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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Immunology and Drug Therapy of Atopic Skin Diseases (Hardcover): C.Bruijnzeel- Koomen, E. Knol, C. Brunijnzeel-Kooman Immunology and Drug Therapy of Atopic Skin Diseases (Hardcover)
C.Bruijnzeel- Koomen, E. Knol, C. Brunijnzeel-Kooman; Edited by M.J. Parnham
R2,433 Discovery Miles 24 330 Ships in 18 - 22 working days

Skin immune system (SIS).- Immunological aspects of allergic inflammation: IgE regulation.- The role of T cells in the pathogenesis of atopic dermatitis.- Immunological aspects of allergic inflammation: eosinophils.- Mast cells.- Cell-to-cell interactions.- Atopic dermatitis.- Allergic contact dermatitis: cosmetics.- Clinical aspects of occupational contact dermatitis.- Clinical aspects: urticaria.- Clinical aspects: drug allergy.- Future developments in treatment of atopic dermatitis.

Bacterial Polysaccharides - Methods and Protocols (Hardcover, 1st ed. 2019): Inka Brockhausen Bacterial Polysaccharides - Methods and Protocols (Hardcover, 1st ed. 2019)
Inka Brockhausen
R5,214 Discovery Miles 52 140 Ships in 18 - 22 working days

This book provides a selection of recently developed methods and protocols in bacterial glycomics to aid in bettering our understanding of the structures and functions of bacterial polysaccharides, their attachments to proteins and lipids, their role in biofilm formation, as well as their biosynthesis. With the emerging bacterial resistance to commonly used antibiotics world-wide, these techniques to study the outer polysaccharides of bacteria, with their functions in bacterial adhesion, colonization, growth, establishment of biofilms, and control virulence and pathogenicity, are increasingly important. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Polysaccharides: Methods and Protocols aims to support researchers contributing to future approaches that will fill our knowledge gaps and define anti-bacterial targets.

T Helper Cell Differentiation and Their Function (Hardcover, 2014 ed.): Bing Sun T Helper Cell Differentiation and Their Function (Hardcover, 2014 ed.)
Bing Sun
R4,986 Discovery Miles 49 860 Ships in 10 - 15 working days

This book will focus on the differentiation and regulation of subsets of CD4+ T cells. It will also cover other aspects of research on these cells, which has made great advances in recent years, such as subsets' plasticity and their role in healthy and disease conditions. The book provides researchers and graduate students with a cutting-edge and comprehensive overview of essential research on CD4+ T cells.

Systems Biology (Hardcover, 2013 ed.): Michael G. Katze Systems Biology (Hardcover, 2013 ed.)
Michael G. Katze
R5,266 R4,675 Discovery Miles 46 750 Save R591 (11%) Ships in 10 - 15 working days

In this volume, a wide-ranging series of reviews reveal how systems biology -- a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists -- is changing the face of infectious disease research. Leading experts discuss how the use of high-throughput and computational approaches are generating exciting -- and often unexpected -- new insights into the microbial-host interactions of a variety of bacterial and viral pathogens, including Salmonella, Yersinia, Mycobacterium, influenza virus, human and simian immunodeficiency virus, and hepatitis C virus. Additional chapters focus on systems approaches to innate immunity, intra- and inter- cellular signaling, biomarker discovery, and the evaluation and rational development of improved vaccines. Systems biology has both been hailed as a paradigm shift that will revolutionize biological science and criticized as overly expensive and complex. While the truth no doubt lies somewhere in between, the approach is yielding increasingly detailed and comprehensive views of biological systems and processes, including those that dictate the host response to infection and disease outcome. Systems Biology of Infectious Disease is highly informative reading for investigators already engaged in systems biology research as well as for those scientists and clinicians who may be seeking an introduction to the field.

Semaphorins - A Diversity of Emerging Physiological and Pathological Activities (Hardcover, 2015 ed.): Atsushi Kumanogoh Semaphorins - A Diversity of Emerging Physiological and Pathological Activities (Hardcover, 2015 ed.)
Atsushi Kumanogoh
R3,894 R3,364 Discovery Miles 33 640 Save R530 (14%) Ships in 10 - 15 working days

This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.

How Helminths Alter Immunity to Infection (Hardcover, 2014 ed.): William Horsnell How Helminths Alter Immunity to Infection (Hardcover, 2014 ed.)
William Horsnell
R2,975 R1,804 Discovery Miles 18 040 Save R1,171 (39%) Ships in 10 - 15 working days

Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.

Development and Function of Myeloid Subsets, Volume 120 (Hardcover): Kenneth M. Murphy, Miriam Merad Development and Function of Myeloid Subsets, Volume 120 (Hardcover)
Kenneth M. Murphy, Miriam Merad
R4,175 Discovery Miles 41 750 Ships in 10 - 15 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Antibody Fc - Linking Adaptive and Innate Immunity (Hardcover, New): Margaret Ackerman, Falk Nimmerjahn Antibody Fc - Linking Adaptive and Innate Immunity (Hardcover, New)
Margaret Ackerman, Falk Nimmerjahn
R3,541 Discovery Miles 35 410 Ships in 10 - 15 working days

"Antibody Fc" is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system

Urticaria, An Issue of Immunology and Allergy Clinics, Volume 34-1 (Hardcover): Malcolm Greaves Urticaria, An Issue of Immunology and Allergy Clinics, Volume 34-1 (Hardcover)
Malcolm Greaves
R1,664 Discovery Miles 16 640 Ships in 10 - 15 working days

Urticaria, or hives, is a skin rash characterized by red, raised bumps which are usually itchy and create a burning sensation. Urticaria can be caused by allergic and non-allergic reactions. For patients with chronic hives, this condition is usually the result of an autoimmune disorder. This issue will cover the latest diagnosis and treatment strategies for this condition at the point of care, across several patient types, such as children and pregnant women.

The Kansas City Meningitis Epidemic, 1911-1913 - Violent and Not Imagined (Hardcover): Margaret R O'Leary, Dennis S.... The Kansas City Meningitis Epidemic, 1911-1913 - Violent and Not Imagined (Hardcover)
Margaret R O'Leary, Dennis S. O'Leary
R747 R666 Discovery Miles 6 660 Save R81 (11%) Ships in 18 - 22 working days
Angioedema, An Issue of Immunology and Allergy Clinics, Volume 33-4 (Hardcover): Bruce L. Zuraw Angioedema, An Issue of Immunology and Allergy Clinics, Volume 33-4 (Hardcover)
Bruce L. Zuraw
R1,672 Discovery Miles 16 720 Ships in 10 - 15 working days

Guest edited by Bruce Zuraw, this issue of Immunology and Allergy Clinics covers angioedema, including topics on hereditary angioedema, prophylactic and on-demand treatmetnts, and more.

Advances in Immunology, Volume 118 (Hardcover, 89 Ed): Frederick W. Alt Advances in Immunology, Volume 118 (Hardcover, 89 Ed)
Frederick W. Alt
R4,160 Discovery Miles 41 600 Ships in 10 - 15 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Transplantation Immunology - Methods and Protocols (Hardcover, 2nd ed. 2013): Andrea A. Zachary, Mary S. Leffell Transplantation Immunology - Methods and Protocols (Hardcover, 2nd ed. 2013)
Andrea A. Zachary, Mary S. Leffell
R5,921 Discovery Miles 59 210 Ships in 18 - 22 working days

After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients. The second edition of Transplantation Immunology: Methods and Protocols expands upon the previous edition with current, detailed methods in transplantation immunology. The new methods chapters cover four major areas that are being applied in compatibility evaluations and ongoing transplantation immunology research. Seven overview chapters provide reviews of the molecular basis for alloreactivity, current understanding of humoral and cellular mechanisms, as well as new developments in thoracic organ transplantation, composite tissue transplantation and in the transplantation of sensitized patients. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transplantation Immunology: Methods and Protocol, Second Edition is devoted to transplantation immunology, both in the practice of compatibility testing and in transplantation research.

Ibuprofen: Pharmacology, Therapeutics and Side Effects (Hardcover, 2012 ed.): K.D. Rainsford Ibuprofen: Pharmacology, Therapeutics and Side Effects (Hardcover, 2012 ed.)
K.D. Rainsford
R4,031 Discovery Miles 40 310 Ships in 18 - 22 working days

Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.

Advances in Immunology, Volume 117 (Hardcover, New): Frederick W. Alt Advances in Immunology, Volume 117 (Hardcover, New)
Frederick W. Alt
R4,156 Discovery Miles 41 560 Ships in 10 - 15 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Advances in Immunology, Volume 119 (Hardcover, New): Frederick W. Alt Advances in Immunology, Volume 119 (Hardcover, New)
Frederick W. Alt
R4,159 Discovery Miles 41 590 Ships in 10 - 15 working days

"Advances in Immunology, " a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Exercise-Induced Bronchoconstriction, An Issue of Immunology and Allergy Clinics, Volume 33-3 (Hardcover): Sandra Anderson Exercise-Induced Bronchoconstriction, An Issue of Immunology and Allergy Clinics, Volume 33-3 (Hardcover)
Sandra Anderson
R1,682 Discovery Miles 16 820 Ships in 10 - 15 working days

Guest edited by Sandra Anderson this issue of Immunology and Allergy Clinics covers all aspects of exercise-induced bronchospasm, including treatment through pharmacologic agents, patient assessments, and biomarkers.

War in the Body - The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines... War in the Body - The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines (Hardcover, 2013 ed.)
W David Wick, Otto O. Yang
R6,833 Discovery Miles 68 330 Ships in 18 - 22 working days

In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.

Molecular Mechanisms in Legionella Pathogenesis (Hardcover, 2014 ed.): Hubert Hilbi Molecular Mechanisms in Legionella Pathogenesis (Hardcover, 2014 ed.)
Hubert Hilbi
R5,022 R4,701 Discovery Miles 47 010 Save R321 (6%) Ships in 10 - 15 working days

Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium "Legionella pneumophila." This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to "L. pneumophila." Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen "L. pneumophila.""

Immunopharmacology (Hardcover, 2nd ed. 2016): Manzoor M. Khan Immunopharmacology (Hardcover, 2nd ed. 2016)
Manzoor M. Khan
R5,836 Discovery Miles 58 360 Ships in 10 - 15 working days

The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010. These events resulted in a gradually narrowing gap between early scientific knowledge and the late development of immune-based therapies. Consequently, the significance and magnitude of these advances warranted a revision of this contribution; this revised edition will provide a deeper understanding of the recent advances and discoveries related to the function of the immune response and their applications in the development of novel therapies to treat human diseases. Some of the key discoveries during the past five years include: the identification of the new subsets of helper T cells; new cytokines and their networks; and novel signal transduction mechanisms. For example, the identification of TH17 subset of helper T cells, in addition to TH1 and TH2 cells, not only advanced our understanding of the function of the basic immune response, but also raised our awareness of the possible etiology and pathogenesis of diseases such as allergy, asthma, rheumatoid arthritis, and other auto-immune/immune system based diseases. The newly identified powerful cytokine networks, that regulate both innate and acquired immune responses, emerged as a result of the finding of new cell types such as innate lymphoid cells and iNKT. Identification of the novel cytokines and their networks has advanced our knowledge of the mechanisms involved in the maintenance of tissue homeostasis, including inflammation and tissue repair during stress and injury. The development of HIV vaccines has also seen dramatic changes over the last few years. There has been a shift from a sole focus on T cell vaccines to a holistic approach that pertains to the induction of both humoral and cellular elements. This entails the induction of antibodies - both binding and neutralizing - to prevent infection. The cellular vaccination produces a safety net of CD8+ T-cell responses to suppress the replication of the virus in the infected patients, and both of the effector arms are aided by helper T cells. From the perspective of clinical applications, significant advances have also been made in: oral immunotherapy for allergic disease, the possible treatment of HIV infection, the development of new monoclonal antibodies and their fragments to treat human diseases, and immune cell based therapies for cancer.

Conditions Mimicking Asthma, An Issue of Immunology and Allergy Clinics (Hardcover): Eugene Choo Conditions Mimicking Asthma, An Issue of Immunology and Allergy Clinics (Hardcover)
Eugene Choo
R1,658 Discovery Miles 16 580 Ships in 10 - 15 working days

Guest edited by Eugene Choo, this issue of Immunology and Allergy Clinics covers the latest research in diagnosing and managing asthma-like diseases. Topics covered include vocal cord dysfunction, dynamic airway collapse, RADS, GERD, sarcoidosis, and more.

Recombinant Virus Vaccines - Methods and Protocols (Hardcover, 1st ed. 2017): Maureen C. Ferran, Gary R. Skuse Recombinant Virus Vaccines - Methods and Protocols (Hardcover, 1st ed. 2017)
Maureen C. Ferran, Gary R. Skuse
R4,770 Discovery Miles 47 700 Ships in 10 - 15 working days

This volume provides readers with methods and protocols for understanding the development of recombinant viruses and their use as vaccines platforms. Recombinant Virus Vaccines: Methods and Protocols details the use of recombinant vaccines that are employed to either produce immunogens in vitro or elicit antibody production in vivo. The chapters in this book are divided into four parts: Part I explores double-stranded DNA viruses; Part II discusses negative sense single-stranded RNA viruses; Part III talks about positive sense single-stranded RNA viruses; and Part IV describes bacteriophages. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Recombinant Virus Vaccines: Methods and Protocols is a valuable resource for scientists and clinicians who are interested in learning about and adopting methods for use in basic and biomedical research directed toward generating and developing recombinant viral vaccines.

Immunoproteomics - Methods and Protocols (Hardcover, 2013 ed.): Kelly M. Fulton, Susan M. Twine Immunoproteomics - Methods and Protocols (Hardcover, 2013 ed.)
Kelly M. Fulton, Susan M. Twine
R4,903 Discovery Miles 49 030 Ships in 10 - 15 working days

Providing current diverse approaches and techniques used to study the immunoproteome, Immunoproteomics: Methods and Protocols collects chapters from key researchers that deliver information to be used in diagnostics, disease progression, and vaccine correlates of protection analysis, to name but a few. This detailed volume includes techniques used for the study of the antibody targets of bacterial pathogens, viruses, and cancer, mass spectrometry-based approaches to characterize T-cell epitopes, chapters on detection and relative quantification of cytokines in serum, as well as in silico prediction of epitopes using sequence-based or modeling approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Immunoproteomics: Methods and Protocols aids researchers in transferring these techniques to their own laboratories in addition to providing a reference to guide researchers toward appropriate techniques.

Genomics of Pattern Recognition Receptors - Applications in Oncology and Cardiovascular Diseases (Hardcover, 2013 ed.): Anton... Genomics of Pattern Recognition Receptors - Applications in Oncology and Cardiovascular Diseases (Hardcover, 2013 ed.)
Anton G. Kutikhin, Arseniy E. Yuzhalin
R4,584 Discovery Miles 45 840 Ships in 10 - 15 working days

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Notch Regulation of the Immune System (Hardcover, 2012 ed.): Freddy Radtke Notch Regulation of the Immune System (Hardcover, 2012 ed.)
Freddy Radtke
R4,013 Discovery Miles 40 130 Ships in 18 - 22 working days

Notch signaling regulates many cell fate decision and differentiation processes during embryonic development and tissue homeostasis. Moreover, disregulation of the pathway is associated with human disorders and cancer. In the last 15 years it became evident that Notch plays important roles in the hematopoietic system as well as in the regulation of immune responses. This special issue on Notch regulation of the immune system summarizes recent advances and covers multiple aspects of Notch signaling within the hematopoietic and the immune system. This issue covers subjects including Notch function in embryonic and adult hematopoietic stem cells, lymphocyte development and function as well as in T cell leukemia."

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