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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunopharmacology (Hardcover, 2nd ed. 2016)
Loot Price: R6,203
Discovery Miles 62 030
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Immunopharmacology (Hardcover, 2nd ed. 2016)
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The concept of immunotherapy was in infancy when the first edition
was written; since then, major advances have been made, not only
with several prominent clinical trials, but also with the approval
of cell-based therapy by the FDA for the treatment of cancer in
2010. These events resulted in a gradually narrowing gap between
early scientific knowledge and the late development of immune-based
therapies. Consequently, the significance and magnitude of these
advances warranted a revision of this contribution; this revised
edition will provide a deeper understanding of the recent advances
and discoveries related to the function of the immune response and
their applications in the development of novel therapies to treat
human diseases. Some of the key discoveries during the past five
years include: the identification of the new subsets of helper T
cells; new cytokines and their networks; and novel signal
transduction mechanisms. For example, the identification of TH17
subset of helper T cells, in addition to TH1 and TH2 cells, not
only advanced our understanding of the function of the basic immune
response, but also raised our awareness of the possible etiology
and pathogenesis of diseases such as allergy, asthma, rheumatoid
arthritis, and other auto-immune/immune system based diseases. The
newly identified powerful cytokine networks, that regulate both
innate and acquired immune responses, emerged as a result of the
finding of new cell types such as innate lymphoid cells and iNKT.
Identification of the novel cytokines and their networks has
advanced our knowledge of the mechanisms involved in the
maintenance of tissue homeostasis, including inflammation and
tissue repair during stress and injury. The development of HIV
vaccines has also seen dramatic changes over the last few years.
There has been a shift from a sole focus on T cell vaccines to a
holistic approach that pertains to the induction of both humoral
and cellular elements. This entails the induction of antibodies -
both binding and neutralizing - to prevent infection. The cellular
vaccination produces a safety net of CD8+ T-cell responses to
suppress the replication of the virus in the infected patients, and
both of the effector arms are aided by helper T cells. From the
perspective of clinical applications, significant advances have
also been made in: oral immunotherapy for allergic disease, the
possible treatment of HIV infection, the development of new
monoclonal antibodies and their fragments to treat human diseases,
and immune cell based therapies for cancer.
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