Chemokines play an important role in recruiting inflammatory
cells into tissues in response to infection and inflammation. They
also play an important role in coordinating the movement of
T-cells, B-cells and dentritic cells, necessary to generate an
immune response (response to injury, allergens, antigens, invading
microorganisms). They selectively attract leukocytes to
inflammatory foci, inducing both cell migration and activation.
They are involved in various diseases, like atherosclerosis, lung
and skin inflammation, multiple sclerosis, or HIV.
Volume 2 of this two-volume set discusses the pathophysiology of
chemokines. It is divided into two parts: a) chemokines in animal
disease models, and b) chemokines as drug targets. Together with
volume 1, which discusses the immunobiology of chemokines, both
volumes give a comprehensive overview of chemokine biology.
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