Immunology is more than a laboratory manual; it is a strategic guide that provides the reader with tips and tricks for more successful lab experiments. The authors explore the current methodological variety of immunology in a simple manner, addressing the assets and drawbacks as well as critical points. Also provided are short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods. This well-written guide is an essential companion for anyone using modern immunological methods in the laboratory.
Shows how to avoid experimental dead ends and develop an instinct for the right experiment at the right time
Contains short and precise summaries of routine procedures (e.g. column chromatography, gel electrophoresis) as well as listings of advantages and disadvantages of alternative methods
Includes over 100 informative illustrations, background information, an extensive glossary, and a table of current CD nomenclature"

Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.

This issue of Immunology and Allergy Clinics, Guest Edited by Dr. Mitchell Grayson, is devoted to Infections and Asthma. Articles in this issue include: Epidemiology of Infections and Development of Asthma; Mechanisms of Respiratory Syncytial Virus Induced Asthma; Importance of Viral Characteristics in Respiratory Syncytial Virus Induced Disease; Human Rhinovirus and Asthma Exacerbation; Rhinovirus Attributes That Contribute to Asthma; Infant Immune Response to Respiratory Viral Infections; The Role of Bacteria in Asthma Pathogenesis; Beyond RSV and RV in the Pathogenesis and Exacerbation of Asthma; Biologics for Asthma and Risk of Infection: Should We Be Concerned?; Sinus Infections and Asthma; Helminths and Asthma: Friend or Foe?; and Primary Infection Prevention Strategies for Asthma.

This issue of Immunology and Allergy Clinics is devoted to Asthma in Childhood and is Guest Edited by Drs. Leonard Bacharier and Theresa Guilbert. Articles in this outstanding issue include: Inception and Natural History of Pediatric Asthma; Recent Diagnosis Techniques in Pediatric Asthma; Management / co-morbidities for Preschool-aged Children with Asthma; Management/ co-morbidities for School-aged Children with Asthma; Effects of the Environment on Disease Activity; New Advances of Self-Management/Adherence Monitoring and Management in Pediatric Asthma; Severe Asthma in Early Childhood; Inner-city Asthma in Early Childhood; Personalized Medicine and Pediatric Asthma; Prevention in Pediatric Asthma; Asthma in the Schools; and New Directions in Pediatric Asthma.

This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.

Get a quick, expert overview of the essentials of today's vaccinations for adults, including current guidelines and recommendations. This concise, clinically-focused resource, edited by Drs. Gregory A. Poland and Jennifer Whitaker, consolidates today's available information on this important topic into one convenient resource, making it an ideal reference for primary care physicians and nurses who need easily accessible information on adult vaccination best practices. Covers essentials of vaccine safety and discussing vaccine hesitancy with patients. Addresses special populations including the elderly, immunocompromised patients, and adult travelers. Provides up-to-date information on zoster vaccines, Zika vaccine prospects, influenza vaccines, meningococcal vaccines, and pneumococcal vaccines.

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.

Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology.

Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.