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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases (Hardcover, 2001 ed.)
Loot Price: R4,819
Discovery Miles 48 190
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Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases (Hardcover, 2001 ed.)
Series: Advances in Experimental Medicine and Biology, 493
Expected to ship within 10 - 15 working days
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This volume focuses on the relationship between the nervous and the
immune system with regard to the effects of drugs of abuse and
infections, including infection caused by the immunodeficiency
virus which causes AIDS, the number one health problem worldwide.
Chapters focus on the brain-immune axis, detailing the effects of
drugs of abuse. It is well known that recreational drugs of abuse
such as morphine, cocaine, and marijuana, as well as other drugs,
including the legal drugs alcohol and nicotine, are used by large
numbers of individuals. Serious concerns have been raised about the
consequences of using such drugs, especially in relation to their
effects on normal physiological responses, including immune
mechanisms. It is now widely recognized not only that many drugs of
abuse have serious consequences on normal parameters of neurologic
and neuroendocrine systems in general but also that effects on
those systems, in turn, may affect indirectly immunity and also
directly affect immune systems. Much data has now been accumulated
showing that drugs of abuse markedly alter the immune response in
human populations as well as in experimental animals, both in vivo
and in vitro. Furthermore, studies on microbial infections have
shown that many drugs of abuse are associated with increased
susceptibility to infectious diseases, especially opportunistic
intracellular microorganisms, including viruses such as HIV which
causes AIDS. The mechanisms whereby drugs of abuse increase the
likelihood of infections by opportunistic microorganisms in humans
as well as in experimental animals are delineated. This volume will
further the understanding of the impact of drugs of abuse on the
brain-immuneaxis and its relationship to immunomodulation and
infection, especially that caused by the AIDS virus.
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