When the world stopped, all hopes rested on finding a vaccine. One team answered the call and were ready to act. But how do you develop a life-saving drug when every second counts and one mistake could be catastrophic?

Married couple and decades-long research partners Ugur Sahin and Özlem Türeci did just that within weeks of the pandemic breaking out. From convincing Big Pharma to support their ambitious project, to navigating political interference from the Trump administration and the European Union, the road to producing the Pfizer/BioNTech vaccine was by no means smooth. But these cutting-edge innovators overcame every obstacle to provide more than two billion doses of the life-saving drug to countries all around the world in record time.

The Vaccine draws back the curtain on one of the most important medical breakthroughs of our age, containing contributions from the fascinating couple themselves, as well as more than 50 scientists, politicians, public health officials, and BioNTech staff.

Shedding a light on the science behind the breakthrough, The Vaccine tells the story of the trailblazers to whom we all owe a debt of gratitude. More suspenseful than a novel, this is a real-life story of an extraordinary race against time to save the world.

This is the story of a race - not against other vaccines or other scientists, but against a deadly and devastating virus.

On 1 January 2020, Sarah Gilbert, Professor of Vaccinology at Oxford University, read an article about four people in China with a strange pneumonia. Within two weeks, she and her team had designed a vaccine against a pathogen that no one had ever seen before. Less than 12 months later, vaccination was rolled out across the world to save millions of lives from Covid-19. In Vaxxers, we hear directly from Professor Gilbert and her colleague Dr Catherine Green as they reveal the inside story of making the Oxford AstraZeneca vaccine and the cutting-edge science and sheer hard work behind it.

This is their story of fighting a pandemic as ordinary people in extraordinary circumstances. Sarah and Cath share the heart-stopping moments in the eye of the storm; they separate fact from fiction; they explain how they made a highly effective vaccine in record time with the eyes of the world watching; and they give us hope for the future.

Vaxxers invites us into the lab to find out how science will save us from this pandemic, and how we can prepare for the inevitable next one.

Handbook of HIV Medicine represents the knowledge, skill and experience of more than sixty experts in HIV medicine, making it the definitive reference book for southern Africa.

This third edition remains invaluable for doctors, medical students, and primary health care workers, presenting an updated approach to critical issues. It is ideal for quick reference in urban and rural clinics and hospital wards.

The handbook is targeted specifically at the needs of the developing world and contains guidelines on antiretroviral therapy, HIV emergencies, and adult and paediatric HIV medicine.

The Immune System, Fourth Edition emphasizes the human immune system and presents immunological concepts in a coherent, concise, and contemporary account of how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the book accessible and easily understandable to students. The Fourth Edition is a major revision that brings the content up-to-date and improves clarity. Based on user feedback, there is now increased continuity and connectivity between chapters. The Immune System is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students' needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/. A free trial for the Garland Science Learning System will be available to use during the Fall 2016 and Spring 2017 semesters. Please contact us directly at [email protected] to sign up!

Explore the premier text for immunology at the advanced undergraduate, graduate and medical school levels. Beginning students appreciate the book's clear writing and informative illustrations, whilst advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

The Immune System is a concise yet thorough human-oriented introduction to how the human immune system works. It provides an up-to-date presentation of the field, written in an accessible style, replete with relevant medical examples. Plentiful illustrations and micrographs complement and illuminate the explanations. The Fifth Edition is supported by InQuizitive, Norton's award-winning, easy-to-use adaptive learning tool that provides student practice and promotes critical thinking.

Essentials of Clinical Immunology provides the most up-to-date, core information required to understand diseases with an immunological basis. Clinically focussed, the sixth edition of this classic text presents theoretical and practical information in a simple yet thorough way. Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients. Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter. A companion website at www.immunologyclinic.com provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

The Sunday Times bestseller that explains the new science behind weight loss and how we can get in shape without counting calories. 'A compelling look at the science of appetite and metabolism' Vogue 'This book tells us the truth about weight loss' Dr Rangan Chatterjee _______________ We've all heard the golden rule: eat less, exercise more and you'll lose weight. But what if it isn't that simple? For over two decades, weight loss surgeon Dr Andrew Jenkinson has treated thousands of people who have become trapped in the endless cycle of dieting. Why We Eat (Too Much), combines case studies from his practice and the new science of metabolism to illuminate how our appetite really works. Debunking myths of about body and systematically explaining why dieting is counter-productive, this unflinching book investigates every aspect of nutrition: from the 'set weight point' that is unique to all of us, to good and bad fats, and from how genes impact our weight to how our hormones are affected after a diet ends. With a new chapter about the link between obesity and COVID-19, this incredible book will help you understand your body better than ever before. _______________ 'Articulate, clear, a joy to read, this is a book that really needed written' Joanna Blythman, author of Swallow This 'Highly persuasive . . . a radical approach to weight loss' Sunday Times 'Debunks the myths around dieting and weight-loss' Telegraph

"Cooking Gluten-free is as easy as 1-2-3...4" "INGREDIENTS"
Imagine mouthwatering Buckwheat Pancakes, Sun-Dried Pesto Pasta, Pork with Parmesan Polenta, and a decadent serving of Orange Ricotta Pudding. All can be prepared using four or fewer ingredients--gluten-free
Kim McCosker and Rachael Bermingham, the internationally bestselling authors who brought you "4 Ingredients," have once again created more than 400 quick, easy, and delicious recipes that require only four ingredients. This time, however, they all meet the specific requirements for a gluten-free diet. Included are fantastic dishes for breakfast, lunch, dinner, and entertaining, as well as gluten-free lunch box meals and recipes for babies and toddlers.
With "4 Ingredients Gluten-Free," home chefs will learn how to:
- Make weeknight family dinners simple, special, and healthy for anyone in the family who is gluten intolerant.
- Provide delicious, home-cooked meals and spend less money.
- Cook with fewer utensils--1 teaspoon, 1 tablespoon, and 1 measuring cup
- Spend less time at the sink. Four ingredients for each dish means less cleanup
Find out what home chefs all over the world have already discovered. "4 Ingredients Gluten-Free "is perfect for the busy, budget-conscious, health-minded cook

This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US. Key Features Reviews combined vaccines used for cattle Summarizes animal models used for vaccine testing Focuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus Provides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity

The perfect balance of theory and practice! Here's the practical introduction you need to understand the essential theoretical principles of clinical immunology and the serological and molecular techniques commonly used in the laboratory. You'll begin with an introduction to the immune system; then explore basic immunologic procedures; examine immune disorders; and study the serological and molecular diagnosis of infectious disease. An easy-to-read, student-friendly approach emphasizes the direct application of theory to clinical laboratory practice. Each chapter is a complete learning module with learning outcomes, chapter outlines, theoretical principles, illustrations, and definitions of relevant terminology. Review questions and case studies help you assess your mastery of the material. A glossary at the end of the book puts must-know information at your fingertips. An access code inside new printed texts unlocks Lab Exercises and Branching Case Studies online at FADavis.com that offer more opportunities to apply theory to clinical laboratory practice.

**AS HEARD ON BBC RADIO FOUR** Food is our greatest ally for good health, but the question of what to eat has never seemed so complicated. Bestselling author and top 100 most-cited scientist Tim Spector has the answers in this definitive, easy-to-follow guide to the new science of eating well. Tim Spector has pioneered a new approach to nutrition, encouraging us to forget misleading calorie counts and nutritional breakdowns. In Food for Life he draws on over a decade of cutting-edge scientific research, along with his own personal insights, to deliver a new and comprehensive approach to what we should all know about food today. Investigating everything from environmental impact and food fraud to allergies and deceptive labelling, Spector also shows us the many wondrous and surprising properties of everyday foods, which scientists are only just beginning to understand. Empowering and practical, Food for Life is nothing less than a new approach to how to eat - for our health and the health of the planet. ** A THE TIMES and SUNDAY TIMES BOOK OF THE YEAR** 'A rigorously academic book that welcomes the layperson with open arms.' The Times

A Silent Fire is a captivating expert account of inflammation's hidden role in many of the diseases of modernity and what we can actually do about it. 'Controlling Inflammation is the key to good health and this beautifully written and researched book is the best way to understand it' TIM SPECTOR, #1 bestselling author of Food for Life 'As gripping as a mystery story and as useful as a self-help book' BEE WILSON, author of First Bite _____ Inflammation is the body's response to injury and foreign microbes. But what if it were also a potential root cause of modern disease? The swelling and soreness of inflammation are caused by the gathering of immune cells to defend and heal our bodies. But as our environments and diets have rapidly changed, new science suggests that our immune systems are increasingly turning against us. Low-level inflammation, simmering quietly and undetected, has recently been identified behind everything from heart disease and cancer to mysterious autoimmune conditions. Hidden inflammation even weakens our immunity and increases the likelihood that our immune system will mount an overwhelming, inappropriate attack against infections. Shilpa Ravella is a specialist doctor at the forefront of this field, working on rare inflammatory disorders, gut transplants, nutrition and the microbiome. In A Silent Fire she interweaves the latest research with unusual case studies from her own practice and the history of immunology to explain what we know about this elusive phenomenon. She also debunks common myths about 'anti-inflammatory' lifestyles and reveals how we can reform our relationships with food and our microbiomes to benefit our own health and the planet's. In the eyes of many experts, inflammation is emerging as a common root of the diseases of modernity. This captivating narrative of scientific discovery explains why - and how we might control it.

Food Allergy and Gluten-Free Weight Loss gives definitive answers to the question, "Why is it so hard to lose weight?" It is because we have missed or ignored the most important pieces in the puzzle of how our bodies determine whether to store or burn fat. Those puzzle pieces are hormones such as insulin, cortisol, leptin, and others. Individuals with food allergies or gluten intolerance face additional weight-loss challenges such as inflammation due to allergies or a diet too high in rice. This book explains how to put your body chemistry and hormones to work for you rather than against you, reduce inflammation which inhibits the action of your master weight control hormone, leptin, and flip your fat switch from "store" to "burn." It includes a flexible healthy eating plan that eliminates hunger, promotes the burning of fat, and reduces inflammation and tells how to customize the plan so it fits you, your allergies or intolerances, and your need for pleasure in what you eat. Information about cooking for special diets, 175 recipes, a list of sources for special foods, and extensive appendix and reference sections are also included.

As with the much-praised prior editions, the third edition of Strelkauskas' Microbiology: A Clinical Approach remains a comprehensive introductory textbook written specifically for pre-nursing, nursing and allied health students. Clinically relevant throughout, it uses the theme of infection as its foundation, fitting closely with the 'One Health' approach that is considered increasingly central to the effective control of zoonoses and to combatting antimicrobial resistance. The third edition has been thoroughly revised and updated to reflect the latest developments, including the emergence of the SARS-CoV-2 virus and associated COVID-19 pandemic. The book is accompanied by a robust instructor ancillary package that allows educators to incorporate readily the book’s unique approach into their lectures and includes additional materials for students to supplement classroom learning and encourage and support study and self-reflection. Key Features: Student-focused, with all elements carefully designed to help students engage with and understand difficult concepts and to spark and hold interest Dedicated learning skill section introduces practical strategies for improving comprehension and retention Numerous text features further support learning and teaching, including chapter overviews, fast facts, case studies and human stories, and ‘why is this important?’ highlights A variety of question-and-answer types for self-testing and reflection to support and assess basic learning, to challenge students to integrate important concepts and ask students to apply what they have just learned to a specific clinical setting or problem All supported by a comprehensive suite of online resources including lecturer support material and, for students, interactive questions, lecture notes, MicroMovies and the BugParade The book is an excellent resource to guide and support inter-professional education in the health sciences and an ideal entry-point to the subject for anyone coming from another discipline and invaluable supplementary reading for medical, microbiology and biomedical science students.

Case Studies in Immunology presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms of that specific disorder. The cases themselves demonstrate how immunological problems are deconstructed in the clinic and each one is followed by a concise summary of the clinical finding with questions that serve as discussion points.

A companion book to the best-selling Immunity Food Fix, The Immunity Food Fix Cookbook delivers 75 delicious superfood recipes that support your body's natural defenses. Studies have shown that nutrition impacts immunity and disease development. What you put on your plate can either heal you or hurt you. The Immunity Food FixCookbook gives you superfood recipes that naturally support robust immunity. Aside from being accessible and delicious, food is less expensive than medication and free of side effects and, unlike supplements, has the most complete form of the nutrient. While adding the top immune-supportive foods to your diet individually can provide benefit, recipes and meals give you the opportunity to combine different immune superfoods for maximum nutrient density, absorption, and flavor appeal. Recipes are organized around the 5 key pillars of immune support: reversing inflammation, detoxification, antioxidants, digestion and microbiome health, and hormone balance and signaling. Supporting your immunity has never been so appealing. Inside, you'll find delicious whole food recipes, including gluten-free, dairy-free, and grain options. Enjoy recipes such as: Soothing & Calming Licorice Lavender Latte Sprouted Quinoa Porridge with Raspberries & Hazelnut Butter Pumpkin Cardamom Oats with Coconut Butter & Orange Zest Egg Muffins with Butternut & Sunflower Seed Pesto Chicken Radicchio Salad with Apple, Celery & Cashews with Apricot Dressing Roasted Butternut & Avocado Salad with Lemon & Kalamata Olives Tuna, Chickpea & Arugula Salad with Lemon & Tarragon Vinaigrette Tomato Peach Fruit Salsa with Black Beans & Lime Cantaloupe & Smoked Salmon Caprese with Lemon Mint Sauce Thai-Spiced Coconut Lentil Soup Savory Mushroom & Chestnut Soup with Thyme Green Tea Rice Bowls with Miso Glazed Salmon Lemony Shrimp Chickpea Pasta with Spinach & Walnuts Fig & Apricot Almond Balls with Pistachio & Cacao Nibs Passion Fruit Panna Cotta Tahini Chocolate Chip Cookies Immune response underpins everything from chronic health conditions, such as diabetes and heart disease, to warding off the common cold to how well one ages. So start boosting your immunity at the very next meal with The Immunity Food Fix Cookbook!

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

The Radiology of AIDS is aimed at candidates for postgraduate examinations in all specialities and especially those doctors with some training in HIV disease who need to assess their knowledge of the subject. This book is particularly applicable to candidates for postgraduate examinations in radiology.

BIOS Instant Notes in Immunology, Third Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams. BIOS Instant Notes in Immunology, Third Edition, is fully up-to-date and covers: * Overview of the Immune System * Cells and Molecules of the Innate Immune System * The Adaptive Immune System * Antibodies * The Antibody Response * The T Cell Response -- Cell-Mediated Immunity * Regulation of the Immune Response * Immunity to Infection * Vaccination * Immunodeficiency -- when the Immune System Fails * Hypersensitivity -- when the Immune System Misbehaves * Autoimmunity and Autoimmune Diseases * Transplantation * Tumor Immunology * Gender and the Immune System * Aging and the Immune System (Immunosenescence) * Immunotherapy

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

This well-illustrated book synthesizes all aspects of allergy, asthma, and related fields such as aerobiology and immunology. Appropriate for allergy practitioners and medical students seeking the latest information on allergy and asthma, it covers aeroallergens and their source plants all over the world.The book focuses on allergies caused by pollen and environmental pollution as well as skin disorders stemming from latex allergies. It contains the latest methods of diagnosis and treatment of allergy and asthma releveant to applied clinical immunology.

The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.