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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Curing Genetic Diseases through Genome Reprogramming, Volume 182 (Hardcover): Gianluca Petris Curing Genetic Diseases through Genome Reprogramming, Volume 182 (Hardcover)
Gianluca Petris
R5,334 R4,472 Discovery Miles 44 720 Save R862 (16%) Ships in 12 - 19 working days

Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy-the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome.

Transporters and Plant Osmotic Stress (Paperback): Aryadeep Roychoudhury, Durgesh Kunar Kumar Tripathi, Rupesh Deshmukh Transporters and Plant Osmotic Stress (Paperback)
Aryadeep Roychoudhury, Durgesh Kunar Kumar Tripathi, Rupesh Deshmukh
R4,756 Discovery Miles 47 560 Ships in 12 - 19 working days

Transporters and Plant Osmotic Stress focuses on the potential negative impact of abiotic stresses on plant health and crop yield. The book focuses on the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters during different osmotic stresses and their probable mechanisms of operation in plant stress tolerance. The comprehensive discussion presented in this book highlights steps appropriate for mitigating multiple forms of abiotic stresses utilizing transporter proteins. Edited by leading experts and authored by top researchers from around the world, Transporters and Plant Osmotic Stress will be valuable to researchers, academicians, and scientists to enhance their knowledge and inspire further research in the field of transporters with respect to abiotic stress responses. It is complimented by its companion book titled Metal and Nutrient Transporters in Abiotic Stress.

Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function, Volume 654 (Hardcover): Daniel L. Minor, Henry... Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function, Volume 654 (Hardcover)
Daniel L. Minor, Henry M. Colecraft
R6,169 R5,165 Discovery Miles 51 650 Save R1,004 (16%) Ships in 12 - 19 working days

Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus.

Advances in Microbial Physiology, Volume 78 (Hardcover): Robert K. Poole, David J. Kelly Advances in Microbial Physiology, Volume 78 (Hardcover)
Robert K. Poole, David J. Kelly
R4,983 R4,179 Discovery Miles 41 790 Save R804 (16%) Ships in 12 - 19 working days

Advances in Microbial Physiology, Volume 78, the latest release in this ongoing series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. This updated release contains the latest information in the field, with comprehensive chapters covering Microbubble Intensification of Bioprocessing, Bacterial cellulose: biosynthesis, production, and applications, Microbial energy management - a product of three broad tradeoffs, and more.

Ion Channels: Channel Production and Optical Methods, Volume 653 (Hardcover): Daniel L. Minor, Henry M. Colecraft Ion Channels: Channel Production and Optical Methods, Volume 653 (Hardcover)
Daniel L. Minor, Henry M. Colecraft
R6,162 R5,158 Discovery Miles 51 580 Save R1,004 (16%) Ships in 12 - 19 working days

Ion Channels Part B, Volume 652 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including NMDAR, Pannexin, and CALHM, Making NaV1.4 and NaV1.7, TRPVs, Purification native nAChRs, GABAR Radu Aricescu, TRPV5/2, NaV1.5, KATP, TRPA1, TREK-1, SARS-CoV-2 3a ion channel, Ion channel conformational dynamics by encoded unnatural amino acid, Fluorescence lifetime measurement of absolute membrane potential, Fluorescent Toxins as Activity Sensors, FRET Analyses of Ion Channel Protein-Protein Interactions, Control of Ion Channel Gating with Photo-Switchable Tweezers, and Counting Subunits in Kv Channel Complexes.

Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences (Hardcover): Xianquan Zhan Metabolomics - Methodology and Applications in Medical Sciences and Life Sciences (Hardcover)
Xianquan Zhan
R3,330 Discovery Miles 33 300 Ships in 10 - 15 working days
Ion Channels: Channel Biochemistry, Reconstitution, and Function, Volume 652 (Hardcover): Daniel L. Minor, Henry M. Colecraft Ion Channels: Channel Biochemistry, Reconstitution, and Function, Volume 652 (Hardcover)
Daniel L. Minor, Henry M. Colecraft
R6,159 R5,155 Discovery Miles 51 550 Save R1,004 (16%) Ships in 12 - 19 working days

Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors.

Drink? - The New Science of Alcohol and Health (Paperback): David Nutt Drink? - The New Science of Alcohol and Health (Paperback)
David Nutt
R469 R438 Discovery Miles 4 380 Save R31 (7%) Ships in 10 - 15 working days
Advances in Clinical Chemistry, Volume 102 (Hardcover): Gregory S. Makowski Advances in Clinical Chemistry, Volume 102 (Hardcover)
Gregory S. Makowski
R6,348 R5,312 Discovery Miles 53 120 Save R1,036 (16%) Ships in 12 - 19 working days

Advances in Clinical Chemistry, Volume 102, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the most up-to-date technologies related to the field of clinical chemistry. Chapters in this new release cover Advances in immunosensor technology, Extracellular Vesicles: Roles and Applications in Drug-Induced Liver Injury, Oxidative stress biomarkers in the preterm infant, Translational biomarkers in the era of precision medicine, Metabolomics applications in coronary artery disease personalized medicine, Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers.

Metal and Nutrient Transporters in Abiotic Stress (Paperback): Aryadeep Roychoudhury, Durgesh Kunar Kumar Tripathi, Rupesh... Metal and Nutrient Transporters in Abiotic Stress (Paperback)
Aryadeep Roychoudhury, Durgesh Kunar Kumar Tripathi, Rupesh Deshmukh
R4,021 Discovery Miles 40 210 Ships in 12 - 19 working days

Metal and Nutrient Transporters in Abiotic Stress focuses on the different forms of environmental stress related to heavy metal, metalloid and nutrient deficiency that have the potential to inflict major damages to crop plants, leading to a massive decrease in crop yield and productivity. The book presents the current state of knowledge of the biochemical and molecular regulation of several classes of membrane transporters related to the uptake of metals/metalloids and nutrient elements during different stresses and their probable mechanisms of operation in plant stress tolerance. Metal and Nutrient Transporters in Abiotic Stress provides a comprehensive discussion that will help in mitigating multiple forms of stresses utilizing transporter proteins. Edited by leading experts and written by a global team of knowledgeable contributors, this book will further stimulate research in the field of transporter proteins and will foster further interests for researchers, academicians and scientists worldwide. It is complimented by its companion book titled Transporters and Plant Osmotic Stress.

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B, Volume 180 (Hardcover): Vijai Singh Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B, Volume 180 (Hardcover)
Vijai Singh
R5,288 R4,426 Discovery Miles 44 260 Save R862 (16%) Ships in 12 - 19 working days

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas.

Apoptosis in Health and Disease - Part A, Volume 125 (Hardcover): Rossen Donev Apoptosis in Health and Disease - Part A, Volume 125 (Hardcover)
Rossen Donev
R5,301 R4,439 Discovery Miles 44 390 Save R862 (16%) Ships in 12 - 19 working days

Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed.

Neurotoxicity of Metals: Old Issues and New Developments, Volume 5 (Hardcover): Michael Aschner, Lucio G. Costa Neurotoxicity of Metals: Old Issues and New Developments, Volume 5 (Hardcover)
Michael Aschner, Lucio G. Costa
R5,929 R4,964 Discovery Miles 49 640 Save R965 (16%) Ships in 12 - 19 working days

The volume discusses novel issues associated with the neurotoxicity of select metals

Intracellular Enzymes - a Course of Lectures Given in the Physiological Laboratory, University of London (Hardcover): Horace... Intracellular Enzymes - a Course of Lectures Given in the Physiological Laboratory, University of London (Hardcover)
Horace Middleton 1870 Vernon
R929 Discovery Miles 9 290 Ships in 10 - 15 working days
Rare-earth element biochemistry: Methanol dehydrogenases and lanthanide biology, Volume 650 (Hardcover): Joseph A. Cotruvo Rare-earth element biochemistry: Methanol dehydrogenases and lanthanide biology, Volume 650 (Hardcover)
Joseph A. Cotruvo
R5,451 R4,563 Discovery Miles 45 630 Save R888 (16%) Ships in 12 - 19 working days

Methods in Enzymology, Volume 650 continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Biophysical methods to study lanthanide-protein interactions, Genetically encoded sensors to study lanthanide biology, Spectrophotometric methods to determine the stability constants of lanthanide-macromolecule complexes, Lanthanide-based probes for amino acid modifications, In vitro selection and application of lanthanide-dependent DNAzymes, LRET biosensors for imaging protein interactions in living cells, Synthetic Modeling of the Structure and Function of the Lanthanide-Dependent, MDH Cofactor, EPR spectroscopy of lanthanides, Macromolecular crystallography for f-element complex characterization, and much more.

Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations Part 2, Volume 33 (Hardcover): Antonella... Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations Part 2, Volume 33 (Hardcover)
Antonella Bongiovanni, Gabriella Pocsfalvi, Mauro Manno, Veronika Kralj-Iglic
R6,183 R5,173 Discovery Miles 51 730 Save R1,010 (16%) Ships in 12 - 19 working days

Biological Membrane Vesicles: Scientific, Biotechnological and Clinical Considerations, Part Two, Volume 33 in the Advances in Biomembranes and Lipid Self-Assembly series, highlights new advances in the field, with sections in this new release covering Biomembranes of extracellular vesicles: The protein component, Protocol for isolation of Microvesicles form blood plasma, Urinary Extracellular vesicles at single patient level for clinical research, Treatment of chronic wounds with platelet and extracellular vesicles enriched plasma, Liposome loading and imaging, The Potential of Extracellular Vesicles for Brain Repair, Nucleic acids cargo of extracellular vesicles: Analysis and physiological function, Propolis flavonoids and terpenes, and much more.

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A, Volume 179 (Hardcover): Vijai Singh Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A, Volume 179 (Hardcover)
Vijai Singh
R4,713 R3,947 Discovery Miles 39 470 Save R766 (16%) Ships in 12 - 19 working days

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics.

Hormones and Stem Cells, Volume 116 (Hardcover): Gerald Litwack Hormones and Stem Cells, Volume 116 (Hardcover)
Gerald Litwack
R5,751 R4,818 Discovery Miles 48 180 Save R933 (16%) Ships in 12 - 19 working days

Vitamins and Hormones serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Advances in CRISPR/Cas and Related Technologies, Volume 178 (Hardcover): Dipanjan Ghosh Advances in CRISPR/Cas and Related Technologies, Volume 178 (Hardcover)
Dipanjan Ghosh
R4,718 R3,953 Discovery Miles 39 530 Save R765 (16%) Ships in 12 - 19 working days

Advances in CRISPR/Cas and related technologies, Volume 179, the latest release in this ongoing series, deals with a wide variety of research topics related to recent advancement in the genome editing techniques. Associated chapters in this new release include Challenges for Therapeutic application of CRISPR Cas techniques, Mitochondrial DNA modification by CRISPR Cas System: Challenges and future direction, Trends in CRISPR Cas technology application in cancer, Modified CRISPR-Cas for next generation application, Application of CRISPR Cas in Synthetic Biology: Challenges and Scopes, History of CRISPR Cas system from bacterial Adaptive Immune System to research application, and more.

Pore-Forming Toxins, Volume 649 (Hardcover): Alejandro Heuck Pore-Forming Toxins, Volume 649 (Hardcover)
Alejandro Heuck
R5,499 R4,611 Discovery Miles 46 110 Save R888 (16%) Ships in 12 - 19 working days

Pore Forming Toxins, Volume 649 in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by field leaders. Chapters in this new release include X-ray crystallography shines a light on pore-forming toxins, Giant unilamellar vesicles for studying activity of pore forming proteins, Combined applications of fluorescence spectroscopy and molecular dynamics simulations in studies of Diphtheria Toxin translocation domain, Biophysical approaches to study actinoporin-lipid interactions, Molecular basis for activation of Actinoporins by lipids, Engineered ClyA for detection of biological molecules, Pore-forming Toxins for the Size-Discrimination of Polymers and Biopolymers: Towards Biomolecules Sequencing, and much more.

Natural Food Additives (Hardcover): Miguel A Prieto, Paz Otero Natural Food Additives (Hardcover)
Miguel A Prieto, Paz Otero
R3,386 Discovery Miles 33 860 Ships in 10 - 15 working days
Advances in Clinical Chemistry, Volume 101 (Hardcover): Gregory S. Makowski Advances in Clinical Chemistry, Volume 101 (Hardcover)
Gregory S. Makowski
R5,599 R4,685 Discovery Miles 46 850 Save R914 (16%) Ships in 12 - 19 working days

Advances in Clinical Chemistry, Volume 101, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this new release including chapters on Exosomes in cancer, Parathyroid hormone, Clinical relevance of biochemical and metabolic changes in osteoarthritis, Early diagnosis with ultrasensitive ELISA, Cytokines and the immune response in obesity-related disorders, Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases, and more.

Protein Kinases in Drug Discovery, Volume 124 (Hardcover): Rossen Donev Protein Kinases in Drug Discovery, Volume 124 (Hardcover)
Rossen Donev
R4,735 R3,970 Discovery Miles 39 700 Save R765 (16%) Ships in 12 - 19 working days

Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.

Hormones and Aging, Volume 115 (Hardcover): Gerald Litwack Hormones and Aging, Volume 115 (Hardcover)
Gerald Litwack
R5,767 R4,834 Discovery Miles 48 340 Save R933 (16%) Ships in 12 - 19 working days

Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more.

Enzymatic Plastic Degradation, Volume 648 (Hardcover): Gert Weber, Uwe T. Bornscheuer, Ren Wei Enzymatic Plastic Degradation, Volume 648 (Hardcover)
Gert Weber, Uwe T. Bornscheuer, Ren Wei
R5,481 R4,593 Discovery Miles 45 930 Save R888 (16%) Ships in 12 - 19 working days

Enzymatic Plastic Degradation, Volume 648 in the Methods in Enzymology series, continues the legacy of this premier serial with chapters authored by leaders in the field. Chapters in this latest release include Evaluating plastic pollution and environmental degradation, Assessment methods for microplastic pollution in the oceans and fresh water, Exploring microbial consortia from various environments for plastic degradation, Characterization of filamentous fungi for attack on synthetic polymers via biological Fenton chemistry, Synthesis of radioactive-labeled nanoplastics for assaying the environmental (microbial) PS degradation, Exploring metagenome for plastic degrading enzymes, Cutinases from thermophilic bacteria (actinomycetes): from identification to functional and structural characterization, and much more.

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