When the world stopped, all hopes rested on finding a vaccine. One team answered the call and were ready to act. But how do you develop a life-saving drug when every second counts and one mistake could be catastrophic?

Married couple and decades-long research partners Ugur Sahin and Özlem Türeci did just that within weeks of the pandemic breaking out. From convincing Big Pharma to support their ambitious project, to navigating political interference from the Trump administration and the European Union, the road to producing the Pfizer/BioNTech vaccine was by no means smooth. But these cutting-edge innovators overcame every obstacle to provide more than two billion doses of the life-saving drug to countries all around the world in record time.

The Vaccine draws back the curtain on one of the most important medical breakthroughs of our age, containing contributions from the fascinating couple themselves, as well as more than 50 scientists, politicians, public health officials, and BioNTech staff.

Shedding a light on the science behind the breakthrough, The Vaccine tells the story of the trailblazers to whom we all owe a debt of gratitude. More suspenseful than a novel, this is a real-life story of an extraordinary race against time to save the world.

This is the story of a race - not against other vaccines or other scientists, but against a deadly and devastating virus.

On 1 January 2020, Sarah Gilbert, Professor of Vaccinology at Oxford University, read an article about four people in China with a strange pneumonia. Within two weeks, she and her team had designed a vaccine against a pathogen that no one had ever seen before. Less than 12 months later, vaccination was rolled out across the world to save millions of lives from Covid-19. In Vaxxers, we hear directly from Professor Gilbert and her colleague Dr Catherine Green as they reveal the inside story of making the Oxford AstraZeneca vaccine and the cutting-edge science and sheer hard work behind it.

This is their story of fighting a pandemic as ordinary people in extraordinary circumstances. Sarah and Cath share the heart-stopping moments in the eye of the storm; they separate fact from fiction; they explain how they made a highly effective vaccine in record time with the eyes of the world watching; and they give us hope for the future.

Vaxxers invites us into the lab to find out how science will save us from this pandemic, and how we can prepare for the inevitable next one.

Handbook of HIV Medicine represents the knowledge, skill and experience of more than sixty experts in HIV medicine, making it the definitive reference book for southern Africa.

This third edition remains invaluable for doctors, medical students, and primary health care workers, presenting an updated approach to critical issues. It is ideal for quick reference in urban and rural clinics and hospital wards.

The handbook is targeted specifically at the needs of the developing world and contains guidelines on antiretroviral therapy, HIV emergencies, and adult and paediatric HIV medicine.

The Immune System is a concise yet thorough human-oriented introduction to how the human immune system works. It provides an up-to-date presentation of the field, written in an accessible style, replete with relevant medical examples. Plentiful illustrations and micrographs complement and illuminate the explanations. The Fifth Edition is supported by InQuizitive, Norton's award-winning, easy-to-use adaptive learning tool that provides student practice and promotes critical thinking.

The Sunday Times bestseller that explains the new science behind weight loss and how we can get in shape without counting calories. 'A compelling look at the science of appetite and metabolism' Vogue 'This book tells us the truth about weight loss' Dr Rangan Chatterjee _______________ We've all heard the golden rule: eat less, exercise more and you'll lose weight. But what if it isn't that simple? For over two decades, weight loss surgeon Dr Andrew Jenkinson has treated thousands of people who have become trapped in the endless cycle of dieting. Why We Eat (Too Much), combines case studies from his practice and the new science of metabolism to illuminate how our appetite really works. Debunking myths of about body and systematically explaining why dieting is counter-productive, this unflinching book investigates every aspect of nutrition: from the 'set weight point' that is unique to all of us, to good and bad fats, and from how genes impact our weight to how our hormones are affected after a diet ends. With a new chapter about the link between obesity and COVID-19, this incredible book will help you understand your body better than ever before. _______________ 'Articulate, clear, a joy to read, this is a book that really needed written' Joanna Blythman, author of Swallow This 'Highly persuasive . . . a radical approach to weight loss' Sunday Times 'Debunks the myths around dieting and weight-loss' Telegraph

This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US. Key Features Reviews combined vaccines used for cattle Summarizes animal models used for vaccine testing Focuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus Provides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity

The perfect balance of theory and practice! Here's the practical introduction you need to understand the essential theoretical principles of clinical immunology and the serological and molecular techniques commonly used in the laboratory. You'll begin with an introduction to the immune system; then explore basic immunologic procedures; examine immune disorders; and study the serological and molecular diagnosis of infectious disease. An easy-to-read, student-friendly approach emphasizes the direct application of theory to clinical laboratory practice. Each chapter is a complete learning module with learning outcomes, chapter outlines, theoretical principles, illustrations, and definitions of relevant terminology. Review questions and case studies help you assess your mastery of the material. A glossary at the end of the book puts must-know information at your fingertips. An access code inside new printed texts unlocks Lab Exercises and Branching Case Studies online at FADavis.com that offer more opportunities to apply theory to clinical laboratory practice.

A Silent Fire is a captivating expert account of inflammation's hidden role in many of the diseases of modernity and what we can actually do about it. 'Controlling Inflammation is the key to good health and this beautifully written and researched book is the best way to understand it' TIM SPECTOR, #1 bestselling author of Food for Life 'As gripping as a mystery story and as useful as a self-help book' BEE WILSON, author of First Bite _____ Inflammation is the body's response to injury and foreign microbes. But what if it were also a potential root cause of modern disease? The swelling and soreness of inflammation are caused by the gathering of immune cells to defend and heal our bodies. But as our environments and diets have rapidly changed, new science suggests that our immune systems are increasingly turning against us. Low-level inflammation, simmering quietly and undetected, has recently been identified behind everything from heart disease and cancer to mysterious autoimmune conditions. Hidden inflammation even weakens our immunity and increases the likelihood that our immune system will mount an overwhelming, inappropriate attack against infections. Shilpa Ravella is a specialist doctor at the forefront of this field, working on rare inflammatory disorders, gut transplants, nutrition and the microbiome. In A Silent Fire she interweaves the latest research with unusual case studies from her own practice and the history of immunology to explain what we know about this elusive phenomenon. She also debunks common myths about 'anti-inflammatory' lifestyles and reveals how we can reform our relationships with food and our microbiomes to benefit our own health and the planet's. In the eyes of many experts, inflammation is emerging as a common root of the diseases of modernity. This captivating narrative of scientific discovery explains why - and how we might control it.

As with the much-praised prior editions, the third edition of Strelkauskas' Microbiology: A Clinical Approach remains a comprehensive introductory textbook written specifically for pre-nursing, nursing and allied health students. Clinically relevant throughout, it uses the theme of infection as its foundation, fitting closely with the 'One Health' approach that is considered increasingly central to the effective control of zoonoses and to combatting antimicrobial resistance. The third edition has been thoroughly revised and updated to reflect the latest developments, including the emergence of the SARS-CoV-2 virus and associated COVID-19 pandemic. The book is accompanied by a robust instructor ancillary package that allows educators to incorporate readily the book’s unique approach into their lectures and includes additional materials for students to supplement classroom learning and encourage and support study and self-reflection. Key Features: Student-focused, with all elements carefully designed to help students engage with and understand difficult concepts and to spark and hold interest Dedicated learning skill section introduces practical strategies for improving comprehension and retention Numerous text features further support learning and teaching, including chapter overviews, fast facts, case studies and human stories, and ‘why is this important?’ highlights A variety of question-and-answer types for self-testing and reflection to support and assess basic learning, to challenge students to integrate important concepts and ask students to apply what they have just learned to a specific clinical setting or problem All supported by a comprehensive suite of online resources including lecturer support material and, for students, interactive questions, lecture notes, MicroMovies and the BugParade The book is an excellent resource to guide and support inter-professional education in the health sciences and an ideal entry-point to the subject for anyone coming from another discipline and invaluable supplementary reading for medical, microbiology and biomedical science students.

A companion book to the best-selling Immunity Food Fix, The Immunity Food Fix Cookbook delivers 75 delicious superfood recipes that support your body's natural defenses. Studies have shown that nutrition impacts immunity and disease development. What you put on your plate can either heal you or hurt you. The Immunity Food FixCookbook gives you superfood recipes that naturally support robust immunity. Aside from being accessible and delicious, food is less expensive than medication and free of side effects and, unlike supplements, has the most complete form of the nutrient. While adding the top immune-supportive foods to your diet individually can provide benefit, recipes and meals give you the opportunity to combine different immune superfoods for maximum nutrient density, absorption, and flavor appeal. Recipes are organized around the 5 key pillars of immune support: reversing inflammation, detoxification, antioxidants, digestion and microbiome health, and hormone balance and signaling. Supporting your immunity has never been so appealing. Inside, you'll find delicious whole food recipes, including gluten-free, dairy-free, and grain options. Enjoy recipes such as: Soothing & Calming Licorice Lavender Latte Sprouted Quinoa Porridge with Raspberries & Hazelnut Butter Pumpkin Cardamom Oats with Coconut Butter & Orange Zest Egg Muffins with Butternut & Sunflower Seed Pesto Chicken Radicchio Salad with Apple, Celery & Cashews with Apricot Dressing Roasted Butternut & Avocado Salad with Lemon & Kalamata Olives Tuna, Chickpea & Arugula Salad with Lemon & Tarragon Vinaigrette Tomato Peach Fruit Salsa with Black Beans & Lime Cantaloupe & Smoked Salmon Caprese with Lemon Mint Sauce Thai-Spiced Coconut Lentil Soup Savory Mushroom & Chestnut Soup with Thyme Green Tea Rice Bowls with Miso Glazed Salmon Lemony Shrimp Chickpea Pasta with Spinach & Walnuts Fig & Apricot Almond Balls with Pistachio & Cacao Nibs Passion Fruit Panna Cotta Tahini Chocolate Chip Cookies Immune response underpins everything from chronic health conditions, such as diabetes and heart disease, to warding off the common cold to how well one ages. So start boosting your immunity at the very next meal with The Immunity Food Fix Cookbook!

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Janis Kuby's groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Judy Owen, Jenni Punt, and Sharon Stranford present the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the study of immune response, enhanced by unsurpassed pedagogical support for the first-time learner.

BIOS Instant Notes in Immunology, Third Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams. BIOS Instant Notes in Immunology, Third Edition, is fully up-to-date and covers: * Overview of the Immune System * Cells and Molecules of the Innate Immune System * The Adaptive Immune System * Antibodies * The Antibody Response * The T Cell Response -- Cell-Mediated Immunity * Regulation of the Immune Response * Immunity to Infection * Vaccination * Immunodeficiency -- when the Immune System Fails * Hypersensitivity -- when the Immune System Misbehaves * Autoimmunity and Autoimmune Diseases * Transplantation * Tumor Immunology * Gender and the Immune System * Aging and the Immune System (Immunosenescence) * Immunotherapy

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation Evaluates various candidate rotavirus and norovirus vaccines Discusses human gut microbiota transplanted Gn pig models Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

Matters of Sport is a tribute to Eric Dunning, the leading sports sociologist in the English-speaking world. This book addresses Dunning's contributions to the sociological and historical study of sport, covering key topics such as hooliganism, celebrity and gender relations.

A broad range of leading academics from Europe and North America reflect on the ways in which Dunning's work has influenced their own research and understanding of sport.

This volume was previously published as a special issue of the journal Sport in Society.

This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out that the immune system does not stand alone, but is profoundly affected by other organ systems, especially the central nervous and the neuroendocrine systems, with cytokines being the common tool of communication. This edition continues on the trailblazing path of the original to once again present current research that informs our evolving understanding of how cytokines function and the clinical implications of cytokine activity. Completely rewritten by the top authorities in their fields, this volume includes 16 entirely new chapters, which document dramatic new developments. It provides a comprehensive overview of the role of cytokines in the neuroendocrine and immune systems, while also addressing the interactions between these systems. It examines cytokine activity and clinical implications from a number of perspectives, including those of immunology, pharmacology, oncology, endocrinology, and psychiatry. Researchers involved with the most specific aspects of cell signaling as well clinicians dealing with the effects of immunosuppression-related diseases will find a wealth of interesting and instantly applicable information. This new edition begins with an extended dedication and tribute to the late Robert A. Good, the father of modern immunology. It documents the life and groundbreaking achievements of Dr. Good who served as an editor for boththe former and current editions of this work.

Key Features: * Explores a highly topical concept of vaccines in a comprehensive and easy to read manner. * Engages the readers with relatable and interesting anecdotes. * Provides a balanced, factual counter to the huge amount of current vaccine misinformation.

In response to the emergence of pathogenic bacteria that cannot be treated with current antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight multidrug-resistant bacteria. Bacteriophage as Antibiotics: Molecular Biology and Applications provides unparalleled, comprehensive information on bacteriophages and their applications, such as phage therapy. It offers techniques, media, and methodology involved in isolating and working with therapeutic phages. Photographs, line drawings, and electron micrographs of phages are also included. With its broad approach, this book is a useful reference for microbiologists, hematologists, and infectious disease researchers.

Contents:
Part 1. Introduction. M.R. Leary, R.M. Kowalski, An Introduction to Social-clinical Psychology. M.R. Leary, J.E. Maddux, Progress Toward a Viable Interface between Social and Clinical-counseling Psychology. Part 2.
Social Psychological Processes in the Development and Maintenance of Emotional and Behavioral Problems. C.A. Anderson, R.S. Miller, A.L. Riger, J.C. Dill, C. Sedikides, Behavioral and Characterological Attributional Styles as Predictors of Depression and Loneliness: Review, Refinement and Test. C. Peterson, R.S. Vaidya, Explanatory Style, Expectations, and Depressive Symptoms. R.F. Baumeister, T.F. Heatherton, Self-regulation Failure: An Overview. C. Peterson, M.E.P. Seligman, K.H. Yurko, L.R. Martin, H.S. Friedman, Catastrophizing and Untimely Death. B.M. Braginsky, D.D. Braginsky, Schizophrenic Patients in the Psychiatric Interview: An Experimental Study of Their Effectiveness at Manipulation. S. Berglas, E.E. Jones, Drug Choice as a Self-handicapping Strategy in Response to Noncontingent Success. C.S. Crandall, Social Cognition of Binge Eating. M.R. Leary, L.S. Schreindorfer, A.L. Haupt, The Role of Self-esteem in Emotional and Behavioral Problems: Why is Low Self-esteem Dysfunctional? F.D. Fincham, T.N. Bradbury, Marital Satisfaction, Depression, and Attributions: A Longitudinal Analysis. J.E. Hokanson, M.P. Rubert, R.A. Welker, G.R. Hollander, C. Hedeen, Interpersonal Concomitants and Antecedents of Depression among College Students. S. Strack, J.C. Coyne, Social Confirmation of Dysphoria: Shared and Private Reactions to Depression. G. Downey, S.I. Feldman, Implications of Rejection Sensitivity for Intimate Relationships. Part 3. Social Psychological Processes in the Perception and Diagnosis of Psychological Problems. D.L. Rosenhan, On Being Sane in Insane Places. E.J. Langer, R.P. Abelson, A Patient by Any Other Name... Clinical Group Difference in Labeling Bias. J. Copeland, M. Snyder, When Counselors Confirm: A Functional Analysis. J.E. Maddux, The Mythology of Psychopathology: A Social Cognitive View of Deviance, Difference, and Disorder. P.W. Corrigan, D.L. Penn, Lessons from Social Psychology on Discrediting Psychiatric Stigma. Part 4. Social Psychological Processes in Clinical Treatment and Psychological Change. J. Frank, American Psychotherapy in Perspective (Excerpt from Persuasion and Healing). D.R. Forsyth, S.R. Strong, The Scientific Study of Counseling and Psychotherapy: A Unificationist View. J.W. Pennebaker, J.K. Kiecolt-Glaser, R. Glaser, Disclosure of Traumas and Immune Function: Health Implications for Psychotherapy. D. Axsom, J. Cooper, Cognitive Dissonance and Psychotherapy: The Role of Effort Justification in Inducing Weight Loss. B.W. McNeill, C.D. Stoltenberg, Reconceptualizing Social Influence in Counseling: The Elaboration Likelihood Model. E.J. Langer, J. Rodin, The Effects of Choice and Enhanced Personal Responsibility for the Aged: A Field Experiment in an Institutional Setting. W.B. Swann, Jr, The Trouble with Change: Self-verification and Allegiance to the Self. Appendix. C.H. Jordan, M.P. Zanna, How to Read a Journal Article in Social Psychology.

Contents:
1. Bacterial and Plant Toxins - General Mode of Action A.E. Frankel and P.D. Hall 2. Diphtheria Toxin-Structure, Function and its Therapeutic Use R.C. Ratts and J.C. VanderSpek 3. Ricin A-Structure, Function and its Clinical Applications M. Colmbatti 4. Pathways of Delivering Toxins into the Cytosol of Target Cells M. Lord, P.J. Day, M.E. Jackson, S.R. Owens, J.C. Simpson, D.C. Smith and L.M. Roberts 5. Engineering Immunotoxins for Improving their Therapeutic Activity Y. Reiter, G. Denkberg and C. Cohen 6. Ligand-receptor Interactions Studied with Chimeric Proteins H. Lorberboum-Galski 7. Chimeric Proteins: a Novel Approach for Eliminating Specific Cell Populations for Targeted Human Therapy A. Ben-Yehudah, R. Belostotsky, R. Aqeilan, Y. Azar, I. Steinberger, A. Fishman, A. Nechushtan, S. Yarkoni and H. Lorberboum-Gaski 8. Chimeric Neurotoxins - a Molecular Neurosurgery Approach P. Lazarovici 9. Targeted Immunotherapy of Autoimmune Diseases by Chimeric Toxins B.A. Holder and J.G. Krueger 10. Immunotoxins for Targeted Cancer Therapy R.J. Kreitman 11. Molecular Targeting of Brain Tumors with Cytotoxins W. Debinski 12. Toxins in the Development of Vaccines C.T. Hsu, C.Y. Ting and J. Hwang

Designed as an introductory textbook "Infection, Resistance and Immunity provides basic and established information on the workings of the immunological system and on infectious processes and their control. With sections on immunological disorders, immunization, immunodiagnosis and epidemiology relating immunology to practical problems in medicine, a section on comparative immunology introduces the student to differences among immunological systems among common species of nonhuman animals. Written for the advanced undergraduate, the focus on host-parasite interactions distinguishes this text from other standard texts, which focus on the cellular mechanisms of the immune response.