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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
This book is intended as a guide for the diagnosis and management of children with celiac disease. It is an excellent learning resource suitable for students and health care providers in the fields of pediatrics, pediatric gastroenterology and pediatric endocrinology. Celiac disease is discussed in detail; gluten allergy and the so-called non-celiac gluten sensitivity are also briefly described. Besides the clinical aspects of the disease, the reader will find suggestions for the correct diagnosis and follow-up of short stature and other celiac related endocrine conditions. This book provides a thorough and critical update on the current knowledge on this unique autoimmune disease.
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.
This book represents the state-of-the-art in the field of skin and
autoimmune rheumatic diseases. It covers systematically a growing
and multifaceted topic which is of great importance in the clinical
practice. It also serves as a sharp educational tool as each
chapter provides summaries and specific highlights to key
references cited into the text. The pathophysiological link between
skin involvement and autoimmunity has been explained in detail, as
well as diagnostic and therapeutic aspects.
Understanding immunology is increasingly important in obstetrics and gynecology. This book explores the role of immunological processes in reproduction. It presents immunologic concepts and illustrates important points with examples familiar to the clinician. It is organized into four sections: fundamentals of the immune system; the immunological paradox of pregnancy; clinical applications of immunology in obstetric and gynecologic practice, and immunopathology in obstetric and gynecologic practice. Written mainly for practicing obstetricians and gynecologists, the research results cited in the book are confined to human experimentation.
Immunology: A Comparative Approach discusses the immunological features of a wide range of living organisms. It considers the merits of the laboratory mouse as an immunological representative; opportunities for bypassing technical obstacles in one model by using another; the immunological implications of changes in overall structure, physiology and way of life; and progress made in the study of defence mechanisms in animals and plants of commercial importance. This book is written for students and research workers with some knowledge of mainstream immunology who are curious about the advances, opportunities and challenges in comparative work.
Advances in Immunology presents current developments as well as
comprehensive reviews in immunology. Articles address the wide
range of topics that comprise immunology, including molecular and
cellular activation mechanisms, phylogeny and molecular evolution,
and clinical modalities. Edited and authored by the foremost
scientists in the field, each volume provides up-to-date
information and directions for future research.
This first thematic issue, of the Advances in Immunology series,
highlights the remarkable new insights into the mechanisms that
govern development and function of T cell lineages. Recent
developments in the understanding of the genetic and epigenetic
mechanisms that regulate development of the two major T cell
lineages will have a fundamental impact on a number of research
fields -immunology, cell biology, hematology and stem cell
research. All of these groups have a vested interest in
comprehending issues such as stem cell self renewal, progenitor
plasticity, lineage commitment and cellular identity. Immunologists
have a special interest in the mechanisms that allow selection of a
T cell repertoire whose members integrate genetic information for T
cell receptor, co-receptor and specialized immunologic function,
since this process lies at the core of adaptive immunity.
Immunology of Endometriosis: Etiology and Management, a volume in the Reproductive Immunology series, provides updates on one of most common gynecological diseases, including basic science concepts and their clinical applications related to endometriosis immunology. Various immunological factors are believed to play roles in the pathogenesis of endometriosis, providing potential targets for the disease. Endometriosis is now considered to be a disease of both endocrine and immune dysregulation. However, recognition of the direct involvement of two major physiological mechanisms brings about a change of focus which might represent an interesting advance in the understanding of this disease and new focus for further research.
Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Volume 81 of Advances in Immunology contains articles on a vast
range of immunology topics including the regulation of the immune
response by the interaction of chemokines and proteases as well as
roles of the Semaphorin Family in immune regulation. It has a
chapter devoted to B Lymphoid Neoplasms of Mice and another on the
Zebrafish as a model organism to study development of the immune
system. This volume will be of interest to immunologists in all
industries.
The primary focus of this book is to provide readers with a comprehensive overview of the recent advances in inflammation, especially in molecular biological and clinical aspects. Chapters contained in this book are written by invited authors from all over the world, who are well-known experts in their respective fields. In the book, chapters discussed include the molecular basis of inflammatory mechanisms, the functional roles of inflammation in diseases and new treatments of anti-inflammation. This book will be useful to all who wish to understand the scientific basis of inflammatory disease.
Advances in Immunology, Volume 152, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, including chapters that cover Renal diseases and the role of complement in their pathogenesis, Factor H and Properdin and their regulation, Complement in neuronal diseases, Complement and the brain.
Immunology of Infection, 2nd Edition, edited by two leading experts
in the field, presents the most appropriate up-to-date experimental
approaches in the detail required for modern microbiological
research. Focusing on the methods most useful for the
Microbiologist interested in analysing host-pathogen relationships,
this volume will be essential reading for all researchers working
in microbiology, immunology, virology, mycology and parasitology.
Chosen as a Book of the Year 2021 by the Financial Times, Sunday Times, Daily Mail, Prospect, Guardian and The Times. 'Vaxxers is so good that the book will be read for long after the pandemic is over' Financial Times 'One of the most epic and pioneering moments in human history' Sir Jeremy Farrar __________ The bestselling inside story of a historic moment for science and for humanity. On 1 January 2020, Professor Sarah Gilbert read an article about four people in China with an illness of unknown cause. Within two weeks, she and her team had designed a new vaccine that would go on to save millions of lives from Covid-19. Capturing a landmark moment, Sarah Gilbert and Catherine Green reveal their story of making the pioneering Oxford AstraZeneca vaccine and fighting a pandemic as ordinary people in extraordinary circumstances. They separate fact from fiction, they explain how they made their highly effective vaccine in record time with the eyes of the world watching, and they give us hope for the future.
This book provides the reader with a comprehensive overview of the
Antiphospholipid syndrome. One of the most important advances in
rheumatology and connective tissue diseases of the last decade. It
provides an explanation for many previously undefined conditions
with no clear pathogenesis encompassing all subspeculations in
internal medicine as well as obstetrics. Clotting problems leading
to strokes and myocardial infarctions (in younger people) as well
as a large variety of other syndromes such as chorea,
hyproadrenalism, pulmonary problems are now being understood.
The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behcet's disease, Sjogren's syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.
A search for a missing son... and a toxic mystery that threatens the
globe.
The FactsBook series has established itself as the best source of
easily accessible and accurate facts about protein groups. Books in
the series use an easy-to-follow format and are meticulously
researched and compiled by experts in the field.
This book represents an essential reference manual for all of the
well-characterized leukemia-lymphoma cell lines currently
available. It provides the most important facts, using the succinct
and user-friendly format that has made the FactsBooks so popular
with scientists and clinical researchers. Introductory chapters
provide background and perspective for culturing malignant
hematopoietic (blood forming) cell lines. These chapters are
followed by over 400 comprehensive individual entries. Each cell
line entry highlights essential clinical, immunological, genetic,
and functional features and includes a comprehensive listing of
references.
A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
This essential methods manual for immunohematologists (or
hematologists and immunohematologists) provides information on
genes that encode antigens on red blood cells, platelets and
neutrophils. The book begins by covering general concepts in
molecular biology and specific protocols such as DNA preparation,
PCR-RFLP and allele-specific PCR. Information on the erythrocyte,
platelet and neutrophil antigen systems and the molecular basis of
polymorphisms are presented clearly in a gene facts sheet format.
Database accession numbers and useful adjuncts such as Request
forms, worksheets for PCR/enzyme digests also serve to benefit the
user. The information is clearly presented and easily accessible
and is complemented by the excellent diagrams and tabular material.
This book is invaluable for both new and experienced researchers in
the field and other related disciplines.
Pathology and Pathogenesis of Human Viral Disease is a
comprehensive reference that examines virus-induced clinical
disease of humans in the context of the responsible virus and its
epidemiology. Encompassing everything from cold and flu viruses to
sexually transmitted diseases, this important resource describes
the cellular and tissue pathological changes attributable to
infection in the context of the pathogenic mechanisms involved. The
author provides a comprehensive review of the older and
contemporary literature, considering both the common and much rarer
complications of infection.
Advances in Cancer Research, Volume 152, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.
Out of the 20 neglected tropical diseases (NTDs) prioritized by the World Health Organization, the leishmaniases rank in the top 3 among those caused by protozoa. The purpose of this book is to provide the reader with a comprehensive and updated overview of all the aspects of leishmaniasis with a worldwide perspective - authors of many chapters include eminent scientists from both the Old and New Worlds. The chapters cover a wide range of topics, classically organized into biology and epidemiology, followed by clinical and control aspects. Following an introductory chapter intended to take the reader into the leishmaniasis complexity, a chapter on Leishmania taxonomy reports on the most recent advances in molecular and phylogenetic data. Parasite biology is then described in detail by means of two separate chapters devoted to phlebotomine vectors and reservoir hosts, respectively. The medical part of the book begins with a chapter on basic immunology and immunopathology associated with Leishmania infection, followed by a classical chapter on clinical aspects of different disease entities. The complexity of disease case management is presented by means of 3 chapters, respectively on diagnosis, treatment of visceral forms and treatment of tegumentary forms. Finally, the last chapter deals with the available approaches to control leishmaniasis and related public health issues. |
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