This is the story of a race - not against other vaccines or other scientists, but against a deadly and devastating virus.

On 1 January 2020, Sarah Gilbert, Professor of Vaccinology at Oxford University, read an article about four people in China with a strange pneumonia. Within two weeks, she and her team had designed a vaccine against a pathogen that no one had ever seen before. Less than 12 months later, vaccination was rolled out across the world to save millions of lives from Covid-19. In Vaxxers, we hear directly from Professor Gilbert and her colleague Dr Catherine Green as they reveal the inside story of making the Oxford AstraZeneca vaccine and the cutting-edge science and sheer hard work behind it.

This is their story of fighting a pandemic as ordinary people in extraordinary circumstances. Sarah and Cath share the heart-stopping moments in the eye of the storm; they separate fact from fiction; they explain how they made a highly effective vaccine in record time with the eyes of the world watching; and they give us hope for the future.

Vaxxers invites us into the lab to find out how science will save us from this pandemic, and how we can prepare for the inevitable next one.

Handbook of HIV Medicine represents the knowledge, skill and experience of more than sixty experts in HIV medicine, making it the definitive reference book for southern Africa.

This third edition remains invaluable for doctors, medical students, and primary health care workers, presenting an updated approach to critical issues. It is ideal for quick reference in urban and rural clinics and hospital wards.

The handbook is targeted specifically at the needs of the developing world and contains guidelines on antiretroviral therapy, HIV emergencies, and adult and paediatric HIV medicine.

COVID-19 Viral Sepsis: Impact on Disparities, Disability, and Health Outcomes introduces the concepts of viral sepsis, its origins, and its implications. COVID-19 is a leading cause of viral sepsis with considerable impact on morbidity and mortality. Early recognition of signs and symptoms of COVID-19 can potentially impact patient outcomes. The book opens with an introduction and overview of sepsis, its clinical manifestations, prevention, and management. It goes on to discuss viral sepsis and sepsis caused by COVID-19. COVID-19, its diagnosis, management, sequelae, long-term consequences, challenges, and opportunities round out the coverage. Users will find valuable key principles related to the recognition, prevention, diagnosis and treatment of sepsis due to COVID-19.

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren's syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource.

Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions. This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases).

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology.

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Practical Aspects of Vaccine Development provides an academic and industry perspective on vaccine development and manufacturing. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and challenges being encountered. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges. Vaccines include a wide range of components including proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, and more. The container closure system may also be unique, and the product may require freezing storage or lyophilization based on the stability of the vaccine components. Based on the route of delivery, novel technologies and devices may be required. Covering formulation development, manufacture, and delivery considerations of vaccine production, this book is essential to formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students.

Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

Advances in Immunology, Volume 140, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology.

Advances in Immunology, Volume 139, the latest issue of a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including chapters on Alzheimer's and its innate receptors, the field of immune orchestration by small molecules, like chemokines and lipids, the role of AID in the first checkpoint, and the design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies.

Advances in Applied Microbiology, Volume 102, the latest release in one of the most widely read and authoritative review sources in microbiology, contains comprehensive reviews of the most current research in applied microbiology. This latest release includes specific chapters on a variety of topics, most notably, Twenty-five Years of Investigating the Universal Stress Protein: Structure, function and applications, Fungal Genomes and Genotyping, Fungi in deep subsurface environments, Spore germination in pathogenic fungi, Host sensing by pathogenic fungi, Advances in the Microbial Ecology of Biohydrometallurgy, and The mycosphere and turnover of contaminants, amongst others.

Advances in Immunology, Volume 137, the latest in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release including sections on Notch and T-Cell signaling/T-Cell memory, Single Cell Analysis of CD8+ and CD4+ T Cell Differentiation, New Developments in the Chemokine Field, the Role of Caveolin-1 in BCR and TCR Receptors, The Unusual Biochemistry of Bovine Immunoglobulins, and the Molecular Aspects of Allergens and Allergy.

Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews on immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna H. Nowak-Wegrzyn, is devoted to Aeroallergen and Food Immunotherapy. Articles in this issue include History of AIT and the future direction of CRD/molecular allergy; Mechanisms of aeroallergen allergen immunotherapy: SCIT and SLIT; Mechanisms underlying induction of tolerance to foods; Biomarkers for allergen immunotherapy; SCIT and SLIT; Novel delivery routes for allergy immunotherapy; Oral immunotherapy for food allergy; SLIT and EPIT for food allergy; The use of adjuvants for enhancing allergen immunotherapy efficacy; Allergen immunotherapy vaccine modification; Allergen immunotherapy outcome assessment in clinical trials and real life; Component resolved diagnosis: can it make specific AIT more specific?; Baked milk and egg diets for milk and egg allergy management; and Allergen immunotherapy practical considerations: adherence and strategies to improve.

This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon Cancer; Predictive and Prognostic Markers in the Treatment of Colorectal Cancer; Surgical Management of Hepatic Metastases of Colorectal Cancer; Combination Therapies in Colorectal Cancer Treatment; A Critical Look at Management of Peritoneal Metastases of Colorectal Cancer; Non-surgical Management of Rectal Cancer; and Ablative Therapies for Metastatic Colorectal Cancer.

Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
Essential reading for any biologist who wants to understand methods of computer-aided vaccine designDescription of available data sources and publicly available software, with detailed analysis of strengths and weaknessesTheoretical concepts and practical examples of database design and development for a virtual screening campaign

Primary immunodeficiency diseases, first recognized 60 years ago, are inherited disorders that affect human adaptive and innate immunity. In most cases, affected individuals experience recurrent infections, but they may also suffer from autoimmune diseases and malignancies. This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases. With up-to-date diagnostic tools and therapeutic options - from prophylactic anti-infective measures to hematopoietic stem cell transplantation and gene therapy - this volume will remain an authoritative resource on this increasingly important area.

This issue of the Medical Clinics of North America brings the internist up to date on the latest approaches to drug hypersensitivity.? Acute symptoms and reactions such as urticaria, angioedema, anaphylaxis, anaphylactic shock are covered.? Delayed symptoms such as MPE, SDRIFE, delayed urticaria, vasculitis, Stevens-Johnson Syndrome, toxic epidermal necrolysis, AGEP, and DRESS/D(i)HS are also covered.? Complex clinical pictures are explored, including the side effects to biologics, anticoagulation (including HIT), and cytostatic drugs (such asoxaliplatin, cisplatin, paclitaxel, and others).? Other topics include perioperative anaphylaxis, betalactam hypersensitivity, and NSAID intolerance.

Written by an immunologist, this book traces the concept of immunity from ancient times up to the present day, examining how changing concepts and technologies have affected the course of the science. It shows how the personalities of scientists and even political and social factors influenced both theory and practice in the field. With fascinating stories of scientific disputes and shifting scientific trends, each chapter examines an important facet of this discipline that has been so central to the development of modern biomedicine. With its biographical dictionary of important scientists and its lists of significant discoveries and books, this volume will provide the most complete historical reference in the field.
Written in an elegant style by long-time practicing immunologist
Discusses the changing theories and technologies that guided the field
Tells of the exciting disputes among prominent scientists
Lists all the important discoveries and books in the field
Explains in detail the many Nobel prize-winning contributions of immunologists"

Tending Adam's Garden describes and explains the way in which our immune system works from a novel perspective. The book uses metaphors and examples to bring the immune system to life and explores the fundamental miracle of nature. Written in plain language for a broad audience, this book encompasses much more than just immunology, exploring more fundamental matters such as causality, information, energy, evolution, cognition and individuality, as well as the strategy of the immune system and its role in health and disease.
* Provides a unique perspective on the immune system from one of the keenest scientific and philosophical brains in the world
* Uses metaphors and case histories to explore themes in an accessible manner
* Written in plain language requiring no specialized vocabulary or specific scientific background in the subject

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.