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Antiviral Chemotherapy 4 - New Directions for Clinical Application and Research (Hardcover, 1996 ed.)
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Antiviral Chemotherapy 4 - New Directions for Clinical Application and Research (Hardcover, 1996 ed.)
Series: Advances in Experimental Medicine and Biology, 394
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The three years since our last conference in San Francisco have
again seen a dramatic expansion of the number of antivirals either
licensed or in the late stages of clinical trials. d4T is now
licensed for HIV infection, famciclovir and the oral pro-drug of
acyclovir, valacyclovir, are now licensed for VZV infections in
some countries. Moreover. oral ganciclovir, cidofovir, and
sorivudine are not far behind. Clinical trials with the second-site
reverse transcriptase inhibitors and the protease inhibitors for
HlV infection are proceeding rapidly and on a broad scale, and the
preliminary results would suggest that several of these classes of
drugs will be licensed as well. Despite this optimism, however,
there is increasing evidence that antiviral-resistant strains of
pathogenic viruses will be a significant problem, perhaps
especially with therapy of HIV infection, and there remains a
desperate need for improved drugs (with either improved efficacy or
decreased toxicity, or both) for CMV and HIV infections. This book
is the edited proceedings of the Fourth Triennial Conference on
Antiviral Chemotherapy, held in San Francisco, in November 1994.
The conference was sponsored by the University of California, San
Francisco, and co-sponsored by the International Society for
Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical
Research in Melbourne, Australia, and the Australian National
Centre for HIV Virology Research. The conference had been organized
to present an overview of the field of antiviral chemotherapy.
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