurogenetics has developed significantly over the past two decades. This has been largely driven by technical advances in the field of molecular genetics both in model systems and in clinical analysis. Indeed, it is hoped that the elucidation and ongoing functionalisation of the human genome may provide new insights into the aetiology, course and, ultimately, treatment of psychiatric illnesses. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

Written by experts on the forefront of investigations of brain function, vision, and perception, the material presented is of an unparalleled scientific quality, and shows that analyses of enormous breadth and sophistication are required to probe the structure and function of brain regions. The articles are highly persuasive in showing what can be achieved by carrying out careful and imaginative experiments. The Cat Primary Visual Cortex should emerge as essential reading for all those interested in cerebral cortical processing of visual signals or researching or working in any field of vision.
Key Features
* Comprehensive account of cat primary visual cortex
* Generous use of illustrations including color
* Covers research from structure to connections to functions
* Chapters by leaders in the field
* Topics presneted on multiple, compatible levels

This text provides an overview of the processes of brain death, exploring the concepts and historical approach of human death, clinical examinations of brain-dead patients, ancillary tests in coma and brain death, bioethical discussions of brain death and its relationship with some consciousness disturbances, and the legal considerations of human death. Unlike other, narrow-focus reference this book encompasses a wide spectrum of issues including medical, legal, bioethical and historical aspects.

The rapid identification and characterization of genes of neurological relevance holds great potential for offering insight into the diagnosis, management, and und- standing of the pathophysiologic mechanisms of neurological diseases. This volume in the Methods in Molecular Biology (TM) series was conceived to highlight many of the contemporary methodological approaches utilized for the characterization of neu- logically relevant gene mutations and their protein products. Although an emphasis has been placed upon descriptions of methodologies with a defined clinical utility, it is hoped that Neurogenetics: Methods and Protocols will appeal not only to clinical laboratory diagnosticians, but also to clinicians, and to biomedical researchers with an interest in advances in disease diagnosis and the functional consequences of neu- logically relevant gene mutations. To meet this challenge, more than 60 authors graciously accepted my invitation to contribute to the 32 chapters of this book. Through their collective commitment and diligence, what has emerged is a comprehensive and timely treatise that covers many methodological aspects of mutation detection and screening, including disc- sions on quantitative PCR, trinucleotide repeat detection, sequence-based mutation detection, molecular detection of imprinted genes, fluorescence in situ hybridization (FISH), in vitro protein expression systems, and studies of protein expression and function. I would like to take this opportunity to formally thank my colleagues for their effort and dedication to this work.

Why do people take their own lives? How can clinicians best plan and carry out intelligent treatment of desperate patients who are giving up on themselves? Suicide, its motivations, characteristics, and psychology are explicated in these papers by the most experienced and renowned experts on the subject. A definitive volume, Essential Papers on Suicide features the work of Ernest Jones; Kate Friedlander; George Murphy, R. H. Wilkinson, S. Gassner, and J. Kayes; Joseph C. Sabbath; Robert E. Litman; Milton Rosenbaum; Charles Swearingen; Avery D. Weisman; Mervin Glasser, Egl Laufer, Moses Laufer and Myer Wohl; Donald A. Schwartz, Don E. Flinn and Paul F. Slawson; Aaron T. Beck, Maria Kovacs and Arlene Weissman; Marie sberg, Lil Traskman and Peter Thoren; Stuart Asch; John T. Maltsberger; Alex D. Pokorny; Erna Furman; Cynthia R. Pfeffer, Robert Plutchik, Mark S. Mizruchi and Robert Lipkins; Myrna M. Weissman, Gerald L. Klerman, Jeffrey S. Markowitz and R. Oullette; Jan Fawcett, William A. Scheftner, Louis Fogg, David C. Clark, Michael A. Young, Don Hedeker, and Robert Gibbons, among others. John T. Maltsberger, M.D., is a Lecturer on Psychiatry at Harvard Medical School. Mark J. Goldblatt, M.D. is an Instructor in Psychiatry at Harvard Medical School.

Ithaslongbeenknownthatamphibiaandotherlowerordervertebrates havethecapacitytoregeneratelimbsaswellasdamagedheartsorbrains. Overthepastdecade,therehasbeenamajorchangeinthewaythatthe potentialforregenerationinmammalsisviewed.Earlier,incontrastto the acceptance of regeneration in amphibia, it was generally believed that there was very limited if any capacity for regeneration in many mammalianorgansystemssuchastheheartandbrain.Thediscoveryof tissue-resident adult stem cells and the description of the properties of embryonic stem cells have altered this view. This change in paradigm VI Preface has led to the hope that these discoveries can be harnessed in medical practicetocurechronicdisablingdiseases. The use of tissue-resident adult stem cells depends on the ability to either mobilize them or to convert them from one lineage to another. These problems do not arise with embryonic stem cells. Instead, their useisfraughtwithethicalandpoliticalissuesaswellasthequestionof howtodirecttheirdifferentiationtowardthedesiredcelltype.Whichever approachistaken,issuesofsafetyhavetobeparamount.Inparticular,the roleofstemcellsintumorigenesisiscriticalinassessingtheirpotential clinicalutility. The Ernst Schering Research Foundation and the Riken Center on DevelopmentalBiologyjointlyorganizedaworkshopon"ThePromises andChallengesofRegenerativeMedicine,"whichtookplaceinKobe, Japan on 20-22 October 2004. The purpose of the workshop was to discuss the present state of knowledge and future directions in this important ?eld. Leading basic scientists and clinicians reviewed and discussedseveraltimelytopicswithinthreemainthemes:(1)evolution, development,andregeneration,includingstemcellsinPlanariaandstem cell niches; (2)embryonic and adult stem cells, including adiscussion of the regulatory system in Japan for human embryonic stem cells; and (3) regeneration in speci?c indications including a discussion of the role of stem cells in organs such as the skin, brain, liver, pancreas, cornea,andthecardiovascularsystem.Inaddition,theroleofstemcells in glioblastoma was presented along with the implications for other tumors.

The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "new" MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and-even more-the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that "translation" is real and not just virtual.

This book introduces a novel approach for examining language and communication in autism spectrum disorder (ASD) - discourse and conversation analysis. The authors offer a set of very different perspectives on these complex issues than are typically presented in psychological and clinical work. Emerging from a range of social scientific fields, discourse and conversation analysis involve fine-grained qualitative analysis of naturally-occurring, rather than laboratory-based, interaction, enabling broad applications. Presented in two parts, this innovative volume first provides a set of pedagogical chapters to develop the reader's knowledge and skills in using these approaches, before moving to showcase the use of discursive methods through a range of original contributions from world-leading scholars, drawn from a range of disciplines including sociology, academic and clinical psychology, speech and language therapy, critical disability studies and social theory, and medicine and psychiatry.

This book deals with the subject of neuroinflammation and attempts to take the reader on a journey from the bench to the bedside. The microglia and their response to brain injury as well as the importance of the chemokine family are discussed. The relevance of neuroinflammation in experimental models of BSE, scrapie and vCJD as well as Alzheimer's disease, stroke and multiple sclerosis is investigated before proceeding to clinical aspects of neuroinflammation and its involvement in human disease pathophysiology. The book provides an excellent introduction to the field of neuroinflammation and its involvement in human neurodegenerative disease.

This unique volume gives readers a front-row seat at an exciting and crucial symposium.

Recent advances in theory and treatment have significantly increased our understanding of obsessive-compulsive disorder (OCD). Yet research on OCD generally falls in categories of either behavioral or biological, and rarely do the two meet. Concepts and Controversies in Obsessive-Compulsive Disorder bridges this gap admirably. Featuring an international panel of 42 experts, this volume focuses in depth ona "and presents opposing viewpoints to a "the seven conceptual and practical disputes that characterize the field today:

- categorical versus dimensional perspectives on symptoms

- animal versus behavioral models

- single OCD entity versus OCD spectrum

- neuropsychiatric versus cognitive-behavioral models

- cognitive therapy versus exposure therapy

- self-directed versus therapist-directed treatment

- medication versus cognitive-behavioral therapy

These issues are presented in a debate format, with each side contributing a position paper on the topic, followed by a rebuttal from the opposite perspective. To further enrich the debate, timely chapters examine special areas such as sexual addictions, body dysmorphic disorder, trichotillomania, Tourettea (TM)s syndrome, and compulsive shopping in the context of OCD.

This level of discussion and argument, with its possibility for collaboration and integration, makes Concepts and Controveries of Obsessive Compulsive Disorder unique and productive reading for students, researchers, and therapists of all orientations as they design the next generation of theory and greater nuances of treatment.

This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.

"Philosophy and the Neurosciences" is the first systematic integration of philosophy of mind and philosophy of science with neuroscience research. As philosophers have come to focus more and more on the relationship between mind and brain, they have had to take greater account of theory and research in the neurosciences. Likewise, as neuroscientists have learned more about cognitive structures and functions, their investigations have expanded and merged with traditional questions from the philosophy of mind.

By introducing key themes in philosophy of mind, philosophy of science and the fundamental concepts of neuroscience, this text provides philosophers with the necessary background to engage the neurosciences and offers neuroscientists an introduction to the relevant tools of philosophical analysis. Study questions, figures, and references to further reading are provided in each chapter to enhance the reader's understanding of how philosophy and the neurosciences are related in their exploration of the human mind.