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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Zebrafish at the Interface of Development and Disease Research, Volume 124 (Hardcover): Kirsten C. Sadler Edepli Zebrafish at the Interface of Development and Disease Research, Volume 124 (Hardcover)
Kirsten C. Sadler Edepli
R4,990 Discovery Miles 49 900 Ships in 12 - 17 working days

Zebrafish at the Interface of Development and Disease Research presents the latest on the shared pathways that govern development and contribute to disease. Zebrafish have traditionally been used to study vertebrate development, providing interesting data on the developmental processes and genes that are implicated in disease. This new release in the series contains informative discussions on congenital heart defects in zebrafish, the use of zebrafish in studying kidney development and disease, and muscle development, homeostasis and disease in zebrafish. Each chapter interweaves the study of zebrafish development and its application to the immune system, the kidney, liver, heart and others.

Obesity and Cancer (Hardcover, 1st ed. 2021): Shashank Kumar, Sanjay Gupta Obesity and Cancer (Hardcover, 1st ed. 2021)
Shashank Kumar, Sanjay Gupta
R4,472 Discovery Miles 44 720 Ships in 12 - 17 working days

This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.

Motor Vehicle Crashes - Economic & Societal Impact, In Depth (Hardcover): Angie Kipling Motor Vehicle Crashes - Economic & Societal Impact, In Depth (Hardcover)
Angie Kipling
R5,812 R5,060 Discovery Miles 50 600 Save R752 (13%) Ships in 12 - 17 working days

In 2010 the total economic cost of motor vehicle crashes in the United States was $277 billion. This represents the present value of lifetime economic costs for 32,999 fatalities, 3.9 million non-fatal injuries, and 24 million damaged vehicles. These figures include both police-reported and unreported crashes. The National Highway Traffic Safety Administration (NHTSA) is charged with improving the safety of our Nation's roadways. The agency accomplishes this by regulating vehicle safety performance, enforcing existing safety requirements, and promoting programs that influence driver behaviour. This book describes the process, assumptions, and methods used by the agency to estimate the impact of its safety regulations and behavioural programs on fatality rates, and measures the impact of these programs on those rates.

Lupus Renal Involvement - A Case-Based Atlas (Paperback): Gyl Eanes Barros Silva, Roberto Silva Costa, Marcio Dantas, Natalino... Lupus Renal Involvement - A Case-Based Atlas (Paperback)
Gyl Eanes Barros Silva, Roberto Silva Costa, Marcio Dantas, Natalino salgado Filho, Stanley De Almeida Araujo
R2,744 Discovery Miles 27 440 Ships in 12 - 17 working days

Systemic lupus erythematosus (SLE or lupus) is a fairly common disease with a relatively high mortality rate that is characterized by multisystemic disorders, including the kidney. Recently, epidemiologic studies also show that the incidence of new SLE cases is increasing. Renal involvement is very common in systemic lupus erythematosus, occurring in up to 2/3 of patients and is a major cause of morbidity and mortality. Lupus nephritis affects glomeruli, tubules, interstitium peritubular capillaries, arteries, and veins with a spectrum of lesion. Although tubular, interstitial, and vascular lesions are common in lupus nephritis and may contribute significantly to overall disease severity, activity, and chronicity, they are not considered in most important classifications (OMS and ISN/RPS). These classifications are based entirely on the evaluation of glomerular alterations. Furthermore, the increasingly recognized, new pathological entity called lupus podocitopathy in the context of SLE, is not also accepted in the above classifications. Amyloidosis, non-lupus nephritides (including IgA nephropathy), therapeutic nephrotoxicity, and lupus in overlap with other connective tissue diseases are occasionally described. Therefore, this new case-based book fills a gap in the literature, and the authors call attention to some clinical entities which are less known and more difficult to recognize. The book design allows correlating morphologic aspects with clinical findings, and determines the prognosis and therapeutic response. It is a useful resource for pathologists, nephrologists, rheumatologist, physicians, and lupus and kidney students. Each case consists of typical histology images, a brief history, diagnosis, discussion, and pearls and pitfalls. The book is based on a multicenter experience, and the importance of kidney biopsy in the differential diagnosis is emphasised.

Immunology - A Foundation Text (Paperback, Rev Ed): B. Davey Immunology - A Foundation Text (Paperback, Rev Ed)
B. Davey
R4,934 Discovery Miles 49 340 Ships in 12 - 17 working days

Immunology: A Foundation Text This book provides an integrated approach to the study of immunology for people who seek a user-friendly', concise and up-to-date foundation text. There can be few subjects that so obviously demand such an approach. Immunology overlaps with the biological disciplines of biochemistry, cell biology, genetics, physiology, microbiology and parasitology - relying on methods and concepts derived from these disciplines, and in turn contributing to them. After describing the components of the immune system, and explaining how they interact, the author goes on to discuss the many important applications of immunology in laboratory techniques and in medicine. In addition to this introductory' material, the book considers new, and likely future developments - giving the reader a taste of the rapid rate of progress in this important field. The author's clear and concise text is supported by a wealth of illustrations (most in two-colour), self-assessment questions and a comprehensive index - making this an essential text for all life science students entering this field, or for health practitioners seeking to update their knowledge.

Aeroallergen and Food Immunotherapy, An Issue of Immunology and Allergy Clinics of North America, Volume 36-1 (Hardcover, UK... Aeroallergen and Food Immunotherapy, An Issue of Immunology and Allergy Clinics of North America, Volume 36-1 (Hardcover, UK ed.)
Linda S. Cox, Anna H Nowak-Wegrzyn
R1,730 Discovery Miles 17 300 Ships in 12 - 17 working days

This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna H. Nowak-Wegrzyn, is devoted to Aeroallergen and Food Immunotherapy. Articles in this issue include History of AIT and the future direction of CRD/molecular allergy; Mechanisms of aeroallergen allergen immunotherapy: SCIT and SLIT; Mechanisms underlying induction of tolerance to foods; Biomarkers for allergen immunotherapy; SCIT and SLIT; Novel delivery routes for allergy immunotherapy; Oral immunotherapy for food allergy; SLIT and EPIT for food allergy; The use of adjuvants for enhancing allergen immunotherapy efficacy; Allergen immunotherapy vaccine modification; Allergen immunotherapy outcome assessment in clinical trials and real life; Component resolved diagnosis: can it make specific AIT more specific?; Baked milk and egg diets for milk and egg allergy management; and Allergen immunotherapy practical considerations: adherence and strategies to improve.

Behcets Disease - Progress in Recent Years & Unmet Needs for the Future (Hardcover): Shunsei Hirohata Behcets Disease - Progress in Recent Years & Unmet Needs for the Future (Hardcover)
Shunsei Hirohata
R5,725 Discovery Miles 57 250 Ships in 12 - 17 working days

Behcet's disease is a chronic relapsing inflammatory disease of unknown etiology involving multiple organs. Along with blindness, other bodily functions are greatly affected by this disease; conditions of the vascular, intestinal and central nervous systems are usually life threatening and require aggressive therapy. Recently, significant progress has been made in several areas of this disease. The introduction of biological agents (such as anti-TNF) have had a positive impact on the effectiveness of treatments. However, there are still a number of unmet needs in various fields of this disease. Despite this, there remains a number of unaddressed issues concerning the treatments of this disease. Several genes have been shown to be associated with this disease, in addition to HLA-B51. Abnormalities in several subsets of T helper cells have been implicated in the pathogenesis of Behcet's disease. Recent advances in the field of innate immunity have shed light on the new aspects of Behcet's disease; that is, this disease has both autoimmunity and autoinflammatory aspects. On the other hand, there are still controversies as to the diagnosis and treatment of recalcitrant manifestations of the disease. This publication highlights the most recent understanding of Behcet's disease and raises several unanswered questions in both basic to clinical treatment of this ailment. The contents of this book are primarily based on the most up-to-date results of research programs sponsored by the Japanese government as well as findings from Korean researchers. In particular, novel classification for neurological involvement (which has been discovered in Japan) led to the establishment of diagnostic criteria and treatment recommendation. Thus, this publication brings forth useful information for a variety of specialists who are involved in the management of this intractable disease.

Translational Immunology - Mechanisms and Pharmacologic Approaches (Hardcover): Seng-Lai Tan Translational Immunology - Mechanisms and Pharmacologic Approaches (Hardcover)
Seng-Lai Tan
R2,797 Discovery Miles 27 970 Ships in 12 - 17 working days

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field.

Novel Methods and Pathways in Cancer Glycobiology Research, Volume 157 (Hardcover): Charles J Dimitroff, Karen Abbott Novel Methods and Pathways in Cancer Glycobiology Research, Volume 157 (Hardcover)
Charles J Dimitroff, Karen Abbott
R3,836 Discovery Miles 38 360 Ships in 12 - 17 working days

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the 'Alliance' is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis 2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer 3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

Autoimmune Neurology, Volume 133 (Hardcover): Sean J. Pittock, Angela Vincent Autoimmune Neurology, Volume 133 (Hardcover)
Sean J. Pittock, Angela Vincent
R5,865 R5,285 Discovery Miles 52 850 Save R580 (10%) Ships in 12 - 17 working days

Autoimmune neurologic disease results when the immune response to the body s own organs run wild and causes the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years significant advances in our understanding of the pathophysiology of autoimmune disorders including biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include, dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists and neuroscientists, and any medical professional working with autoimmune disease and disorders.

*Comprehensive coverage of autoimmune neurology *Details the latest techniques for the study, diagnosis and treatment of diseases and disorders including dementia, neuromuscular disease, epilepsy, sleep disorders *A focused reference for clinical practitioners and the clinical neurology and neurology research communities"

The Paradox of the Immune System - Protection, Chronic Inflammation, Autoimmune Disease, Cancer, and Pandemics (Paperback):... The Paradox of the Immune System - Protection, Chronic Inflammation, Autoimmune Disease, Cancer, and Pandemics (Paperback)
Louis J. Catania
R3,545 Discovery Miles 35 450 Ships in 12 - 17 working days

The Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives.

Personalized Immunosuppression in Transplantation - Role of Biomarker Monitoring and Therapeutic Drug Monitoring (Hardcover):... Personalized Immunosuppression in Transplantation - Role of Biomarker Monitoring and Therapeutic Drug Monitoring (Hardcover)
Michael Oellerich, Amitava DasGupta
R2,052 R1,891 Discovery Miles 18 910 Save R161 (8%) Ships in 12 - 17 working days

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

Colorectal Cancer, An Issue of Hematology/Oncology Clinics, Volume 29-1 (Hardcover, Uk Ed.): Leonard B Saltz Colorectal Cancer, An Issue of Hematology/Oncology Clinics, Volume 29-1 (Hardcover, Uk Ed.)
Leonard B Saltz
R1,979 Discovery Miles 19 790 Ships in 12 - 17 working days

This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon Cancer; Predictive and Prognostic Markers in the Treatment of Colorectal Cancer; Surgical Management of Hepatic Metastases of Colorectal Cancer; Combination Therapies in Colorectal Cancer Treatment; A Critical Look at Management of Peritoneal Metastases of Colorectal Cancer; Non-surgical Management of Rectal Cancer; and Ablative Therapies for Metastatic Colorectal Cancer.

Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination, Volume 1 (Paperback): Yehuda Shoenfeld, Arad Dotan Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination, Volume 1 (Paperback)
Yehuda Shoenfeld, Arad Dotan
R3,575 Discovery Miles 35 750 Ships in 12 - 17 working days

Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.

T Lymphocyte Subpopulations in Immunotoxicology (Hardcover): I. Kimber T Lymphocyte Subpopulations in Immunotoxicology (Hardcover)
I. Kimber
R7,757 Discovery Miles 77 570 Ships in 12 - 17 working days

T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses.

Developing Costimulatory Molecules for Immunotherapy of Diseases (Paperback): Manzoor Ahmad Mir Developing Costimulatory Molecules for Immunotherapy of Diseases (Paperback)
Manzoor Ahmad Mir
R2,760 Discovery Miles 27 600 Ships in 12 - 17 working days

Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases.

Natural Hosts of SIV - Implication in AIDS (Hardcover): Aftab A Ansari, Guido Silvestri Natural Hosts of SIV - Implication in AIDS (Hardcover)
Aftab A Ansari, Guido Silvestri
R3,198 R2,785 Discovery Miles 27 850 Save R413 (13%) Ships in 12 - 17 working days

"Natural Hosts of SIV: Implications in AIDS" thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.
Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal modelsProvides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIVHighlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

Celiac Disease and Gluten - Multidisciplinary Challenges and Opportunities (Hardcover): Peter Koehler, Herbert Wieser,... Celiac Disease and Gluten - Multidisciplinary Challenges and Opportunities (Hardcover)
Peter Koehler, Herbert Wieser, Katharina Konitzer
R2,059 R1,880 Discovery Miles 18 800 Save R179 (9%) Ships in 12 - 17 working days

"Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities" is a unique reference work the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, onlyfive percentare properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. A helpful tool for researchers and medical practitioners alike, "Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities" helps refine research targets, and provides a comprehensive overview on the multidisciplinary approaches to all crucial aspects related to celiac disease.
Presents key information from medical and food science research, as well as provides clinical insightsProvides direct corollary insights between source and symptomWritten by experts whose detailed experiments and results have shaped our understanding of celiac disease"

Ribosome-inactivating Proteins - Ricin and Related  Proteins (Hardcover): F. Stirpe Ribosome-inactivating Proteins - Ricin and Related Proteins (Hardcover)
F. Stirpe
R3,580 Discovery Miles 35 800 Ships in 12 - 17 working days

This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.

Primary Immunodeficiency Disorders - A Historic and Scientific Perspective (Hardcover): Amos Etzioni, Hans D. Ochs Primary Immunodeficiency Disorders - A Historic and Scientific Perspective (Hardcover)
Amos Etzioni, Hans D. Ochs
R2,034 Discovery Miles 20 340 Ships in 12 - 17 working days

"

Primary Immunodeficiency Disorders: A Historic and Scientific Perspective "provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future.

This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way.
Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseasesSummarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was establishedProvides stimulating discussions on developing new medical therapies
Highlights the importance of studying humans to understand mechanisms of disease that affect humans

New Antimicrobials: For the Present and the Future (Hardcover, 1st ed. 2023): I.W. Fong New Antimicrobials: For the Present and the Future (Hardcover, 1st ed. 2023)
I.W. Fong
R4,400 Discovery Miles 44 000 Ships in 10 - 15 working days

This is a timely and essential companion to the recently published Antimicrobial Resistance in the 21st Century, Second Edition. Antimicrobial resistance is a major threat to global population health, with government reports projecting it could result in over 10 million deaths in the next 35 years. Development of new agents to combat this threat is one of the WHO's top priorities, but in 2017, it conceded that the current drug development pipeline was insufficient to mitigate the threat. This book discusses recent progress and bolster new agent discovery and development, by providing researchers and students who will soon enter the field with a thorough guide to the advancements made in the last decade.  Coverage includes new systemic antimicrobials approved since 2010, with detailed analysis of antibiotics, antivirals, antifungals, and antiparasitics, as well as agents in development for future use. Discussion of each drug will include its chemical nature, pharmacology/pharmacokinetics, antimicrobial spectrum, dosage, adverse reactions, drug interactions, microbial resistance, indications, clinical efficacy compared to older agents, and lists of similar agents with cost comparison. This volume is designed for researchers and students of infectious disease and medical microbiology, as well as clinicians in need of a comprehensive guide to newly developed agents. 

Transplant Immunology (Paperback): X. Li Transplant Immunology (Paperback)
X. Li
R2,022 Discovery Miles 20 220 Ships in 12 - 17 working days

With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: * Transplant-related complications * Immune responses to transplants * Emerging issues in transplantation * Biomarkers of Allograft rejection and tolerance * T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Immunotherapy - A Novel Facet of Modern Therapeutics (Hardcover, 1st ed. 2021): Sujata P. Sawarkar, Vandana S. Nikam, Shariq... Immunotherapy - A Novel Facet of Modern Therapeutics (Hardcover, 1st ed. 2021)
Sujata P. Sawarkar, Vandana S. Nikam, Shariq Syed
R3,916 Discovery Miles 39 160 Ships in 12 - 17 working days

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Cell Biology of the B Cell Receptor, Volume 123 (Hardcover): Hidde Ploegh Cell Biology of the B Cell Receptor, Volume 123 (Hardcover)
Hidde Ploegh
R4,311 Discovery Miles 43 110 Ships in 12 - 17 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Advances in Immunology, Volume 122 (Hardcover): Frederick W. Alt Advances in Immunology, Volume 122 (Hardcover)
Frederick W. Alt
R4,312 Discovery Miles 43 120 Ships in 12 - 17 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

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