Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

This book describes appropriate statistical models that are commonly utilized in neuropsychology. The book discusses such issues as developing normative data for neuropsychological measures, assessing the validity of neuropsychological tests, and quantifying change "over time" through longitudinal analyses. The rationale for and allure of the volume is the fact that there are no publications that dovetail the two subdisciplines of applied statistics and neuropsychology. The overall objective of this book is to provide a pragmatic and concrete source for applying methodological and statistical techniques in research studies whose emphasis includes neuropsychology. Since there are a plethora of technique to arrive at similar answers, each method with its strengths and weaknesses will be delineated. The beauty of the book will be that it will hopefully demystify commonly encountered issues faced with researchers. More specifically, it will provide a "how to do it" approach.

This serial was established under the editorship of Dr. Norman R. Ellis in 1966. As a result of his editorial effort and the contributions of many authors, the serial is now recognized as the area's best source of reviews of behavioral research on mental retardation. From its inception, active research scientists and graduate students in mental retardation have looked to this serial as a major source of critical reviews of research and theory in the area.

Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such asC.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set. A brochure listing each title in the "International Library of Psychology" series is available upon request.

In Neurosis and Human Growth, Dr. Horney discusses the neurotic process as a special form of the human development, the antithesis of healthy growth. She unfolds the different stages of this situation, describing neurotic claims, the tyranny or inner dictates and the neurotic's solutions for relieving the tensions of conflict in such emotional attitudes as domination, self-effacement, dependency, or resignation. Throughout, she outlines with penetrating insight the forces that work for and against the person's realization of his or her potentialities. First Published in 1950. Routledge is an imprint of Taylor & Francis, an informa company.

In OUR INNER CONFLICTS, Karen Horney develops a dynamic theory of neurosis centered on the basic conflict among attitudes of moving toward, moving against, and moving away from people. Karen Horney has been called one of the most original psychoanalysts after Freud.

From the 19th Collegium Internationale Neuro-psychopharmacolgicum (CINP) Congress in 1994 comes this long-awaited collection that explores traditional herbal medicines as they relate to the treatment of neuropsychiatric diseases today. Dr. Shigenobu Hanba, co-chair of the symposium, joins together with co-editor Dr. Elliot Richelson and other distinguished scientists from around the world to discuss the role that age-old medicinals can play in modern-day therapy. For clinical and basic scientists alike, Herbal Medicines for Neuropsychiatric Disorders provides a comprehensive overview of the status of traditional herbal medicines as they relate to the treatment of neurospychiatric diseases. It will also serve as a source for detailed information on specific natural products and their constituents, as well as a reference point from which to begin a more in-depth exploration of this fascinating field.
Eastern cultures have been using herbal medicines for centuries and mainstream practitioners in many countries continue to use them as valid and effective forms of therapy for neuropsychiatric disorders. An important exception in Western culture, of course, is the United States, where governmental standards for safety and efficacy often pose obstacles for the speedy approval of drugs based on what some might label folkloric remedies. However, in the U.S. today, scientists are now conducting research with traditional herbal medicines with the belief that they offer enormous possibilities for the discovery of new drugs that would provide the basis of a new and effective psychopharmacology.
Along with detailed information on this research, the readers of Herbal Medicines for Neuropsychiatric Disorders explore ancient cultures to gain a greater perspective on the herbal medicines of Japan, China and India. Further reading offers chemical and pharmacological studies of various herbal medicines, as well as reports of studies in which behavioral and biochemical effects of various herbal preparations were tested on senescence-acclerated mice.

Since the first edition was published in 2003, an enormous amount of research into Asperger Syndrome (AS) and autism spectrum disorders has been conducted. New genetic and epigenetic theories, updated findings on viable therapies, and targeted skill-building programs provide a solid foundation of information for professionals to use in practice and impart to concerned families. The Second Edition of Asperger Syndrome synthesizes the current state of the field, beginning with the controversy over the proposed linking of the condition with autism in the DSM-5. This comprehensive guide gives readers a deeper understanding of the disorder, detailing the effective strategies and therapies available to improve the lives of young people with AS and ensure their successful transition from childhood to adolescence to adulthood. Focusing on core deficit and treatment areas, expert contributors analyze the evidence base on behavioral and pharmacological interventions as well as educational strategies geared toward bolstering cognitive and social skills. In addition to epidemiology, etiology, diagnosis, and assessment, this volume offers the most current information on: Counseling and other therapeutic strategies for children with AS and their families. Early intervention for children and youth with AS. Social skills instruction for children with AS. Evaluating evidence-based instruction for children with AS. Comprehensive education-based mental health services for students diagnosed on the autism spectrum. Practical advice for families, from a parent of a child with AS. The Second Edition of Asperger Syndrome is an essential reference for researchers, clinicians, and scientist-practitioners in clinical child, school, and developmental psychology; child and adolescent psychiatry; education; rehabilitation medicine/therapy; social work; and pediatrics.

Moving beyond the debate over whether and to what degree mild head injury has lasting neuropsychological sequelae, this book is predicated on the assumption that it does cause some problems in some circumstances for some people. It focuses on the practical questions of who is injured, how injuries manifest themselves, and what evaluation and treatment strategies are optimal, for families as well as patients. The distinguished authors bring to their task not only scientific expertise but extensive day-to-day clinical experience. This book will be widely welcomed as the first comprehensive overview of what we have learned from research and clinical experience about these difficult cases.

The need for effective therapy to treat Alzheimer 's disease is greater than ever, but there is still no drug therapy that can stop or reverse the progression of the disease. There is, however, a great deal of anticipation over the imminent development of effective therapies as a result of the identification of promising targets for drug development. This book investigates these targets and examines ongoing strategies to develop effective therapies for this devastating neurodegenerative condition.

Brain metastases are the most dreaded complication of systemic cancer, affecting some 170,000 people a year, a far greater incidence than primary brain tumors. This book presents current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neurosurgeons, radiation oncologists, medical oncologists, and neuron-oncologists, and as an overview for physicians in training.

nly two things are certain in life, one is that all of us will inevita Obly grow older, the other is that at some point during or at the end of this process we shall die. Inherent to the passage of time is a deterio ration in the structural and functional integrity of our bodies, this pro gressing to such an extent that one or more organ systems will eventu ally begin to fail with the continued health and well-being of the individual coming under threat. Age-associated deficiencies in the musculo-skeletal, cardiovascular, or endocrine systems producing arthri tis, hypertension, stroke or diabetes are all too apparent in our elderly population yet internally caused failures in the function of the nervous system provide the common, and mostly intractable, problems of memory and intellect or locomotion that face and frustrate clinicians. Perhaps the most important factor which can decide the outcome of research studies professing to examine the effects of the passage of time (i. e. the 'process of aging') on the function of the nervous system, or indeed any other organ system, is the selection of appropriate or repre sentative subjects for investigation. The heart of this problem lies in defining what might be considered as 'normal' aging as distinct from age-associated disease; setting the 'goal posts of normality' continues to 1 be a matter of considerable debate."

A guide for the design and implementation of treatment programs, this book emphasizes clinical issues over research and offers valuable suggestions for dealing with problems that arise in treatment. Contributors describe their work in prisons, psychiatric institutions, and community settings. Special attention is given to culturally sensitive treatments and to special populations, including professionals, clergy, juveniles, women, and the physically challenged.

In this book the authors relate and discuss the idea that perceptual processes can be considered at many levels. A phenomenon that appears at one level may not be the same as a superficially similar phenomenon that appears at a different level. For example "induced motion" can be analyzed in terms of eye movements or at the retinal level or at a much higher cognitive level: how do these analyses fit together? The concept of levels also makes us think of the flow of information between levels, which leads to a consideration of the roles of top-down and bottom-up (or feed-forward, feed-back) flow. There are sections devoted to vestibular processing, eye movement processing and processing during brightness perception. The final section covers levels of processing in spatial vision. All scientists and graduate students working in vision will be interested in this book as well as people involved in using visual processes in computer animations, display design or the sensory systems of machines.

An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.

'A beautiful memoir in which Oliver Sacks comes wonderfully to life ... Exquisitely wrought, heartrending and joyous' Joyce Carol Oates

Bill Hayes came to New York in 2009 with a one-way ticket and only the vaguest idea of how he would get by. But, at forty-eight years old, having spent decades in San Francisco, he craved change. Grieving over the death of his partner, he quickly discovered the profound consolations of the city's incessant rhythms, the sight of the Empire State Building against the night sky, and New Yorkers themselves, kindred souls that Hayes, a lifelong insomniac, encountered on late-night strolls with his camera.

And he unexpectedly fell in love again, with his friend and neighbor, the writer and neurologist Oliver Sacks, whose exuberance is captured in funny and touching vignettes throughout. What emerges is a portrait of Sacks at his most personal and endearing, from falling in love for the first time at age seventy-five to facing illness and death (Sacks died of cancer in August 2015). Insomniac City is both a meditation on grief and a celebration of life. Filled with Hayes's distinctive street photos of everyday New Yorkers, the book is a love song to the city and to all who have felt the particular magic and solace it offers.

Just as autism is a continuum of disorders, it is associated with a broad range of neurodevelopmental, social, and communication deficits. For individuals with autism spectrum disorders (ASD), augmentative and alternative communication (AAC) has a major impact on their daily lives, often reducing the occurrence of challenging behaviors.

"Aided Augmentative Communication for Individuals with Autism Spectrum Disorders" is a practical guide to the field, offering readers a solid grounding in ASD, related complex communication needs (CCN), and AAC, especially visual and computer-based technologies. Widely used interventions and tools in AAC are reviewed-not just how they work, but why they work-to aid practitioners in choosing those most suited to individual clients or students. Issues in evaluation for aided AAC and debates concerning its usability round out the coverage. Readers come away with a deeper understanding of the centrality of communication for clients with ASD and the many possibilities for intervention.

Key areas of coverage include:

AAC and assessment of people with ASD and CCN.Interdisciplinary issues and collaboration in assessment and treatment.AAC intervention mediated by natural communication partners.Functional communication training with AAC.The controversy surrounding facilitated communication.Sign language versus AAC.

"Aided Augmentative Communication for Individuals with Autism Spectrum Disorders" is an essential resource for clinicians/practitioners, researchers, and graduate students in such fields as child and school psychology, speech pathology, language education, developmental psychology, behavior therapy, and educational technology."

There are more than 100 billion brain cells in our heads, and every single one represents a fragment of thought and feeling. And yet each cell is a mystery of beauty, with branching, intricate patterns like shattered glass. Richard Wingate has been scrutinizing them for decades, yet he is still moved when he looks at one through a microscope and traces their shape by hand. With absorbing lyricism and clarity, Wingate shows how each type of cell possesses its own personality and history, illustrating a milestone of scientific discovery and exploring the stories of pioneering scientists like Ramon y Cajal and Francis Crick, and capturing their own fascinating shapes and patterns. Discover the ethereal world of the brain with this elegant little book - and find out how we all think and feel.

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair.

This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome.
Comprehensive review of the latest developments in neuroinflammation
Includes contributions from leading authorities

The conceptualization of dementia has changed dramatically in recent years with the claim that, through early detection and by controlling several risk factors, a prevention of dementia is possible. Although encouraging and providing hope against this feared condition, this claim is open to scrutiny. This volume looks at how this new conceptualization ignores many of the factors which influence a dementia sufferers’ prognosis, including their history with education, food and exercise as well as their living in different epistemic cultures. The central aim is to question the concept of prevention and analyze its impact on aging people and aging societies.

13C- and H-MRS of Cultured Neurones and Glia; U. Sonnewald, et al. Measurement of Intracellular Cations; H. Bachelard, R. Badar-Goffer. In Vivo Nitrogen MRS Studies of Rat Brain Metabolism; K. Kanamori, B.D. Ross. Traumatic Brain Injury; R. Vink, T.K. McIntosh. Animal Models of Stroke; T.L.C. Luvisotto, G.R. Sutherland. In Vivo Magnetic Resonance Imaging and Spectroscopy: Application to Brain Tumors; B.D. Ross, et al. Diffusion-Weighted Magnetic Resonance Imaging; M. King, et al. High Speed Echo Planar Imaging and Its Application to Stroke; P. Gowland, P. Mansfield. Brain Activation Studies Using Magnetic Resonance Imaging; S. Williams, et al. MRI and Proton MRS in the Evaluation of Multiple Sclerosis; D.L. Arnold, et al. Phosphorous and Proton Magnetic Resonance Spectroscopy of the Brain of the Newborn Human Infant; E.B. Cady. Localized 1H-MRS in Brain Disorders; J. Frahm, F. Hanefeld. Glossary. Index.

This book draws on contemporary theory and recent findings to provide researchers, professionals, undergraduate and graduate students with essential resources, allowing them to better understand and support children, youth and adults with autism and significant communication impairments. The book consists of 11 chapters organized into 3 sections detailing typical and atypical prelinguistic development for individuals on the autism spectrum, together with a range of assessment and intervention approaches that clinicians and educators can draw on in practice. The book adopts a lifespan perspective, recognizing that there is an important and particularly challenging sub-group of children on the spectrum who remain minimally verbal beyond the age of 8 years. Each chapter summarizes current research on a selected topic, identifies key challenges faced by researchers, educators and clinicians, and considers the implications for research and practice. The concluding chapter considers issues of research translation and how educators and clinicians can encourage the use of evidence-based practices for prelinguistic and minimally verbal individuals.

Neuroinformatics presents cutting-edge techniques for the synergistic study of neuroinformatics. The book facilitates the efforts of discovering neuroscience through the sharing of data and the use of computational models. It demonstrates the use of neuroinformatic components as a mechanism for understanding complex disorders. It contains detailed explanations, advantages, and disadvantages of traditional and non-invasive imaging methods.

Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.