Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more.

Advances in Clinical Chemistry, Volume 98, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more.

Advances in Clinical Chemistry, Volume 97, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with chapters in this new release covering metaproteomic analysis of human gut microbiome in digestive and metabolic diseases, liquid biopsy in ovarian cancer, advances in extracellular vesicles analysis, long non-coding RNA HOTAIR in cervical cancer: molecular marker, mechanistic insight, and therapeutic target, genomics of hypertriglyceridemia, cell free DNA biology and its involvement in breast carcinogenesis, and more.

Biostimulants in Alleviation of Metal Toxicity in Plants: Emerging Trends and Opportunities focuses on the role of substances or micro-organisms whose presence can address issues of metal contamination in soils, seeds and plants. Including a range of biostimulant tools, the book highlights both endogenous and exogenous application. Written and edited by a global team of experts, this book presents an overview on biostimulants in determining metal toxicity. As plants encounter a wide range of environmental challenges during their lifecycle, among which metal toxicity is a common form of abiotic stress, this book thoroughly covers important topics on the subject matter. Once inside a plant system, toxic metals may initiate a variety of physiological alterations in plants, including adversely impacted seed germination, root and shoot growth, chloroplasts ultrastructure and photosynthesis, nutrients assimilation, carbohydrates metabolism, and plant hormonal status which, collectively, results in reduced plants yields. In addition to several naturally occurring physiological and metabolic re-programing responses, plants may also modify their root and shoot systems in order to dilute entered amount of toxic metals. As an additional tool biostimulants have emerged as one of the important plant protectors under adverse conditions.

The Chemical Dialogue Between Plants and Beneficial Microorganisms provides foundational insights on plant beneficial microorganisms and their impact on the health and productivity of plants. Providing in-depth and recent updates about unexplored aspects of plant microbes interactions, the book includes the biological repertoire of arbuscular mycorrhizal association, molecular architecture of Rhizobium-plant symbiosis, and endophytes in transcriptional plasticity during host colonization by endophytes. The book also includes details about the mechanism of different plant beneficial microorganisms, how these differ, and their cross signaling. This book will be an important reference for researchers working on different plant beneficial microorganisms and their molecular arsenal.

Plant Life under Changing Environment: Responses and Management presents the latest insights, reflecting the significant progress that has been made in understanding plant responses to various changing environmental impacts, as well as strategies for alleviating their adverse effects, including abiotic stresses. Growing from a focus on plants and their ability to respond, adapt, and survive, Plant Life under Changing Environment: Responses and Management addresses options for mitigating those responses to ensure maximum health and growth. Researchers and advanced students in environmental sciences, plant ecophysiology, biochemistry, molecular biology, nano-pollution climate change, and soil pollution will find this an important foundational resource.

The volume deals with other aspect (s) of metabolic activities of plants under abiotic stress. This book discusses techniques for improving yield potential and adaptiveness to unfavorable environmental conditions. This book also addresses how knowledge of the changes in physiological mechanisms can contribute in understanding the yield structure under abiotic stress. 1. Abiotic Stress and Metabolic Responses in Plants 2. Abiotic Stress and Secondary Metabolites in Plants 3. Microbes: Support and Protect Plants against Abiotic Stresses 4. Abiotic Stress and Physiological Traits in Plants 5. Abiotic Stress and Heat Shock Proteins (HSPs) in Plants

Abiotic stress factors frequently constrain the growth and productivity of major crop species. The single greatest abiotic stress factor that limits crop growth worldwide is water availability. While genetic increases in yield potential are best expressed in optimum environments, they are also associated with enhanced yields under drought and nitrogen deficiency. These gains are especially relevant given that further large increases in the area under irrigation are not expected, and land deterioration associated with intensive agriculture threatens those areas already irrigated. This book is intended to cover all known factors of abiotic stresses and their respective effects on some of the important aspects of physiological processes in plants.1. Abiotic Stress and Crop Yield 2. Physiology of Grain Legume Yield Under Abiotic Stress 3. Photosynthesis and Physiological Parameters Under Intercropping Condition 4. Role of Growth Regulators Under Abiotic Stress 5. Plant Water Relationship Under Abiotic Stress 6. Dry Matter Partitioning Under AbioticS tress 7. Effect of Pesticides on Physiological Processes in Plants

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

Enzymatic Polymerizations, Volume 627 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

DNA Repair, Volume 45 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair, Translesion polymerases, mechanism and function, The Rev1-Pol? Mutasome: Structure and Interactions in Translesion Synthesis, Challenges for base excision repair enzymes: acquiring access to damaged DNA in chromatin Nucleotide excision repair, DNA damage recognition mechanisms in mammalian nucleotide excision repair, Advances in understanding DNA mismatch repair, and more.

Post-translational Modifications That Modulate Enzyme Activity, Volume 626 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Updated chapters include Crosstalk between cellular metabolism and histone acetylation, Isolation of protein complexes and modifications that regulate transcriptional machinery, High-throughput phosphoproteome mapping through multiplexed mass spectrometry, Differentiation of D and L epimerization in proteins, Biochemical analysis of protein arginylation, Site-specific Determination of lysine acetylation stoichiometries on the proteome-scale, Genomic and biochemical analysis of RNA post-transcriptional modifications, Isolation and characterization of glycosylated (neuro)peptides, and more.

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.

Progress in Molecular Biology and Translational Science, Volume 167, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to Models and Biological Targets in Drug Discovery for Attention Deficit Hyperactivity Disorder, Novel Targets for Parkinson-Depression Co-morbidity. Utility of Cannabidiol (CBD) in Neuropsychiatric Disorders: A Short Review of the Recent Pre-clinical and Clinical Findings, The Many Sides of Microglia in Alcohol Use Disorders, Stress, Anxiety, Molecular Targets and More, Calcineurin Signaling in Psychiatric Disorders, Emerging Evidence for the Role of Pituitary Adenylate Cyclase- Activating Peptide (PACAP) in Neuropsychiatric Disorders, and more.

Nonheme Iron Enzymes: Structures and Mechanisms, Volume 117, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.

Applied Plant Biotechnology for Improvement of Resistance to Biotic Stress applies biotechnology insights that seek to improve plant genomes, thus helping them achieve higher resistance and optimal hormone signaling to increase crop yield. The book provides an analysis of the current state-of-the-art in plant biotechnology as applied to improving resistance to biotic stress. In recent years, significant progress has been made towards understanding the interplay between plants and their hosts, particularly the role of plant immunity in regulating, attenuating or neutralizing invading pathogens. As a result, there is a great need to integrate these insights with methods from biotechnology.