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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Advances in Immunology, Volume 89 (Hardcover, 89th edition): Frederick W. Alt Advances in Immunology, Volume 89 (Hardcover, 89th edition)
Frederick W. Alt
R4,350 Discovery Miles 43 500 Ships in 12 - 17 working days

Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Celiac Disease - An Update (Paperback): Mauro Bozzola, Christina Meazza, Giuseppe Maggiore, Silvia Nastasio Celiac Disease - An Update (Paperback)
Mauro Bozzola, Christina Meazza, Giuseppe Maggiore, Silvia Nastasio
R1,393 Discovery Miles 13 930 Ships in 12 - 17 working days

This book is intended as a guide for the diagnosis and management of children with celiac disease. It is an excellent learning resource suitable for students and health care providers in the fields of pediatrics, pediatric gastroenterology and pediatric endocrinology. Celiac disease is discussed in detail; gluten allergy and the so-called non-celiac gluten sensitivity are also briefly described. Besides the clinical aspects of the disease, the reader will find suggestions for the correct diagnosis and follow-up of short stature and other celiac related endocrine conditions. This book provides a thorough and critical update on the current knowledge on this unique autoimmune disease.

RAS: Past, Present, and Future, Volume 153 (Hardcover): John P. O'Bryan, Gary Piazza RAS: Past, Present, and Future, Volume 153 (Hardcover)
John P. O'Bryan, Gary Piazza
R3,856 Discovery Miles 38 560 Ships in 12 - 17 working days

Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.

The Skin in Systemic Autoimmune Diseases, Volume 5 (Hardcover): Piercarlo Sarzi-Puttini The Skin in Systemic Autoimmune Diseases, Volume 5 (Hardcover)
Piercarlo Sarzi-Puttini; Edited by Andrea Doria, Annegret Kuhn, Giampietro Girolomoni; Series edited by Ronald Asherson
R3,158 Discovery Miles 31 580 Ships in 12 - 17 working days

This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects.
This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity.
* Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity
* Box summaries at the end of each chapter highlight important topics
* Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

The Immunology of Human Reproduction (Hardcover): Isaac T. Manyonda The Immunology of Human Reproduction (Hardcover)
Isaac T. Manyonda
R5,094 Discovery Miles 50 940 Ships in 12 - 17 working days

Understanding immunology is increasingly important in obstetrics and gynecology. This book explores the role of immunological processes in reproduction. It presents immunologic concepts and illustrates important points with examples familiar to the clinician. It is organized into four sections: fundamentals of the immune system; the immunological paradox of pregnancy; clinical applications of immunology in obstetric and gynecologic practice, and immunopathology in obstetric and gynecologic practice. Written mainly for practicing obstetricians and gynecologists, the research results cited in the book are confined to human experimentation.

Immunology - A Comparative Approach (Paperback): R.J. Turner Immunology - A Comparative Approach (Paperback)
R.J. Turner
R5,134 Discovery Miles 51 340 Ships in 12 - 17 working days

Immunology: A Comparative Approach discusses the immunological features of a wide range of living organisms. It considers the merits of the laboratory mouse as an immunological representative; opportunities for bypassing technical obstacles in one model by using another; the immunological implications of changes in overall structure, physiology and way of life; and progress made in the study of defence mechanisms in animals and plants of commercial importance. This book is written for students and research workers with some knowledge of mainstream immunology who are curious about the advances, opportunities and challenges in comparative work.

Advances in Immunology, Volume 84 (Hardcover, New ed): Frederick W. Alt Advances in Immunology, Volume 84 (Hardcover, New ed)
Frederick W. Alt
R4,349 Discovery Miles 43 490 Ships in 12 - 17 working days

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
* Interactions between NK Cells and B Lymphocytes
* Multitasking of helix-loop-helix proteins in lymphopoiesis
* The pathogenesis of Diabetes in the NOD Mouse

T Cell Subsets, Volume 83 - Cellular Selection, Commitment and Identity (Hardcover, New): Frederick W. Alt T Cell Subsets, Volume 83 - Cellular Selection, Commitment and Identity (Hardcover, New)
Frederick W. Alt; Volume editing by H Cantor, Laurie Glimcher
R4,353 Discovery Miles 43 530 Ships in 12 - 17 working days

This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.
T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers

Immunology of Endometriosis - Pathogenesis and Management (Paperback): Kaori Koga Immunology of Endometriosis - Pathogenesis and Management (Paperback)
Kaori Koga
R3,132 Discovery Miles 31 320 Ships in 12 - 17 working days

Immunology of Endometriosis: Etiology and Management, a volume in the Reproductive Immunology series, provides updates on one of most common gynecological diseases, including basic science concepts and their clinical applications related to endometriosis immunology. Various immunological factors are believed to play roles in the pathogenesis of endometriosis, providing potential targets for the disease. Endometriosis is now considered to be a disease of both endocrine and immune dysregulation. However, recognition of the direct involvement of two major physiological mechanisms brings about a change of focus which might represent an interesting advance in the understanding of this disease and new focus for further research.

Advances in Immunology, Volume 82 (Hardcover): Frederick W. Alt Advances in Immunology, Volume 82 (Hardcover)
Frederick W. Alt
R4,894 Discovery Miles 48 940 Ships in 12 - 17 working days

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Advances in Immunology, Volume 81 (Hardcover): Frederick W. Alt Advances in Immunology, Volume 81 (Hardcover)
Frederick W. Alt
R4,361 Discovery Miles 43 610 Ships in 12 - 17 working days

Volume 81 of Advances in Immunology contains articles on a vast range of immunology topics including the regulation of the immune response by the interaction of chemokines and proteases as well as roles of the Semaphorin Family in immune regulation. It has a chapter devoted to B Lymphoid Neoplasms of Mice and another on the Zebrafish as a model organism to study development of the immune system. This volume will be of interest to immunologists in all industries.
* Edited by a new editor, Frederick W. Alt
* Covers molecular mechanisms of host-pathogen interaction
* Discusses prions and the immune system

Chronic Inflammation - Causes, Treatment Options & Role in Disease (Hardcover): Wei-Chiao Chang, Wen-Chang Chang Chronic Inflammation - Causes, Treatment Options & Role in Disease (Hardcover)
Wei-Chiao Chang, Wen-Chang Chang
R4,161 R3,785 Discovery Miles 37 850 Save R376 (9%) Ships in 12 - 17 working days

The primary focus of this book is to provide readers with a comprehensive overview of the recent advances in inflammation, especially in molecular biological and clinical aspects. Chapters contained in this book are written by invited authors from all over the world, who are well-known experts in their respective fields. In the book, chapters discussed include the molecular basis of inflammatory mechanisms, the functional roles of inflammation in diseases and new treatments of anti-inflammation. This book will be useful to all who wish to understand the scientific basis of inflammatory disease.

Advances in Immunology, Volume 152 (Hardcover): Frederick W. Alt Advances in Immunology, Volume 152 (Hardcover)
Frederick W. Alt
R4,843 Discovery Miles 48 430 Ships in 12 - 17 working days

Advances in Immunology, Volume 152, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, including chapters that cover Renal diseases and the role of complement in their pathogenesis, Factor H and Properdin and their regulation, Complement in neuronal diseases, Complement and the brain.

Immunology of Infection, Volume 32 (Paperback, 2nd edition): Stefan H.E. Kaufmann, Dieter Kabelitz Immunology of Infection, Volume 32 (Paperback, 2nd edition)
Stefan H.E. Kaufmann, Dieter Kabelitz
R4,418 Discovery Miles 44 180 Ships in 12 - 17 working days

Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology.
This new edition of Immunology of Infection provides ready-to-use "recipes," and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition.
Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research.
Key Features:
* Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection
* Cytometric analysis of cytokine secretion by immune cells
* Describes tetramer technology for the quantitative analysis of antigen specific T cell responses
* analysis of host cells and pathogens involved in the host-microbe interplay
* Covers techniques useful for the analysis of human and murine systems
* Includes techniques for the prediction and determination of MHC ligands and T cell epitopes
* Covers the fundamentals and practice of DNA vaccines
* Describes methods for the isolation and propagation of human dendritic cells

Vaxxers - A Pioneering Moment in Scientific History (Paperback): Sarah Gilbert, Catherine Green Vaxxers - A Pioneering Moment in Scientific History (Paperback)
Sarah Gilbert, Catherine Green
R312 R257 Discovery Miles 2 570 Save R55 (18%) Ships in 9 - 15 working days

Chosen as a Book of the Year 2021 by the Financial Times, Sunday Times, Daily Mail, Prospect, Guardian and The Times. 'Vaxxers is so good that the book will be read for long after the pandemic is over' Financial Times 'One of the most epic and pioneering moments in human history' Sir Jeremy Farrar __________ The bestselling inside story of a historic moment for science and for humanity. On 1 January 2020, Professor Sarah Gilbert read an article about four people in China with an illness of unknown cause. Within two weeks, she and her team had designed a new vaccine that would go on to save millions of lives from Covid-19. Capturing a landmark moment, Sarah Gilbert and Catherine Green reveal their story of making the pioneering Oxford AstraZeneca vaccine and fighting a pandemic as ordinary people in extraordinary circumstances. They separate fact from fiction, they explain how they made their highly effective vaccine in record time with the eyes of the world watching, and they give us hope for the future.

The Antiphospholipid Syndrome II - Autoimmune Thrombosis (Hardcover, 2nd ed.): R. Cervera, J.C. Piette, Y. Shoenfeld The Antiphospholipid Syndrome II - Autoimmune Thrombosis (Hardcover, 2nd ed.)
R. Cervera, J.C. Piette, Y. Shoenfeld
R5,275 R4,759 Discovery Miles 47 590 Save R516 (10%) Ships in 12 - 17 working days

This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

Genetics of Rare Autoimmune Diseases (Hardcover, 1st ed. 2019): Javier Martin, Francisco David Carmona Genetics of Rare Autoimmune Diseases (Hardcover, 1st ed. 2019)
Javier Martin, Francisco David Carmona
R3,172 Discovery Miles 31 720 Ships in 10 - 15 working days

The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behcet's disease, Sjogren's syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

The Eyes Of Darkness (Paperback): Dean Koontz The Eyes Of Darkness (Paperback)
Dean Koontz
R215 R153 Discovery Miles 1 530 Save R62 (29%) Ships in 3 - 5 working days

A search for a missing son... and a toxic mystery that threatens the globe.

'Did a 1981 Dean Koontz thriller predict the coronavirus outbreak?' Daily Mail
'Dean Koontz is not just a master of our darkest dreams, but also a literary juggler' The Times

From bestselling phenomenon Dean Koontz, The Eyes of Darkness is a gripping thriller following a mother's search for her son - a journey that unlocks the deadliest of secrets.

It's a year since Tina Evans lost her little boy Danny in a tragic accident.
Then a shattering message appears on the blackboard in Danny's old room: NOT DEAD.
Is it someone's idea of a grim joke? Or something far more sinister?

The search for an answer drives Tina through the neon clamour of Las Vegas nightlife.
The sun-scorched desert. The frozen mountains of the High Sierra.

People face a dreadful danger as a buried truth struggles to surface.
A truth so frightening that its secret must be kept at the price of any life - any man, any woman...any child.

The Immunoglobulin FactsBook (Paperback): Marie-Paule Lefranc, Gerard Lefranc The Immunoglobulin FactsBook (Paperback)
Marie-Paule Lefranc, Gerard Lefranc
R2,244 Discovery Miles 22 440 Ships in 12 - 17 working days

The FactsBook series has established itself as the best source of easily accessible and accurate facts about protein groups. Books in the series use an easy-to-follow format and are meticulously researched and compiled by experts in the field.
The Immunoglobulin FactsBook is the first published reference for all 203 human functional and ORF immunoglobulin genes. It is complete and standardized and employs nomenclature approved by the HUGO Nomenclature Committee.

The Leukemia-Lymphoma Cell Line Factsbook (Paperback): Hans G. Drexler The Leukemia-Lymphoma Cell Line Factsbook (Paperback)
Hans G. Drexler
R2,331 Discovery Miles 23 310 Ships in 12 - 17 working days

This book represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional features and includes a comprehensive listing of references.
Key Features
* the full spectrum of malignant cell lines from all hematopoietic cell lineages
* sister cell lines and relevant subclones
* clinical data: patient, diagnosis, treatment status, and specimen source
* authentication of derivation and availability
* immunophenotype
* cytogenetic karyotype
* translocations and fusion genes
* receptor gene rearrangements and genetic alterations
* cell cultures aspects: establishment, medium, doubling time, growth
* cytochemical profile
* cytokine production and response to cytokines
* proto-oncogene and transcription factor expression/alteration
* functional features: differentiation induction, heterotransplantability
* special unique features
* key references

Mast Cells and Basophils (Hardcover): Gianni Marone, Lawrence M. Lichtenstein, Stephen J. Galli Mast Cells and Basophils (Hardcover)
Gianni Marone, Lawrence M. Lichtenstein, Stephen J. Galli
R3,502 Discovery Miles 35 020 Ships in 12 - 17 working days

A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

Molecular Protocols in Transfusion Medicine (Paperback): Gregory A. Denomme, Maria Rios, Marion E. Reid Molecular Protocols in Transfusion Medicine (Paperback)
Gregory A. Denomme, Maria Rios, Marion E. Reid
R2,133 Discovery Miles 21 330 Ships in 12 - 17 working days

This essential methods manual for immunohematologists (or hematologists and immunohematologists) provides information on genes that encode antigens on red blood cells, platelets and neutrophils. The book begins by covering general concepts in molecular biology and specific protocols such as DNA preparation, PCR-RFLP and allele-specific PCR. Information on the erythrocyte, platelet and neutrophil antigen systems and the molecular basis of polymorphisms are presented clearly in a gene facts sheet format. Database accession numbers and useful adjuncts such as Request forms, worksheets for PCR/enzyme digests also serve to benefit the user. The information is clearly presented and easily accessible and is complemented by the excellent diagrams and tabular material. This book is invaluable for both new and experienced researchers in the field and other related disciplines.
Key Features
* Essential for hematologists and those involoved in tissue typing and the study of human genetic polymorphisms
* Presents clearly and concisely the information on a particular variant and the technique used to detect it
* Organized by antigen and provides sequences of polymorphisms and primers
* Details the general concepts and critical information on genes, their products, and sources of relevant nucleic acids
* Includes protocols that allow investigators to set up assays with minimal effort (protocols include primers, reagents, reaction conditions, sizes of amplified products, restriction fragment digests, and the relevant safety information)
* Provides information that helps interpret results in clinical settings
* Contains additional sources of information (e.g., key references, web site addresses, glossary, Database accession numbers, request
forms, and worksheets for PCR/enzyme digests)

Pathology and Pathogenesis of Human Viral Disease (Hardcover): John E. Craighead Pathology and Pathogenesis of Human Viral Disease (Hardcover)
John E. Craighead
R3,363 Discovery Miles 33 630 Ships in 12 - 17 working days

Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. Encompassing everything from cold and flu viruses to sexually transmitted diseases, this important resource describes the cellular and tissue pathological changes attributable to infection in the context of the pathogenic mechanisms involved. The author provides a comprehensive review of the older and contemporary literature, considering both the common and much rarer complications of infection.
Pathology and Pathogenesis of Human Viral Disease is written from the unique perspective of the clinical pathologist. It will help clinicians and pathologists gain a better understanding of changes that occur in viral infected cells, tissues, and organs. It will also serve as a pathology source book for virologists, internists, and pediatricians.
Key Features
* Provides a comprehensive, worldwide perspective of viral disease pathology
* Bridges the fields of pathology and virology; integrating clinical disease with cell and tissue pathology
* Addresses topics from the perspective of the clinical pathologist
* Illustrates unique, viral induced pathological lesions
* Considers common and uncommon complications of infection

Advances in Cancer Research, Volume 152 (Hardcover): Paul B. Fisher, Kenneth D. Tew Advances in Cancer Research, Volume 152 (Hardcover)
Paul B. Fisher, Kenneth D. Tew
R4,305 Discovery Miles 43 050 Ships in 12 - 17 working days

Advances in Cancer Research, Volume 152, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.

The Leishmaniases: Old Neglected Tropical Diseases (Hardcover, 1st ed. 2018): Fabrizio Bruschi, Luigi Gradoni The Leishmaniases: Old Neglected Tropical Diseases (Hardcover, 1st ed. 2018)
Fabrizio Bruschi, Luigi Gradoni
R4,417 Discovery Miles 44 170 Ships in 10 - 15 working days

Out of the 20 neglected tropical diseases (NTDs) prioritized by the World Health Organization, the leishmaniases rank in the top 3 among those caused by protozoa. The purpose of this book is to provide the reader with a comprehensive and updated overview of all the aspects of leishmaniasis with a worldwide perspective - authors of many chapters include eminent scientists from both the Old and New Worlds. The chapters cover a wide range of topics, classically organized into biology and epidemiology, followed by clinical and control aspects. Following an introductory chapter intended to take the reader into the leishmaniasis complexity, a chapter on Leishmania taxonomy reports on the most recent advances in molecular and phylogenetic data. Parasite biology is then described in detail by means of two separate chapters devoted to phlebotomine vectors and reservoir hosts, respectively. The medical part of the book begins with a chapter on basic immunology and immunopathology associated with Leishmania infection, followed by a classical chapter on clinical aspects of different disease entities. The complexity of disease case management is presented by means of 3 chapters, respectively on diagnosis, treatment of visceral forms and treatment of tegumentary forms. Finally, the last chapter deals with the available approaches to control leishmaniasis and related public health issues.

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