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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology

Systems Biology (Hardcover, 2013 ed.): Michael G. Katze Systems Biology (Hardcover, 2013 ed.)
Michael G. Katze
R5,602 R4,968 Discovery Miles 49 680 Save R634 (11%) Ships in 12 - 19 working days

In this volume, a wide-ranging series of reviews reveal how systems biology -- a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists -- is changing the face of infectious disease research. Leading experts discuss how the use of high-throughput and computational approaches are generating exciting -- and often unexpected -- new insights into the microbial-host interactions of a variety of bacterial and viral pathogens, including Salmonella, Yersinia, Mycobacterium, influenza virus, human and simian immunodeficiency virus, and hepatitis C virus. Additional chapters focus on systems approaches to innate immunity, intra- and inter- cellular signaling, biomarker discovery, and the evaluation and rational development of improved vaccines. Systems biology has both been hailed as a paradigm shift that will revolutionize biological science and criticized as overly expensive and complex. While the truth no doubt lies somewhere in between, the approach is yielding increasingly detailed and comprehensive views of biological systems and processes, including those that dictate the host response to infection and disease outcome. Systems Biology of Infectious Disease is highly informative reading for investigators already engaged in systems biology research as well as for those scientists and clinicians who may be seeking an introduction to the field.

How Helminths Alter Immunity to Infection (Hardcover, 2014 ed.): William Horsnell How Helminths Alter Immunity to Infection (Hardcover, 2014 ed.)
William Horsnell
R3,165 R1,914 Discovery Miles 19 140 Save R1,251 (40%) Ships in 12 - 19 working days

Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.

Development and Function of Myeloid Subsets, Volume 120 (Hardcover): Kenneth M. Murphy, Miriam Merad Development and Function of Myeloid Subsets, Volume 120 (Hardcover)
Kenneth M. Murphy, Miriam Merad
R4,436 Discovery Miles 44 360 Ships in 12 - 19 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Angioedema, An Issue of Immunology and Allergy Clinics, Volume 33-4 (Hardcover): Bruce L. Zuraw Angioedema, An Issue of Immunology and Allergy Clinics, Volume 33-4 (Hardcover)
Bruce L. Zuraw
R1,774 Discovery Miles 17 740 Ships in 12 - 19 working days

Guest edited by Bruce Zuraw, this issue of Immunology and Allergy Clinics covers angioedema, including topics on hereditary angioedema, prophylactic and on-demand treatmetnts, and more.

Biological DNA Sensor - The Impact of Nucleic Acids on Diseases and Vaccinology (Hardcover): Ken Ishii, Choon Kit Tang Biological DNA Sensor - The Impact of Nucleic Acids on Diseases and Vaccinology (Hardcover)
Ken Ishii, Choon Kit Tang
R3,112 R2,850 Discovery Miles 28 500 Save R262 (8%) Ships in 12 - 19 working days

"Biological DNA Sensor" defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines.

Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. "Biological DNA Sensor" approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.
Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

Lyophilized Biologics and Vaccines - Modality-Based Approaches (Hardcover, 2015 ed.): Dushyant Varshney, Man Mohan Singh Lyophilized Biologics and Vaccines - Modality-Based Approaches (Hardcover, 2015 ed.)
Dushyant Varshney, Man Mohan Singh
R4,695 Discovery Miles 46 950 Ships in 10 - 15 working days

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products. Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulations Details the latest developments in instrumental analysis and controlled ice nucleation technology Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics Details an exhaustive update on quality-by-design and process analytical technology approaches, illustrated superbly by case studies and FDA perspective Provides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studies Provides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launch Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

War in the Body - The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines... War in the Body - The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines (Hardcover, 2013 ed.)
W David Wick, Otto O. Yang
R7,411 Discovery Miles 74 110 Ships in 12 - 19 working days

In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.

Antibody Fc - Linking Adaptive and Innate Immunity (Hardcover, New): Margaret Ackerman, Falk Nimmerjahn Antibody Fc - Linking Adaptive and Innate Immunity (Hardcover, New)
Margaret Ackerman, Falk Nimmerjahn
R3,762 Discovery Miles 37 620 Ships in 12 - 19 working days

"Antibody Fc" is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system

Immunopharmacology (Hardcover, 2nd ed. 2016): Manzoor M. Khan Immunopharmacology (Hardcover, 2nd ed. 2016)
Manzoor M. Khan
R6,203 Discovery Miles 62 030 Ships in 12 - 19 working days

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies - both binding and neutralizing - to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer.

Advances in Immunology, Volume 119 (Hardcover, New): Frederick W. Alt Advances in Immunology, Volume 119 (Hardcover, New)
Frederick W. Alt
R4,419 Discovery Miles 44 190 Ships in 12 - 19 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Recombinant Virus Vaccines - Methods and Protocols (Hardcover, 1st ed. 2017): Maureen C. Ferran, Gary R. Skuse Recombinant Virus Vaccines - Methods and Protocols (Hardcover, 1st ed. 2017)
Maureen C. Ferran, Gary R. Skuse
R5,069 Discovery Miles 50 690 Ships in 12 - 19 working days

This volume provides readers with methods and protocols for understanding the development of recombinant viruses and their use as vaccines platforms. Recombinant Virus Vaccines: Methods and Protocols details the use of recombinant vaccines that are employed to either produce immunogens in vitro or elicit antibody production in vivo. The chapters in this book are divided into four parts: Part I explores double-stranded DNA viruses; Part II discusses negative sense single-stranded RNA viruses; Part III talks about positive sense single-stranded RNA viruses; and Part IV describes bacteriophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Recombinant Virus Vaccines: Methods and Protocols is a valuable resource for scientists and clinicians who are interested in learning about and adopting methods for use in basic and biomedical research directed toward generating and developing recombinant viral vaccines.

Immunopharmacology and Inflammation (Hardcover, 1st ed. 2018): Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada Immunopharmacology and Inflammation (Hardcover, 1st ed. 2018)
Carlo Riccardi, Francesca Levi-Schaffer, Ekaterini Tiligada
R6,324 Discovery Miles 63 240 Ships in 12 - 19 working days

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Molecular Mechanisms in Legionella Pathogenesis (Hardcover, 2014 ed.): Hubert Hilbi Molecular Mechanisms in Legionella Pathogenesis (Hardcover, 2014 ed.)
Hubert Hilbi
R5,342 R4,995 Discovery Miles 49 950 Save R347 (6%) Ships in 12 - 19 working days

Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium "Legionella pneumophila." This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to "L. pneumophila." Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen "L. pneumophila.""

Advances in Immunology, Volume 118 (Hardcover, 89 Ed): Frederick W. Alt Advances in Immunology, Volume 118 (Hardcover, 89 Ed)
Frederick W. Alt
R4,420 Discovery Miles 44 200 Ships in 12 - 19 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Complement Activation in Malaria Immunity and Pathogenesis (Hardcover, 1st ed. 2018): Jose A. Stoute Complement Activation in Malaria Immunity and Pathogenesis (Hardcover, 1st ed. 2018)
Jose A. Stoute
R2,873 Discovery Miles 28 730 Ships in 10 - 15 working days

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Exercise-Induced Bronchoconstriction, An Issue of Immunology and Allergy Clinics, Volume 33-3 (Hardcover): Sandra Anderson Exercise-Induced Bronchoconstriction, An Issue of Immunology and Allergy Clinics, Volume 33-3 (Hardcover)
Sandra Anderson
R1,785 Discovery Miles 17 850 Ships in 12 - 19 working days

Guest edited by Sandra Anderson this issue of Immunology and Allergy Clinics covers all aspects of exercise-induced bronchospasm, including treatment through pharmacologic agents, patient assessments, and biomarkers.

Transplantation Immunology - Methods and Protocols (Hardcover, 2nd ed. 2013): Andrea A. Zachary, Mary S. Leffell Transplantation Immunology - Methods and Protocols (Hardcover, 2nd ed. 2013)
Andrea A. Zachary, Mary S. Leffell
R6,334 Discovery Miles 63 340 Ships in 12 - 19 working days

After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.

Ibuprofen: Pharmacology, Therapeutics and Side Effects (Hardcover, 2012 ed.): K.D. Rainsford Ibuprofen: Pharmacology, Therapeutics and Side Effects (Hardcover, 2012 ed.)
K.D. Rainsford
R4,370 Discovery Miles 43 700 Ships in 10 - 15 working days

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.

Advances in Immunology, Volume 117 (Hardcover, New): Frederick W. Alt Advances in Immunology, Volume 117 (Hardcover, New)
Frederick W. Alt
R4,416 Discovery Miles 44 160 Ships in 12 - 19 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Immunotherapy - A Novel Facet of Modern Therapeutics (Hardcover, 1st ed. 2021): Sujata P. Sawarkar, Vandana S. Nikam, Shariq... Immunotherapy - A Novel Facet of Modern Therapeutics (Hardcover, 1st ed. 2021)
Sujata P. Sawarkar, Vandana S. Nikam, Shariq Syed
R4,928 Discovery Miles 49 280 Ships in 12 - 19 working days

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

Safety of Biologics Therapy - Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins,... Safety of Biologics Therapy - Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins (Hardcover, 1st ed. 2016)
Brian A. Baldo
R4,729 Discovery Miles 47 290 Ships in 10 - 15 working days

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Reactions to Aspirin and Other Non-steroidal Anti-inflammatory Drugs , An Issue of Immunology and Allergy Clinics, Volume 33-2... Reactions to Aspirin and Other Non-steroidal Anti-inflammatory Drugs , An Issue of Immunology and Allergy Clinics, Volume 33-2 (Hardcover)
Don Stevenson, Marek Kowalski
R1,756 Discovery Miles 17 560 Ships in 12 - 19 working days

This issue of Immunology and Allergy Clinics covers aspirin and other NSAID-exacerbated respiratory diseases (AERD), as well as other aspirin sensitivity syndromes

Sugar Chains - Decoding the Functions of Glycans (Hardcover, 2015 ed.): Tadashi Suzuki, Kazuaki Ohtsubo, Naoyuki Taniguchi Sugar Chains - Decoding the Functions of Glycans (Hardcover, 2015 ed.)
Tadashi Suzuki, Kazuaki Ohtsubo, Naoyuki Taniguchi
R4,800 R3,656 Discovery Miles 36 560 Save R1,144 (24%) Ships in 12 - 19 working days

This book presents the latest breakthrough results in glycobiology regarding the roles of glycans in relation to quality control and transport of protein, the immune system, viral infection, stem cells, the neural system, and various diseases such as cancer, diabetes, chronic obstructive pulmonary disease, muscular dystrophy, and schizophrenia. Although glycoscience has long been regarded as a very specialized field with no simple analytical method, the recent explosive progress in research continues to provide limitless evidence that glycan chains are the key component in various biological phenomena. Cell surface glycans, for example, change with developmental stages or environmental conditions and thus represent a "face" of the cell that is utilized for identification of iPS and ES cells and as biomarkers in diagnosis or detection of cancer. This book comprises 17 chapters, each of which poses outstanding "glyco-related" questions enabling non-specialists to have a clearer idea about what the future direction for further investigation of glycans in their own research fields will be. Also including basic information to understand the nature of glycans, this title serves as an excellent "textbook" for researchers in diverse research fields who are not familiar with, but nevertheless interested in, glycan chains or sugar chains.

Asthma, An Issue of Nursing Clinics, Volume 48-1 (Hardcover): Cathy Catrambone, Linda Follenweider Asthma, An Issue of Nursing Clinics, Volume 48-1 (Hardcover)
Cathy Catrambone, Linda Follenweider
R1,762 Discovery Miles 17 620 Ships in 12 - 19 working days

This issue of Nursing Clinics, Guest Edited by Cathy Catrambone, PhD, RN, at Rush University, focuses on Asthma. Article topics will include Assessment of Asthma, Pharmacotherapy, Asthma management, Asthma action plans, Pediatric Asthma, and Asthma and Obesity.

Conditions Mimicking Asthma, An Issue of Immunology and Allergy Clinics (Hardcover): Eugene Choo Conditions Mimicking Asthma, An Issue of Immunology and Allergy Clinics (Hardcover)
Eugene Choo
R1,758 Discovery Miles 17 580 Ships in 12 - 19 working days

Guest edited by Eugene Choo, this issue of Immunology and Allergy Clinics covers the latest research in diagnosing and managing asthma-like diseases. Topics covered include vocal cord dysfunction, dynamic airway collapse, RADS, GERD, sarcoidosis, and more.

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