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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
A search for a missing son... and a toxic mystery that threatens the
globe.
Exercise immunology is an important, emerging sub-discipline within exercise physiology, concerned with the relationship between exercise, immune function and infection risk. This book offers a comprehensive, up-to-date and evidence-based introduction to exercise immunology, including the physiological and molecular mechanisms that determine immune function and the implications for health and performance in sport and everyday life. Written by a team of leading exercise physiologists, the book describes the characteristics of the immune system and how its components are organised to form an immune response. It explains the physiological basis of the relationship between stress, physical activity, immune function and infection risk, and identifies the ways in which exercise and nutrition interact with immune function in athletes and non-athletes. The book shows students how to evaluate the strengths and limitations of the evidence linking physical activity, immune system integrity and health, and explains why exercise is associated with anti-inflammatory effects that are potentially beneficial to long-term health. Every chapter includes useful features, such as clear summaries, definitions of key terms, discussions of seminal research studies and practical guidelines for athletes on ways to minimise infection risk, with additional learning resources available on a companion website. This is an essential textbook for any course on exercise immunology or advanced exercise physiology.
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
This unique book is a first-of-its-kind resource, comprehensively guiding readers through the epidemiology, pathophysiology, recent diagnostic criteria, and management options for patients with Food Protein-Induced Enterocolitis Syndrome (FPIES). Food-Protein Induced Enterocolitis Syndrome: Diagnosis and Management opens with a historical perspective of this condition, before moving into discussions of epidemiology and pathophysiology. FPIES can be difficult to diagnose as the symptoms overlap with multiple other conditions, and so clear differential diagnosis will be reviewed for both chronic FPIES, as well as acute FPIES. Later chapters are case-based, providing detailed multiple perspectives on the diagnosis and management of FPIES in patients with varying complicating factors and severity. Later chapters will tackle issues of quality of life in patient care, nutritional management for patients, and discussing working with parents and families to improve communication and at-home care. Parents, families and caregivers will also find chapters useful and relatable. A final chapter will look to the future of FPIES, addressing new research, guidelines, and implications for clinicians working with pediatric patients with FPIES, and for their families. Concise and practical, this book will be an ideal reference for allergists, pediatricians, family practice clinicians, gastroenterologists, nutritionists, and all other health care providers who encounter FPIES, and assist them in providing up-to-date, quality care for pediatric patients affected by this condition.
**SHORTLISTED FOR THE WELLCOME BOOK PRIZE** **A GUARDIAN SCIENCE BOOK OF THE YEAR** 'Riveting ... invites comparison to Rebecca Skloot's The Immortal Life of Henrietta Lacks' Nature The epic and controversial story of a major breakthrough in cell biology that led to the conquest of rubella and other devastating diseases. Until the late 1960s, tens of thousands of children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant. There was no vaccine and little understanding of how the disease devastated foetuses. In June 1962, a young biologist in Philadelphia produced the first safe, clean cells that made possible the mass-production of vaccines against many common childhood diseases. Two years later, in the midst of a German measles epidemic, his colleague developed the vaccine that would one day effectively wipe out rubella for good. This vaccine - and others made with those cells - have since protected hundreds of millions of people worldwide, the vast majority of them preschool children. Meredith Wadman's account of this great leap forward in medicine is a fascinating and revelatory read.
This book represents the state-of-the-art in the field of skin and
autoimmune rheumatic diseases. It covers systematically a growing
and multifaceted topic which is of great importance in the clinical
practice. It also serves as a sharp educational tool as each
chapter provides summaries and specific highlights to key
references cited into the text. The pathophysiological link between
skin involvement and autoimmunity has been explained in detail, as
well as diagnostic and therapeutic aspects.
Understanding immunology is increasingly important in obstetrics and gynecology. This book explores the role of immunological processes in reproduction. It presents immunologic concepts and illustrates important points with examples familiar to the clinician. It is organized into four sections: fundamentals of the immune system; the immunological paradox of pregnancy; clinical applications of immunology in obstetric and gynecologic practice, and immunopathology in obstetric and gynecologic practice. Written mainly for practicing obstetricians and gynecologists, the research results cited in the book are confined to human experimentation.
Advances in Cancer Research, volume 153 provides a timely review of the biology, biochemistry, and current approaches to therapeutically target the RAS oncoprotein, the most frequently mutated oncogene family in human cancers. 2021 saw the approval of the first direct RAS inhibitor (sotorasib) for use in treating non-small cell lung cancers harboring KRAS(G12C) mutations. The successful approval and use of this drug highlights that the once "undruggable" RAS is indeed pharmacologically tractable. This volume provides an overview of efforts to develop additional approaches to therapeutically target oncogenic RAS. In addition, the reader will find excellent reviews on the history and research efforts to understand the biochemistry and oncogenic activity of RAS in human cancers.
Immunology: A Comparative Approach discusses the immunological features of a wide range of living organisms. It considers the merits of the laboratory mouse as an immunological representative; opportunities for bypassing technical obstacles in one model by using another; the immunological implications of changes in overall structure, physiology and way of life; and progress made in the study of defence mechanisms in animals and plants of commercial importance. This book is written for students and research workers with some knowledge of mainstream immunology who are curious about the advances, opportunities and challenges in comparative work.
Advances in Immunology presents current developments as well as
comprehensive reviews in immunology. Articles address the wide
range of topics that comprise immunology, including molecular and
cellular activation mechanisms, phylogeny and molecular evolution,
and clinical modalities. Edited and authored by the foremost
scientists in the field, each volume provides up-to-date
information and directions for future research.
This first thematic issue, of the Advances in Immunology series,
highlights the remarkable new insights into the mechanisms that
govern development and function of T cell lineages. Recent
developments in the understanding of the genetic and epigenetic
mechanisms that regulate development of the two major T cell
lineages will have a fundamental impact on a number of research
fields -immunology, cell biology, hematology and stem cell
research. All of these groups have a vested interest in
comprehending issues such as stem cell self renewal, progenitor
plasticity, lineage commitment and cellular identity. Immunologists
have a special interest in the mechanisms that allow selection of a
T cell repertoire whose members integrate genetic information for T
cell receptor, co-receptor and specialized immunologic function,
since this process lies at the core of adaptive immunity.
Winner, 2018 Donald W. Light Award for Applied Medical Sociology, American Sociological Association Medical Sociology Section Winner, 2018 Distinguished Scholarship Award presented by the Pacific Sociology Association Honorable Mention, 2017 ESS Mirra Komarovsky Book Award presented by the Eastern Sociological Society Outstanding Book Award for the Section on Altruism, Morality, and Social Solidarity presented by the American Sociological Association A rich, multi-faceted examination into the attitudes and beliefs of parents who choose not to immunize their children The measles outbreak at Disneyland in December 2014 spread to a half-dozen U.S. states and sickened 147 people. It is just one recent incident that the medical community blames on the nationās falling vaccination rates. Still, many parents continue to claim that the risks that vaccines pose to their children are far greater than their benefits. Given the research and the unanimity of opinion within the medical community, many ask how such parentsāwho are most likely to be white, college educated, and with a family income over $75,000ācould hold such beliefs. For over a decade, Jennifer Reich has been studying the phenomenon of vaccine refusal from the perspectives of parents who distrust vaccines and the corporations that make them, as well as the health care providers and policy makers who see them as essential to ensuring community health. Reich reveals how parents who opt out of vaccinations see their decision: what they fear, what they hope to control, and what they believe is in their childās best interest. Based on interviews with parents who fully reject vaccines as well as those who believe in āslow vax,ā or altering the number of and time between vaccinations, the author provides a fascinating account of these parentsā points of view. Placing these stories in dialogue with those of pediatricians who see the devastation that can be caused by vaccine-preventable diseases and the policy makers who aim to create healthy communities, Calling the Shots offers a unique opportunity to understand the points of disagreement on what is best for children, communities, and public health, and the ways in which we can bridge these differences.
Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Volume 81 of Advances in Immunology contains articles on a vast
range of immunology topics including the regulation of the immune
response by the interaction of chemokines and proteases as well as
roles of the Semaphorin Family in immune regulation. It has a
chapter devoted to B Lymphoid Neoplasms of Mice and another on the
Zebrafish as a model organism to study development of the immune
system. This volume will be of interest to immunologists in all
industries.
"Plant Food Allergens is concerned with a paradox of immense,
potentially life-threatening significance to about 1 in 100 adults
and 1 in 10 children. The paradox is that certain nutritious
proteins from wholesome foods can act as if the were harmful,
sometimes deadly poisons, to these people who possess an allergy to
them. In order to study the complex problems of food allergy a EU
funded network, called PROTALL was set up, bringing together a wide
range of clinicians and scientists. This important book is largely
based on the outcome of its investigations."
"Written by over 30 acknowledged experts and carefully edited by
Dr Clare Mills and Professor Peter Shewry, themselves well known
internationally; this important work covers all major aspects of
the subject. Commencing with introductory chapters, the
comprehensive contents of Plant Food Allergens includes details of
the major allergens including: plant lipid transfer proteins, the
2S albumin proteins, the cereal a-amylase/trypsin family, latex and
plant chitinases, profilins, bet v 1-homologous allergens and plant
seed globulins. The book concludes with important chapters on the
assessment of the allergenicity of novel and GM foods, and the
monitoring of and technological effects on allergenicity of
proteins in the food industry. "
"Plant Food Allergens is an essential purchase for a wide range
of scientists and clinicians including plant and agricultural
scientists, chemists, allergy specialists, food scientists and
technologists, pharmacologists, physiologists and nutritionists.
Libraries in all research establishments and universities
researching and teaching these subjects will need copies of this
important book on their shelves"
"Dr Clare Mills is based at The Institute of Food Research,
Norwich, UK.
This book aims to describe the achievements, policy and system of immunization management in China during the last 60 years. Immunization is one of the most effective and cost-effective means to prevent infectious diseases. The Chinese government has long attached great importance to immunization, and with several generations of effort, China has made great achievements through its immunization program.The book consists of 9 chapters, including the introduction of vaccination and immunization policy, immunization services, innovative vaccines, immunization activities in China. The book also demonstrates some of the hardships and difficulties behind the immunization achievements, and introduces the effort of Expanded Program of Immunization (EPI) staff and the support and assistance from the international community.
Immunology of Infection, 2nd Edition, edited by two leading experts
in the field, presents the most appropriate up-to-date experimental
approaches in the detail required for modern microbiological
research. Focusing on the methods most useful for the
Microbiologist interested in analysing host-pathogen relationships,
this volume will be essential reading for all researchers working
in microbiology, immunology, virology, mycology and parasitology.
This book provides the reader with a comprehensive overview of the
Antiphospholipid syndrome. One of the most important advances in
rheumatology and connective tissue diseases of the last decade. It
provides an explanation for many previously undefined conditions
with no clear pathogenesis encompassing all subspeculations in
internal medicine as well as obstetrics. Clotting problems leading
to strokes and myocardial infarctions (in younger people) as well
as a large variety of other syndromes such as chorea,
hyproadrenalism, pulmonary problems are now being understood.
The FactsBook series has established itself as the best source of
easily accessible and accurate facts about protein groups. Books in
the series use an easy-to-follow format and are meticulously
researched and compiled by experts in the field.
This book represents an essential reference manual for all of the
well-characterized leukemia-lymphoma cell lines currently
available. It provides the most important facts, using the succinct
and user-friendly format that has made the FactsBooks so popular
with scientists and clinical researchers. Introductory chapters
provide background and perspective for culturing malignant
hematopoietic (blood forming) cell lines. These chapters are
followed by over 400 comprehensive individual entries. Each cell
line entry highlights essential clinical, immunological, genetic,
and functional features and includes a comprehensive listing of
references.
A study of mast cells and basophils, designed for the use of immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Case Studies in Allergic Disorders is designed for undergraduate and graduate students in immunology, medical students, and resident physicians. It describes the basic cellular and molecular mechanisms involved in the pathogenesis of commonly occurring allergic diseases and introduces the rationale for targeted treatment of allergy. Replicating the successful approach of Case Studies in Immunology, the book presents mechanisms of hypersensitivity through a selection of clinical cases that reinforce and extend the basic science. The cases are largely drawn from the records of Children's Hospital Boston. Linking the discussion of pathogenesis to actual clinical presentation establishes important connections between the bench and bedside. The book can be used as either a stand-alone text or asa companion to Janeway's Immunobiology and The Immune System.
This essential methods manual for immunohematologists (or
hematologists and immunohematologists) provides information on
genes that encode antigens on red blood cells, platelets and
neutrophils. The book begins by covering general concepts in
molecular biology and specific protocols such as DNA preparation,
PCR-RFLP and allele-specific PCR. Information on the erythrocyte,
platelet and neutrophil antigen systems and the molecular basis of
polymorphisms are presented clearly in a gene facts sheet format.
Database accession numbers and useful adjuncts such as Request
forms, worksheets for PCR/enzyme digests also serve to benefit the
user. The information is clearly presented and easily accessible
and is complemented by the excellent diagrams and tabular material.
This book is invaluable for both new and experienced researchers in
the field and other related disciplines. |
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