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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Antimicrobial Peptides and Innate Immunity (Hardcover, 2013 ed.)
Loot Price: R5,197
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Antimicrobial Peptides and Innate Immunity (Hardcover, 2013 ed.)
Series: Progress in Inflammation Research
Expected to ship within 12 - 17 working days
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Antimicrobial peptides have been the subject of intense research in
the past decades, and are now considered as an essential part of
the defense system in bacteria, plants, animals and humans. This
book provides an update on these effector molecules of the innate
immune system both for researchers who are already actively
involved in the area, and for those with a general interest in the
topic. The book starts with an overview of the evolution of
cysteine- containing antimicrobial peptides (including defensins),
and the role of these peptides in host defense in plants and micro-
organisms. The realization that antimicrobial peptides also display
functions distinct from their direct antimicrobial action is the
focus of the next chapters, and puts these peptides center stage in
immunity and wound repair. Further chapters discuss the role of
antimicrobial peptides in disease, by providing an overview of
mechanisms in bacterial resistance to antimicrobial peptides and a
discussion of their role in inflammatory bowel disease, cystic
fibrosis lung disease and chronic obstructive pulmonary disease.
Finally, the book shows how knowledge of the function of
antimicrobial peptides and their regulation can be used to design
new therapies for inflammatory and infectious disorders. This is a
very important area of research because of the increase in
resistance of micro-organisms to conventional antibiotics.
Therefore the use of synthetic or recombinant peptides, or agents
that stimulate the endogenous production of antimicrobial peptides,
provides an attractive alternative for conventional antibiotics.
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