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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Mechanisms of Lymphocyte Activation and Immune Regulation V - Molecular Basis of Signal Transduction (Hardcover, 1994 ed.)
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Mechanisms of Lymphocyte Activation and Immune Regulation V - Molecular Basis of Signal Transduction (Hardcover, 1994 ed.)
Series: Advances in Experimental Medicine and Biology, 365
Expected to ship within 10 - 15 working days
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Signaling through antigen receptor initiates a complex series of
events resulting in the activation of genes that regulate the
development, proliferation and differentiation of lymphocytes.
During the past few years, rapid progress has been made in
understanding the molecular basis of signaling pathways mediated by
antigen and cytokine receptors. These pathways involve protein
tyrosine kinases which are coupled to downstream regulatory
molecules, including small guanine nucleotide binding proteins (e.
g. p21'OS), serine threonine kinases (e. g. , members of the ERK
family), and a large group of transcription factors. More recently,
there have been breakthroughs in elucidating the genetic defects
underlying three X-linked primary immunodeficiency diseases in
humans. This volume surveys aspects of these rapidly developing
areas of research. The book is divided into 5 different sections.
Section I deals with signaling pathways in B lymphocytes. It
includes a contemporary assessment of B cell antigen receptor
structures, and discussion of the role of Ig-a/lg-B polypeptides in
linking the antigen receptor to intracellular signal transduction
pathways. The role of accessory molecules in the regulation of
signaling by the B cell antigen receptor is also considered.
Section II adopts a similar approach to the analysis of the antigen
receptor on T lymphocytes. The importance of specialized signaling
motifs in the CD3 polypeptides, mechanisms whereby these motifs may
interact with the lymphocyte-specific protein tyrosine kinases, and
the downstream consequences of these interactions are reviewed. In
addition, the role of antigen-induced apoptosis in the generation
of immunological tolerance is discussed.
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