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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.
This issue of Hematology/Oncology Clinics of North America, devoted to Colorectal Cancer, is edited by Dr. Leonard B. Saltz. Articles in this issue include: Diet and Lifestyle Influences on Colorectal Cancer; Diagnosis and Management of Germline and Somatic Mutations in Mismatch Repair-deficient Colorectal Cancer; Adjuvant Chemotherapy in Stage II, III, and Resected Stage IV Colon Cancer; Predictive and Prognostic Markers in the Treatment of Colorectal Cancer; Surgical Management of Hepatic Metastases of Colorectal Cancer; Combination Therapies in Colorectal Cancer Treatment; A Critical Look at Management of Peritoneal Metastases of Colorectal Cancer; Non-surgical Management of Rectal Cancer; and Ablative Therapies for Metastatic Colorectal Cancer.
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.
T Lymphocyte Subpopulations in Immunotoxicology Edited by Ian Kimber ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, Cheshire, UK and Mary Jane K. Selgrade US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, NC, USA Immunotoxicology is a diverse discipline that embraces the investigation of the adverse health effects that may result from the interaction of xenobiotics with the immune system. T lymphocytes orchestrate adaptive immune responses and are of central importance in the consideration of immunotoxicity. These cells and/or the tissue responsible for their functional maturation (the thymus) have been implicated as the primary or secondary targets for chemical insult. Moreover, T lymphocytes play pivotal roles in the induction and elicitation of chemical and protein allergy and in the pathogenesis of autoimmune disease. Classically, T lymphocytes have been divided into two main populations: CD4 helper T cells and CD8 suppressor/cytotoxic T cells. It is now apparent that there exists within both populations considerable functional heterogeneity, characterized usually by variable cytokine secretion patterns. Two major subpopulations of T helper (Th) cells have been identified and designated Th1 and Th2, with similar, but less well characterized, sub-types of cytotoxic (Tc) cells having been described also. The discovery of functional subpopulations of Th (and Tc) cells has profoundly influenced our view of the immune response and, in particular, our appreciation of the way in which the immune system can tailor responses to meet challenges of different types. This has also translated into a much more detailed understanding of certain immunopathologic processes and the role of T lymphocytes in the development of allergic, autoimmune and inflammatory diseases. This book explores the role of T lymphocyte subpopulations in the development and expression of immunotoxic effects. Constituent chapters reveal that a consideration of the impact of chemicals on these diverse T cell populations and the polarization of T cell responses has already contributed greatly to our understanding of the mechanisms underlying immunotoxicity, including immune suppression and allergic and autoimmune responses.
Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases.
'In an era of heightened awareness of our immune system, the threat of pandemics, the rise of autoimmunity, and the revelatory new science that everything from heart disease to cancer, Alzheimer's to autism, and depression to diabetes is linked to disordered immune function and inflammation, The Immunotype Breakthrough is the most important guide available today to understand and optimise our immune function. It is an essential roadmap for anyone with an immune system (essentially everyone!), anyone looking to optimise their health and avoid today's modern plague - inflammation.' DR MARK HYMAN, New York Times-bestselling author of The Pegan Diet. 'The immune system has been overlooked and misunderstood for far too long. In The Immunotype Breakthrough, Dr Moday gives us a glimpse into her speciality and explains the recent research in a way that we can all understand. Best of all, she gives us action steps we can each take to prioritise our immune system to elevate our overall health.' DR WILL COLE, New York Times-bestselling author of Intuitive Fasting 'This is a must-read for anyone who has experienced the pitfalls of conventional medicine and is ready to balance their immune system for optimal health.' DR AMY MYERS, author of The Autoimmune Solution and Thyroid Connection 'A revolutionary book from one of the best immunity experts around. The Immunotype Breakthrough explains the latest science on immunity, and offers unique, customisable advice to help you balance your immune system. A must-read for anyone interested in living a long and healthy life." JASON WACHOB, Founder & Co-CEO of mindbodygreen.com To most of us, the immune system is a mysterious and complex network of cells, receptors, and messengers that we only notice when it goes awry. But our immune response, or lack of, affects nearly every aspect of our bodies and our health. Much has been made of 'boosting' immunity, but what exactly does that mean? And what if boosting isn't really what our immune systems need? In The Immunotype Breakthrough, functional medicine doctor and immunity specialist Dr Heather Moday explains that, for the most part, what our immune systems truly need is not boosting, but balancing. She identifies four distinct immunotypes, and helps you find yours: Smouldering: too much inflammation, resulting in diabetes, dementia, heart disease Misguided: an immune system which attacks your own cells and organs, causing autoimmune diseases Hyperactive: overreactive to harmless substances, causing allergies Weak: an immune system that doesn't react fast or effectively enough, causing frequent colds, flu or bronchitis Drawing on a wealth of cutting-edge research, Dr Moday explains that our immune systems are fluid and significantly influenced by our behaviours, diet, habits, and environment. By identifying your personal immunotype, and implementing Dr Moday's Immune Restoration Plan, you can make focused, individualised lifestyle changes to bring your immune system back into balance. With interactive quizzes to help readers zero in on their own specific needs, The Immunotype Breakthrough is a revolutionary programme that will lead to holistic health, vitality, and longevity for everyone.
"Natural Hosts of SIV: Implications in AIDS" thoroughly reviews
the possible mechanisms by which African nonhuman primate natural
hosts of lentiviruses remain essentially disease-free while other
hosts exhibit disease and death. The book ultimately indicates
directions for further research and potential translations of this
compelling phenomenon into novel approaches to treat and prevent
HIV. When Asian non-human primate non-natural hosts are
experimentally infected with viruses isolated from African species,
disease and death normally results. Meanwhile, these African
nonhuman primate natural hosts maintain similar levels of plasma
and cellular viremia and exhibit compellingly different,
essentially disease-free, states. This work attempts to answer the
question of how the natural host remains disease resistant.
"Celiac Disease and Gluten: Multidisciplinary Challenges and
Opportunities" is a unique reference work the first to integrate
the insights of the causes and effects of celiac disease from the
chemistry of reaction-causing foods to the diagnosis, pathogenesis,
and symptoms that lead to proper diagnoses and treatment. With an
estimated three million people in the United States alone affected
by celiac disease, an autoimmune digestive disease, onlyfive
percentare properly diagnosed. Drawing on the connection between
foods containing gluten and the resulting symptoms, this resource
offers distinctive information that directly explores and links
food science, medical diagnostics, and treatment information. A
helpful tool for researchers and medical practitioners alike,
"Celiac Disease and Gluten: Multidisciplinary Challenges and
Opportunities" helps refine research targets, and provides a
comprehensive overview on the multidisciplinary approaches to all
crucial aspects related to celiac disease.
This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.
" Primary Immunodeficiency Disorders: A Historic and Scientific Perspective "provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from
clinical problem to lab and back to the clinic, based on historical
experiences. Its chapters proceed from the discovery of the T and B
cell lineages through the first BMT for immunodeficiency disorder;
lab investigation and gene therapy for PID; the discovery of the
gene for AT and its function; understanding cytokine defects; and
many other stops along the way.
The authorized companion to the #1 New York Times bestseller Grain
Brain, with more than 150 life-changing gluten-free recipes for
complete health and vitality.
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
This book provides patients and their physicians (especially "non-oncologist" health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient's own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today's daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors' expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.
Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering self-referential immune recognition through C-type lectin receptors, genetic susceptibility to autoimmunity, activation and regulation of the cGAS-STING pathway and the implications of IL-15 trans-presentation on the immune response.
This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2ndEdition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject s fascinating appeal. The content of this new edition has been completely updated to
include current information on all aspects of basic and clinical
immunology. The superbly drawn figures are now in full color,
complemented by full color plates throughout the book. The text is
further enhanced by the inclusion of numerous tables, special topic
boxes and brief notes that provide interesting insights. At the end
of each chapter, a self-test quiz allows students to monitor their
mastery of major concepts, while a set of conceptual questions
prompts them to extrapolate further and extend their critical
thinking. Moreover, as part of the Academic Cell line of textbooks,
Primer to The Immune Response, 2nd Edition contains research
passages that shine a spotlight on current experimental work
reported in Cell Press articles. These articles also form the basis
of case studies that are found in the associated online study guide
and are designed to reinforce clinical connections.
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
"Biological DNA Sensor" defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books,
dsDNA and its immunogenic properties has never received the
complete treatment given in this book. "Biological DNA Sensor"
approaches the impact of dsDNA's immunogenicity on disease and
vaccinology holistically. It paints a complete and concise picture
on the topic so you can understand this area of study and make more
informed choices for your respective research needs. Chapters are
authored by researchers who are renowned for their research focus,
ensuring that this book provides the most complete views on the
topics.
Advances in Immunology, Volume 155, the latest release in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Sections of note cover B cell/GC material.
"Antibody Fc" is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous
vaccines and are the most rapidly growing class of drugs, with
applications ranging from cancer and infectious disease to
autoimmunity. Researchers have long understood the variable domain
of antibodies, which are responsible for antigen recognition, and
can provide protection by blocking the function of their target
antigen. However, recent developments in our understanding of the
protection mediated by antibodies have highlighted the critical
nature of the antibody constant, or Fc domain, in the biological
activity of antibodies. The Fc domain allows antibodies to link the
adaptive and innate immune systems, providing specificity to a wide
range of innate effector cells. In addition, they provide a
feedback loop to regulate the character of the immune response via
interactions with B cells and antigen-presenting cells.
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field
With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area. Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation. Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field. Key chapters include: * Transplant-related complications * Immune responses to transplants * Emerging issues in transplantation * Biomarkers of Allograft rejection and tolerance * T cells and the principles of immune responses In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.
"Advances in Immunology, " a long-established and highly respected
publication, presents current developments as well as comprehensive
reviews in immunology. Articles address the wide range of topics
that comprise immunology, including molecular and cellular
activation mechanisms, phylogeny and molecular evolution, and
clinical modalities. Edited and authored by the foremost scientists
in the field, each volume provides up-to-date information and
directions for the future. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field |
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