Break the rules, not the fast with world-renowned biohacker and New York Times bestselling author Dave Asprey.

For more than a decade, the Bulletproof founder Dave Asprey has shared his unique point of view and expertise to help fans become the best versions of themselves. From living longer to getting smarter, maximising performance to practising mindfulness, Dave's followers look to him for his take on the most effective techniques to become healthier and more powerful than most doctors think is possible. Asprey has been fasting for years, long before it gained widespread popularity, and if you're a fan of The Bulletproof Diet, you have been enjoying some of the benefits of Intermittent Fasting too.

In Fast This Way, Dave asks readers to forget everything they think they know about the ancient practice and takes them on a journey through cutting-edge science to examine the ways novice fasters and Intermittent Fasting loyalists can up-end their relationship with food and upgrade their fasting game beyond calorie restriction.

• What IF eating the right foods at the right time can actually enhance your fast?
• What IF how you work out and sleep could trick your body into thinking you are fasting?
• What IF it were easy to skip a meal, or two, or three?
• What IF fasting is different for women, can be personalised to your genes, and can impact your mental health?
• What IF all fasts could be created equal?

Fast This Way is a compelling read through the latest thinking on fasting and gives readers the manual and toolkit to make the most of their fasts and their personal biology.

Ideal for those studying biochemistry for the first time, this proven book balances scientific detail with readability and shows you how principles of biochemistry affect your everyday life. Designed throughout to help you succeed (and excel!), the book includes in-text questions that help you master key concepts, end-of-chapter problem sets grouped by problem type that help you prepare for exams, and state-of-the art visuals that help you understand key processes and concepts. In addition, visually dynamic "Hot Topics" cover the latest advances in the field, while "Biochemical Connections" demonstrate how biochemistry affects other fields, such as health and sports medicine. The accompanying OWL homework offers end-of-chapter problems in digital form, giving you on-demand access to hints, solutions, and other information directly related to the problem.

The Poisoners is a history of four devastating chapters in the making of the region, seen through the disturbing use of toxins and accusations of poisoning circulated by soldiers, spies, and politicians in Zimbabwe and South Africa.

Imraan Coovadia’s fascinating new book exposes the secret use of poisons and diseases in the Rhodesian bush war and independent Zimbabwe, and the apparent connection to the 2001 anthrax attacks in the United States; the enquiry into the chemical and biological warfare programme in South Africa known as Project Coast, discovered through the arrest and failed prosecution of Dr Wouter Basson; the use of toxic compounds such as Virodene to treat patients at the height of the Aids epidemic in South Africa, and the insistence of the government that proven therapies like Nevirapine, which could have saved hundreds of thousands of lives, were in fact poisons; and the history of poisoning and accusations of poisoning in the modern history of the African National Congress, from its guerrilla camps in Angola to Jacob Zuma’s suggestion that his fourth wife collaborated with a foreign intelligence agency to have him murdered.

But The Poisoners is not merely a book of history. It is also a meditation, by a most perceptive commentator, on the meaning of race, on the unhappy history of black and white in southern Africa, and on the nature of good and evil.

The identification and quantification of the widespread occurrence of trace organic chemicals at minute concentrations in the aqueous environment impacted by human activities is a result of rapid advances in environmental analytical chemistry. The body of knowledge regarding the characterization, fate and transport of these chemicals of emerging concern (CECs) in the natural water environment and engineered water treatment processes, as well as their toxicity, has grown substantially over the last two decades. Recently, the focus in the environmental chemistry community has shifted from these CEC parent compounds to the fate, transport, and toxicity of transformation products, which are generated through abiotic and biotic mechanisms in natural systems and during engineered advanced water treatment processes. This two-part book focuses on the studies and recent advancements towards the development of more harmonized strategies and workflows using non-target and suspects screening methods, including suitable bioassay approaches to assess the overall relevance of transformation products. Volume I covers the relevance of transformation products and international strategies to manage CECs, new methods for a comprehensive assessment of transformation products, and the fate and transport of transformation products in natural systems. This book is ideal for environmental scientists and engineers, particularly chemists, environmental engineers, public health officials, regulators, other chemistry-related professionals, and students.

Even the most cursory survey of the chemical literature reveals that modern NMR spectroscopy has indeed fulfilled its potential as a powerful and indispensable tool for probing molecular structure, providing detail that is comparable to, and sometimes surpasses that, of X-ray crystallography. As NMR spectroscopy's 70th anniversary approaches, the diversity of chemical problems to which this technique can be applied continues to grow across many scientific fields. Beyond the laboratory setting, the technology underlying NMR is now a widely used and critical medical diagnostic technique, Magnetic Resonance Imaging (MRI). Unfortunately, the number of applications of NMR spectroscopy across so many STEM-related fields presents significant challenges in how best to introduce this powerful technique in meaningful ways at the undergraduate level. Inspired by the development of the field, and building upon the work of previous symposia and an ACS symposium series book on this topic (3), a symposium was developed, entitled "NMR Spectroscopy in the Undergraduate Curriculum," for the 239th American Chemical Society National Meeting in San Francisco. This book brings together all of the presenters who have been successful in developing and successfully integrating NMR spectroscopy pedagogy across their undergraduate curriculums. Their knowledge and experiences will aid readers who are interested in expanding and invigorating their own curriculum.

Levels of mycotoxin contamination in agricultural commodities are regulated in more than 100 countries, and exposure to these naturally occurring toxins presents serious risks to the health of humans and animals with negative impacts to commodity values. This symposium series book presents significant scientific developments in the multifaceted approach to reducing exposure to these naturally occurring toxins. A broad-spectrum of subject matter of the multidisciplinary field of mycotoxin research is conveniently compiled in this single volume, and general themes include prevention, control, exposure, molecular biology, biosynthesis, analytical methodology, and emerging techniques. The book opens with an overview of prevention of mycotoxin production by means of biological control and human exposure to contaminated foods, including tofu, apples, figs, and a broad range of fruits.
The second section focuses on molecular biological approaches to control mycotoxin exposure. Topics covered include genomic approaches, detoxification, structure-activity studies of biosynthetic precursors, and mycotoxin biosynthesis. The success of these strategies is supported by the reduction of mycotoxin occurrence and incidence in foods. Accurate estimates of mycotoxin concentration in foods are important for food safety and wholesomeness.
The final section covers analytical approaches, including sampling plans for foods and dietary supplements, extraction efficiency of mycotoxins from naturally contaminated grains, traditional detection methods such as chromatography/mass spectrometry, and emerging techniques such as the use of molecularly imprinted polymers for purification and isolation and cyclodextrins for fluorescent enhancement of several mycotoxins.

Chirality as an environmental phenomenon was dealt with in a thorough and interesting manner in a series of three symposia entitled "Modern Chiral Pesticides: Enantioselectivity and Its Consequences," sponsored by the Agrochemical Division of the American Chemical Society and held in Washington, DC (2005), Boston, MA (2007) and San Francisco, CA (2010). All three symposia included speakers from industry, government and academia, representing several European countries, China, and the United States. Corresponding to this broad group of countries, institutions and speakers, the range of topics touched on almost all facets of chirality as it is manifested in environmental and human exposure and toxicity. The 40 oral and 20 poster presentations indeed approached comprehensive coverage: analysis of enantiomers and other stereoisomers; preparative separation of enantiomers; stereoselective occurrences of chiral pesticides in environment soil and water and in wildlife and human tissues and fluids; stereoselective degradation and metabolism of chiral pesticides; and stereoselective toxicity.
This book is a result of manuscript contributions by some of the oral and poster presenters to the third symposium in 2010. In addition to symposium participants, invitations were extended to the environmental chiral chemistry community in general, including most of the speakers in the 2005 and 2007 symposia, in an attempt to attain good coverage of this rather broad topic. Thus, this ACS Symposium book will generate many new ideas from interested readers and inform them of useful techniques for experimental exploration of the somewhat exotic, but important, area of chiral chemistry of pesticides.

A combination of population growth, public health failures, environmental degradation and rapid global transportation has resulted in a world that is at increasing risk to vectorborne and other infectious diseases. A large percentage of emerging diseases are vectorborne and over one-third of the agents on the list of greatest concern from bioterrorism are vectorborne. Many of these diseases are viral that have no effective drug or vaccine treatments. Drug and insecticide resistance is now common and has greatly compromised our ability to provide effective and affordable control. Parasitic diseases, including malaria, leishmmaniasis and African trypanosomiasis are likewise increasing in many parts of the world. Control programs for onchocerciasis and to some extent filariasis are reducing the impact of these diseases, largely due to the availability of filaricides such as ivermectin. Chagas disease has also declined significantly through home improvements and indoor insecticide application against the domicilary kissing bug vectors.
Despite these gains, this tend has not been sustainable. Instead, infectious disease is now responsible for greater than 25% of all deaths and nearly 50% of premature deaths among those under 45 years of age, and 63% for children less than 4 years of age. A significant proportion of these deaths is attributed to vectorborne diseases, particularly from malaria ( 11%). Indeed, more that 1 million people are killed annually by malaria, about 3000 per day. It is estimated that 700,000 children under the age of 5 die of malaria and at least 300 million are ill due to malaria each year. In response, the American Institute of Medicine (2003) has called for a renewed effort to rebuild public health infrastructures needed to conduct disease surveillance and vector control programs and to increase research to provide improved pesticides and their use, new repellents, new biopestcides and biocontrol agents to augment pesticidal control, as well as novel strategies to interrupt pathogen transmission.
With these goals in mind, we convened the first vector control symposium as part of the scientific program of the 3rd Pan-Pacific Conference of Pesticide Science in 2003. Five years after (2008), we re-convened this expanded topic at the 4th Pan-Pacific Conference on Pesticide Science and the scientific presentations made over two days comprise this current volume, Advances in Human Vector Control. The book covers two major areas: 1) Current Status and Control Practices, covering malaria, dengue, Chagas, human lice, cockroach and house dust mite issues; and 2) Novel Approaches and Resistance Management of these diseases. Chapters are provided by internationally-recognized experts who are actively involved in vector control and management, providing an up to date summary of this critically important area of public health. The effective use of novel control strategies is stressed and the status of recently acquired genomic approaches is critically reviewed.

This ACS Symposium Series is the product of a symposium held at the 241st National Meeting of the American Chemical Society in Anaheim, CA on March 27-31, 2011. It includes chapters on new biobased building blocks such as the furandicarboxylic acid, polyesters and polyamides from adipic, succinic and sebacic acids with aliphatic diols such as 1,3-propylene glycol, 1,4-butanediol, 1,12-dodecylenediol and isosorbide. The conversion of hydroxymethylfurfural, the dehydration product of hexose sugars, to succinic acid and 1,4-butanediol to produce poly(butylene succinate) is described in one chapter. Also the synthesis of new polymers from plant-derived olefinic monomers such as tulipalin A and studies of composites from cotton by-products are featured in other chapters. There is a strong emphasis on biocatalytic synthesis and polymerization within the book. Chapter topics include the synthesis of ?-hydroxyfatty acids and polymers therefrom, an interesting discussion on the structural differences of the products of the biocatalytic and chemical catalytic synthesis of polyesters from oleic diacid and glycerol and the ability to produce polylactic acid (PLA) and PLA-PHA copolyesters within a "microbial cell factory". Other areas of interest explored in other chapters include recent developments of biobased polymer fibers and oleate-based pressure sensitive adhesives and composites. One chapter describes a large increase in cold-drawn fiber tensile strength by the blending of a small amount of ultrahigh molecular weight (MW) poly(3-hydroxybutyrate) with a much lower MW 3-hydroxybutyrate polymer. The addition of a rubber and inorganic fillers to normally brittle PLA was found to dramatically improve its ductility. Finally, there are several chapters on seed oil-based polyurethanes, one on fibers from soy proteins and composites from starch.

In the past, the stability of milk and milk products was the primary consideration, but this is no longer the principal objective due to the evolution of modern sanitary practices as well as pasteurization. Today, the manufacture of dairy products of consistently good flavor and texture is crucial. In previous flavor studies, researchers identified hundreds of volatile compounds, with little or no attention paid to their sensory contribution to overall flavor of dairy products. The availability of powerful chromatographic separation techniques like high resolution gas chromatography in combination with mass spectrometry and olfactory detection ports have revolutionized the work on characterization of dairy flavor. This along with recent developments in sensory methods and our increased knowledge about the genomics of diary culture organisms have allowed great advancements in our understanding of dairy flavor chemistry. Flavor of Dairy Products covers the evolution of dairy flavor research and presents updated information in the areas of instrumental analysis, biochemistry, processing and shelf-life issues related to the flavor of dairy products.

Consumers, regulators, and the food industry increasingly require that foods comply not only with label descriptions of food content, but also with information regarding the food's origin. For example, the wine industry has a long history of labeling wines based on varietal, regional, or age (vintage)-related properties. However, regulatory agencies are now beginning to require methods to confirm this label information. Food retailers are also facing voluntary or mandatory labeling requirements that will indicate regional or country-of-origin, species and/or varietal information. As a result, development of reliable analytical methods to confirm the authenticity of the label information is needed. This book presents the latest research on food and wine authentication. The chapters are authored by leading international scientists whose research focuses on the development and application of analytical methodologies used for the authentication of food and beverages.

Measuring metabolic rates is central to important questions in many areas of scientific research. Unfortunately these measurements are anything but straightforward, and numerous pitfalls await the novice and even the experienced investigator.
Measuring Metabolic Rates de-mystifies the field, explaining every common variation of metabolic rate measurement, from century-old manometric methods through ingenious syringe-based techniques, direct calorimetry, aquatic respirometry, stable-isotope metabolic measurement and every type of flow-through respirometry. Each variation is described in enough detail to allow it to be applied in practice. Background information on different analyzer and equipment types allows users to choose the best instruments for their application. Respirometry equations - normally a topic of terror and confusion to researchers - are derived and described in enough detail to make their selection and use effortless.
Vital topics such as manual and automated baselining, implementing multi-animal systems, and the correct analysis and presentation of metabolic data are covered in enough detail to turn a respirometry neophyte into a hardened metabolic warrior, ready to take on the task of publication in peer-reviewed journals.

The Porphyrin Handbook, Volume 15: Phthalocyanines: Synthesis provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into five chapters, this volume begins with an overview of the importance of compounds such as heme and chlorophyll that play vital roles in the biological systems responsible for the transportation of oxygen to cells in the body. This text then explores the different methods used for the preparation of phthalocyanine and its metallated derivatives. Other chapters consider the detailed survey of phthalocyanine formation, characterization, and purification. This book discusses as well the synthesis of low-symmetry phthalocyanines and related compounds. The final chapter deals with a survey of the structure, synthesis, and physiochemical properties of porphyrazines with annulated heterocycles. This book is a valuable resource for research scientists, engineers, and clinicians.

The Porphyrin Handbook, Volume 14: Medical Aspects of Porphyrins provides information pertinent to every aspect of the chemistry, synthesis, spectroscopy, and structure of phthalocyanines. This book examines the biology and medical implications of porphyrin systems. Organized into 12 chapters, this volume begins with an overview of the underlying diagnostic features, mechanisms, and available treatments of erythropoietic disorders due to defective heme biosynthesis. This text then examines the physiopathology of acute intermittent porphyria, which is transmitted as autosomal dominant disorders with incomplete penetrance. Other chapters consider the main characteristics of congenital erythropoietic porphyria, which includes an increased synthesis, accumulation, ad excretion of porphyrins. This book discusses as well the biochemistry, pathophysiology, and clinical features of variegate porphyria in the light of several essential advances in the understanding, management, and diagnosis of variegate porphyria. The final chapter deals with the legal use of herbal and complementary medicines. This book is a valuable resource for research scientists, engineers, and clinicians.

Derived from the classic text originated by Lubert Stryer and continued by John Tymoczko and Jeremy Berg, Biochemistry: A Short Course focuses on the major topics taught in a one-semester biochemistry course. With its brief chapters and relevant examples, this thoroughly updated new edition helps students see the connections between the biochemistry they are studying and their own lives. Biochemistry: A Short Course is now supported in Achieve, Macmillan's new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for chemistry students. Achieve includes an interactive eBook as well as our renowned assessments and innovative, interactive Metabolic Map. Students will be able to focus their study with adaptive quizzing and more clearly see the relevance of chemistry through case studies. Instructor resources, including tools for active learning, are all housed in this exciting new platform.

The authoritative reference, written with a framework for understanding. Available for the first time in Achieve, the definitive reference text for biochemistry Lehninger Principles of Biochemistry, 8e helps students focus on the most important aspects of biochemistry-- the principles! Dave Nelson, Michael Cox, and new co-author Aaron Hoskins identify the most important principles of biochemistry and direct student attention to these with icons and resources targeted to each principle. The 8th edition has been fully updated for focus, approachability, and up-to-date content. New and updated end-of-chapter questions -all available in the Achieve problem library with error-specific feedback and thorough solutions. These questions went through a rigorous development process to ensure they were robust, engaging and accurate. Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.

Available for the first time in Achieve, the definitive reference text for biochemistry Lehninger Principles of Biochemistry, 8e helps students focus on the most important aspects of biochemistry- the principles! Dave Nelson, Michael Cox, and new co-author Aaron Hoskins identify the most important principles of biochemistry and direct student attention to these with icons and resources targeted to each principle. The 8th edition has been fully updated for focus, approachability, and up-to-date content. New and updated end-of-chapter questions -all available in the Achieve problem library with error-specific feedback and thorough solutions. These questions went through a rigorous development process to ensure they were robust, engaging and accurate. Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. Achieve supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. The pairing of a powerful new platform with outstanding biochemistry content provides an unrivaled learning experience.

'D-Amino Acids in Chemistry, Life Sciences and Biotechnology' presents a collection of state of the art contributions from leading scientists in D-amino acid research, a field that has significant implications in relation to health care, research in age-related and neuronal diseases, pharmaceutical chemistry and food science.
The increasing importance of D-amino acids and the need for a forum to exchange ideas and hypothesis led to the foundation of the 'D-Amino Acid Research Society' in Japan, followed by the First International Conference on D-Amino Acid Research in 2009. The majority of the contributions published in D-Amino Acids in Chemistry, Life Sciences and Biotechnology result from this event and reflect the long-standing interest of the Guest Editors and their co-workers and collaborators in the field of D-amino acid research.

The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.