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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Celiac Disease - From the Bench to the Clinic (Hardcover): Luis Rodrigo, Carlos Hernandez-Lahoz Celiac Disease - From the Bench to the Clinic (Hardcover)
Luis Rodrigo, Carlos Hernandez-Lahoz
R2,770 Discovery Miles 27 700 Ships in 10 - 15 working days
Statistics in Clinical and Observational Vaccine Studies (Hardcover, 2nd ed. 2020): Jozef Nauta Statistics in Clinical and Observational Vaccine Studies (Hardcover, 2nd ed. 2020)
Jozef Nauta
R2,868 Discovery Miles 28 680 Ships in 12 - 19 working days

This book offers an overview of the statistical methods used in clinical and observational vaccine studies. Pursuing a practical rather than theoretical approach, it presents a range of real-world examples with SAS codes, making the application of the methods straightforward. This revised edition has been significantly expanded to reflect the current interest in this area. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the analysis of immunogenicity data. Discussed are, amongst others, maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of data of equivalence, and non-inferiority immunogenicity studies. Other topics covered include fitting protection curves to data from vaccine efficacy studies, and the analysis of vaccine safety data. In addition, the book features four new chapters on vaccine field studies: an introductory one, one on randomized vaccine efficacy studies, one on observational vaccine effectiveness studies, and one on the meta-analysis of vaccine efficacy studies. The book offers useful insights for statisticians and epidemiologists working in the pharmaceutical industry or at vaccines institutes, as well as graduate students interested in pharmaceutical statistics.

Systemic Lupus Erythematosus - Basic, Applied and Clinical Aspects (Paperback, 2nd edition): George Tsokos Systemic Lupus Erythematosus - Basic, Applied and Clinical Aspects (Paperback, 2nd edition)
George Tsokos
R3,811 Discovery Miles 38 110 Ships in 12 - 19 working days

This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general.

Celiac Disease (Hardcover): Jianyuan Chai Celiac Disease (Hardcover)
Jianyuan Chai
R2,766 Discovery Miles 27 660 Ships in 10 - 15 working days
A Clinician's Guide to Allergic Diseases (Hardcover): Kevin Parker A Clinician's Guide to Allergic Diseases (Hardcover)
Kevin Parker
R3,340 R3,024 Discovery Miles 30 240 Save R316 (9%) Ships in 10 - 15 working days
Colon Cancer Diagnosis and Therapy - Volume 1 (Hardcover, 1st ed. 2021): Ganji Purnachandra Nagaraju, Dhananjay Shukla, Naveen... Colon Cancer Diagnosis and Therapy - Volume 1 (Hardcover, 1st ed. 2021)
Ganji Purnachandra Nagaraju, Dhananjay Shukla, Naveen Kumar Vishvakarma
R4,405 Discovery Miles 44 050 Ships in 10 - 15 working days

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Colon Cancer Diagnosis and Therapy - Volume 2 (Hardcover, 1st ed. 2021): Naveen Kumar Vishvakarma, Ganji Purnachandra Nagaraju,... Colon Cancer Diagnosis and Therapy - Volume 2 (Hardcover, 1st ed. 2021)
Naveen Kumar Vishvakarma, Ganji Purnachandra Nagaraju, Dhananjay Shukla
R5,166 Discovery Miles 51 660 Ships in 10 - 15 working days

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Systemic Sclerosis: Immunopathology and Clinical Aspects (Hardcover): Riley Tate Systemic Sclerosis: Immunopathology and Clinical Aspects (Hardcover)
Riley Tate
R2,368 Discovery Miles 23 680 Ships in 12 - 19 working days
Neurocognitive Complications of HIV-Infection - Neuropathogenesis to Implications for Clinical Practice (Hardcover, 1st ed.... Neurocognitive Complications of HIV-Infection - Neuropathogenesis to Implications for Clinical Practice (Hardcover, 1st ed. 2021)
Lucette A. Cysique, Sean B. Rourke
R5,685 Discovery Miles 56 850 Ships in 10 - 15 working days

This volume aims at presenting the latest international research and discoveries in the neurocognitive aspects and complications in HIV/AIDS, and how this understanding can shape and inform how we think about clinical practice and patient care in HIV/AIDS as well as lead to a better understanding of the underlying neuropathogenesis. The chapter, "Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders", of this book is available open access under a CC BY 4.0 license at link.springer.com

Immunology (Hardcover): Werner Luttmann, Kai Bratke, Michael Kupper, Daniel Myrtek Immunology (Hardcover)
Werner Luttmann, Kai Bratke, Michael Kupper, Daniel Myrtek
R1,940 R1,356 Discovery Miles 13 560 Save R584 (30%) Ships in 12 - 19 working days

Immunology is more than a laboratory manual; it is a strategic guide that provides the reader with tips and tricks for more successful lab experiments. The authors explore the current methodological variety of immunology in a simple manner, addressing the assets and drawbacks as well as critical points. Also provided are short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods. This well-written guide is an essential companion for anyone using modern immunological methods in the laboratory.
Shows how to avoid experimental dead ends and develop an instinct for the right experiment at the right time
Contains short and precise summaries of routine procedures (e.g. column chromatography, gel electrophoresis) as well as listings of advantages and disadvantages of alternative methods
Includes over 100 informative illustrations, background information, an extensive glossary, and a table of current CD nomenclature"

Mucosal Vaccines - Innovation for Preventing Infectious Diseases (Paperback): David W. Pascual Mucosal Vaccines - Innovation for Preventing Infectious Diseases (Paperback)
David W. Pascual
R5,660 Discovery Miles 56 600 Ships in 12 - 19 working days

Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.

The Foundations of Immunology and their Pertinence to Medicine (Hardcover): Peter Bretscher The Foundations of Immunology and their Pertinence to Medicine (Hardcover)
Peter Bretscher
R880 Discovery Miles 8 800 Ships in 10 - 15 working days
State-of-Art in Innate Immunity (Hardcover): Silvia Fischer, Elisabeth Deindl State-of-Art in Innate Immunity (Hardcover)
Silvia Fischer, Elisabeth Deindl
R1,638 R1,414 Discovery Miles 14 140 Save R224 (14%) Ships in 10 - 15 working days
Infections and Asthma, An Issue of Immunology and Allergy Clinics of North America, Volume 39-3 (Hardcover): Mitchell Grayson Infections and Asthma, An Issue of Immunology and Allergy Clinics of North America, Volume 39-3 (Hardcover)
Mitchell Grayson
R2,048 Discovery Miles 20 480 Ships in 12 - 19 working days

This issue of Immunology and Allergy Clinics, Guest Edited by Dr. Mitchell Grayson, is devoted to Infections and Asthma. Articles in this issue include: Epidemiology of Infections and Development of Asthma; Mechanisms of Respiratory Syncytial Virus Induced Asthma; Importance of Viral Characteristics in Respiratory Syncytial Virus Induced Disease; Human Rhinovirus and Asthma Exacerbation; Rhinovirus Attributes That Contribute to Asthma; Infant Immune Response to Respiratory Viral Infections; The Role of Bacteria in Asthma Pathogenesis; Beyond RSV and RV in the Pathogenesis and Exacerbation of Asthma; Biologics for Asthma and Risk of Infection: Should We Be Concerned?; Sinus Infections and Asthma; Helminths and Asthma: Friend or Foe?; and Primary Infection Prevention Strategies for Asthma.

Clinical Use of Anti-infective Agents - A Guide on How to Prescribe Drugs Used to Treat Infections (Hardcover, 2nd ed. 2021):... Clinical Use of Anti-infective Agents - A Guide on How to Prescribe Drugs Used to Treat Infections (Hardcover, 2nd ed. 2021)
Robert W. Finberg, Roy Guharoy
R3,156 Discovery Miles 31 560 Ships in 10 - 15 working days

This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses. It includes a detailed explanation of different classes of drugs, outlining their spectrum, pharmacokinetics, side effects, and dosing in clinical settings. This book has been designed as a reference tool for pharmacists, clinicians, nurse practitioners, and clinical microbiologists, as well as a teaching vehicle for students studying infection and patient treatment. Each section includes references allowing for in-depth study of specific agents, Q&As, and illustrative case studies accompanied by commentary on how to approach patients and organisms, optimal methods of making a diagnosis, and prescribing treatment.

Asthma in Early Childhood, An Issue of Immunology and Allergy Clinics of North America, Volume 39-2 (Hardcover): Theresa... Asthma in Early Childhood, An Issue of Immunology and Allergy Clinics of North America, Volume 39-2 (Hardcover)
Theresa Guilbert, Leonard B Bacharie
R2,044 Discovery Miles 20 440 Ships in 12 - 19 working days

This issue of Immunology and Allergy Clinics is devoted to Asthma in Childhood and is Guest Edited by Drs. Leonard Bacharier and Theresa Guilbert. Articles in this outstanding issue include: Inception and Natural History of Pediatric Asthma; Recent Diagnosis Techniques in Pediatric Asthma; Management / co-morbidities for Preschool-aged Children with Asthma; Management/ co-morbidities for School-aged Children with Asthma; Effects of the Environment on Disease Activity; New Advances of Self-Management/Adherence Monitoring and Management in Pediatric Asthma; Severe Asthma in Early Childhood; Inner-city Asthma in Early Childhood; Personalized Medicine and Pediatric Asthma; Prevention in Pediatric Asthma; Asthma in the Schools; and New Directions in Pediatric Asthma.

Tumor Microenvironment - Hematopoietic Cells - Part B (Hardcover, 1st ed. 2020): Alexander Birbrair Tumor Microenvironment - Hematopoietic Cells - Part B (Hardcover, 1st ed. 2020)
Alexander Birbrair
R4,385 Discovery Miles 43 850 Ships in 10 - 15 working days

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells - Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Principles and Methods of Immunotoxicology (Hardcover, 3rd edition): Jacques Descotes Principles and Methods of Immunotoxicology (Hardcover, 3rd edition)
Jacques Descotes
R6,264 Discovery Miles 62 640 Ships in 10 - 15 working days

This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.

Lectin in Host Defense Against Microbial Infections (Hardcover, 1st ed. 2020): Shie-Liang Hsieh Lectin in Host Defense Against Microbial Infections (Hardcover, 1st ed. 2020)
Shie-Liang Hsieh
R4,118 Discovery Miles 41 180 Ships in 10 - 15 working days

This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous 'pathogen-associated molecular patterns' or 'damage-associated molecular patterns'. As such, microbes' interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.

Sarcoidosis and Granulomatosis - Diagnosis and Management (Hardcover): Mohammad Hosein K. Motamedi Sarcoidosis and Granulomatosis - Diagnosis and Management (Hardcover)
Mohammad Hosein K. Motamedi
R3,334 Discovery Miles 33 340 Ships in 10 - 15 working days
Microbial Pathogenesis - Infection and Immunity (Hardcover, 2nd ed. 2021): Uday Kishore Microbial Pathogenesis - Infection and Immunity (Hardcover, 2nd ed. 2021)
Uday Kishore
R4,944 Discovery Miles 49 440 Ships in 12 - 19 working days

This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium. There is also a general discussion of the innate and adaptive immune responses against primary and opportunistic infections. The overall purpose of the book is to aid in the development of anti-viral and anti-microbial targets.

Allergic Diseases (Hardcover): Kevin Parker Allergic Diseases (Hardcover)
Kevin Parker
R3,336 R3,020 Discovery Miles 30 200 Save R316 (9%) Ships in 10 - 15 working days
Androgen Action in Prostate Cancer (Hardcover, 2009 ed.): Donald Tindall, James Mohler Androgen Action in Prostate Cancer (Hardcover, 2009 ed.)
Donald Tindall, James Mohler
R4,535 Discovery Miles 45 350 Ships in 10 - 15 working days

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.

Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

Translational Inflammation, Volume 4 (Paperback): Jeffrey Actor, Keri C. Smith Translational Inflammation, Volume 4 (Paperback)
Jeffrey Actor, Keri C. Smith
R3,339 R3,121 Discovery Miles 31 210 Save R218 (7%) Ships in 12 - 19 working days

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology.

Vaccinations (Paperback): Gregory Poland Vaccinations (Paperback)
Gregory Poland
R2,118 Discovery Miles 21 180 Ships in 12 - 19 working days

Get a quick, expert overview of the essentials of today's vaccinations for adults, including current guidelines and recommendations. This concise, clinically-focused resource, edited by Drs. Gregory A. Poland and Jennifer Whitaker, consolidates today's available information on this important topic into one convenient resource, making it an ideal reference for primary care physicians and nurses who need easily accessible information on adult vaccination best practices. Covers essentials of vaccine safety and discussing vaccine hesitancy with patients. Addresses special populations including the elderly, immunocompromised patients, and adult travelers. Provides up-to-date information on zoster vaccines, Zika vaccine prospects, influenza vaccines, meningococcal vaccines, and pneumococcal vaccines.

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